Zfhx4 (zinc finger homeobox 4) - Rat Genome Database

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Gene: Zfhx4 (zinc finger homeobox 4) Rattus norvegicus
Analyze
Symbol: Zfhx4
Name: zinc finger homeobox 4
RGD ID: 1563022
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZFHX4 (zinc finger homeobox 4); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC310250; RGD1563022; similar to zinc-finger homeodomain protein 4; zinc finger homeobox protein 4; zinc finger homeodomain 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8298,131,996 - 98,321,070 (-)NCBIGRCr8
mRatBN7.2296,224,763 - 96,408,245 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl296,224,767 - 96,408,228 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2102,769,126 - 102,952,321 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02100,890,220 - 101,073,413 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0295,941,374 - 96,124,613 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0298,423,565 - 98,610,368 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl298,423,569 - 98,610,368 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02118,157,856 - 118,345,227 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4298,549,509 - 98,734,901 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera291,739,962 - 91,923,160 (-)NCBICelera
Cytogenetic Map2q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
cisplatin  (ISO)
clobetasol  (ISO)
crotonaldehyde  (ISO)
Cuprizon  (EXP)
cytarabine  (ISO)
dexamethasone  (ISO)
dichloromethane  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
geldanamycin  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
ketamine  (EXP)
melphalan  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:24440720  


Genomics

Comparative Map Data
Zfhx4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8298,131,996 - 98,321,070 (-)NCBIGRCr8
mRatBN7.2296,224,763 - 96,408,245 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl296,224,767 - 96,408,228 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2102,769,126 - 102,952,321 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02100,890,220 - 101,073,413 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0295,941,374 - 96,124,613 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0298,423,565 - 98,610,368 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl298,423,569 - 98,610,368 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02118,157,856 - 118,345,227 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4298,549,509 - 98,734,901 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera291,739,962 - 91,923,160 (-)NCBICelera
Cytogenetic Map2q23NCBI
ZFHX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38876,681,247 - 76,867,281 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl876,681,239 - 76,867,281 (+)EnsemblGRCh38hg38GRCh38
GRCh37877,593,482 - 77,779,517 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36877,756,070 - 77,942,076 (+)NCBINCBI36Build 36hg18NCBI36
Build 34877,778,834 - 77,940,711NCBI
Celera873,586,882 - 73,772,899 (+)NCBICelera
Cytogenetic Map8q21.13NCBI
HuRef873,079,827 - 73,265,620 (+)NCBIHuRef
CHM1_1877,645,108 - 77,831,116 (+)NCBICHM1_1
T2T-CHM13v2.0877,110,392 - 77,296,418 (+)NCBIT2T-CHM13v2.0
Zfhx4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3935,276,268 - 5,480,921 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl35,283,586 - 5,480,917 (+)EnsemblGRCm39 Ensembl
GRCm3835,218,218 - 5,415,861 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl35,218,526 - 5,415,857 (+)EnsemblGRCm38mm10GRCm38
MGSCv3735,218,554 - 5,415,855 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3635,224,745 - 5,397,584 (+)NCBIMGSCv36mm8
Celera35,302,820 - 5,500,317 (+)NCBICelera
Cytogenetic Map3A1NCBI
cM Map31.96NCBI
Zfhx4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554443,938,830 - 4,116,076 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554443,938,830 - 4,116,076 (-)NCBIChiLan1.0ChiLan1.0
ZFHX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2792,415,091 - 92,601,929 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1868,043,186 - 68,229,782 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0873,206,659 - 73,392,531 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1874,844,366 - 75,030,190 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl874,844,374 - 75,030,190 (+)Ensemblpanpan1.1panPan2
ZFHX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12924,689,152 - 24,849,048 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2924,667,180 - 24,846,270 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2924,929,902 - 25,111,936 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02924,779,377 - 24,961,780 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2924,781,333 - 24,959,003 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12924,878,361 - 25,037,052 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02924,895,008 - 25,053,849 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02925,247,073 - 25,406,115 (+)NCBIUU_Cfam_GSD_1.0
Zfhx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530354,302,796 - 54,487,818 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367021,694,685 - 1,872,942 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZFHX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl459,387,007 - 59,575,073 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1459,384,202 - 59,580,913 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2464,861,519 - 65,053,217 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZFHX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1872,206,263 - 72,396,852 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl872,208,282 - 72,396,818 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603968,883,502 - 69,071,916 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zfhx4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474414,400,990 - 14,597,276 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474414,401,079 - 14,597,220 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfhx4
859 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:528
Count of miRNA genes:257
Interacting mature miRNAs:327
Transcripts:ENSRNOT00000011641
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)276539322102785628Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)276539322102785628Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat
1598863Cm65Cardiac mass QTL 652.3heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)292337601137337601Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
2300165Bmd49Bone mineral density QTL 494.80.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)288862519133862519Rat
2300170Bmd45Bone mineral density QTL 4512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2300185Bmd46Bone mineral density QTL 468.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)288862519133862519Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)264366971109366971Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
7207808Bmd89Bone mineral density QTL 894.1femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)288862519133862519Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat

Markers in Region
D2Rat122  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2296,345,489 - 96,345,626 (+)MAPPERmRatBN7.2
Rnor_6.0298,545,920 - 98,546,056NCBIRnor6.0
Rnor_5.02118,280,211 - 118,280,347UniSTSRnor5.0
RGSC_v3.4298,671,711 - 98,671,848RGDRGSC3.4
RGSC_v3.4298,671,712 - 98,671,848UniSTSRGSC3.4
RGSC_v3.1298,616,673 - 98,616,810RGD
Celera291,860,460 - 91,860,596UniSTS
SHRSP x BN Map236.5198RGD
SHRSP x BN Map236.5198UniSTS
Cytogenetic Map2q24UniSTS
D2Got53  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2296,319,306 - 96,319,473 (+)MAPPERmRatBN7.2
Rnor_6.0298,518,886 - 98,519,052NCBIRnor6.0
Rnor_5.02118,253,177 - 118,253,343UniSTSRnor5.0
RGSC_v3.4298,644,660 - 98,644,827RGDRGSC3.4
RGSC_v3.4298,644,661 - 98,644,827UniSTSRGSC3.4
RGSC_v3.1298,589,623 - 98,589,789RGD
Celera291,834,441 - 91,834,607UniSTS
RH 3.4 Map2680.1UniSTS
RH 3.4 Map2680.1RGD
RH 2.0 Map2633.7RGD
Cytogenetic Map2q24UniSTS
D2Got416  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2296,278,942 - 96,279,160 (+)MAPPERmRatBN7.2
Rnor_6.0298,478,239 - 98,478,456NCBIRnor6.0
Rnor_5.02118,212,530 - 118,212,747UniSTSRnor5.0
RGSC_v3.4298,603,687 - 98,603,904UniSTSRGSC3.4
Celera291,794,102 - 91,794,319UniSTS
Cytogenetic Map2q24UniSTS
RH45950  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2296,227,580 - 96,227,734 (+)MAPPERmRatBN7.2
Rnor_6.0298,426,383 - 98,426,536NCBIRnor6.0
Rnor_5.02118,160,674 - 118,160,827UniSTSRnor5.0
RGSC_v3.4298,552,323 - 98,552,476UniSTSRGSC3.4
Cytogenetic Map2q24UniSTS
C130041O22Rik  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2296,227,469 - 96,227,860 (+)MAPPERmRatBN7.2
Rnor_6.0298,426,272 - 98,426,662NCBIRnor6.0
Rnor_5.02118,160,563 - 118,160,953UniSTSRnor5.0
RGSC_v3.4298,552,212 - 98,552,602UniSTSRGSC3.4
Cytogenetic Map2q24UniSTS
AI007855  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2296,228,211 - 96,228,382 (+)MAPPERmRatBN7.2
Rnor_6.0298,427,014 - 98,427,184NCBIRnor6.0
Rnor_5.02118,161,305 - 118,161,475UniSTSRnor5.0
RGSC_v3.4298,552,954 - 98,553,124UniSTSRGSC3.4
Celera291,743,376 - 91,743,546UniSTS
RH 3.4 Map2678.3UniSTS
Cytogenetic Map2q24UniSTS
ZFH4__4938  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2296,227,379 - 96,228,152 (+)MAPPERmRatBN7.2
Rnor_6.0298,426,182 - 98,426,954NCBIRnor6.0
Rnor_5.02118,160,473 - 118,161,245UniSTSRnor5.0
RGSC_v3.4298,552,122 - 98,552,894UniSTSRGSC3.4
Celera291,742,575 - 91,743,316UniSTS
Cytogenetic Map2q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 49 8 3
Low 2 10 57 41 8 41 8 11 25 4 25 8 8
Below cutoff 1 26 9 21 5

Sequence


RefSeq Acc Id: ENSRNOT00000011641   ⟹   ENSRNOP00000011641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl296,224,767 - 96,408,228 (-)Ensembl
Rnor_6.0 Ensembl298,423,569 - 98,610,368 (-)Ensembl
RefSeq Acc Id: NM_001191702   ⟹   NP_001178631
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8298,131,996 - 98,315,469 (-)NCBI
mRatBN7.2296,224,767 - 96,408,245 (-)NCBI
Rnor_6.0298,423,569 - 98,610,368 (-)NCBI
Rnor_5.02118,157,856 - 118,345,227 (-)NCBI
Celera291,739,962 - 91,923,160 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232162   ⟹   XP_006232224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8298,131,996 - 98,315,230 (-)NCBI
mRatBN7.2296,227,491 - 96,407,998 (-)NCBI
Rnor_6.0298,423,565 - 98,610,068 (-)NCBI
Rnor_5.02118,157,856 - 118,345,227 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006232164   ⟹   XP_006232226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8298,131,996 - 98,314,203 (-)NCBI
mRatBN7.2296,227,491 - 96,406,036 (-)NCBI
Rnor_6.0298,423,565 - 98,606,528 (-)NCBI
Rnor_5.02118,157,856 - 118,345,227 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063281757   ⟹   XP_063137827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8298,131,996 - 98,321,070 (-)NCBI
RefSeq Acc Id: XM_063281758   ⟹   XP_063137828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8298,131,996 - 98,314,203 (-)NCBI
RefSeq Acc Id: XM_063281759   ⟹   XP_063137829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8298,131,996 - 98,321,070 (-)NCBI
RefSeq Acc Id: NP_001178631   ⟸   NM_001191702
- UniProtKB: D4A3U5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232224   ⟸   XM_006232162
- Peptide Label: isoform X1
- UniProtKB: D4A3U5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232226   ⟸   XM_006232164
- Peptide Label: isoform X1
- UniProtKB: D4A3U5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011641   ⟸   ENSRNOT00000011641
RefSeq Acc Id: XP_063137829   ⟸   XM_063281759
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063137827   ⟸   XM_063281757
- Peptide Label: isoform X1
- UniProtKB: D4A3U5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137828   ⟸   XM_063281758
- Peptide Label: isoform X2
Protein Domains
C2H2-type   Homeobox

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563022 AgrOrtholog
BioCyc Gene G2FUF-53666 BioCyc
Ensembl Genes ENSRNOG00000008765 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011641.6 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_U1 UniProtKB/TrEMBL
NCBI Gene 310250 ENTREZGENE
PANTHER ZINC FINGER HOMEOBOX PROTEIN UniProtKB/TrEMBL
  ZINC FINGER HOMEOBOX PROTEIN 4 UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfhx4 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008765 RatGTEx
SMART HOX UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
  ZnF_U1 UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt D4A3U5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-17 Zfhx4  zinc finger homeobox 4  Zfhx4  zinc finger homeodomain 4   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Zfhx4  zinc finger homeodomain 4   Zfhx4_predicted  zinc finger homeodomain 4 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Zfhx4_predicted  zinc finger homeodomain 4 (predicted)  RGD1563022_predicted  similar to zinc-finger homeodomain protein 4 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1563022_predicted  similar to zinc-finger homeodomain protein 4 (predicted)  LOC310250  similar to zinc-finger homeodomain protein 4  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC310250  similar to zinc-finger homeodomain protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL