Fmr1nb (FMR1 neighbor) - Rat Genome Database

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Gene: Fmr1nb (FMR1 neighbor) Rattus norvegicus
Analyze
Symbol: Fmr1nb
Name: FMR1 neighbor
RGD ID: 1564059
Description: Predicted to be located in membrane. Orthologous to human FMR1NB (FMR1 neighbor); INTERACTS WITH Monobutylphthalate; 1,2-dichloroethane (ortholog); 5-aza-2'-deoxycytidine (ortholog).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: fragile X mental retardation 1 neighbor; LOC293918; RGD1564059; similar to NYSAR35
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X152,354,238 - 152,377,051 (+)NCBIGRCr8
mRatBN7.2X147,309,613 - 147,332,426 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX147,309,663 - 147,332,418 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX149,513,596 - 149,536,394 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X153,047,935 - 153,070,726 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X150,588,577 - 150,612,124 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X154,631,546 - 154,653,777 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX154,631,547 - 154,653,758 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01150,354,842 - 150,377,036 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X154,833,444 - 154,856,109 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1134,039,225 - 134,062,054 (-)NCBICelera
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Fmr1nb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X152,354,238 - 152,377,051 (+)NCBIGRCr8
mRatBN7.2X147,309,613 - 147,332,426 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX147,309,663 - 147,332,418 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX149,513,596 - 149,536,394 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X153,047,935 - 153,070,726 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X150,588,577 - 150,612,124 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X154,631,546 - 154,653,777 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX154,631,547 - 154,653,758 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01150,354,842 - 150,377,036 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X154,833,444 - 154,856,109 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1134,039,225 - 134,062,054 (-)NCBICelera
Cytogenetic MapXq37NCBI
FMR1NB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X147,981,337 - 148,026,665 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX147,981,337 - 148,026,665 (+)EnsemblGRCh38hg38GRCh38
GRCh37X147,062,857 - 147,108,185 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X146,870,541 - 146,915,877 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X146,768,394 - 146,813,726NCBI
CeleraX147,414,813 - 147,460,151 (+)NCBICelera
Cytogenetic MapXq27.3-q28NCBI
HuRefX136,023,421 - 136,069,563 (+)NCBIHuRef
CHM1_1X146,973,820 - 147,019,238 (+)NCBICHM1_1
T2T-CHM13v2.0X146,246,086 - 146,292,191 (+)NCBIT2T-CHM13v2.0
Fmr1nb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X67,805,460 - 67,848,167 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX67,805,445 - 67,848,173 (+)EnsemblGRCm39 Ensembl
GRCm38X68,761,839 - 68,804,561 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX68,761,839 - 68,804,567 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X66,015,014 - 66,057,736 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X65,022,599 - 65,065,107 (+)NCBIMGSCv36mm8
MGSCv36X51,919,311 - 51,961,819 (+)NCBIMGSCv36mm8
Cytogenetic MapXA7.1NCBI
cM MapX34.86NCBI
Fmr1nb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955498611,443 - 643,011 (+)NCBIChiLan1.0ChiLan1.0
FMR1NB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X147,294,950 - 147,340,669 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X147,298,556 - 147,344,276 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X137,005,935 - 137,051,290 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X147,435,061 - 147,479,581 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX147,434,908 - 147,479,723 (+)Ensemblpanpan1.1panPan2
FMR1NB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X116,308,537 - 116,342,097 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX116,308,616 - 116,340,556 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX102,201,386 - 102,234,950 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X118,367,671 - 118,401,235 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X115,480,558 - 115,514,122 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X117,692,129 - 117,725,690 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X117,418,485 - 117,452,784 (+)NCBIUU_Cfam_GSD_1.0
Fmr1nb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X114,350,225 - 114,385,411 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365131,230,966 - 1,264,362 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FMR1NB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X120,421,266 - 120,458,866 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X137,852,693 - 137,888,912 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FMR1NB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X122,704,558 - 122,749,680 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606560,349,622 - 60,392,592 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fmr1nb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624883703,032 - 756,022 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fmr1nb
27 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 7
Low 11
Below cutoff 2 3 2 1 2 1 2 1 10 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000090728   ⟹   ENSRNOP00000072440
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX147,309,663 - 147,332,418 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116951   ⟹   ENSRNOP00000086485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX147,309,665 - 147,332,417 (+)Ensembl
RefSeq Acc Id: NM_001400936   ⟹   NP_001387865
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X152,354,238 - 152,377,051 (+)NCBI
mRatBN7.2X147,309,613 - 147,332,426 (+)NCBI
RefSeq Acc Id: NM_001400937   ⟹   NP_001387866
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X152,354,238 - 152,377,051 (+)NCBI
mRatBN7.2X147,309,613 - 147,332,426 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001387865 (Get FASTA)   NCBI Sequence Viewer  
  NP_001387866 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072440
  ENSRNOP00000072440.2
  ENSRNOP00000086485
  ENSRNOP00000086485.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000072440   ⟸   ENSRNOT00000090728
RefSeq Acc Id: ENSRNOP00000086485   ⟸   ENSRNOT00000116951
RefSeq Acc Id: NP_001387865   ⟸   NM_001400936
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K2Z5 (UniProtKB/TrEMBL),   A0A8I6A5X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001387866   ⟸   NM_001400937
- Peptide Label: isoform 2
- UniProtKB: A0A8I6A5X6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2Z5-F1-model_v2 AlphaFold A0A0G2K2Z5 1-236 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702035
Promoter ID:EPDNEW_R12557
Type:initiation region
Name:LOC103690293_1
Description:fragile X mental retardation 1 neighbor protein-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X154,653,743 - 154,653,803EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564059 AgrOrtholog
BioCyc Gene G2FUF-739 BioCyc
Ensembl Genes ENSRNOG00000053397 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090728 ENTREZGENE
  ENSRNOT00000090728.2 UniProtKB/TrEMBL
  ENSRNOT00000116951 ENTREZGENE
  ENSRNOT00000116951.1 UniProtKB/TrEMBL
NCBI Gene 293918 ENTREZGENE
PANTHER FRAGILE X MENTAL RETARDATION 1 NEIGHBOR PROTEIN UniProtKB/TrEMBL
  FRAGILE X MENTAL RETARDATION 1 NEIGHBOR PROTEIN UniProtKB/TrEMBL
PhenoGen Fmr1nb PhenoGen
RatGTEx ENSRNOG00000053397 RatGTEx
UniProt A0A0G2K2Z5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A5X6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-31 Fmr1nb  FMR1 neighbor  Fmr1nb  fragile X mental retardation 1 neighbor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Fmr1nb  fragile X mental retardation 1 neighbor   Fmr1nb_predicted  fragile X mental retardation 1 neighbor (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Fmr1nb_predicted  fragile X mental retardation 1 neighbor (predicted)  RGD1564059_predicted  similar to NYSAR35 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1564059_predicted  similar to NYSAR35 (predicted)  LOC293918  similar to NYSAR35  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC293918  similar to NYSAR35      Symbol and Name status set to provisional 70820 PROVISIONAL