Tstd3 (thiosulfate sulfurtransferase like domain containing 3) - Rat Genome Database

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Gene: Tstd3 (thiosulfate sulfurtransferase like domain containing 3) Rattus norvegicus
Analyze
Symbol: Tstd3
Name: thiosulfate sulfurtransferase like domain containing 3
RGD ID: 1563572
Description: Orthologous to human TSTD3 (thiosulfate sulfurtransferase like domain containing 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC500420; LOC500420; similar to CG12279-PA; thiosulfate sulfurtransferase (rhodanese)-like domain containing 3; thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3; uncharacterized protein LOC500420
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8540,091,438 - 40,101,509 (-)NCBIGRCr8
mRatBN7.2535,294,652 - 35,304,093 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl535,294,645 - 35,304,101 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx537,418,966 - 37,428,457 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0539,011,711 - 39,021,186 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0538,951,221 - 38,960,694 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0535,892,783 - 35,902,243 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl535,892,737 - 35,902,262 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0540,549,081 - 40,558,549 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4536,493,245 - 36,502,679 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera534,311,972 - 34,320,649 (-)NCBICelera
Cytogenetic Map5q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data
Tstd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8540,091,438 - 40,101,509 (-)NCBIGRCr8
mRatBN7.2535,294,652 - 35,304,093 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl535,294,645 - 35,304,101 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx537,418,966 - 37,428,457 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0539,011,711 - 39,021,186 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0538,951,221 - 38,960,694 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0535,892,783 - 35,902,243 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl535,892,737 - 35,902,262 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0540,549,081 - 40,558,549 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4536,493,245 - 36,502,679 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera534,311,972 - 34,320,649 (-)NCBICelera
Cytogenetic Map5q21NCBI
TSTD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38699,521,049 - 99,587,775 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl699,520,976 - 99,589,899 (+)EnsemblGRCh38hg38GRCh38
GRCh37699,968,925 - 99,981,061 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366100,075,591 - 100,087,784 (+)NCBINCBI36Build 36hg18NCBI36
Celera6100,618,093 - 100,623,927 (+)NCBICelera
Cytogenetic Map6q16.2NCBI
HuRef697,409,239 - 97,421,428 (+)NCBIHuRef
CHM1_16100,231,848 - 100,244,022 (+)NCBICHM1_1
T2T-CHM13v2.06100,695,384 - 100,761,219 (+)NCBIT2T-CHM13v2.0
Tstd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39421,757,382 - 21,767,211 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl421,757,382 - 21,767,212 (-)EnsemblGRCm39 Ensembl
GRCm38421,757,382 - 21,767,211 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl421,757,382 - 21,767,212 (-)EnsemblGRCm38mm10GRCm38
MGSCv37421,684,529 - 21,694,358 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36421,683,986 - 21,703,739 (-)NCBIMGSCv36mm8
Celera421,502,393 - 21,512,223 (-)NCBICelera
Cytogenetic Map4A3NCBI
cM Map48.91NCBI
Tstd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541125,392,449 - 25,403,237 (+)NCBIChiLan1.0ChiLan1.0
TSTD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25119,563,788 - 119,633,326 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16117,448,432 - 117,512,599 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0697,361,666 - 97,426,467 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16101,244,302 - 101,307,789 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6101,249,439 - 101,278,532 (+)Ensemblpanpan1.1panPan2
TSTD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11257,718,754 - 57,732,075 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1257,718,821 - 57,731,014 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1257,475,801 - 57,489,902 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01258,540,339 - 58,554,457 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11257,896,824 - 57,910,923 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01257,743,563 - 57,757,828 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01257,989,361 - 58,002,710 (+)NCBIUU_Cfam_GSD_1.0
Tstd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511890,016,573 - 90,016,837 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364789,228,258 - 9,229,545 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSTD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1166,459,042 - 66,467,856 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2175,135,765 - 75,141,389 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TSTD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11374,303,207 - 74,362,551 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604046,634,587 - 46,695,257 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tstd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248105,487,669 - 5,498,787 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tstd3
39 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:109
Interacting mature miRNAs:133
Transcripts:ENSRNOT00000030559
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)52483871044045280Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat

Markers in Region
AU015084  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2535,320,665 - 35,320,777 (+)MAPPERmRatBN7.2
Rnor_6.0535,918,816 - 35,918,927NCBIRnor6.0
Rnor_5.0540,575,342 - 40,575,453UniSTSRnor5.0
RGSC_v3.4536,519,201 - 36,519,312UniSTSRGSC3.4
Celera534,337,357 - 34,337,468UniSTS
Cytogenetic Map5q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000030559   ⟹   ENSRNOP00000029537
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl535,294,645 - 35,304,090 (-)Ensembl
Rnor_6.0 Ensembl535,892,737 - 35,902,262 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108025   ⟹   ENSRNOP00000091302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl535,294,645 - 35,304,101 (-)Ensembl
RefSeq Acc Id: NM_001100797   ⟹   NP_001094267
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8540,091,438 - 40,100,878 (-)NCBI
mRatBN7.2535,294,652 - 35,304,093 (-)NCBI
RefSeq Acc Id: XM_063288207   ⟹   XP_063144277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8540,091,438 - 40,101,509 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001094267 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144277 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI04710 (Get FASTA)   NCBI Sequence Viewer  
  EDL98516 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029537.3
  ENSRNOP00000091302.1
Ensembl Acc Id: ENSRNOP00000029537   ⟸   ENSRNOT00000030559
Ensembl Acc Id: ENSRNOP00000091302   ⟸   ENSRNOT00000108025
RefSeq Acc Id: NP_001094267   ⟸   NM_001100797
- UniProtKB: G3V8W9 (UniProtKB/TrEMBL),   Q3SWT2 (UniProtKB/TrEMBL),   A6IIE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144277   ⟸   XM_063288207
- Peptide Label: isoform X1
- UniProtKB: Q3SWT2 (UniProtKB/TrEMBL),   A6IIE6 (UniProtKB/TrEMBL),   G3V8W9 (UniProtKB/TrEMBL)
Protein Domains
Rhodanese

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V8W9-F1-model_v2 AlphaFold G3V8W9 1-157 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693606
Promoter ID:EPDNEW_R4120
Type:multiple initiation site
Name:Tstd3_1
Description:thiosulfate sulfurtransferase -like domain containing 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0535,902,151 - 35,902,211EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563572 AgrOrtholog
BioCyc Gene G2FUF-41815 BioCyc
BioCyc Pathway PWY-5350 [thiosulfate disproportionation IV (rhodanese)] BioCyc
  PWY-7927 [sulfide oxidation IV (mitochondria)] BioCyc
BioCyc Pathway Image PWY-5350 BioCyc
  PWY-7927 BioCyc
Ensembl Genes ENSRNOG00000028185 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030559.6 UniProtKB/TrEMBL
  ENSRNOT00000108025.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.250.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7318105 IMAGE-MGC_LOAD
InterPro Rhodanese-like UniProtKB/TrEMBL
  Rhodanese-like_dom_sf UniProtKB/TrEMBL
MGC_CLONE MGC:125160 IMAGE-MGC_LOAD
NCBI Gene 500420 ENTREZGENE
PANTHER THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED UniProtKB/TrEMBL
  THIOSULFATE SULFURTRANSFERASE/RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3 UniProtKB/TrEMBL
Pfam Rhodanese UniProtKB/TrEMBL
PhenoGen Tstd3 PhenoGen
PROSITE RHODANESE_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028185 RatGTEx
SMART RHOD UniProtKB/TrEMBL
Superfamily-SCOP Rhodanese-like UniProtKB/TrEMBL
UniProt A0A8I6GJH7_RAT UniProtKB/TrEMBL
  A6IIE6 ENTREZGENE, UniProtKB/TrEMBL
  G3V8W9 ENTREZGENE, UniProtKB/TrEMBL
  Q3SWT2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-07-20 Tstd3  thiosulfate sulfurtransferase like domain containing 3  Tstd3  thiosulfate sulfurtransferase (rhodanese)-like domain containing 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-09-18 Tstd3  thiosulfate sulfurtransferase (rhodanese)-like domain containing 3  LOC500420  similar to CG12279-PA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC500420  similar to CG12279-PA      Symbol and Name status set to provisional 70820 PROVISIONAL