Coq10a (coenzyme Q10A) - Rat Genome Database

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Gene: Coq10a (coenzyme Q10A) Rattus norvegicus
Analyze
Symbol: Coq10a
Name: coenzyme Q10A
RGD ID: 1562447
Description: Predicted to enable ubiquinone binding activity. Predicted to be involved in cellular respiration. Predicted to be active in mitochondrion. Orthologous to human COQ10A (coenzyme Q10A); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: coenzyme Q-binding protein COQ10 homolog A, mitochondrial; coenzyme Q10 homolog A; coenzyme Q10 homolog A (S. cerevisiae); coenzyme Q10 homolog A (yeast); LOC362810; RGD1562447; similar to Hypothetical protein FLJ32452
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,376,591 - 1,387,694 (-)NCBIGRCr8
mRatBN7.27792,089 - 798,392 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7792,089 - 800,161 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,552,841 - 3,558,558 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,428,825 - 5,434,542 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,727,519 - 5,733,273 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,780,930 - 2,788,189 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,780,930 - 2,786,949 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,759,394 - 2,766,319 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,654,164 - 1,659,948 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7665,683 - 671,290 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17824807   PMID:27770269   PMID:36443592  


Genomics

Comparative Map Data
Coq10a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,376,591 - 1,387,694 (-)NCBIGRCr8
mRatBN7.27792,089 - 798,392 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7792,089 - 800,161 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,552,841 - 3,558,558 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,428,825 - 5,434,542 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,727,519 - 5,733,273 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,780,930 - 2,788,189 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,780,930 - 2,786,949 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,759,394 - 2,766,319 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,654,164 - 1,659,948 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7665,683 - 671,290 (-)NCBICelera
Cytogenetic Map7q11NCBI
COQ10A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,266,942 - 56,270,966 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,266,890 - 56,270,966 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,660,726 - 56,664,750 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,946,909 - 54,951,017 (+)NCBINCBI36Build 36hg18NCBI36
Celera1256,313,423 - 56,317,531 (+)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1253,699,339 - 53,703,447 (+)NCBIHuRef
CHM1_11256,628,047 - 56,632,155 (+)NCBICHM1_1
T2T-CHM13v2.01256,234,586 - 56,238,610 (+)NCBIT2T-CHM13v2.0
Coq10a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,198,965 - 128,204,849 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,198,969 - 128,204,866 (-)EnsemblGRCm39 Ensembl
GRCm3810128,363,096 - 128,370,056 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,363,100 - 128,368,997 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710127,800,153 - 127,807,093 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,766,046 - 127,772,986 (-)NCBIMGSCv36mm8
Celera10130,751,368 - 130,758,308 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.53NCBI
Coq10a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,878,813 - 3,880,095 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,878,844 - 3,880,429 (+)NCBIChiLan1.0ChiLan1.0
COQ10A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,061,171 - 38,066,070 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,057,939 - 38,065,955 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,644,452 - 32,648,804 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,896,587 - 32,900,371 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,896,587 - 32,900,572 (-)Ensemblpanpan1.1panPan2
COQ10A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110580,022 - 583,264 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10552,720 - 582,829 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10643,313 - 646,521 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010588,541 - 591,749 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10588,543 - 591,689 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110565,982 - 569,190 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010808,966 - 812,174 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010933,057 - 936,271 (+)NCBIUU_Cfam_GSD_1.0
Coq10a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,194,095 - 58,197,788 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646672,047 - 679,053 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646672,202 - 676,140 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COQ10A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,665,252 - 21,669,045 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,665,252 - 21,670,323 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,156,557 - 23,160,338 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COQ10A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,219,833 - 52,223,926 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,219,699 - 52,223,277 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,761,111 - 193,766,152 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Coq10a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,737,040 - 11,740,287 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,726,753 - 11,740,985 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Coq10a
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:84
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000047530
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000047530   ⟹   ENSRNOP00000044290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7792,089 - 797,838 (-)Ensembl
Rnor_6.0 Ensembl72,780,930 - 2,786,856 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086939   ⟹   ENSRNOP00000070841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7792,089 - 800,161 (-)Ensembl
Rnor_6.0 Ensembl72,781,286 - 2,786,949 (-)Ensembl
RefSeq Acc Id: NM_001108727   ⟹   NP_001102197
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,376,591 - 1,382,340 (-)NCBI
mRatBN7.27792,089 - 797,838 (-)NCBI
Rnor_6.072,780,930 - 2,786,856 (-)NCBI
Rnor_5.072,759,394 - 2,766,319 (-)NCBI
RGSC_v3.471,654,164 - 1,659,948 (-)RGD
Celera7665,683 - 671,290 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240759   ⟹   XP_006240821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,376,593 - 1,387,694 (-)NCBI
mRatBN7.27792,127 - 798,378 (-)NCBI
Rnor_6.072,780,932 - 2,788,189 (-)NCBI
Rnor_5.072,759,394 - 2,766,319 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079365   ⟹   XP_038935293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,376,593 - 1,387,694 (-)NCBI
mRatBN7.27792,091 - 798,392 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102197 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240821 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935293 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL84866 (Get FASTA)   NCBI Sequence Viewer  
  EDL84867 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044290.3
  ENSRNOP00000070841.2
RefSeq Acc Id: NP_001102197   ⟸   NM_001108727
- UniProtKB: D3ZX74 (UniProtKB/TrEMBL),   A6KSC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240821   ⟸   XM_006240759
- Peptide Label: isoform X1
- UniProtKB: A6KSC5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044290   ⟸   ENSRNOT00000047530
Ensembl Acc Id: ENSRNOP00000070841   ⟸   ENSRNOT00000086939
RefSeq Acc Id: XP_038935293   ⟸   XM_039079365
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JYY6 (UniProtKB/TrEMBL)
Protein Domains
Coenzyme Q-binding protein COQ10 START

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZX74-F1-model_v2 AlphaFold D3ZX74 1-217 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562447 AgrOrtholog
BioCyc Gene G2FUF-35375 BioCyc
Ensembl Genes ENSRNOG00000029571 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047530.5 UniProtKB/TrEMBL
  ENSRNOT00000086939.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.530.20 UniProtKB/TrEMBL
InterPro COQ10-like UniProtKB/TrEMBL
  Polyket_cyc UniProtKB/TrEMBL
  START-like_dom UniProtKB/TrEMBL
KEGG Report rno:362810 UniProtKB/TrEMBL
NCBI Gene 362810 ENTREZGENE
PANTHER COENZYME Q-BINDING PROTEIN COQ10 HOMOLOG A, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR12901 UniProtKB/TrEMBL
Pfam Polyketide_cyc UniProtKB/TrEMBL
PhenoGen Coq10a PhenoGen
RatGTEx ENSRNOG00000029571 RatGTEx
Superfamily-SCOP Bet v1-like UniProtKB/TrEMBL
UniProt A0A0G2JYY6 ENTREZGENE, UniProtKB/TrEMBL
  A6KSC5 ENTREZGENE, UniProtKB/TrEMBL
  A6KSC6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZX74 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-06-24 Coq10a  coenzyme Q10A  Coq10a  coenzyme Q10 homolog A (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-15 Coq10a  coenzyme Q10 homolog A (S. cerevisiae)  Coq10a  coenzyme Q10 homolog A (yeast)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Coq10a  coenzyme Q10 homolog A (yeast)   Coq10a_predicted  coenzyme Q10 homolog A (yeast) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Coq10a_predicted  coenzyme Q10 homolog A (yeast) (predicted)  RGD1562447_predicted  similar to Hypothetical protein FLJ32452 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1562447_predicted  similar to Hypothetical protein FLJ32452 (predicted)  LOC362810  similar to Hypothetical protein FLJ32452  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC362810  similar to Hypothetical protein FLJ32452      Symbol and Name status set to provisional 70820 PROVISIONAL