Greb1l (GREB1 like retinoic acid receptor coactivator) - Rat Genome Database

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Gene: Greb1l (GREB1 like retinoic acid receptor coactivator) Rattus norvegicus
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Symbol: Greb1l
Name: GREB1 like retinoic acid receptor coactivator
RGD ID: 1562371
Description: Predicted to act upstream of or within several processes, including kidney development; paramesonephric duct development; and reproductive structure development. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and renal agenesis. Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator); INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic AMP.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: growth regulation by estrogen in breast cancer 1 like; growth regulation by estrogen in breast cancer-like; LOC498819; RGD1562371; similar to GREB1 protein isoform a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8181,665,468 - 1,902,291 (+)NCBIGRCr8
mRatBN7.2181,392,330 - 1,629,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,392,725 - 1,628,067 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0181,537,315 - 1,784,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,723,565 - 1,784,233 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,757,633 - 1,821,402 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0181,704,334 - 1,742,157 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,795,820 - 1,908,522 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera181,273,512 - 1,511,753 (+)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:29100090   PMID:29100091  


Genomics

Comparative Map Data
Greb1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8181,665,468 - 1,902,291 (+)NCBIGRCr8
mRatBN7.2181,392,330 - 1,629,483 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,392,725 - 1,628,067 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0181,537,315 - 1,784,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,723,565 - 1,784,233 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,757,633 - 1,821,402 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0181,704,334 - 1,742,157 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4181,795,820 - 1,908,522 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera181,273,512 - 1,511,753 (+)NCBICelera
Cytogenetic Map18p13NCBI
GREB1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381821,242,232 - 21,526,112 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1821,242,232 - 21,526,112 (+)EnsemblGRCh38hg38GRCh38
GRCh371818,822,193 - 19,106,073 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361817,076,317 - 17,356,789 (+)NCBINCBI36Build 36hg18NCBI36
Build 341817,076,200 - 17,342,674NCBI
Celera1815,628,176 - 15,908,773 (+)NCBICelera
Cytogenetic Map18q11.1-q11.2NCBI
HuRef1815,669,485 - 15,949,616 (+)NCBIHuRef
CHM1_11818,749,282 - 19,029,843 (+)NCBICHM1_1
T2T-CHM13v2.01821,427,291 - 21,711,206 (+)NCBIT2T-CHM13v2.0
Greb1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391810,324,933 - 10,562,945 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1810,325,177 - 10,562,940 (+)EnsemblGRCm39 Ensembl
GRCm381810,324,933 - 10,562,945 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1810,325,177 - 10,562,940 (+)EnsemblGRCm38mm10GRCm38
MGSCv371810,325,177 - 10,562,939 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361810,325,175 - 10,562,939 (+)NCBIMGSCv36mm8
MGSCv361810,327,252 - 10,429,003 (+)NCBIMGSCv36mm8
Celera1810,354,956 - 10,592,831 (+)NCBICelera
Cytogenetic Map18A1NCBI
cM Map185.0NCBI
Greb1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540210,104,225 - 10,201,479 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554029,865,934 - 10,204,990 (+)NCBIChiLan1.0ChiLan1.0
GREB1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21738,660,383 - 38,942,862 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11824,352,918 - 24,635,444 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01814,482,493 - 14,763,789 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11818,120,919 - 18,402,948 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1818,244,575 - 18,400,335 (+)Ensemblpanpan1.1panPan2
GREB1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1766,489,124 - 66,758,207 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl766,503,999 - 66,639,013 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha765,943,213 - 66,212,115 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0766,553,669 - 66,823,094 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl766,566,632 - 66,703,721 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1766,231,940 - 66,488,010 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0766,242,907 - 66,511,844 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0766,544,142 - 66,813,301 (-)NCBIUU_Cfam_GSD_1.0
Greb1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494462,574,871 - 62,832,489 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365501,122,260 - 1,238,682 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365501,110,679 - 1,240,463 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GREB1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6106,419,943 - 106,691,625 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16106,545,882 - 106,693,711 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2698,943,800 - 99,199,449 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GREB1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11858,960,397 - 59,104,188 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1858,963,914 - 59,103,993 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605033,745,325 - 34,041,840 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Greb1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477010,225,669 - 10,345,173 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477010,223,131 - 10,471,309 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Greb1l
1219 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:25
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000033468
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat

Markers in Region
RH131132  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,539,251 - 1,539,471 (+)MAPPERmRatBN7.2
Rnor_6.0181,685,936 - 1,686,155NCBIRnor6.0
Rnor_5.0181,731,947 - 1,732,166UniSTSRnor5.0
RGSC_v3.4181,818,161 - 1,818,380UniSTSRGSC3.4
Celera181,421,558 - 1,421,777UniSTS
RH 3.4 Map1810.3UniSTS
Cytogenetic Map18p13UniSTS
RH131955  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,595,838 - 1,596,058 (+)MAPPERmRatBN7.2
Rnor_6.0181,753,708 - 1,753,927NCBIRnor6.0
Rnor_5.0181,787,681 - 1,787,900UniSTSRnor5.0
Celera181,478,108 - 1,478,327UniSTS
RH 3.4 Map1810.3UniSTS
Cytogenetic Map18p13UniSTS
AU047007  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,506,556 - 1,506,704 (+)MAPPERmRatBN7.2
Rnor_6.0181,653,242 - 1,653,389NCBIRnor6.0
Rnor_5.0181,699,253 - 1,699,400UniSTSRnor5.0
RGSC_v3.4181,784,411 - 1,784,558UniSTSRGSC3.4
Celera181,388,726 - 1,388,873UniSTS
Cytogenetic Map18p13UniSTS
RH138057  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2181,627,713 - 1,627,922 (+)MAPPERmRatBN7.2
Rnor_6.0181,785,660 - 1,785,868NCBIRnor6.0
Rnor_5.0181,819,633 - 1,819,841UniSTSRnor5.0
RGSC_v3.4181,931,159 - 1,931,367UniSTSRGSC3.4
Celera181,509,984 - 1,510,192UniSTS
RH 3.4 Map1812.5UniSTS
Cytogenetic Map18p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 3 2 2 8 9
Low 34 53 38 19 38 8 8 66 35 32 11 8
Below cutoff 3 6 1 1 1 3

Sequence


RefSeq Acc Id: ENSRNOT00000033468   ⟹   ENSRNOP00000029000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl181,392,725 - 1,628,067 (+)Ensembl
Rnor_6.0 Ensembl181,723,565 - 1,784,233 (+)Ensembl
RefSeq Acc Id: XM_039097265   ⟹   XP_038953193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8181,665,469 - 1,902,291 (+)NCBI
mRatBN7.2181,392,330 - 1,629,483 (+)NCBI
RefSeq Acc Id: XM_039097266   ⟹   XP_038953194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8181,766,117 - 1,902,291 (+)NCBI
mRatBN7.2181,492,428 - 1,629,483 (+)NCBI
RefSeq Acc Id: XM_039097267   ⟹   XP_038953195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8181,665,469 - 1,902,291 (+)NCBI
mRatBN7.2181,392,330 - 1,629,483 (+)NCBI
RefSeq Acc Id: XM_039097268   ⟹   XP_038953196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8181,665,469 - 1,902,291 (+)NCBI
mRatBN7.2181,392,330 - 1,629,483 (+)NCBI
RefSeq Acc Id: XM_039097269   ⟹   XP_038953197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8181,766,116 - 1,902,291 (+)NCBI
mRatBN7.2181,492,428 - 1,629,483 (+)NCBI
RefSeq Acc Id: XM_039097270   ⟹   XP_038953198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8181,665,473 - 1,902,291 (+)NCBI
mRatBN7.2181,392,331 - 1,629,483 (+)NCBI
RefSeq Acc Id: XM_039097272   ⟹   XP_038953200
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8181,665,468 - 1,902,291 (+)NCBI
mRatBN7.2181,392,330 - 1,629,483 (+)NCBI
RefSeq Acc Id: ENSRNOP00000029000   ⟸   ENSRNOT00000033468
RefSeq Acc Id: XP_038953195   ⟸   XM_039097267
- Peptide Label: isoform X1
- UniProtKB: A6KNE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953196   ⟸   XM_039097268
- Peptide Label: isoform X1
- UniProtKB: A6KNE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953193   ⟸   XM_039097265
- Peptide Label: isoform X1
- UniProtKB: A6KNE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953200   ⟸   XM_039097272
- Peptide Label: isoform X3
- UniProtKB: A6KNE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953198   ⟸   XM_039097270
- Peptide Label: isoform X2
- UniProtKB: F1LTR0 (UniProtKB/TrEMBL),   A6KNE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953197   ⟸   XM_039097269
- Peptide Label: isoform X1
- UniProtKB: A6KNE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953194   ⟸   XM_039097266
- Peptide Label: isoform X1
- UniProtKB: A6KNE1 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LTR0-F1-model_v2 AlphaFold F1LTR0 1-1457 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562371 AgrOrtholog
BioCyc Gene G2FUF-8417 BioCyc
Ensembl Genes ENSRNOG00000023492 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033468.7 UniProtKB/TrEMBL
InterPro GREB1 UniProtKB/TrEMBL
  GREB1-like_2nd UniProtKB/TrEMBL
  GREB1-like_cpSF2 UniProtKB/TrEMBL
  GREB1_C UniProtKB/TrEMBL
  GREB1_N UniProtKB/TrEMBL
  TAGT UniProtKB/TrEMBL
NCBI Gene 498819 ENTREZGENE
PANTHER PTHR15720 UniProtKB/TrEMBL
  PTHR15720:SF12 UniProtKB/TrEMBL
Pfam cpSF2-GREB1 UniProtKB/TrEMBL
  GREB1 UniProtKB/TrEMBL
  GREB1_2nd UniProtKB/TrEMBL
  GREB1_C UniProtKB/TrEMBL
  TAGT UniProtKB/TrEMBL
PhenoGen Greb1l PhenoGen
RatGTEx ENSRNOG00000023492 RatGTEx
UniProt A6KNE1 ENTREZGENE, UniProtKB/TrEMBL
  F1LTR0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-04 Greb1l  GREB1 like retinoic acid receptor coactivator  Greb1l  growth regulation by estrogen in breast cancer 1 like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-22 Greb1l  growth regulation by estrogen in breast cancer 1 like  Greb1l  growth regulation by estrogen in breast cancer-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-25 Greb1l  growth regulation by estrogen in breast cancer-like  RGD1562371  similar to GREB1 protein isoform a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562371  similar to GREB1 protein isoform a   RGD1562371_predicted  similar to GREB1 protein isoform a (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562371_predicted  similar to GREB1 protein isoform a (predicted)  LOC498819  similar to GREB1 protein isoform a  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498819  similar to GREB1 protein isoform a      Symbol and Name status set to provisional 70820 PROVISIONAL