Cycsl3 (cytochrome c, somatic like 3) - Rat Genome Database

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Gene: Cycsl3 (cytochrome c, somatic like 3) Rattus norvegicus
No known orthologs.
Symbol: Cycsl3 (Ensembl: RGD1562558)
Name: cytochrome c, somatic like 3 (Ensembl:similar to Cytochrome c, somatic)
RGD ID: 1562558
Description: Predicted to enable electron transfer activity; heme binding activity; and metal ion binding activity. Predicted to be involved in apoptotic process. Predicted to be part of respirasome. Human ortholog(s) of this gene implicated in cholangiocarcinoma; lung non-small cell carcinoma; pancreatic cancer; and thrombocytopenia. Orthologous to human CYCS (cytochrome c, somatic); INTERACTS WITH acrylamide.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AC114204.1; cytochrome c, somatic-like; LOC290019; RGD1562558; similar to Cytochrome c, somatic
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81526,251,236 - 26,251,532 (-)NCBIGRCr8
mRatBN7.21523,777,662 - 23,777,958 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1523,777,662 - 23,777,958 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01527,407,836 - 27,408,487 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1527,407,962 - 27,408,258 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01531,345,658 - 31,345,972 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41526,310,104 - 26,310,418 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1524,106,373 - 24,107,024 (-)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
acrylamide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions



Variants in Cycsl3
4 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat



Nucleotide Sequences
RefSeq Transcripts XM_039094055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000043588   ⟹   ENSRNOP00000044211
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1523,777,662 - 23,777,958 (-)Ensembl
RefSeq Acc Id: XM_039094055   ⟹   XP_038949983
Rat AssemblyChrPosition (strand)Source
GRCr81526,251,236 - 26,251,532 (-)NCBI
mRatBN7.21523,777,662 - 23,777,958 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038949983 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044211
RefSeq Acc Id: XP_038949983   ⟸   XM_039094055
- UniProtKB: D3ZXV2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000044211   ⟸   ENSRNOT00000043588
Protein Domains
Cytochrome c

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZXV2-F1-model_v2 AlphaFold D3ZXV2 1-98 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562558 AgrOrtholog
BioCyc Gene G2FUF-14074 BioCyc
Ensembl Genes ENSRNOG00000029613 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043588 ENTREZGENE
  ENSRNOT00000043588.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.760.10 UniProtKB/TrEMBL
InterPro Cyt_c-like_dom UniProtKB/TrEMBL
  Cyt_c-like_dom_sf UniProtKB/TrEMBL
  Cyt_c_1A/1B UniProtKB/TrEMBL
  PTHR11961 UniProtKB/TrEMBL
Pfam Cytochrom_C UniProtKB/TrEMBL
PhenoGen Cycsl3 PhenoGen
RatGTEx ENSRNOG00000029613 RatGTEx
Superfamily-SCOP SSF46626 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Cycsl3  cytochrome c, somatic like 3  RGD1562558  similar to Cytochrome c, somatic  Symbol and Name Changed 1299863 APPROVED
2022-06-02 RGD1562558  similar to Cytochrome c, somatic  AC114204.1    Data merged from RGD:15003765 737654 PROVISIONAL
2019-11-08 AC114204.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2008-04-30 RGD1562558  similar to Cytochrome c, somatic   RGD1562558_predicted  similar to Cytochrome c, somatic (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562558_predicted  similar to Cytochrome c, somatic (predicted)  LOC290019  similar to Cytochrome c, somatic  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC290019  similar to Cytochrome c, somatic      Symbol and Name status set to provisional 70820 PROVISIONAL