Aqp12a (aquaporin 12A) - Rat Genome Database

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Gene: Aqp12a (aquaporin 12A) Rattus norvegicus
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Symbol: Aqp12a
Name: aquaporin 12A
RGD ID: 1562727
Description: Predicted to enable channel activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to several human genes including AQP12A (aquaporin 12A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Aqp12; Aqp12b; aquaporin 12; aquaporin 12B; aquaporin-12; LOC367316; RGD1562727; similar to aquaporin 12
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,001,939 - 101,007,425 (+)NCBIGRCr8
mRatBN7.2993,554,527 - 93,560,011 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,554,527 - 93,560,011 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9101,990,119 - 101,995,579 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,125,911 - 107,131,371 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09105,482,066 - 105,487,533 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,156,154 - 100,166,218 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,156,154 - 100,166,218 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0999,819,237 - 99,824,384 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,277,514 - 92,282,986 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera991,090,782 - 91,096,107 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15809071   PMID:32735865   PMID:38511591  


Genomics

Comparative Map Data
Aqp12a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,001,939 - 101,007,425 (+)NCBIGRCr8
mRatBN7.2993,554,527 - 93,560,011 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl993,554,527 - 93,560,011 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9101,990,119 - 101,995,579 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,125,911 - 107,131,371 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09105,482,066 - 105,487,533 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,156,154 - 100,166,218 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,156,154 - 100,166,218 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0999,819,237 - 99,824,384 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4992,277,514 - 92,282,986 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera991,090,782 - 91,096,107 (+)NCBICelera
Cytogenetic Map9q36NCBI
AQP12A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,691,866 - 240,698,483 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2240,691,866 - 240,698,483 (+)EnsemblGRCh38hg38GRCh38
GRCh372241,631,283 - 241,637,900 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,279,935 - 241,286,573 (+)NCBINCBI36Build 36hg18NCBI36
Build 342241,351,251 - 241,357,889NCBI
Celera2235,289,033 - 235,295,670 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2233,390,957 - 233,397,465 (+)NCBIHuRef
CHM1_12241,636,638 - 241,643,326 (+)NCBICHM1_1
T2T-CHM13v2.02241,187,861 - 241,195,208 (+)NCBIT2T-CHM13v2.0
Aqp12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39192,934,056 - 92,939,991 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl192,934,056 - 92,939,991 (+)EnsemblGRCm39 Ensembl
GRCm38193,006,334 - 93,012,269 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,006,334 - 93,012,269 (+)EnsemblGRCm38mm10GRCm38
MGSCv37194,902,911 - 94,908,846 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,836,740 - 94,842,672 (+)NCBIMGSCv36mm8
Celera195,955,202 - 95,961,271 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.72NCBI
LOC117979297
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213143,376,992 - 143,383,328 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B143,391,550 - 143,398,293 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B127,947,156 - 127,954,054 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3

Variants

.
Variants in Aqp12a
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:55
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000005935
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)992491589100929786Rat

Markers in Region
AI071423  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2993,559,758 - 93,559,956 (+)MAPPERmRatBN7.2
Rnor_6.09100,165,966 - 100,166,163NCBIRnor6.0
Rnor_5.0999,824,132 - 99,824,329UniSTSRnor5.0
RGSC_v3.4992,282,734 - 92,282,931UniSTSRGSC3.4
Celera991,095,855 - 91,096,052UniSTS
RH 3.4 Map9797.4UniSTS
Cytogenetic Map9q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6
Low 3 4 4 8 4 12
Below cutoff 18 14 6 14 1 1 8 2 10 7 1

Sequence


RefSeq Acc Id: ENSRNOT00000005935   ⟹   ENSRNOP00000005935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl993,554,527 - 93,560,011 (+)Ensembl
Rnor_6.0 Ensembl9100,156,154 - 100,166,218 (+)Ensembl
RefSeq Acc Id: NM_001109009   ⟹   NP_001102479
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,001,939 - 101,007,425 (+)NCBI
mRatBN7.2993,554,527 - 93,560,011 (+)NCBI
Rnor_6.09100,156,154 - 100,166,218 (+)NCBI
Rnor_5.0999,819,237 - 99,824,384 (+)NCBI
RGSC_v3.4992,277,514 - 92,282,986 (+)RGD
Celera991,090,782 - 91,096,107 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102479 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL91964 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005935
  ENSRNOP00000005935.3
RefSeq Acc Id: NP_001102479   ⟸   NM_001109009
- Peptide Label: precursor
- UniProtKB: D4A9T6 (UniProtKB/TrEMBL),   A6JQX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005935   ⟸   ENSRNOT00000005935

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A9T6-F1-model_v2 AlphaFold D4A9T6 1-290 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696870
Promoter ID:EPDNEW_R7394
Type:initiation region
Name:Aqp12a_1
Description:aquaporin 12A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09100,156,154 - 100,156,214EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562727 AgrOrtholog
BioCyc Gene G2FUF-26659 BioCyc
Ensembl Genes ENSRNOG00000004452 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005935 ENTREZGENE
  ENSRNOT00000005935.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/TrEMBL
InterPro Aquaporin_11/12 UniProtKB/TrEMBL
  Aquaporin_12 UniProtKB/TrEMBL
  Aquaporin_like UniProtKB/TrEMBL
  MIP UniProtKB/TrEMBL
KEGG Report rno:367316 UniProtKB/TrEMBL
NCBI Gene 367316 ENTREZGENE
PANTHER AQUAPORIN UniProtKB/TrEMBL
  PTHR21191:SF8 UniProtKB/TrEMBL
Pfam MIP UniProtKB/TrEMBL
PhenoGen Aqp12a PhenoGen
PIRSF Aquaporin_11/12 UniProtKB/TrEMBL
PRINTS AQUAPORIN12 UniProtKB/TrEMBL
  MINTRINSICP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004452 RatGTEx
Superfamily-SCOP MIP UniProtKB/TrEMBL
UniProt A6JQX3 ENTREZGENE, UniProtKB/TrEMBL
  D4A9T6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Aqp12b  aquaporin 12B  Aqp12  aquaporin 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Aqp12  aquaporin 12  RGD1562727_predicted  similar to aquaporin 12 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562727_predicted  similar to aquaporin 12 (predicted)  LOC367316  similar to aquaporin 12  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC367316  similar to aquaporin 12      Symbol and Name status set to provisional 70820 PROVISIONAL