Astl (astacin like metalloendopeptidase) - Rat Genome Database

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Gene: Astl (astacin like metalloendopeptidase) Rattus norvegicus
Analyze
Symbol: Astl
Name: astacin like metalloendopeptidase
RGD ID: 1562279
Description: Predicted to enable aspartic-type peptidase activity; glutamic-type peptidase activity; and metalloendopeptidase activity. Predicted to be involved in several processes, including negative regulation of binding activity of sperm to zona pellucida; positive regulation of protein processing; and prevention of polyspermy. Predicted to be located in cortical granule and plasma membrane. Orthologous to human ASTL (astacin like metalloendopeptidase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; glycidol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: astacin-like metalloendopeptidase; astacin-like metalloendopeptidase (M12 family); LOC296129; RGD1562279; similar to oocyte astacin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,016,444 - 135,032,177 (+)NCBIGRCr8
mRatBN7.23114,563,135 - 114,580,295 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,563,135 - 114,578,868 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,452,397 - 118,468,141 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,047,958 - 127,063,702 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,708,329 - 124,724,073 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,783,717 - 119,799,450 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,783,717 - 119,799,450 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,310,094 - 126,325,827 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,845,320 - 114,861,053 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3113,402,096 - 113,417,834 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22206759   PMID:22472438  


Genomics

Comparative Map Data
Astl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,016,444 - 135,032,177 (+)NCBIGRCr8
mRatBN7.23114,563,135 - 114,580,295 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3114,563,135 - 114,578,868 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3118,452,397 - 118,468,141 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,047,958 - 127,063,702 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03124,708,329 - 124,724,073 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03119,783,717 - 119,799,450 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3119,783,717 - 119,799,450 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,310,094 - 126,325,827 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43114,845,320 - 114,861,053 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3113,402,096 - 113,417,834 (+)NCBICelera
Cytogenetic Map3q36NCBI
ASTL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38296,122,818 - 96,138,564 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl296,122,818 - 96,138,502 (-)EnsemblGRCh38hg38GRCh38
GRCh37296,788,557 - 96,804,241 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36296,153,316 - 96,167,902 (-)NCBINCBI36Build 36hg18NCBI36
Build 34296,211,462 - 96,226,049NCBI
Celera291,230,396 - 91,244,982 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef290,750,866 - 90,765,452 (-)NCBIHuRef
CHM1_1296,793,916 - 96,808,503 (-)NCBICHM1_1
T2T-CHM13v2.0296,629,422 - 96,645,168 (-)NCBIT2T-CHM13v2.0
Astl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,180,559 - 127,199,575 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,180,559 - 127,199,571 (+)EnsemblGRCm39 Ensembl
GRCm382127,338,639 - 127,357,655 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2127,338,639 - 127,357,651 (+)EnsemblGRCm38mm10GRCm38
MGSCv372127,164,375 - 127,183,387 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362127,030,080 - 127,049,092 (+)NCBIMGSCv36mm8
Celera2128,584,628 - 128,599,928 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map261.93NCBI
Astl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554703,719,254 - 3,732,607 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554703,719,254 - 3,732,598 (-)NCBIChiLan1.0ChiLan1.0
ASTL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21232,169,814 - 32,185,721 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A32,172,596 - 32,188,480 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A103,176,662 - 103,192,542 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A97,048,871 - 97,063,747 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A97,049,184 - 97,063,747 (-)Ensemblpanpan1.1panPan2
ASTL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11734,594,701 - 34,608,708 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1734,594,026 - 34,607,961 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1734,363,562 - 34,378,272 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01735,365,149 - 35,379,752 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1735,365,007 - 35,379,047 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11734,494,438 - 34,509,160 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01734,562,766 - 34,577,482 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01734,769,924 - 34,784,663 (+)NCBIUU_Cfam_GSD_1.0
Astl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629283,005,750 - 83,015,976 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936744259,188 - 268,928 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936744259,188 - 268,919 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASTL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl347,059,040 - 47,070,664 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1347,058,104 - 47,071,681 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2349,198,467 - 49,211,812 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASTL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.114568,071 - 577,182 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041167,978,725 - 167,994,724 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Astl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247492,241,511 - 2,254,640 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Astl
67 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:73
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000039043
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3107693393152693393Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3112287552135181505Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium 4
Low 2 13 11
Below cutoff 1 4 19 12 12 12 3 18 13 2

Sequence


RefSeq Acc Id: ENSRNOT00000039043   ⟹   ENSRNOP00000037567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3114,563,135 - 114,578,868 (+)Ensembl
Rnor_6.0 Ensembl3119,783,717 - 119,799,450 (+)Ensembl
RefSeq Acc Id: NM_001106504   ⟹   NP_001099974
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83135,016,444 - 135,032,177 (+)NCBI
mRatBN7.23114,563,135 - 114,578,868 (+)NCBI
Rnor_6.03119,783,717 - 119,799,450 (+)NCBI
Rnor_5.03126,310,094 - 126,325,827 (+)NCBI
RGSC_v3.43114,845,320 - 114,861,053 (+)RGD
Celera3113,402,096 - 113,417,834 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099974 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL80114 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037567
  ENSRNOP00000037567.4
RefSeq Acc Id: NP_001099974   ⟸   NM_001106504
- Peptide Label: precursor
- UniProtKB: A6HQ13 (UniProtKB/TrEMBL),   D3ZX09 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000037567   ⟸   ENSRNOT00000039043
Protein Domains
Peptidase M12A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZX09-F1-model_v2 AlphaFold D3ZX09 1-439 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562279 AgrOrtholog
BioCyc Gene G2FUF-47994 BioCyc
Ensembl Genes ENSRNOG00000022603 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039043 ENTREZGENE
  ENSRNOT00000039043.5 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
InterPro MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12A UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
KEGG Report rno:296129 UniProtKB/TrEMBL
NCBI Gene 296129 ENTREZGENE
PANTHER ASTACIN-LIKE METALLOENDOPEPTIDASE UniProtKB/TrEMBL
  DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING UniProtKB/TrEMBL
Pfam Astacin UniProtKB/TrEMBL
PhenoGen Astl PhenoGen
PRINTS ASTACIN UniProtKB/TrEMBL
PROSITE ASTACIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022603 RatGTEx
SMART ZnMc UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt A6HQ13 ENTREZGENE, UniProtKB/TrEMBL
  D3ZX09 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 Astl  astacin like metalloendopeptidase  Astl  astacin-like metalloendopeptidase (M12 family)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Astl  astacin-like metalloendopeptidase (M12 family)  RGD1562279_predicted  similar to oocyte astacin (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562279_predicted  similar to oocyte astacin (predicted)  LOC296129  similar to oocyte astacin  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC296129  similar to oocyte astacin      Symbol and Name status set to provisional 70820 PROVISIONAL