Ophn1 (oligophrenin 1) - Rat Genome Database

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Pathways
Gene: Ophn1 (oligophrenin 1) Rattus norvegicus
Analyze
Symbol: Ophn1
Name: oligophrenin 1
RGD ID: 1563435
Description: Enables ionotropic glutamate receptor binding activity. Involved in maintenance of postsynaptic specialization structure and regulation of synaptic vesicle endocytosis. Is active in glutamatergic synapse and presynapse. Human ortholog(s) of this gene implicated in X-linked mental retardation with cerebellar hypoplasia and distinctive facial appearance. Orthologous to human OPHN1 (oligophrenin 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC688676; LOC688676; Oligophrenin-1; Opn1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X63,599,746 - 63,976,678 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX63,603,042 - 63,976,633 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX65,088,787 - 65,460,138 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X68,589,342 - 68,960,693 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X66,150,102 - 66,521,448 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X68,185,865 - 68,579,518 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX68,189,161 - 68,563,137 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X69,060,378 - 69,453,851 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X86,519,900 - 86,801,421 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX64,002,740 - 64,359,348 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cytoskeleton  (IBA,ISO)
cytoplasm  (IBA,IEA,ISO)
dendrite  (IEA,ISO)
dendritic spine  (IBA,ISO)
glutamatergic synapse  (EXP,IDA,IMP,ISO)
postsynapse  (IEA)
presynapse  (IDA,IEA,ISO)
synapse  (ISO)
terminal bouton  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Novel intragenic deletion in OPHN1 in a family causing XLMR with cerebellar hypoplasia and distinctive facial appearance. Al-Owain M, etal., Clin Genet. 2011 Apr;79(4):363-70. doi: 10.1111/j.1399-0004.2010.01462.x.
2. Oligophrenin 1 (OPHN1) gene mutation causes syndromic X-linked mental retardation with epilepsy, rostral ventricular enlargement and cerebellar hypoplasia. Bergmann C, etal., Brain. 2003 Jul;126(Pt 7):1537-44. Epub 2003 May 21.
3. Delineation of the clinical phenotype associated with OPHN1 mutations based on the clinical and neuropsychological evaluation of three families. Chabrol B, etal., Am J Med Genet A. 2005 Nov 1;138(4):314-7.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis. Govek EE, etal., Nat Neurosci. 2004 Apr;7(4):364-72. Epub 2004 Mar 14.
6. Deletion of the OPHN1 gene detected by aCGH. Madrigal I, etal., J Intellect Disabil Res. 2008 Mar;52(Pt 3):190-4. doi: 10.1111/j.1365-2788.2007.00997.x.
7. The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors. Nadif Kasri N, etal., Genes Dev. 2009 Jun 1;23(11):1289-302.
8. The Rho-linked mental retardation protein OPHN1 controls synaptic vesicle endocytosis via endophilin A1. Nakano-Kobayashi A, etal., Curr Biol. 2009 Jul 14;19(13):1133-9. doi: 10.1016/j.cub.2009.05.022. Epub 2009 May 28.
9. The X-linked mental retardation protein OPHN1 interacts with Homer1b/c to control spine endocytic zone positioning and expression of synaptic potentiation. Nakano-Kobayashi A, etal., J Neurosci. 2014 Jun 25;34(26):8665-71. doi: 10.1523/JNEUROSCI.0894-14.2014.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Mutations in the oligophrenin-1 gene (OPHN1) cause X linked congenital cerebellar hypoplasia. Philip N, etal., J Med Genet. 2003 Jun;40(6):441-6.
12. Insertion of 16 amino acids in the BAR domain of the oligophrenin 1 protein causes mental retardation and cerebellar hypoplasia in an Italian family. Pirozzi F, etal., Hum Mutat. 2011 Nov;32(11):E2294-307. doi: 10.1002/humu.21567. Epub 2011 Sep 14.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. A novel in-frame deletion affecting the BAR domain of OPHN1 in a family with intellectual disability and hippocampal alterations. Santos-Rebou├žas CB, etal., Eur J Hum Genet. 2014 May;22(5):644-51. doi: 10.1038/ejhg.2013.216. Epub 2013 Oct 9.
17. A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbalpha. Valnegri P, etal., Nat Neurosci. 2011 Aug 28;14(10):1293-301. doi: 10.1038/nn.2911.
Additional References at PubMed
PMID:12932438   PMID:15026118   PMID:18954304   PMID:22891260   PMID:27160703   PMID:35871097  


Genomics

Comparative Map Data
Ophn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X63,599,746 - 63,976,678 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX63,603,042 - 63,976,633 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX65,088,787 - 65,460,138 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X68,589,342 - 68,960,693 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X66,150,102 - 66,521,448 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X68,185,865 - 68,579,518 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX68,189,161 - 68,563,137 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X69,060,378 - 69,453,851 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X86,519,900 - 86,801,421 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX64,002,740 - 64,359,348 (-)NCBICelera
Cytogenetic MapXq22NCBI
OPHN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X68,042,344 - 68,433,841 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX67,949,349 - 68,433,913 (-)EnsemblGRCh38hg38GRCh38
GRCh37X67,262,186 - 67,653,337 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X67,179,440 - 67,570,372 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X67,045,735 - 67,436,668NCBI
CeleraX67,613,664 - 68,004,666 (-)NCBICelera
Cytogenetic MapXq12NCBI
HuRefX61,092,466 - 61,481,527 (-)NCBIHuRef
CHM1_1X67,154,622 - 67,546,029 (-)NCBICHM1_1
T2T-CHM13v2.0X66,475,136 - 66,867,394 (-)NCBIT2T-CHM13v2.0
Ophn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X97,597,886 - 97,934,691 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX97,597,883 - 97,934,631 (-)EnsemblGRCm39 Ensembl
GRCm38X98,554,280 - 98,891,082 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX98,554,277 - 98,891,025 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X95,752,854 - 96,086,324 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X94,760,234 - 95,093,704 (-)NCBIMGSCv36mm8
CeleraX85,501,536 - 85,832,824 (-)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX42.94NCBI
Ophn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554757,581,675 - 8,018,139 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554757,576,629 - 8,019,132 (-)NCBIChiLan1.0ChiLan1.0
OPHN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1X67,701,635 - 68,086,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X57,288,297 - 57,674,685 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X67,354,364 - 67,740,003 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX67,359,364 - 67,739,114 (-)Ensemblpanpan1.1panPan2
OPHN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X52,418,390 - 52,983,155 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX52,455,373 - 52,982,244 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX43,271,709 - 43,797,820 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X53,420,053 - 53,943,003 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX53,423,094 - 53,942,104 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X51,391,501 - 51,917,738 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X52,722,901 - 53,243,080 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X52,643,831 - 53,170,125 (-)NCBIUU_Cfam_GSD_1.0
Ophn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X49,111,728 - 49,477,619 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366356,923 - 244,408 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366356,966 - 243,209 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPHN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX54,055,092 - 54,616,959 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X54,056,504 - 54,617,045 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X60,818,920 - 61,106,085 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OPHN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X57,906,868 - 58,291,358 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX57,911,555 - 58,290,900 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660835,360,305 - 5,607,870 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ophn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248911,908,044 - 2,425,144 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248911,907,233 - 2,429,714 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ophn1
1287 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:302
Count of miRNA genes:193
Interacting mature miRNAs:221
Transcripts:ENSRNOT00000034772
Prediction methods:Microtar, Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
70221Bp56Blood pressure QTL 564.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X5704214165612192Rat

Markers in Region
DXRat31  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X63,958,410 - 63,958,542 (+)MAPPERmRatBN7.2
Rnor_6.0X68,544,586 - 68,544,715NCBIRnor6.0
Rnor_5.0X69,418,921 - 69,419,050UniSTSRnor5.0
RGSC_v3.4X86,886,522 - 86,886,652RGDRGSC3.4
RGSC_v3.4X86,886,523 - 86,886,652UniSTSRGSC3.4
RGSC_v3.1X86,959,573 - 86,960,070RGD
CeleraX64,342,523 - 64,342,652UniSTS
RH 2.0 Map2115.6RGD
FHH x ACI MapX23.52RGD
Cytogenetic MapXq31UniSTS
PMC169877P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X63,886,820 - 63,887,358 (+)MAPPERmRatBN7.2
mRatBN7.2323,603,189 - 23,603,720 (+)MAPPERmRatBN7.2
Rnor_6.0324,171,597 - 24,172,127NCBIRnor6.0
Rnor_6.0X68,471,397 - 68,471,934NCBIRnor6.0
Rnor_5.0329,388,989 - 29,389,519UniSTSRnor5.0
Rnor_5.0X69,346,132 - 69,346,669UniSTSRnor5.0
RGSC_v3.4X86,814,796 - 86,815,333UniSTSRGSC3.4
RGSC_v3.4319,691,805 - 19,692,335UniSTSRGSC3.4
Celera322,015,742 - 22,016,272UniSTS
CeleraX64,275,723 - 64,276,260UniSTS
Cytogenetic Map3q22UniSTS
Cytogenetic MapXq31UniSTS
BE106637  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X63,603,196 - 63,603,360 (+)MAPPERmRatBN7.2
Rnor_6.0X68,189,316 - 68,189,479NCBIRnor6.0
Rnor_5.0X69,063,829 - 69,063,992UniSTSRnor5.0
RGSC_v3.4X86,520,055 - 86,520,218UniSTSRGSC3.4
CeleraX64,002,895 - 64,003,058UniSTS
Cytogenetic MapXq31UniSTS
AA998661  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X63,610,306 - 63,610,423 (+)MAPPERmRatBN7.2
Rnor_6.0X68,196,426 - 68,196,542NCBIRnor6.0
Rnor_5.0X69,070,939 - 69,071,055UniSTSRnor5.0
RGSC_v3.4X86,527,165 - 86,527,281UniSTSRGSC3.4
CeleraX64,010,005 - 64,010,121UniSTS
Cytogenetic MapXq31UniSTS
PMC305603P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X63,885,649 - 63,885,862 (+)MAPPERmRatBN7.2
mRatBN7.2357,847,231 - 57,847,443 (+)MAPPERmRatBN7.2
Rnor_6.0359,679,764 - 59,679,975NCBIRnor6.0
Rnor_6.0X68,470,226 - 68,470,438NCBIRnor6.0
Rnor_5.0366,153,408 - 66,153,619UniSTSRnor5.0
Rnor_5.0X69,344,961 - 69,345,173UniSTSRnor5.0
RGSC_v3.4X86,813,625 - 86,813,837UniSTSRGSC3.4
RGSC_v3.4355,476,205 - 55,476,416UniSTSRGSC3.4
Celera357,386,085 - 57,386,296UniSTS
CeleraX64,274,552 - 64,274,764UniSTS
Cytogenetic Map3q22UniSTS
Cytogenetic MapXq31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 38 3 2 1 1 68 13 22 11 1
Low 3 5 52 39 17 39 7 10 6 22 19 7
Below cutoff 2 2 2

Sequence


RefSeq Acc Id: ENSRNOT00000034772   ⟹   ENSRNOP00000035867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX63,603,042 - 63,976,633 (-)Ensembl
Rnor_6.0 EnsemblX68,189,161 - 68,563,137 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076193   ⟹   ENSRNOP00000068017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX63,603,128 - 63,975,868 (-)Ensembl
Rnor_6.0 EnsemblX68,189,195 - 68,562,873 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX68,347,515 - 68,355,247 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076720   ⟹   ENSRNOP00000067984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX68,561,685 - 68,562,301 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000106069   ⟹   ENSRNOP00000096923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX63,609,699 - 63,976,633 (-)Ensembl
RefSeq Acc Id: NM_001107848   ⟹   NP_001101318
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X63,603,042 - 63,976,633 (-)NCBI
Rnor_6.0X68,189,161 - 68,563,137 (-)NCBI
Rnor_5.0X69,060,378 - 69,453,851 (-)NCBI
RGSC_v3.4X86,519,900 - 86,801,421 (-)RGD
CeleraX64,002,740 - 64,359,348 (-)RGD
Sequence:
RefSeq Acc Id: XM_006257072   ⟹   XP_006257134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X63,603,076 - 63,976,678 (-)NCBI
Rnor_6.0X68,185,865 - 68,563,373 (-)NCBI
Rnor_5.0X69,060,378 - 69,453,851 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099689   ⟹   XP_038955617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X63,599,746 - 63,771,763 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101318 (Get FASTA)   NCBI Sequence Viewer  
  XP_006257134 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955617 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95953 (Get FASTA)   NCBI Sequence Viewer  
  EDL95954 (Get FASTA)   NCBI Sequence Viewer  
  P0CAX5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001101318   ⟸   NM_001107848
- UniProtKB: P0CAX5 (UniProtKB/Swiss-Prot),   A6IQ59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257134   ⟸   XM_006257072
- Peptide Label: isoform X1
- UniProtKB: P0CAX5 (UniProtKB/Swiss-Prot),   A6IQ59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000035867   ⟸   ENSRNOT00000034772
RefSeq Acc Id: ENSRNOP00000068017   ⟸   ENSRNOT00000076193
RefSeq Acc Id: ENSRNOP00000067984   ⟸   ENSRNOT00000076720
RefSeq Acc Id: XP_038955617   ⟸   XM_039099689
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000096923   ⟸   ENSRNOT00000106069
Protein Domains
PH   Rho-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0CAX5-F1-model_v2 AlphaFold P0CAX5 1-802 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563435 AgrOrtholog
BioCyc Gene G2FUF-2165 BioCyc
Ensembl Genes ENSRNOG00000026573 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000035867 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000068017.2 UniProtKB/TrEMBL
  ENSRNOP00000096923.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034772 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000076193.2 UniProtKB/TrEMBL
  ENSRNOT00000106069.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GRAF_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OPHN1_BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_GRAF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:312108 UniProtKB/Swiss-Prot
NCBI Gene 312108 ENTREZGENE
PANTHER OLIGOPHRENIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OLIGOPHRENIN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BAR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ophn1 PhenoGen
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AVR8_RAT UniProtKB/TrEMBL
  A0A8L2UPA7_RAT UniProtKB/TrEMBL
  A6IQ59 ENTREZGENE, UniProtKB/TrEMBL
  OPHN1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Ophn1  oligophrenin 1  LOC688676  hypothetical protein LOC688676  Data Merged 737654 PROVISIONAL
2008-04-30 Ophn1  oligophrenin 1   Ophn1_predicted  oligophrenin 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-19 LOC688676  hypothetical protein LOC688676      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 Ophn1_predicted  oligophrenin 1 (predicted)  Ophn1  oligophrenin 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Ophn1  oligophrenin 1      Symbol and Name status set to provisional 70820 PROVISIONAL