Supt7l (SPT7 like, STAGA complex subunit gamma) - Rat Genome Database

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Gene: Supt7l (SPT7 like, STAGA complex subunit gamma) Rattus norvegicus
Analyze
Symbol: Supt7l
Name: SPT7 like, STAGA complex subunit gamma
RGD ID: 1562206
Description: Predicted to enable transcription coactivator activity. Predicted to be involved in maintenance of protein location in nucleus. Predicted to be located in nucleoplasm. Predicted to be part of SAGA complex. Orthologous to human SUPT7L (SPT7 like, STAGA complex subunit gamma); PARTICIPATES IN RNA polymerase II transcription initiation pathway; INTERACTS WITH bisphenol A; finasteride; gentamycin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC313905; RGD1562206; similar to STAGA complex 65 gamma subunit; SPT7-like STAGA complex gamma subunit; STAGA complex 65 subunit gamma; suppressor of Ty 7 (S. cerevisiae)-like; suppressor of Ty 7-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,653,928 - 30,664,066 (+)NCBIGRCr8
mRatBN7.2624,933,941 - 24,944,656 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl624,933,923 - 24,944,654 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,234,790 - 25,244,932 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,550,689 - 25,560,829 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,029,913 - 25,040,042 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,241,672 - 26,251,810 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,241,672 - 26,251,809 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,065,222 - 36,075,360 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4624,994,268 - 25,004,406 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera624,428,645 - 24,438,783 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (ISO)
nucleus  (ISO)
SAGA complex  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
5. ATAC-king the complexity of SAGA during evolution. Spedale G, etal., Genes Dev. 2012 Mar 15;26(6):527-41. doi: 10.1101/gad.184705.111.
Additional References at PubMed
PMID:11564863   PMID:12477932   PMID:15870280  


Genomics

Comparative Map Data
Supt7l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8630,653,928 - 30,664,066 (+)NCBIGRCr8
mRatBN7.2624,933,941 - 24,944,656 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl624,933,923 - 24,944,654 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,234,790 - 25,244,932 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0625,550,689 - 25,560,829 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,029,913 - 25,040,042 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,241,672 - 26,251,810 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,241,672 - 26,251,809 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,065,222 - 36,075,360 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4624,994,268 - 25,004,406 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera624,428,645 - 24,438,783 (+)NCBICelera
Cytogenetic Map6q14NCBI
SUPT7L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,642,568 - 27,663,614 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl227,650,809 - 27,663,840 (-)EnsemblGRCh38hg38GRCh38
GRCh37227,873,676 - 27,886,481 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,727,183 - 27,739,953 (-)NCBINCBI36Build 36hg18NCBI36
Celera227,719,150 - 27,731,920 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,614,635 - 27,627,405 (-)NCBIHuRef
CHM1_1227,804,418 - 27,817,184 (-)NCBICHM1_1
T2T-CHM13v2.0227,685,653 - 27,706,702 (-)NCBIT2T-CHM13v2.0
Supt7l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,671,913 - 31,684,106 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,671,908 - 31,685,151 (-)EnsemblGRCm39 Ensembl
GRCm38531,514,569 - 31,526,762 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,514,564 - 31,527,807 (-)EnsemblGRCm38mm10GRCm38
MGSCv37531,816,942 - 31,829,135 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,791,150 - 31,803,266 (-)NCBIMGSCv36mm8
Celera528,993,458 - 29,005,651 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map517.27NCBI
Supt7l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,601,767 - 9,617,188 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,584,863 - 9,617,194 (-)NCBIChiLan1.0ChiLan1.0
SUPT7L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21298,852,384 - 98,863,164 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A98,856,710 - 98,867,133 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A27,648,724 - 27,661,760 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,734,763 - 27,747,802 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,734,763 - 27,747,802 (-)Ensemblpanpan1.1panPan2
LOC475708
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,550,614 - 21,580,113 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,566,827 - 21,688,006 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1721,454,676 - 21,483,948 (-)NCBIDog10K_Boxer_Tasha
Supt7l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,869,698 - 65,879,856 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364934,960,420 - 4,973,452 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364934,959,725 - 4,969,780 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SUPT7L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,531,689 - 111,542,000 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,531,670 - 111,542,000 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23118,497,761 - 118,507,867 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SUPT7L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11479,965,583 - 79,977,693 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1479,966,684 - 79,980,864 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604532,172,696 - 32,184,594 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Supt7l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,675,056 - 9,682,685 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247389,673,966 - 9,684,706 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Supt7l
41 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:121
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000006543
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat

Markers in Region
BE119710  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2624,943,873 - 24,944,023 (+)MAPPERmRatBN7.2
Rnor_6.0626,251,605 - 26,251,754NCBIRnor6.0
Rnor_5.0636,075,155 - 36,075,304UniSTSRnor5.0
RGSC_v3.4625,004,201 - 25,004,350UniSTSRGSC3.4
Celera624,438,578 - 24,438,727UniSTS
RH 3.4 Map688.5UniSTS
Cytogenetic Map6q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 29 16 11 16 69 29 34 10
Low 1 17 28 25 8 25 8 11 5 6 7 1 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000006543   ⟹   ENSRNOP00000006543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl624,933,923 - 24,944,654 (+)Ensembl
Rnor_6.0 Ensembl626,241,672 - 26,251,809 (+)Ensembl
RefSeq Acc Id: NM_001108010   ⟹   NP_001101480
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8630,653,928 - 30,664,066 (+)NCBI
mRatBN7.2624,933,941 - 24,944,079 (+)NCBI
Rnor_6.0626,241,672 - 26,251,810 (+)NCBI
Rnor_5.0636,065,222 - 36,075,360 (+)NCBI
RGSC_v3.4624,994,268 - 25,004,406 (+)RGD
Celera624,428,645 - 24,438,783 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101480 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68944 (Get FASTA)   NCBI Sequence Viewer  
  EDM02906 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006543
  ENSRNOP00000006543.3
RefSeq Acc Id: NP_001101480   ⟸   NM_001108010
- UniProtKB: B5DF66 (UniProtKB/TrEMBL),   A6HA51 (UniProtKB/TrEMBL),   F7F3B7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006543   ⟸   ENSRNOT00000006543
Protein Domains
Bromodomain associated

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DF66-F1-model_v2 AlphaFold B5DF66 1-412 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694433
Promoter ID:EPDNEW_R4957
Type:initiation region
Name:Supt7l_1
Description:SPT7-like STAGA complex gamma subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,241,658 - 26,241,718EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562206 AgrOrtholog
BioCyc Gene G2FUF-38364 BioCyc
Ensembl Genes ENSRNOG00000004927 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006543 ENTREZGENE
  ENSRNOT00000006543.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/TrEMBL
InterPro BTP UniProtKB/TrEMBL
  Histone-fold UniProtKB/TrEMBL
  SUPT7L UniProtKB/TrEMBL
KEGG Report rno:313905 UniProtKB/TrEMBL
NCBI Gene 313905 ENTREZGENE
PANTHER PTHR28598 UniProtKB/TrEMBL
  STAGA COMPLEX 65 SUBUNIT GAMMA UniProtKB/TrEMBL
Pfam Bromo_TP UniProtKB/TrEMBL
PhenoGen Supt7l PhenoGen
RatGTEx ENSRNOG00000004927 RatGTEx
SMART BTP UniProtKB/TrEMBL
UniProt A6HA51 ENTREZGENE, UniProtKB/TrEMBL
  B5DF66 ENTREZGENE
  F7F3B7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B5DF66 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Supt7l  SPT7 like, STAGA complex subunit gamma  Supt7l  SPT7-like STAGA complex gamma subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-10-01 Supt7l  SPT7-like STAGA complex gamma subunit  Supt7l  suppressor of Ty 7 (S. cerevisiae)-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Supt7l  suppressor of Ty 7 (S. cerevisiae)-like  RGD1562206_predicted  similar to STAGA complex 65 gamma subunit (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562206_predicted  similar to STAGA complex 65 gamma subunit (predicted)  LOC313905  similar to STAGA complex 65 gamma subunit  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC313905  similar to STAGA complex 65 gamma subunit      Symbol and Name status set to provisional 70820 PROVISIONAL