Fahd2a (fumarylacetoacetate hydrolase domain containing 2A) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Fahd2a (fumarylacetoacetate hydrolase domain containing 2A) Rattus norvegicus
Analyze
Symbol: Fahd2a
Name: fumarylacetoacetate hydrolase domain containing 2A
RGD ID: 1563674
Description: Predicted to enable oxaloacetate tautomerase activity. Predicted to be involved in oxaloacetate metabolic process. Predicted to be located in mitochondrion. Orthologous to several human genes including FAHD2A (fumarylacetoacetate hydrolase domain containing 2A); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fahd2; fumarylacetoacetate hydrolase domain-containing protein 2; fumarylacetoacetate hydrolase domain-containing protein 2A; LOC296131; oxaloacetate tautomerase Fahd2a, mitochondrial; RGD1563674; similar to RIKEN cDNA B430104H02
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,110,480 - 135,118,653 (-)NCBIGRCr8
GRCr8 Ensembl3135,109,482 - 135,118,853 (-)EnsemblGRCr8 Ensembl
mRatBN7.23114,657,176 - 114,665,349 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,655,865 - 114,665,356 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,546,518 - 118,554,707 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,142,077 - 127,150,266 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,802,450 - 124,810,639 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03120,003,215 - 120,011,392 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3120,002,364 - 120,011,364 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03127,321,203 - 127,329,383 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,939,359 - 114,947,515 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3113,495,646 - 113,503,802 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:18614015  


Genomics

Comparative Map Data
Fahd2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,110,480 - 135,118,653 (-)NCBIGRCr8
GRCr8 Ensembl3135,109,482 - 135,118,853 (-)EnsemblGRCr8 Ensembl
mRatBN7.23114,657,176 - 114,665,349 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,655,865 - 114,665,356 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,546,518 - 118,554,707 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,142,077 - 127,150,266 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,802,450 - 124,810,639 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03120,003,215 - 120,011,392 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3120,002,364 - 120,011,364 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03127,321,203 - 127,329,383 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,939,359 - 114,947,515 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3113,495,646 - 113,503,802 (-)NCBICelera
Cytogenetic Map3q36NCBI
FAHD2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38295,402,708 - 95,421,656 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl295,402,708 - 95,416,616 (+)EnsemblGRCh38hg38GRCh38
GRCh37296,068,456 - 96,082,364 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36295,432,175 - 95,442,606 (+)NCBINCBI36Build 36hg18NCBI36
Build 34295,490,321 - 95,500,753NCBI
Celera290,421,569 - 90,432,000 (+)NCBICelera
Cytogenetic Map2q11.1NCBI
HuRef290,095,394 - 90,105,821 (+)NCBIHuRef
CHM1_1296,072,763 - 96,083,194 (+)NCBICHM1_1
T2T-CHM13v2.0295,909,154 - 95,928,138 (+)NCBIT2T-CHM13v2.0
Fahd2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,278,135 - 127,286,491 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,278,135 - 127,286,485 (-)EnsemblGRCm39 Ensembl
GRCm382127,436,215 - 127,444,571 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,436,215 - 127,444,565 (-)EnsemblGRCm38mm10GRCm38
MGSCv372127,261,951 - 127,270,301 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362127,127,656 - 127,135,946 (-)NCBIMGSCv36mm8
Celera2128,678,251 - 128,686,589 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.01NCBI
Fahd2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554703,624,462 - 3,632,949 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554703,624,462 - 3,632,949 (+)NCBIChiLan1.0ChiLan1.0
FAHD2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21231,218,794 - 31,235,535 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A31,221,556 - 31,238,319 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A102,185,923 - 102,197,189 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Fahd2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,923,012 - 82,930,693 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936744175,882 - 183,675 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936744175,948 - 183,631 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAHD2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1355,147,373 - 55,171,302 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103241057
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114437,719 - 446,738 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl14437,662 - 446,552 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023667445552 - 1,309 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fahd2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247492,138,410 - 2,152,673 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247492,138,188 - 2,152,673 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fahd2a
33 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:78
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000018922
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
RH142366  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83135,110,618 - 135,111,031 (+)Marker Load Pipeline
mRatBN7.23114,657,314 - 114,657,727 (+)MAPPERmRatBN7.2
Rnor_6.03120,003,354 - 120,003,766NCBIRnor6.0
Rnor_5.03127,328,832 - 127,329,244UniSTSRnor5.0
RGSC_v3.43114,939,495 - 114,939,907UniSTSRGSC3.4
Celera3113,495,782 - 113,496,194UniSTS
RH 3.4 Map3997.3UniSTS
Cytogenetic Map3q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000018922   ⟹   ENSRNOP00000018922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3135,109,482 - 135,118,853 (-)Ensembl
mRatBN7.2 Ensembl3114,656,065 - 114,665,356 (-)Ensembl
Rnor_6.0 Ensembl3120,002,364 - 120,011,364 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094091   ⟹   ENSRNOP00000085254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3135,110,164 - 135,118,853 (-)Ensembl
mRatBN7.2 Ensembl3114,655,865 - 114,665,356 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109233   ⟹   ENSRNOP00000079379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3135,110,480 - 135,118,853 (-)Ensembl
mRatBN7.2 Ensembl3114,657,176 - 114,665,356 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116219   ⟹   ENSRNOP00000080668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3114,658,175 - 114,665,343 (-)Ensembl
RefSeq Acc Id: NM_001134834   ⟹   NP_001128306
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83135,110,480 - 135,118,653 (-)NCBI
mRatBN7.23114,657,176 - 114,665,349 (-)NCBI
Rnor_6.03120,003,218 - 120,011,374 (-)NCBI
Rnor_5.03127,321,203 - 127,329,383 (+)NCBI
RGSC_v3.43114,939,359 - 114,947,515 (-)RGD
Celera3113,495,646 - 113,503,802 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001128306 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66933 (Get FASTA)   NCBI Sequence Viewer  
  B2RYW9 (Get FASTA)   NCBI Sequence Viewer  
  EDL80117 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000079379
RefSeq Acc Id: NP_001128306   ⟸   NM_001134834
- UniProtKB: B2RYW9 (UniProtKB/Swiss-Prot),   A6HQ16 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018922   ⟸   ENSRNOT00000018922
Ensembl Acc Id: ENSRNOP00000079379   ⟸   ENSRNOT00000109233
Ensembl Acc Id: ENSRNOP00000080668   ⟸   ENSRNOT00000116219
Ensembl Acc Id: ENSRNOP00000085254   ⟸   ENSRNOT00000094091
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYW9-F1-model_v2 AlphaFold B2RYW9 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692405
Promoter ID:EPDNEW_R2930
Type:multiple initiation site
Name:Fahd2a_1
Description:fumarylacetoacetate hydrolase domain containing 2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03120,011,362 - 120,011,422EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563674 AgrOrtholog
BioCyc Gene G2FUF-47991 BioCyc
BioCyc Pathway TYRFUMCAT-PWY [L-tyrosine degradation I] BioCyc
BioCyc Pathway Image TYRFUMCAT-PWY BioCyc
Ensembl Genes ENSRNOG00000013974 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000109233 ENTREZGENE
Gene3D-CATH 3.90.850.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6921785 IMAGE-MGC_LOAD
InterPro FAH UniProtKB/Swiss-Prot
  Fumarylacetoacetase-like_C UniProtKB/Swiss-Prot
  Fumarylacetoacetase_C_sf UniProtKB/Swiss-Prot
KEGG Report rno:296131 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188927 IMAGE-MGC_LOAD
NCBI Gene 296131 ENTREZGENE
PANTHER FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A UniProtKB/Swiss-Prot
  FUMARYLACETOACETATE HYDROLASE DOMAIN-CONTAINING PROTEIN 2A-RELATED UniProtKB/Swiss-Prot
Pfam FAA_hydrolase UniProtKB/Swiss-Prot
PhenoGen Fahd2a PhenoGen
RatGTEx ENSRNOG00000013974 RatGTEx
Superfamily-SCOP SSF56529 UniProtKB/Swiss-Prot
UniProt A0A8I5ZMZ1_RAT UniProtKB/TrEMBL
  A0A8I5ZQK0_RAT UniProtKB/TrEMBL
  A0A8I5ZZS1_RAT UniProtKB/TrEMBL
  A0A8L2Q9F8_RAT UniProtKB/TrEMBL
  A6HQ16 ENTREZGENE, UniProtKB/TrEMBL
  B2RYW9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Fahd2a  fumarylacetoacetate hydrolase domain containing 2A   Fahd2a_predicted  fumarylacetoacetate hydrolase domain containing 2A (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Fahd2a_predicted  fumarylacetoacetate hydrolase domain containing 2A (predicted)  RGD1563674_predicted  similar to RIKEN cDNA B430104H02 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1563674_predicted  similar to RIKEN cDNA B430104H02 (predicted)  LOC296131  similar to RIKEN cDNA B430104H02  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC296131  similar to RIKEN cDNA B430104H02      Symbol and Name status set to provisional 70820 PROVISIONAL