Dock4 (dedicator of cytokinesis 4) - Rat Genome Database
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Gene: Dock4 (dedicator of cytokinesis 4) Rattus norvegicus
Analyze
Symbol: Dock4
Name: dedicator of cytokinesis 4
RGD ID: 1561724
Description: Predicted to have PDZ domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in cell chemotaxis; negative regulation of vascular associated smooth muscle contraction; and positive regulation of vascular associated smooth muscle cell migration. Predicted to localize to several cellular components, including Golgi apparatus; nucleolus; and stereocilium. Orthologous to human DOCK4 (dedicator of cytokinesis 4); PARTICIPATES IN platelet-derived growth factor signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: MODEL
Also known as: dedicator of cytokinesis protein 4; LOC366608; RGD1561724; similar to mKIAA0716 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2657,512,929 - 57,902,597 (+)NCBI
Rnor_6.0 Ensembl660,566,196 - 60,782,556 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0660,374,839 - 60,782,648 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0669,962,956 - 70,320,855 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0670,333,585 - 70,369,177 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4659,903,426 - 60,136,543 (+)NCBIRGSC3.4rn4RGSC3.4
Celera656,552,544 - 56,940,868 (+)NCBICelera
Cytogenetic Map6q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)
Golgi apparatus  (IEA,ISO)
membrane  (ISO)
nucleolus  (IEA,ISO)
plasma membrane  (IEA,ISO)
stereocilium  (ISO)
stereocilium bundle  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:16464467   PMID:18615735   PMID:20679435   PMID:22158624   PMID:23536706  


Genomics

Comparative Map Data
Dock4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2657,512,929 - 57,902,597 (+)NCBI
Rnor_6.0 Ensembl660,566,196 - 60,782,556 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0660,374,839 - 60,782,648 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0669,962,956 - 70,320,855 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0670,333,585 - 70,369,177 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4659,903,426 - 60,136,543 (+)NCBIRGSC3.4rn4RGSC3.4
Celera656,552,544 - 56,940,868 (+)NCBICelera
Cytogenetic Map6q21NCBI
DOCK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7111,726,110 - 112,206,411 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl7111,726,110 - 112,206,407 (-)EnsemblGRCh38hg38GRCh38
GRCh387111,726,110 - 112,206,399 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377111,366,166 - 111,846,454 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367111,153,400 - 111,633,698 (-)NCBINCBI36hg18NCBI36
Build 347110,962,280 - 111,440,144NCBI
Celera7106,178,467 - 106,658,751 (-)NCBI
Cytogenetic Map7q31.1NCBI
HuRef7105,734,071 - 106,214,221 (-)NCBIHuRef
CHM1_17111,300,360 - 111,780,666 (-)NCBICHM1_1
CRA_TCAGchr7v27110,734,721 - 111,215,001 (-)NCBI
Dock4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391240,495,956 - 40,896,873 (+)NCBIGRCm39mm39
GRCm39 Ensembl1240,495,951 - 40,896,873 (+)Ensembl
GRCm381240,445,957 - 40,846,874 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1240,445,952 - 40,846,874 (+)EnsemblGRCm38mm10GRCm38
MGSCv371241,172,640 - 41,573,082 (+)NCBIGRCm37mm9NCBIm37
MGSCv361240,956,476 - 41,356,918 (+)NCBImm8
Celera1241,872,490 - 42,274,555 (+)NCBICelera
Cytogenetic Map12B1NCBI
cM Map1218.06NCBI
Dock4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541015,550,235 - 15,777,103 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541015,548,041 - 15,835,382 (-)NCBIChiLan1.0ChiLan1.0
DOCK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17116,400,535 - 116,872,055 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7116,400,535 - 116,871,755 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07103,697,418 - 104,169,469 (-)NCBIMhudiblu_PPA_v0panPan3
DOCK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1451,451,059 - 51,859,040 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11451,448,910 - 51,859,366 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dock4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936795823,730 - 1,262,584 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOCK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1833,423,218 - 33,879,368 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11833,423,199 - 33,879,368 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21836,256,470 - 36,652,374 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DOCK4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12180,548,079 - 81,022,410 (-)NCBI
ChlSab1.1 Ensembl2180,547,655 - 80,812,702 (-)Ensembl
Dock4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473917,705,893 - 18,152,679 (+)NCBI

Position Markers
D6Mit4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0660,606,186 - 60,606,431NCBIRnor6.0
Rnor_5.0670,193,933 - 70,194,178UniSTSRnor5.0
RGSC_v3.4659,946,628 - 59,946,874RGDRGSC3.4
RGSC_v3.4659,946,629 - 59,946,874UniSTSRGSC3.4
RGSC_v3.1659,949,755 - 59,950,000RGD
RH 3.4 Map6406.6UniSTS
RH 3.4 Map6406.6RGD
RH 2.0 Map6589.2RGD
Cytogenetic Map6q21UniSTS
D6Rat58  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0660,662,751 - 60,662,950NCBIRnor6.0
Rnor_6.0660,662,751 - 60,663,159NCBIRnor6.0
Rnor_5.0670,250,498 - 70,250,906UniSTSRnor5.0
Rnor_5.0670,250,498 - 70,250,697UniSTSRnor5.0
RGSC_v3.4660,003,377 - 60,003,576UniSTSRGSC3.4
RGSC_v3.4660,003,376 - 60,003,576RGDRGSC3.4
RGSC_v3.1660,006,502 - 60,006,702RGD
Celera656,825,029 - 56,825,228UniSTS
FHH x ACI Map650.3599UniSTS
FHH x ACI Map650.3599RGD
Cytogenetic Map6q21UniSTS
D6Got73  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0660,631,927 - 60,632,167NCBIRnor6.0
Rnor_5.0670,219,674 - 70,219,914UniSTSRnor5.0
RGSC_v3.4659,971,900 - 59,972,141RGDRGSC3.4
RGSC_v3.4659,971,901 - 59,972,141UniSTSRGSC3.4
RGSC_v3.1659,975,027 - 59,975,267RGD
Celera656,794,355 - 56,794,591UniSTS
RH 3.4 Map6422.6RGD
RH 3.4 Map6422.6UniSTS
RH 2.0 Map6601.7RGD
Cytogenetic Map6q21UniSTS
BF403292  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0660,504,810 - 60,505,020NCBIRnor6.0
Rnor_5.0670,092,518 - 70,092,728UniSTSRnor5.0
RGSC_v3.4659,842,216 - 59,842,426UniSTSRGSC3.4
Celera656,667,880 - 56,668,090UniSTS
RH 3.4 Map6404.1UniSTS
Cytogenetic Map6q21UniSTS
BE120673  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0660,731,740 - 60,731,925NCBIRnor6.0
Rnor_5.0670,319,056 - 70,319,241UniSTSRnor5.0
RGSC_v3.4660,083,461 - 60,083,646UniSTSRGSC3.4
Celera656,893,406 - 56,893,591UniSTS
RH 3.4 Map6409.0UniSTS
Cytogenetic Map6q21UniSTS
AU047538  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0660,698,442 - 60,698,605NCBIRnor6.0
Rnor_5.0670,286,189 - 70,286,352UniSTSRnor5.0
RGSC_v3.4660,038,798 - 60,038,961UniSTSRGSC3.4
Celera656,860,217 - 56,860,380UniSTS
Cytogenetic Map6q21UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6175623393Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)6112039375023446Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)62537030111715717Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)6616172276002731Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6616172276002731Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)67009971115379601Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61681010761810107Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61681010761810107Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)61941788764417887Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62151530265784818Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63436743680490628Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63499565675623393Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63626028860606186Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63626028884763275Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63760898075023446Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63810630883106308Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)63819641260606431Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64167904686679046Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64167904686679046Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64167904686679046Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)648432758108268790Rat
4889848Pur25Proteinuria QTL 25140.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65980306594001333Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)660606431108154445Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)660606431108154445Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:64
Count of miRNA genes:23
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000006709, ENSRNOT00000075193
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 64 3 7 11
Low 1 43 53 41 19 41 8 11 10 32 34 8
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006709   ⟹   ENSRNOP00000006709
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl660,566,196 - 60,782,556 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075193   ⟹   ENSRNOP00000065056
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl660,566,196 - 60,782,556 (+)Ensembl
RefSeq Acc Id: XM_008764654   ⟹   XP_008762876
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0660,374,839 - 60,782,648 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017603164   ⟹   XP_017458653
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Celera656,552,544 - 56,940,868 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039078124   ⟹   XP_038934052
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2657,512,929 - 57,902,597 (+)NCBI
RefSeq Acc Id: XM_039078125   ⟹   XP_038934053
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2657,652,780 - 57,902,597 (+)NCBI
RefSeq Acc Id: XM_039078126   ⟹   XP_038934054
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2657,512,929 - 57,902,597 (+)NCBI
RefSeq Acc Id: XM_039078128   ⟹   XP_038934056
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2657,512,929 - 57,902,597 (+)NCBI
RefSeq Acc Id: XM_039078129   ⟹   XP_038934057
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2657,512,929 - 57,902,597 (+)NCBI
RefSeq Acc Id: XM_039078130   ⟹   XP_038934058
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2657,512,929 - 57,857,054 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_008762876   ⟸   XM_008764654
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017458653   ⟸   XM_017603164
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000006709   ⟸   ENSRNOT00000006709
RefSeq Acc Id: ENSRNOP00000065056   ⟸   ENSRNOT00000075193
RefSeq Acc Id: XP_038934052   ⟸   XM_039078124
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038934057   ⟸   XM_039078129
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038934056   ⟸   XM_039078128
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038934054   ⟸   XM_039078126
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038934058   ⟸   XM_039078130
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038934053   ⟸   XM_039078125
- Peptide Label: isoform X2
Protein Domains
C2 DOCK-type   DOCKER   SH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561724 AgrOrtholog
Ensembl Genes ENSRNOG00000004823 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000006709 UniProtKB/TrEMBL
  ENSRNOP00000065056 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006709 UniProtKB/TrEMBL
  ENSRNOT00000075193 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.350 UniProtKB/TrEMBL
  1.20.58.740 UniProtKB/TrEMBL
  1.25.40.410 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  C2_Dock-B UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DHR-1_domain UniProtKB/TrEMBL
  DHR-2 UniProtKB/TrEMBL
  DOCK UniProtKB/TrEMBL
  DOCK4 UniProtKB/TrEMBL
  DOCK4_SH3 UniProtKB/TrEMBL
  DOCK_C UniProtKB/TrEMBL
  DOCK_C_lobe_A UniProtKB/TrEMBL
  DOCK_C_lobe_C UniProtKB/TrEMBL
  DOCK_N UniProtKB/TrEMBL
  DOCK_N_sub1 UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
NCBI Gene 366608 ENTREZGENE
PANTHER PTHR45653 UniProtKB/TrEMBL
  PTHR45653:SF7 UniProtKB/TrEMBL
Pfam Ded_cyto UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/TrEMBL
  DOCK_N UniProtKB/TrEMBL
PhenoGen Dock4 PhenoGen
PROSITE DHR_1 UniProtKB/TrEMBL
  DHR_2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt F1LZ81_RAT UniProtKB/TrEMBL
  M0R6K4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-25 Dock4  dedicator of cytokinesis 4  RGD1561724  similar to mKIAA0716 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561724  similar to mKIAA0716 protein   RGD1561724_predicted  similar to mKIAA0716 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561724_predicted  similar to mKIAA0716 protein (predicted)  LOC366608  similar to mKIAA0716 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC366608  similar to mKIAA0716 protein      Symbol and Name status set to provisional 70820 PROVISIONAL