Rps12l5 (ribosomal protein S12 like 5) - Rat Genome Database

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Gene: Rps12l5 (ribosomal protein S12 like 5) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Rps12l5 (Ensembl: RGD1562265)
Name: ribosomal protein S12 like 5 (Ensembl:similar to ribosomal protein S12)
RGD ID: 1562265
Description: Predicted to be involved in translation; INTERACTS WITH rotenone.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 40S ribosomal protein S12-like; LOC313283; RGD1562265; similar to ribosomal protein S12
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8548,408,995 - 48,409,425 (+)NCBIGRCr8
mRatBN7.2543,612,528 - 43,612,958 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl543,612,545 - 43,612,943 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx545,741,421 - 45,741,851 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0547,340,669 - 47,341,099 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0547,289,866 - 47,290,296 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0544,270,057 - 44,270,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0548,896,396 - 48,896,794 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4545,384,176 - 45,384,574 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera542,418,627 - 42,419,025 (+)NCBICelera
Cytogenetic Map5q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
rotenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Rps12l5
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:19
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000042939
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)52483871044045280Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53321566578215665Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53321566578215665Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)534730116104251008Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)534944474113558310Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)53518915368564008Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000042939   ⟹   ENSRNOP00000045390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl543,612,545 - 43,612,943 (+)Ensembl
RefSeq Acc Id: NM_001402071   ⟹   NP_001389000
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8548,408,995 - 48,409,425 (+)NCBI
mRatBN7.2543,612,528 - 43,612,958 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001389000 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045390
  ENSRNOP00000045390.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000045390   ⟸   ENSRNOT00000042939
RefSeq Acc Id: NP_001389000   ⟸   NM_001402071
- UniProtKB: D4AAJ3 (UniProtKB/TrEMBL)
Protein Domains
Ribosomal protein eL8/eL30/eS12/Gadd45

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAJ3-F1-model_v2 AlphaFold D4AAJ3 1-132 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-41757 BioCyc
Ensembl Genes ENSRNOG00000069296 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042939 ENTREZGENE
  ENSRNOT00000042939.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1330.30 UniProtKB/TrEMBL
InterPro L30e-like UniProtKB/TrEMBL
  Ribosomal_L7Ae/L30e/S12e/Gad45 UniProtKB/TrEMBL
  Ribosomal_S12e UniProtKB/TrEMBL
NCBI Gene 313283 ENTREZGENE
PANTHER 40S RIBOSOMAL PROTEIN S12-RELATED UniProtKB/TrEMBL
  PTHR11843 UniProtKB/TrEMBL
Pfam Ribosomal_L7Ae UniProtKB/TrEMBL
PhenoGen Rps12l5 PhenoGen
PRINTS RIBSOMALS12E UniProtKB/TrEMBL
RatGTEx ENSRNOG00000069296 RatGTEx
Superfamily-SCOP SSF55315 UniProtKB/TrEMBL
UniProt D4AAJ3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Rps12l5  ribosomal protein S12 like 5  RGD1562265  similar to ribosomal protein S12  Symbol and Name Changed 1299863 APPROVED
2022-06-02 RGD1562265  similar to ribosomal protein S12  RGD1562265  similar to ribosomal protein S12  Data merged from RGD:149736283 737654 PROVISIONAL
2021-08-09 RGD1562265  similar to ribosomal protein S12      Symbol and Name status set to provisional 45752 PROVISIONAL
2008-04-30 RGD1562265  similar to ribosomal protein S12   RGD1562265_predicted  similar to ribosomal protein S12 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1562265_predicted  similar to ribosomal protein S12 (predicted)  LOC313283  similar to ribosomal protein S12  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC313283  similar to ribosomal protein S12      Symbol and Name status set to provisional 70820 PROVISIONAL