Tmem198b (transmembrane protein 198b) - Rat Genome Database

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Pathways
Gene: Tmem198b (transmembrane protein 198b) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Tmem198b
Name: transmembrane protein 198b
RGD ID: 1562342
Description: Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in cytoplasmic vesicle and plasma membrane; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC500762; LOC500762; RGD1562342; similar to RIKEN cDNA 1110012D08; uncharacterized protein LOC500762
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,814,208 - 1,819,421 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl71,814,210 - 1,818,544 (-)EnsemblGRCr8
mRatBN7.271,229,709 - 1,234,920 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,229,711 - 1,234,045 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx73,992,832 - 3,997,226 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,868,493 - 5,872,887 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.076,165,388 - 6,169,782 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.073,224,831 - 3,230,129 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,224,833 - 3,229,167 (-)Ensemblrn6Rnor6.0
Rnor_5.073,196,401 - 3,201,704 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.472,099,867 - 2,104,201 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera71,100,462 - 1,104,805 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Tmem198b
13 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:412
Count of miRNA genes:207
Interacting mature miRNAs:232
Transcripts:ENSRNOT00000008929
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
AI072476  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,229,339 - 1,229,553 (+)MAPPERmRatBN7.2
Rnor_6.073,224,462 - 3,224,675NCBIRnor6.0
Rnor_5.073,196,032 - 3,196,245UniSTSRnor5.0
RGSC_v3.472,099,496 - 2,099,709UniSTSRGSC3.4
Celera71,100,091 - 1,100,304UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 89 59 6 352 189 11 140 80 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001109281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001439850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC141508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000008929   ⟹   ENSRNOP00000008929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl71,814,210 - 1,818,544 (-)Ensembl
mRatBN7.2 Ensembl71,229,711 - 1,234,045 (-)Ensembl
Rnor_6.0 Ensembl73,224,833 - 3,229,167 (-)Ensembl
RefSeq Acc Id: NM_001109281   ⟹   NP_001102751
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,814,210 - 1,818,544 (-)NCBI
mRatBN7.271,229,711 - 1,234,045 (-)NCBI
Rnor_6.073,224,833 - 3,229,167 (-)NCBI
Rnor_5.073,196,401 - 3,201,704 (-)NCBI
RGSC_v3.472,099,867 - 2,104,201 (-)RGD
Celera71,100,462 - 1,104,805 (-)RGD
Sequence:
RefSeq Acc Id: XM_017595041   ⟹   XP_017450530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,814,208 - 1,818,502 (-)NCBI
mRatBN7.271,229,709 - 1,234,557 (-)NCBI
Rnor_6.073,224,831 - 3,229,074 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079728   ⟹   XP_038935656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,814,208 - 1,819,201 (-)NCBI
mRatBN7.271,229,709 - 1,234,702 (-)NCBI
RefSeq Acc Id: XM_039079729   ⟹   XP_038935657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,814,208 - 1,819,191 (-)NCBI
mRatBN7.271,229,709 - 1,234,692 (-)NCBI
RefSeq Acc Id: XM_039079730   ⟹   XP_038935658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,814,208 - 1,819,421 (-)NCBI
mRatBN7.271,229,709 - 1,234,920 (-)NCBI
RefSeq Acc Id: XM_039079731   ⟹   XP_038935659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,814,208 - 1,819,419 (-)NCBI
mRatBN7.271,229,709 - 1,234,919 (-)NCBI
RefSeq Acc Id: XM_063264093   ⟹   XP_063120163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,814,208 - 1,819,201 (-)NCBI
RefSeq Acc Id: NP_001102751   ⟸   NM_001109281
- UniProtKB: D3ZAM6 (UniProtKB/TrEMBL),   A6KSI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450530   ⟸   XM_017595041
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000008929   ⟸   ENSRNOT00000008929
RefSeq Acc Id: XP_038935658   ⟸   XM_039079730
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038935659   ⟸   XM_039079731
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038935656   ⟸   XM_039079728
- Peptide Label: isoform X1
- UniProtKB: D3ZAM6 (UniProtKB/TrEMBL),   A6KSI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935657   ⟸   XM_039079729
- Peptide Label: isoform X1
- UniProtKB: D3ZAM6 (UniProtKB/TrEMBL),   A6KSI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120163   ⟸   XM_063264093
- Peptide Label: isoform X1
- UniProtKB: A6KSI8 (UniProtKB/TrEMBL),   D3ZAM6 (UniProtKB/TrEMBL)
Protein Domains
TM7S3/TM198-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAM6-F1-model_v2 AlphaFold D3ZAM6 1-345 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694953
Promoter ID:EPDNEW_R5477
Type:single initiation site
Name:Tmem198b_1
Description:transmembrane protein 198b
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.073,229,155 - 3,229,215EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562342 AgrOrtholog
BioCyc Gene G2FUF-35331 BioCyc
Ensembl Genes ENSRNOG00000006827 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008929 ENTREZGENE
  ENSRNOT00000008929.4 UniProtKB/TrEMBL
InterPro DUF4203 UniProtKB/TrEMBL
  TMEM198 UniProtKB/TrEMBL
KEGG Report rno:500762 UniProtKB/TrEMBL
NCBI Gene 500762 ENTREZGENE
PANTHER PTHR31247 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 198B UniProtKB/TrEMBL
Pfam DUF4203 UniProtKB/TrEMBL
PhenoGen Tmem198b PhenoGen
RatGTEx ENSRNOG00000006827 RatGTEx
UniProt A6KSI8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZAM6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-11 Tmem198b  transmembrane protein 198b  RGD1562342  similar to RIKEN cDNA 1110012D08  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562342  similar to RIKEN cDNA 1110012D08   RGD1562342_predicted  similar to RIKEN cDNA 1110012D08 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562342_predicted  similar to RIKEN cDNA 1110012D08 (predicted)  LOC500762  similar to RIKEN cDNA 1110012D08  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500762  similar to RIKEN cDNA 1110012D08      Symbol and Name status set to provisional 70820 PROVISIONAL