Dgkk (diacylglycerol kinase kappa) - Rat Genome Database

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Gene: Dgkk (diacylglycerol kinase kappa) Rattus norvegicus
Analyze
Symbol: Dgkk
Name: diacylglycerol kinase kappa
RGD ID: 1561510
Description: Predicted to enable diacylglycerol kinase activity. Predicted to be involved in several processes, including diacylglycerol metabolic process; lipid phosphorylation; and response to oxidative stress. Predicted to be located in plasma membrane. Orthologous to human DGKK (diacylglycerol kinase kappa); INTERACTS WITH bisphenol A; endosulfan; paracetamol.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC367745; RGD1561510; similar to Hypothetical protein C130007D14
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X15,581,991 - 15,713,814 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX15,583,572 - 15,712,987 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X16,441,318 - 16,526,046 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX16,442,899 - 16,537,888 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X17,226,359 - 17,311,107 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X27,667,118 - 27,751,828 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX15,656,570 - 15,788,013 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16210324  


Genomics

Comparative Map Data
Dgkk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X15,581,991 - 15,713,814 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX15,583,572 - 15,712,987 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X16,441,318 - 16,526,046 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX16,442,899 - 16,537,888 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X17,226,359 - 17,311,107 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X27,667,118 - 27,751,828 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX15,656,570 - 15,788,013 (-)NCBICelera
Cytogenetic MapXq12NCBI
DGKK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X50,365,409 - 50,470,825 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX50,365,409 - 50,470,825 (-)EnsemblGRCh38hg38GRCh38
GRCh37X50,108,408 - 50,213,824 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X50,128,637 - 50,230,477 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX54,155,478 - 54,257,318 (-)NCBICelera
Cytogenetic MapXp11.22NCBI
HuRefX47,555,690 - 47,658,066 (-)NCBIHuRef
CHM1_1X50,191,709 - 50,293,446 (-)NCBICHM1_1
T2T-CHM13v2.0X49,636,842 - 49,742,255 (-)NCBIT2T-CHM13v2.0
Dgkk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X6,691,103 - 6,814,602 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX6,690,410 - 6,814,602 (+)EnsemblGRCm39 Ensembl
GRCm38X6,779,306 - 6,948,363 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX6,779,306 - 6,948,363 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X6,450,607 - 6,525,489 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv37X6,356,432 - 6,356,762 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X6,030,445 - 6,103,753 (+)NCBIMGSCv36mm8
CeleraX4,515,162 - 4,633,179 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
Dgkk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555431,468,328 - 1,601,101 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555431,468,328 - 1,601,101 (-)NCBIChiLan1.0ChiLan1.0
DGKK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X50,237,234 - 50,342,181 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX50,240,773 - 50,342,050 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X42,525,307 - 42,630,539 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DGKK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X43,041,721 - 43,229,431 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX43,044,242 - 43,230,590 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX17,419,149 - 17,516,827 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X43,180,946 - 43,278,623 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX43,181,082 - 43,350,361 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X43,166,766 - 43,264,446 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X43,154,088 - 43,251,770 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X43,248,960 - 43,346,646 (-)NCBIUU_Cfam_GSD_1.0
Dgkk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X35,560,753 - 35,696,285 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367211,804,746 - 1,934,527 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049367211,804,746 - 1,934,854 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DGKK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX44,001,176 - 44,180,179 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X44,001,172 - 44,180,142 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X48,928,273 - 49,107,063 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DGKK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X47,156,308 - 47,265,027 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX47,156,317 - 47,264,824 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666086745,247 - 853,950 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dgkk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248931,896,083 - 2,081,503 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248931,892,511 - 2,081,634 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dgkk
389 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:46
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000060247
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat

Markers in Region
BM385349  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X15,688,790 - 15,688,961 (+)MAPPERmRatBN7.2
Rnor_6.0X16,547,429 - 16,547,599NCBIRnor6.0
Rnor_5.0X17,331,811 - 17,331,981UniSTSRnor5.0
RGSC_v3.4X27,772,532 - 27,772,702UniSTSRGSC3.4
CeleraX15,762,018 - 15,762,188UniSTS
RH 3.4 MapX165.5UniSTS
Cytogenetic MapXq13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system
High
Medium 1
Low 12 20 12 12 48 4 19
Below cutoff 12 13 13 13 26 14 12

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000060247   ⟹   ENSRNOP00000056998
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX15,585,602 - 15,712,987 (-)Ensembl
Rnor_6.0 EnsemblX16,444,932 - 16,537,888 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093156   ⟹   ENSRNOP00000076098
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX15,634,042 - 15,673,451 (-)Ensembl
Rnor_6.0 EnsemblX16,493,413 - 16,532,089 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093647   ⟹   ENSRNOP00000076321
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX15,583,572 - 15,667,390 (-)Ensembl
Rnor_6.0 EnsemblX16,442,899 - 16,526,028 (-)Ensembl
RefSeq Acc Id: XM_039100305   ⟹   XP_038956233
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X15,581,991 - 15,713,814 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038956233 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83866 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: ENSRNOP00000076321   ⟸   ENSRNOT00000093647
RefSeq Acc Id: ENSRNOP00000076098   ⟸   ENSRNOT00000093156
RefSeq Acc Id: ENSRNOP00000056998   ⟸   ENSRNOT00000060247
RefSeq Acc Id: XP_038956233   ⟸   XM_039100305
Protein Domains
DAGKc   PH   Phorbol-ester/DAG-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LZW2-F1-model_v2 AlphaFold F1LZW2 1-1081 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561510 AgrOrtholog
BioCyc Gene G2FUF-2874 BioCyc
Ensembl Genes ENSRNOG00000039323 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000056998 ENTREZGENE
  ENSRNOP00000056998.4 UniProtKB/TrEMBL
  ENSRNOP00000076098.1 UniProtKB/TrEMBL
  ENSRNOP00000076321.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060247 ENTREZGENE
  ENSRNOT00000060247.4 UniProtKB/TrEMBL
  ENSRNOT00000093156.2 UniProtKB/TrEMBL
  ENSRNOT00000093647.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.40.50.10330 UniProtKB/TrEMBL
InterPro ATP-NAD_kinase_dom_1 UniProtKB/TrEMBL
  ATP-NAD_kinase_PpnK-typ UniProtKB/TrEMBL
  C1-like_sf UniProtKB/TrEMBL
  DGK UniProtKB/TrEMBL
  Diacylglycerol_kin_accessory UniProtKB/TrEMBL
  Diacylglycerol_kinase_cat_dom UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Prot_Kinase_C-like_PE/DAG-bd UniProtKB/TrEMBL
NCBI Gene 367745 ENTREZGENE
PANTHER PTHR11255 UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  DAGK_acc UniProtKB/TrEMBL
  DAGK_cat UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
PhenoGen Dgkk PhenoGen
PROSITE DAGK UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART DAGKa UniProtKB/TrEMBL
  DAGKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP SSF111331 UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A1W2Q613_RAT UniProtKB/TrEMBL
  A0A1W2Q6N4_RAT UniProtKB/TrEMBL
  F1LZW2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-29 Dgkk  diacylglycerol kinase kappa  RGD1561510_predicted  similar to Hypothetical protein C130007D14 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561510_predicted  similar to Hypothetical protein C130007D14 (predicted)  LOC367745  similar to Hypothetical protein C130007D14  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC367745  similar to Hypothetical protein C130007D14      Symbol and Name status set to provisional 70820 PROVISIONAL