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Gene: Isca2 (iron-sulfur cluster assembly 2) Rattus norvegicus
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Symbol: Isca2
Name: iron-sulfur cluster assembly 2
RGD ID: 1563216
Description: Predicted to have 2 iron, 2 sulfur cluster binding activity; 4 iron, 4 sulfur cluster binding activity; and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by [4Fe-4S] cluster transfer. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 4. Orthologous to human ISCA2 (iron-sulfur cluster assembly 2); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,6-dinitrotoluene; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Hbld1; HESB like domain containing 1; hypothetical protein LOC500694; iron-sulfur cluster assembly 2 homolog; iron-sulfur cluster assembly 2 homolog (S. cerevisiae); iron-sulfur cluster assembly 2 homolog, mitochondrial; LOC500694; RGD1563216; similar to HESB like domain containing 1; uncharacterized protein LOC500694
Orthologs:
Homo sapiens (human) : ISCA2 (iron-sulfur cluster assembly 2)  HGNC  Alliance
Mus musculus (house mouse) : Isca2 (iron-sulfur cluster assembly 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Isca2 (iron-sulfur cluster assembly 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ISCA2 (iron-sulfur cluster assembly 2)
Canis lupus familiaris (dog) : ISCA2 (iron-sulfur cluster assembly 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Isca2 (iron-sulfur cluster assembly 2)
Sus scrofa (pig) : ISCA2 (iron-sulfur cluster assembly 2)
Chlorocebus sabaeus (African green monkey) : ISCA2 (iron-sulfur cluster assembly 2)
Heterocephalus glaber (naked mole-rat) : Isca2 (iron-sulfur cluster assembly 2)
more info ...
Related Pseudogenes: Isca2-ps1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06108,488,678 - 108,490,188 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,488,678 - 108,490,188 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06117,059,002 - 117,060,512 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,815,061 - 108,816,650 (+)NCBIRGSC3.4rn4RGSC3.4
Celera6102,243,383 - 102,244,893 (+)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Isca2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1563216
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.