Defb33 (defensin beta 33) - Rat Genome Database

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Gene: Defb33 (defensin beta 33) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Defb33
Name: defensin beta 33
RGD ID: 1562959
Description: Predicted to enable CCR6 chemokine receptor binding activity and chemoattractant activity. Predicted to be involved in cell chemotaxis and defense response to bacterium. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BD-33; beta-defensin 33; defensin, beta 33
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,297,203 - 77,303,982 (-)NCBIGRCr8
mRatBN7.21670,594,762 - 70,601,543 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,594,786 - 70,601,563 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1675,871,591 - 75,878,354 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,317,274 - 79,323,986 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,566,712 - 74,573,426 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,578,681 - 75,585,475 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1675,578,706 - 75,581,325 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01675,179,852 - 75,186,633 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41675,385,293 - 75,387,911 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1668,456,595 - 68,459,215 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16033865  


Genomics

Variants

.
Variants in Defb33
83 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:39
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000058031
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 7
Low 1 1
Below cutoff 1 2 2 3 1 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000058031   ⟹   ENSRNOP00000054840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1670,594,786 - 70,601,563 (-)Ensembl
Rnor_6.0 Ensembl1675,578,706 - 75,581,325 (-)Ensembl
RefSeq Acc Id: NM_001037523   ⟹   NP_001032612
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81677,297,203 - 77,303,967 (-)NCBI
mRatBN7.21670,594,762 - 70,601,528 (-)NCBI
Rnor_6.01675,578,706 - 75,581,325 (-)NCBI
Rnor_5.01675,179,852 - 75,186,633 (-)NCBI
RGSC_v3.41675,385,293 - 75,387,911 (-)RGD
Celera1668,456,595 - 68,459,215 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094808   ⟹   XP_038950736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81677,297,224 - 77,303,982 (-)NCBI
mRatBN7.21670,594,762 - 70,601,543 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001032612 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950736 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT51901 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054840.2
GenBank Protein Q32ZG1 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001032612   ⟸   NM_001037523
- Peptide Label: precursor
- UniProtKB: Q32ZG1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054840   ⟸   ENSRNOT00000058031
RefSeq Acc Id: XP_038950736   ⟸   XM_039094808
- Peptide Label: isoform X1
- UniProtKB: Q32ZG1 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q32ZG1-F1-model_v2 AlphaFold Q32ZG1 1-62 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562959 AgrOrtholog
BioCyc Gene G2FUF-10822 BioCyc
Ensembl Genes ENSRNOG00000038128 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058031.2 UniProtKB/TrEMBL
KEGG Report rno:641647 UniProtKB/Swiss-Prot
NCBI Gene 641647 ENTREZGENE
PANTHER BETA-DEFENSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BETA-DEFENSIN 33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Defb33 PhenoGen
RatGTEx ENSRNOG00000038128 RatGTEx
UniProt A0A8L2QS94_RAT UniProtKB/TrEMBL
  DFB33_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-11-07 Defb33  defensin beta 33    beta-defensin 33  Name updated 1299863 APPROVED
2006-02-09 Defb33  beta-defensin 33      Symbol and Name status set to provisional 70820 PROVISIONAL