Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | Prrg1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of PRRG1 mRNA | CTD | PMID:22206623 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of PRRG1 mRNA | CTD | PMID:32145629 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PRRG1 mRNA | CTD | PMID:32109520 and PMID:33387578 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Prrg1 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of PRRG1 mRNA | CTD | PMID:26251327 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | PRRG1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRRG1 mRNA | CTD | PMID:28628672 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Prrg1 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of PRRG1 mRNA | CTD | PMID:28973697 | 5-fluorouracil | decreases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Fluorouracil results in decreased expression of PRRG1 mRNA | CTD | PMID:17039268 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of PRRG1 mRNA | CTD | PMID:24780913 | acetamide | decreases expression | EXP | | 6480464 | acetamide results in decreased expression of PRRG1 mRNA | CTD | PMID:31881176 | aflatoxin B1 | affects expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of PRRG1 protein | CTD | PMID:20106945 | aflatoxin B1 | decreases methylation | ISO | PRRG1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of PRRG1 gene | CTD | PMID:27153756 | antirheumatic drug | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of PRRG1 mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PRRG1 mRNA | CTD | PMID:33212167 | arsane | affects methylation | ISO | PRRG1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of PRRG1 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | PRRG1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of PRRG1 gene | CTD | PMID:25304211 | arsenous acid | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of PRRG1 mRNA | CTD | PMID:20458559 | benzo[a]pyrene | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of PRRG1 mRNA | CTD | PMID:20106945 | benzo[a]pyrene | increases methylation | ISO | PRRG1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of PRRG1 exon | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | PRRG1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PRRG1 5' UTR and Benzo(a)pyrene affects the methylation of PRRG1 promoter | CTD | PMID:27901495 | benzo[a]pyrene | decreases expression | ISO | Prrg1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of PRRG1 mRNA | CTD | PMID:19770486 | bis(2-ethylhexyl) phthalate | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of PRRG1 mRNA | CTD | PMID:31163220 | bisphenol A | increases expression | ISO | Prrg1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of PRRG1 mRNA | CTD | PMID:25594700 and PMID:30951980 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PRRG1 mRNA | CTD | PMID:33296240 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PRRG1 mRNA | CTD | PMID:30816183 | bisphenol A | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of PRRG1 mRNA | CTD | PMID:29275510 | bisphenol A | multiple interactions | ISO | PRRG1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRRG1 mRNA | CTD | PMID:28628672 | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of PRRG1 mRNA | CTD | PMID:33453195 | chlordecone | increases expression | ISO | Prrg1 (Mus musculus) | 6480464 | Chlordecone results in increased expression of PRRG1 mRNA | CTD | PMID:29980752 | cisplatin | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of PRRG1 mRNA | CTD | PMID:27392435 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of PRRG1 mRNA | CTD | PMID:27523638 | cyclosporin A | decreases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of PRRG1 mRNA | CTD | PMID:27989131 | dexamethasone | multiple interactions | ISO | PRRG1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRRG1 mRNA | CTD | PMID:28628672 | diarsenic trioxide | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of PRRG1 mRNA | CTD | PMID:20458559 | dioxygen | multiple interactions | ISO | Prrg1 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PRRG1 mRNA | CTD | PMID:30529165 | dorsomorphin | multiple interactions | ISO | PRRG1 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of PRRG1 mRNA | CTD | PMID:29803840 | endosulfan | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Endosulfan results in increased expression of PRRG1 mRNA | CTD | PMID:26615145 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of PRRG1 mRNA | CTD | PMID:29391264 | entinostat | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | entinostat results in increased expression of PRRG1 mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | ISO | PRRG1 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRRG1 mRNA | CTD | PMID:27188386 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of PRRG1 mRNA | CTD | PMID:24793618 | folic acid | decreases expression | ISO | Prrg1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of PRRG1 mRNA | CTD | PMID:25629700 | genistein | decreases expression | ISO | Prrg1 (Mus musculus) | 6480464 | Genistein results in decreased expression of PRRG1 mRNA | CTD | PMID:32186404 | indometacin | multiple interactions | ISO | PRRG1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PRRG1 mRNA | CTD | PMID:28628672 | lead(0) | affects expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Lead affects the expression of PRRG1 mRNA | CTD | PMID:28903495 | leflunomide | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | leflunomide results in increased expression of PRRG1 mRNA | CTD | PMID:28988120 | mercury dibromide | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | mercuric bromide results in increased expression of PRRG1 mRNA | CTD | PMID:26272509 | mercury dibromide | multiple interactions | ISO | PRRG1 (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRRG1 mRNA | CTD | PMID:27188386 | methylmercury chloride | decreases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of PRRG1 mRNA | CTD | PMID:28001369 | nickel sulfate | decreases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | nickel sulfate results in decreased expression of PRRG1 mRNA | CTD | PMID:22714537 | ozone | multiple interactions | ISO | Prrg1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of PRRG1 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of PRRG1 mRNA | CTD | PMID:27106289 and PMID:34911549 | panobinostat | multiple interactions | ISO | PRRG1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRRG1 mRNA | CTD | PMID:27188386 | panobinostat | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | panobinostat results in increased expression of PRRG1 mRNA | CTD | PMID:26272509 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of PRRG1 mRNA | CTD | PMID:33387578 | permethrin | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Permethrin results in increased expression of PRRG1 mRNA | CTD | PMID:37047231 | phenylmercury acetate | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of PRRG1 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | PRRG1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRRG1 mRNA | CTD | PMID:27188386 | potassium chromate | decreases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of PRRG1 mRNA | CTD | PMID:22714537 | resorcinol | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | resorcinol results in increased expression of PRRG1 mRNA | CTD | PMID:22623647 | rotenone | decreases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Rotenone results in decreased expression of PRRG1 mRNA | CTD | PMID:29955902 | SB 431542 | multiple interactions | ISO | PRRG1 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium arsenite | multiple interactions | ISO | PRRG1 (Homo sapiens) | 6480464 | sodium arsenite promotes the reaction [PRRG1 protein binds to CAPRIN1 protein] | CTD | PMID:33939924 | sunitinib | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PRRG1 mRNA | CTD | PMID:31533062 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of PRRG1 mRNA | CTD | PMID:34492290 | titanium dioxide | decreases expression | ISO | Prrg1 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of PRRG1 mRNA | CTD | PMID:29264374 | trichostatin A | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of PRRG1 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | PRRG1 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRRG1 mRNA | CTD | PMID:27188386 | triptonide | decreases expression | ISO | Prrg1 (Mus musculus) | 6480464 | triptonide results in decreased expression of PRRG1 mRNA | CTD | PMID:33045310 | urethane | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Urethane results in increased expression of PRRG1 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PRRG1 mRNA | CTD | PMID:25979313 | valproic acid | multiple interactions | ISO | PRRG1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRRG1 mRNA | CTD | PMID:27188386 | valproic acid | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PRRG1 mRNA | CTD | PMID:23179753 more ... | vorinostat | increases expression | ISO | PRRG1 (Homo sapiens) | 6480464 | vorinostat results in increased expression of PRRG1 mRNA | CTD | PMID:26272509 | vorinostat | multiple interactions | ISO | PRRG1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRRG1 mRNA | CTD | PMID:27188386 | |