Gene: Lefty1 (left right determination factor 1) Rattus norvegicus
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Symbol: Lefty1
Name: left right determination factor 1
Description: ENCODES a protein that exhibits nodal binding (ortholog); INVOLVED IN anterior/posterior axis specification (ortholog); cell migration involved in gastrulation (ortholog); determination of left/right symmetry (ortholog); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; FOUND IN extracellular region (ortholog); INTERACTS WITH bisphenol A; furan; 17beta-estradiol (ortholog)
AGR Description: Predicted to have cytokine activity, nodal binding activity, and transforming growth factor beta receptor binding activity; predicted to be involved in several processes, including SMAD protein signal transduction, anterior/posterior axis specification, and regulation of signal transduction; predicted to localize to the extracellular space; orthologous to several human genes including LEFTY1 (left-right determination factor 1).
Merged Description: Predicted to have cytokine activity, nodal binding activity, and transforming growth factor beta receptor binding activity; predicted to be involved in several processes, including SMAD protein signal transduction, anterior/posterior axis specification, and regulation of signal transduction; predicted to localize to the extracellular space; orthologous to several human genes including LEFTY1 (left-right determination factor 1); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH bisphenol A; furan; 17beta-estradiol (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: left-right determination factor 1; LOC498299; RGD1561867; similar to Stra3 protein
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01399,212,778 - 99,217,786 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013104,212,236 - 104,215,633 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,664,408 - 96,667,805 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1392,199,283 - 92,202,680 (+)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Lefty1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1561867
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.