Zpr1 (ZPR1 zinc finger) - Rat Genome Database

Name: Zpr1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Zpr1 (ZPR1 zinc finger) Rattus norvegicus

Analyze

Symbol:

Zpr1

Name:

ZPR1 zinc finger

RGD ID:

1562173

Description:

Predicted to have receptor tyrosine kinase binding activity; translation initiation factor binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including blastocyst growth; nervous system development; and positive regulation of RNA metabolic process. Predicted to localize to several cellular components, including growth cone; nuclear lumen; and perikaryon. Orthologous to human ZPR1 (ZPR1 zinc finger); INTERACTS WITH bisphenol A; dibutyl phthalate; fenvalerate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

LOC500989; RGD1562173; similar to zinc finger protein; Zfp259; zinc finger protein 259; zinc finger protein ZPR1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ZPR1 (ZPR1 zinc finger)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Zpr1 (ZPR1 zinc finger)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Zpr1 (ZPR1 zinc finger)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ZPR1 (ZPR1 zinc finger)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ZPR1 (ZPR1 zinc finger)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Zpr1 (ZPR1 zinc finger)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ZPR1 (ZPR1 zinc finger)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	ZPR1 (ZPR1 zinc finger)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Zpr1 (ZPR1 zinc finger)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ZPR1 (ZPR1 zinc finger)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Zpr1 (ZPR1 zinc finger)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	zpr1 (ZPR1 zinc finger)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	W03F9.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	ZPR1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	Zpr1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	46,564,898 - 46,574,719 (+)	NCBI
Rnor_6.0 Ensembl	8	50,563,047 - 50,572,621 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	8	50,563,047 - 50,572,621 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	49,189,009 - 49,198,583 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	49,257,107 - 49,266,681 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	8	46,146,914 - 46,156,613 (+)	NCBI		Celera
Cytogenetic Map	8	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Dwarfism (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

aflatoxin B1 (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

ciguatoxin CTX1B (ISO)

cobalt dichloride (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP,ISO)

ethanol (ISO)

fenvalerate (EXP)

fipronil (EXP)

flutamide (EXP)

folic acid (ISO)

furan (EXP,ISO)

gentamycin (EXP)

hexane (EXP)

indometacin (ISO)

nefazodone (EXP)

nickel atom (ISO)

nimesulide (EXP)

perfluorononanoic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

rotenone (EXP,ISO)

silver atom (ISO)

silver(0) (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

triphenyl phosphate (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process involved in development (ISO)

axon development (IBA,ISO)

Cajal body organization (IBA,ISO)

cell population proliferation (IBA)

cellular response to epidermal growth factor stimulus (ISO)

DNA endoreduplication (ISO)

inner cell mass cell proliferation (ISO)

microtubule cytoskeleton organization (ISO)

negative regulation of motor neuron apoptotic process (ISO)

positive regulation of gene expression (IBA,ISO)

positive regulation of growth (ISO)

positive regulation of protein import into nucleus (IBA,ISO)

positive regulation of RNA splicing (ISO)

positive regulation of transcription involved in G1/S transition of mitotic cell cycle (ISO)

pre-mRNA catabolic process (ISO)

regulation of myelination (ISO)

spinal cord development (ISO)

trophectodermal cell proliferation (ISO)

Cellular Component

axon (IBA,ISO)

Cajal body (IBA,ISO)

cytoplasm (IBA,ISO)

Gemini of coiled bodies (ISO)

growth cone (ISO)

neuronal cell body (ISO)

nucleolus (ISO)

nucleoplasm (ISO)

nucleus (IBA,ISO)

perikaryon (ISO)

Molecular Function

protein binding (ISO)

receptor tyrosine kinase binding (ISO)

translation initiation factor binding (IBA,ISO)

zinc ion binding (ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8650580	PMID:9763455	PMID:9852145	PMID:11283611	PMID:15767679	PMID:16648254	PMID:17068332	PMID:22422766

Genomics

Comparative Map Data

Zpr1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	46,564,898 - 46,574,719 (+)	NCBI
Rnor_6.0 Ensembl	8	50,563,047 - 50,572,621 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	8	50,563,047 - 50,572,621 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	49,189,009 - 49,198,583 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	49,257,107 - 49,266,681 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	8	46,146,914 - 46,156,613 (+)	NCBI		Celera
Cytogenetic Map	8	q22	NCBI

ZPR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	11	116,773,799 - 116,788,039 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	11	116,773,799 - 116,789,272 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	11	116,644,515 - 116,658,739 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	116,154,486 - 116,163,949 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	11	116,154,486 - 116,163,949	NCBI
Celera	11	113,804,668 - 113,814,129 (-)	NCBI
Cytogenetic Map	11	q23.3	NCBI
HuRef	11	112,581,245 - 112,590,732 (-)	NCBI		HuRef
CHM1_1	11	116,533,546 - 116,543,394 (-)	NCBI		CHM1_1

Zpr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	46,184,362 - 46,193,941 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	9	46,184,362 - 46,193,941 (+)	Ensembl
GRCm38	9	46,273,064 - 46,282,643 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	46,273,064 - 46,282,643 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	46,081,147 - 46,090,726 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	9	46,024,161 - 46,032,597 (+)	NCBI			mm8
Celera	9	43,562,072 - 43,571,685 (+)	NCBI		Celera
Cytogenetic Map	9	A5.2	NCBI

Zpr1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	18,116,531 - 18,127,552 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955412	18,117,957 - 18,127,552 (-)	NCBI	ChiLan1.0	ChiLan1.0

ZPR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	11	115,547,951 - 115,557,883 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	115,547,973 - 115,557,883 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	11	111,613,940 - 111,623,539 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

ZPR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	5	16,778,832 - 16,787,105 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	5	16,778,803 - 16,787,493 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Zpr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936542	2,058,048 - 2,067,468 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ZPR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	44,166,040 - 44,180,307 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	44,167,422 - 44,178,137 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	49,241,411 - 49,250,617 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ZPR1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	108,144,247 - 108,153,533 (-)	NCBI
ChlSab1.1 Ensembl	1	108,144,609 - 108,153,480 (-)	Ensembl

Zpr1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624784	12,202,519 - 12,212,257 (-)	NCBI

Position Markers

D8Got344

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	8	50,561,961 - 50,562,114	NCBI	Rnor6.0
Rnor_5.0	8	49,187,923 - 49,188,076	UniSTS	Rnor5.0
RGSC_v3.4	8	49,256,021 - 49,256,174	UniSTS	RGSC3.4
Celera	8	46,145,828 - 46,145,981	UniSTS
Cytogenetic Map	8	q23	UniSTS

BE102182

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	8	50,568,074 - 50,568,229	NCBI	Rnor6.0
Rnor_5.0	8	49,194,036 - 49,194,191	UniSTS	Rnor5.0
RGSC_v3.4	8	49,262,134 - 49,262,289	UniSTS	RGSC3.4
Celera	8	46,152,066 - 46,152,221	UniSTS
RH 3.4 Map	8	470.4	UniSTS
Cytogenetic Map	8	q23	UniSTS

RH139127

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	8	50,561,075 - 50,561,201	NCBI	Rnor6.0
Rnor_5.0	8	49,187,037 - 49,187,163	UniSTS	Rnor5.0
RGSC_v3.4	8	49,255,135 - 49,255,261	UniSTS	RGSC3.4
Celera	8	46,144,942 - 46,145,068	UniSTS
RH 3.4 Map	8	478.2	UniSTS
Cytogenetic Map	8	q23	UniSTS

RH139835

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	8	50,571,172 - 50,571,369	NCBI	Rnor6.0
Rnor_5.0	8	49,197,134 - 49,197,331	UniSTS	Rnor5.0
RGSC_v3.4	8	49,265,232 - 49,265,429	UniSTS	RGSC3.4
Celera	8	46,155,164 - 46,155,361	UniSTS
RH 3.4 Map	8	474.3	UniSTS
Cytogenetic Map	8	q23	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2317032	Ginf2	Gastrointestinal inflammation QTL 2	3.21	0.005	liver integrity trait (VT:0010547)	liver granuloma severity score (CMO:0002157)	8	7368076	52368076	Rat
2317036	Livw3	Liver weight QTL 3	2.43	0.01	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	8	7368076	52368076	Rat
2317048	Ginf1	Gastrointestinal inflammation QTL 1	3.52	0.005	cecum mucosa thickness (VT:0010234)	enterocolitis severity score (CMO:0002138)	8	7368076	52368076	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	8738677	53738677	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	9531047	119211942	Rat
1354627	Despr14	Despair related QTL 14		0.0056	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	10388439	55388439	Rat
1354595	Despr4	Despair related QTL 4	2.16	0.0036	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	8	10388439	55388439	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10938911	120496129	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	11373267	57541668	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	11448251	56448251	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	11448251	56448251	Rat
1558646	Swd5	Spike wave discharge measurement QTL 5	3.45	0.00036	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge frequency (CMO:0001742)	8	17666555	62666555	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	20717592	65717592	Rat
631271	Lecl1	Lens clarity QTL 1		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	8	21464919	91140553	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	21813070	100873963	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	27841496	72841496	Rat
1359021	Bp271	Blood pressure QTL 271	1.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	28168023	50708951	Rat
631648	Stl5	Serum triglyceride level QTL 5	4	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	29867983	59908353	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	29867983	106526740	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	29867983	106526740	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	29867983	106526740	Rat
2303564	Gluco43	Glucose level QTL 43	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	30144800	75144800	Rat
2303572	Insul13	Insulin level QTL 13	2		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	8	30144800	75144800	Rat
1331804	Cm30	Cardiac mass QTL 30	3.77443		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	8	30918112	58858224	Rat
1300146	Rf17	Renal function QTL 17	2.9		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	8	30918112	75918112	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	30918112	107206309	Rat
2302278	Gluco36	Glucose level QTL 36	4.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	32201981	54065241	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	32201981	75971421	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	32888352	101374135	Rat
1331744	Bp217	Blood pressure QTL 217	3.398		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	33558660	62857995	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	33558660	65717592	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	33558660	65717592	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	33558660	65717592	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	33558660	65717592	Rat
1359033	Bp273	Blood pressure QTL 273			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	33558660	65717592	Rat
11556286	Cm81	Cardiac mass QTL 81		0.01	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	33558660	65717592	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	33558660	89058369	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	33558660	89058369	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	33558660	89058369	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	33558660	89058369	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	33558660	109028082	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	33558660	109028082	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	33558660	109028082	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	33558764	113580387	Rat
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	35041414	80041414	Rat
1582222	Epfw2	Epididymal fat weight QTL 2	3.2	0.0005	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	8	35925594	80925594	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	39230130	106506973	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39927901	84927901	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	39958022	84958022	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	44219197	89542960	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	44219197	100873963	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	44458129	118087517	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	45712344	80003418	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	45712344	90712344	Rat
631216	Stl9	Serum triglyceride level QTL 9	4.71	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	8	45712475	75971259	Rat
5684993	Bmd84	Bone mineral density QTL 84	4.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	8	46588437	54065241	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46588437	96998640	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	47200750	106394378	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	47200750	106394378	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	47200750	106394378	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	47200750	106394378	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	47200750	106394378	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	47200750	106394378	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	50529480	128036471	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	50529480	128036471	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	50529480	128036471	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	50529480	128036471	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	50529563	106506973	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	168
Count of miRNA genes:	113
Interacting mature miRNAs:	137
Transcripts:	ENSRNOT00000025149
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	33	57	41	19	41	2	5	74	35	41	11	2
Low		10					6	6					6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001137646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039081941	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC135409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000198	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000025149 ⟹ ENSRNOP00000025149

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	8	50,563,047 - 50,572,621 (+)	Ensembl

RefSeq Acc Id:

NM_001137646 ⟹ NP_001131118

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	46,565,146 - 46,574,719 (+)	NCBI
Rnor_6.0	8	50,563,047 - 50,572,621 (+)	NCBI
Rnor_5.0	8	49,189,009 - 49,198,583 (+)	NCBI
RGSC_v3.4	8	49,257,107 - 49,266,681 (+)	RGD
Celera	8	46,146,914 - 46,156,613 (+)	RGD

Sequence:

show sequence

CCGGAAGCTTTCACTCGAGTAGCGCGTGGGGTAATGTCGGCCAGCGGGGCTGTGCAGCCCGGAC
CTCCGGGGGCTGCCGTCGGCCCCTCGCCCACCGCGGCTGCGTTATCAGACACCGGACCTTTGTT
CCGGCCCCTCAGCGCCGAGGATGAGGAGCAGCAGCCCACTGAGATCGAGTCACTGTGCATGAAC
TGTTACCGGAACGGCACGACGCGACTTCTGCTCACTAAGATCCCCTTCTTTAGAGAAATAATCG
TGAGCTCCTTTTCCTGTGAGCACTGTGGCTGGAACAACACCGAGATCCAGTCAGCAGGAAGGAT
CCAGGACCAAGGAGTGCGCTACACCTTGACCGTTAAGGGCCAAGAGGACATGAACAGAGAAGTG
GTGAAGACAGACTCAGCCACCACAAGGATCCCCGAGCTGGATTTTGAAATTCCAGCTTTCAGCC
AGAAGGGAGCTCTGACCACTGTGGAAGGACTCATAAGCCGCGCAATCTTGGGCCTGGAACAGGA
CCAGCCGACACGACGGGCAATGGAAGGTGCTATAGCCGAAAGAATTGATGAGTTCATTGGCAAA
CTGAAGGACCTAAAGCAAATGGCTTCCCCGTTCACGCTGATCATTGATGATCCCTCGGGAAACA
GCTTTGTAGAAAACCCACACGCTCCTCAAAAAGATAGCGCCTTGGTGATCACATACTACGACCG
GACCCCACAGCAAGCTGAGATGCTGGGGCTCCAAGCAGAAGCACCAGAAGAGAAGTCGGAAGAG
GAAGACCTTAGAAACGAAGTGCTCCAGTTCAACACAAACTGCCCAGAGTGCAACGCCCCCGCTC
AGACCAACATGAAGCTTGTCCAAATCCCCCACTTTAAAGAGGTTATCATCATGGCCACCAACTG
TGAGAGGTGTGGGCATCGGACTAATGAGGTGAAGTCTGGAGGAGCTGTAGAACCTTTGGGTACC
AGGATTACCCTCCACATCACAGATCCCTCAGACATGACCAGAGACCTCCTCAAGTCTGAGACCT
GTAGTGTAGAAATCCCAGAGCTCGAGTTTGAACTGGGAATGGCTGTACTTGGGGGCAAGTTCAC
CACTCTCGAAGGACTGCTGAAAGACATCCGAGAATTGGTAACCAAAAACCCATTCACGCTGGGC
GACAGCTCCAATCCTGACCAGTCAGAGAAACTGCAGGAGTTTAGCCAGAAGTTGGGCCAGATCA
TCGAGGGCAAGATGAAAGCCCACTTTATCATGAATGATCCAGCAGGAAACAGTTACCTGCAGAA
CGTGTATGCACCTGAAGATGACCCGGAGATGAAGGTAGAGCGGTACAAGCGCTCCTTTGACCAA
AATGAGGAGCTCGGCCTCAATGACATGAAGACAGAGGGCTATGAGGCAGACCTGGCCCCACAGC
GGTAGCAGTGGGCAGCCCACAGGCCAGCTGCAGGGCACTCACACTGCAGGGTTCTTTGTTACTG
TTGGAGAAGGCTGAGTGTTCAAGCCCTCCTCCGTGGTGAGGAGGAAACCACCTGAGTTAGAAAT
CTAAGCACACGAGGTTAGCAGCTGACAATGATGCGGCTGCAGGCCTACTGTGCTTCTTGACCTT
CCTTTGGCGGTTTTAAGTCAGTGTGAGAAGAACGCCACAAACACCATGCGTCTGCCATCACCTT
TTGTCTGTCAGCTCTCTGGCCTCCAGTGCTGGACCTTTGAAGTCTGAAGTGTGGAGAAGCGAAA
TACAAGTTGCAGCTGGCTTTGGGCTTATGCAGTGCTAACTTTCAGCATAGAAGAATGACTGAGG
GCAGGCACAGGTAAAGGAGCTTACATTAAAGTGATGGCTTTTAAACAACACCTGCCTCGGCATT
TGTGTCCTTCCTGAATACCATGGTGTTAGAGCCCAGCTGCCTAAGTTGGGTCACACTGAGTCAC
ACACACCTGCAGTCCCAGCATGGAGGATAGCTTGAGCCATAGTGAGATTCTGTCTAAATGAAAA
GAAAATAGGAAAAAAAATTAGTTTCCCAAACAAATCTTCAGGTGGCTGCTGTCACTGGGCTGTC
AGAGGCAGCATTTCAGTTACTCCAACAGACCATCGTGCCTGCTCTGAGCCCGGCACACGTGTGG
AGTCCAGCTGTTCTCATGCATCTTAAAGTAGTCTGGAAAGCAGGGTGGCACATACCTTAATCCC
AGCAGAAGCAGGCGGGTCTTTGGGCCAATCTGGTCTACAGAGCAAGTTCCAGGACAGCCTGGGC
TACGTGGAGAAACCCTGTTTTGAGACAAAACAAATCAGACTGGATAACCTGCAGCACCCGTGGT
TGGCCCCTGCTAGCAAAAACCAGAGCCGGGCAGTATGAAGATGTATGGGTTCCTGTACTTAAAC
AAACTTAGCATCTATGAAGGAGGCTAATAAAACTGATGGCCATGTCATGGTTTATACATAGTCC
TGCTACTTGGGAAACTGGGGAAGAAGGGAAACAAATTTAGGGGCAGCCTGGGCAATTTAATTTA
GTAAGGTGTTCAACATTCAAAAAGGGGTGGGGATGAATTTATCCTATAGAACTCTTGCCTACCA
TGTGTGAAAGGGCTTGGGTTTAATCCTCAGCACCAGATGAAGAAAAAACAGTTGTGAGCGTTAA
GTGAGTCACAAACACTTAAGTCTATAGAAGAAAGGCTAGAATCTTCCTAGCTTTCTTTTCTTTG
TCGCTGAATCCATGTCGTCTTCACTGGGAAGATTCCACATCATTTTCTTGAGAGACAATACCAA
AGGTGAGAAGGTCAGTACAGGTTTGATAAAAACCTATCAAATTTTCATAGTCACAATACTAGGG
ATGGAGTTTGACTTCCCCTAAGTGGTACCTGGAAGCCTGTTCCAGACTTCCCACCAAAGGTATT
TATACCATTAAAAGTG

hide sequence

RefSeq Acc Id:

XM_039081941 ⟹ XP_038937869

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	46,564,898 - 46,573,653 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001131118	(Get FASTA)	NCBI Sequence Viewer
	XP_038937869	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL95399	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001131118 ⟸ NM_001137646

- UniProtKB:

D3ZWN1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSASGAVQPGPPGAAVGPSPTAAALSDTGPLFRPLSAEDEEQQPTEIESLCMNCYRNGTTRLLL
TKIPFFREIIVSSFSCEHCGWNNTEIQSAGRIQDQGVRYTLTVKGQEDMNREVVKTDSATTRIP
ELDFEIPAFSQKGALTTVEGLISRAILGLEQDQPTRRAMEGAIAERIDEFIGKLKDLKQMASPF
TLIIDDPSGNSFVENPHAPQKDSALVITYYDRTPQQAEMLGLQAEAPEEKSEEEDLRNEVLQFN
TNCPECNAPAQTNMKLVQIPHFKEVIIMATNCERCGHRTNEVKSGGAVEPLGTRITLHITDPSD
MTRDLLKSETCSVEIPELEFELGMAVLGGKFTTLEGLLKDIRELVTKNPFTLGDSSNPDQSEKL
QEFSQKLGQIIEGKMKAHFIMNDPAGNSYLQNVYAPEDDPEMKVERYKRSFDQNEELGLNDMKT
EGYEADLAPQR

hide sequence

RefSeq Acc Id:

ENSRNOP00000025149 ⟸ ENSRNOT00000025149

RefSeq Acc Id:	XP_038937869 ⟸ XM_039081941
- Peptide Label:	isoform X1

Protein Domains

Zpr1

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695931

Promoter ID:

EPDNEW_R6456

Type:

multiple initiation site

Name:

Zpr1_1

Description:

ZPR1 zinc finger

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	50,563,059 - 50,563,119	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
8	49189948	49189949	G	C	snv	LEC/Tj (KyushuU), IS/Kyo (KyushuU)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1562173	AgrOrtholog
Ensembl Genes	ENSRNOG00000018481	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000025149	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025149	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	2.20.25.420	UniProtKB/TrEMBL
	2.60.120.1040	UniProtKB/TrEMBL
InterPro	Znf_ZPR1	UniProtKB/TrEMBL
	ZPR1	UniProtKB/TrEMBL
	ZPR1_A/B_dom	UniProtKB/TrEMBL
	ZPR1_ZnF1/2	UniProtKB/TrEMBL
KEGG Report	rno:500989	UniProtKB/TrEMBL
NCBI Gene	500989	ENTREZGENE
PANTHER	PTHR10876	UniProtKB/TrEMBL
Pfam	zf-ZPR1	UniProtKB/TrEMBL
PhenoGen	Zpr1	PhenoGen
SMART	Zpr1	UniProtKB/TrEMBL
TIGRFAMs	ZPR1_znf	UniProtKB/TrEMBL
UniProt	D3ZWN1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-06-28	Zpr1	ZPR1 zinc finger	Zfp259	zinc finger protein 259	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-29	Zfp259	zinc finger protein 259	RGD1562173_predicted	similar to zinc finger protein (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1562173_predicted	similar to zinc finger protein (predicted)	LOC500989	similar to zinc finger protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC500989	similar to zinc finger protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar