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Gene: Isca2 (iron-sulfur cluster assembly 2) Rattus norvegicus
Symbol: Isca2
Name: iron-sulfur cluster assembly 2
RGD ID: 1563216
Description: Predicted to have 2 iron, 2 sulfur cluster binding activity; 4 iron, 4 sulfur cluster binding activity; and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by [4Fe-4S] cluster transfer. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 4. Orthologous to human ISCA2 (iron-sulfur cluster assembly 2); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,6-dinitrotoluene; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Hbld1; HESB like domain containing 1; hypothetical protein LOC500694; iron-sulfur cluster assembly 2 homolog; iron-sulfur cluster assembly 2 homolog (S. cerevisiae); iron-sulfur cluster assembly 2 homolog, mitochondrial; LOC500694; RGD1563216; similar to HESB like domain containing 1; uncharacterized protein LOC500694
Homo sapiens (human) : ISCA2 (iron-sulfur cluster assembly 2)  HGNC  Alliance
Mus musculus (house mouse) : Isca2 (iron-sulfur cluster assembly 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Isca2 (iron-sulfur cluster assembly 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ISCA2 (iron-sulfur cluster assembly 2)
Canis lupus familiaris (dog) : ISCA2 (iron-sulfur cluster assembly 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Isca2 (iron-sulfur cluster assembly 2)
Sus scrofa (pig) : ISCA2 (iron-sulfur cluster assembly 2)
Chlorocebus sabaeus (African green monkey) : ISCA2 (iron-sulfur cluster assembly 2)
Heterocephalus glaber (naked mole-rat) : Isca2 (iron-sulfur cluster assembly 2)
more info ...
Related Pseudogenes: Isca2-ps1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.06108,488,678 - 108,490,188 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,488,678 - 108,490,188 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06117,059,002 - 117,060,512 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,815,061 - 108,816,650 (+)NCBIRGSC3.4rn4RGSC3.4
Celera6102,243,383 - 102,244,893 (+)NCBICelera
Cytogenetic Map6q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Isca2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1563216
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.