Prrg1 (proline rich and Gla domain 1) - Rat Genome Database

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Gene: Prrg1 (proline rich and Gla domain 1) Rattus norvegicus
Analyze
Symbol: Prrg1
Name: proline rich and Gla domain 1
RGD ID: 1561320
Description: Predicted to enable calcium ion binding activity. Predicted to be located in membrane. Predicted to be active in extracellular space. Orthologous to human PRRG1 (proline rich and Gla domain 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC363472; proline rich Gla (G-carboxyglutamic acid) 1; RGD1561320; similar to hypothetical protein; transmembrane gamma-carboxyglutamic acid protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X46,381,329 - 46,493,677 (-)NCBIGRCr8
mRatBN7.2X42,494,256 - 42,606,612 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX42,494,256 - 42,606,588 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX43,833,736 - 43,943,461 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X47,301,067 - 47,410,801 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X44,965,814 - 45,075,542 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X45,698,240 - 45,806,238 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX45,698,237 - 45,806,198 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X45,920,009 - 46,028,742 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X64,203,026 - 64,316,641 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX43,145,061 - 43,253,915 (-)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Prrg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X46,381,329 - 46,493,677 (-)NCBIGRCr8
mRatBN7.2X42,494,256 - 42,606,612 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX42,494,256 - 42,606,588 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX43,833,736 - 43,943,461 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X47,301,067 - 47,410,801 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X44,965,814 - 45,075,542 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X45,698,240 - 45,806,238 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX45,698,237 - 45,806,198 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X45,920,009 - 46,028,742 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X64,203,026 - 64,316,641 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX43,145,061 - 43,253,915 (-)NCBICelera
Cytogenetic MapXq21NCBI
PRRG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X37,349,364 - 37,457,291 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX37,349,309 - 37,457,292 (+)EnsemblGRCh38hg38GRCh38
GRCh37X37,208,617 - 37,316,544 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X37,130,773 - 37,201,463 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X36,964,818 - 37,072,736NCBI
CeleraX41,346,185 - 41,454,238 (+)NCBICelera
Cytogenetic MapXp21.1NCBI
HuRefX34,955,127 - 35,062,967 (+)NCBIHuRef
CHM1_1X37,239,598 - 37,347,627 (+)NCBICHM1_1
T2T-CHM13v2.0X36,752,902 - 36,860,846 (+)NCBIT2T-CHM13v2.0
Prrg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X77,493,216 - 77,627,539 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX77,493,219 - 77,627,502 (-)EnsemblGRCm39 Ensembl
GRCm38X78,449,610 - 78,583,914 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX78,449,613 - 78,583,896 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X75,694,952 - 75,829,235 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X74,704,396 - 74,836,613 (-)NCBIMGSCv36mm8
CeleraX69,782,814 - 69,916,788 (-)NCBICelera
Cytogenetic MapXBNCBI
cM MapX38.34NCBI
Prrg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955587287,845 - 388,557 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955587289,906 - 388,534 (-)NCBIChiLan1.0ChiLan1.0
PRRG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X39,004,983 - 39,113,114 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X39,008,358 - 39,116,490 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X29,806,505 - 29,914,627 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X37,433,739 - 37,541,340 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX37,433,328 - 37,541,340 (+)Ensemblpanpan1.1panPan2
PRRG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X31,856,586 - 32,141,855 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX31,870,092 - 32,138,147 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX19,344,176 - 19,490,722 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X32,038,867 - 32,185,095 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX32,038,867 - 32,185,087 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X32,122,908 - 32,268,825 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X32,086,788 - 32,232,928 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X32,186,570 - 32,332,759 (+)NCBIUU_Cfam_GSD_1.0
Prrg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X24,348,497 - 24,447,177 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365024,189,254 - 4,291,140 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365024,189,283 - 4,288,089 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRRG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX33,091,149 - 33,232,556 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X33,064,499 - 33,232,556 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X36,740,734 - 36,882,357 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRRG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605637,827,100 - 37,931,661 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prrg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476218,273,434 - 18,378,802 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476218,273,401 - 18,379,796 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prrg1
404 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:306
Count of miRNA genes:178
Interacting mature miRNAs:197
Transcripts:ENSRNOT00000066663
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat

Markers in Region
AU048072  
Rat AssemblyChrPosition (strand)SourceJBrowse
CeleraX43,252,714 - 43,252,754UniSTS
Cytogenetic MapXq22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 4 4 2 2 6 10 33 10 2
Low 3 42 51 37 19 37 6 9 68 25 6 1 6
Below cutoff 1 2

Sequence


RefSeq Acc Id: ENSRNOT00000066663   ⟹   ENSRNOP00000063292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX42,494,256 - 42,606,588 (-)Ensembl
Rnor_6.0 EnsemblX45,698,237 - 45,806,198 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100193   ⟹   ENSRNOP00000091704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX42,494,273 - 42,606,526 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103255   ⟹   ENSRNOP00000087825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX42,494,287 - 42,513,723 (-)Ensembl
RefSeq Acc Id: NM_001191888   ⟹   NP_001178817
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X46,383,958 - 46,493,607 (-)NCBI
mRatBN7.2X42,496,885 - 42,606,546 (-)NCBI
Rnor_6.0X45,700,869 - 45,806,169 (-)NCBI
Rnor_5.0X45,920,009 - 46,028,742 (-)NCBI
CeleraX43,145,061 - 43,253,915 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256963   ⟹   XP_006257025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X46,381,329 - 46,493,673 (-)NCBI
mRatBN7.2X42,494,256 - 42,606,612 (-)NCBI
Rnor_6.0X45,698,240 - 45,806,238 (-)NCBI
Rnor_5.0X45,920,009 - 46,028,742 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256965   ⟹   XP_006257027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X46,381,329 - 46,493,677 (-)NCBI
mRatBN7.2X42,494,256 - 42,606,612 (-)NCBI
Rnor_6.0X45,698,240 - 45,806,238 (-)NCBI
Rnor_5.0X45,920,009 - 46,028,742 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602104   ⟹   XP_017457593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X46,381,329 - 46,493,479 (-)NCBI
mRatBN7.2X42,494,256 - 42,606,461 (-)NCBI
Rnor_6.0X45,698,240 - 45,806,084 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602106   ⟹   XP_017457595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X46,381,329 - 46,493,561 (-)NCBI
mRatBN7.2X42,494,256 - 42,606,461 (-)NCBI
Rnor_6.0X45,698,240 - 45,806,084 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602107   ⟹   XP_017457596
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X46,381,329 - 46,493,596 (-)NCBI
mRatBN7.2X42,494,256 - 42,606,596 (-)NCBI
Rnor_6.0X45,698,240 - 45,806,093 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063280139   ⟹   XP_063136209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X46,381,329 - 46,493,479 (-)NCBI
RefSeq Acc Id: XM_063280140   ⟹   XP_063136210
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X46,381,329 - 46,493,483 (-)NCBI
RefSeq Acc Id: XM_063280141   ⟹   XP_063136211
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X46,381,329 - 46,493,479 (-)NCBI
RefSeq Acc Id: XM_063280142   ⟹   XP_063136212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X46,384,765 - 46,493,673 (-)NCBI
RefSeq Acc Id: NP_001178817   ⟸   NM_001191888
- UniProtKB: A0A8I6A9I3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257027   ⟸   XM_006256965
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ACL3 (UniProtKB/TrEMBL),   A0A8I6A9I3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257025   ⟸   XM_006256963
- Peptide Label: isoform X1
- UniProtKB: D3ZUF5 (UniProtKB/TrEMBL),   A0A8I6A9I3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457596   ⟸   XM_017602107
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ACL3 (UniProtKB/TrEMBL),   A0A8I6A9I3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457595   ⟸   XM_017602106
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ACL3 (UniProtKB/TrEMBL),   A0A8I6A9I3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457593   ⟸   XM_017602104
- Peptide Label: isoform X1
- UniProtKB: D3ZUF5 (UniProtKB/TrEMBL),   A0A8I6A9I3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000063292   ⟸   ENSRNOT00000066663
RefSeq Acc Id: ENSRNOP00000087825   ⟸   ENSRNOT00000103255
RefSeq Acc Id: ENSRNOP00000091704   ⟸   ENSRNOT00000100193
RefSeq Acc Id: XP_063136210   ⟸   XM_063280140
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063136209   ⟸   XM_063280139
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063136211   ⟸   XM_063280141
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063136212   ⟸   XM_063280142
- Peptide Label: isoform X4
Protein Domains
Gla

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUF5-F1-model_v2 AlphaFold D3ZUF5 1-217 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701825
Promoter ID:EPDNEW_R12349
Type:multiple initiation site
Name:Prrg1_1
Description:proline rich and Gla domain 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X45,806,214 - 45,806,274EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561320 AgrOrtholog
BioCyc Gene G2FUF-2392 BioCyc
Ensembl Genes ENSRNOG00000026044 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066663 ENTREZGENE
  ENSRNOT00000066663.4 UniProtKB/TrEMBL
  ENSRNOT00000100193.1 UniProtKB/TrEMBL
  ENSRNOT00000103255.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.740.10 UniProtKB/TrEMBL
InterPro Coagulation_fac_subgr_Gla_dom UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/TrEMBL
  GLA_domain UniProtKB/TrEMBL
NCBI Gene 363472 ENTREZGENE
PANTHER COAGULATION FACTOR UniProtKB/TrEMBL
  TRANSMEMBRANE GAMMA-CARBOXYGLUTAMIC ACID PROTEIN 1 UniProtKB/TrEMBL
Pfam Gla UniProtKB/TrEMBL
PhenoGen Prrg1 PhenoGen
PRINTS GLABLOOD UniProtKB/TrEMBL
PROSITE GLA_1 UniProtKB/TrEMBL
  GLA_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026044 RatGTEx
SMART GLA UniProtKB/TrEMBL
Superfamily-SCOP VitK_dep_GLA UniProtKB/TrEMBL
UniProt A0A8I6A9I3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACL3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZUF5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Prrg1  proline rich and Gla domain 1  Prrg1  proline rich Gla (G-carboxyglutamic acid) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Prrg1  proline rich Gla (G-carboxyglutamic acid) 1  RGD1561320_predicted  similar to hypothetical protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561320_predicted  similar to hypothetical protein (predicted)  LOC363472  similar to hypothetical protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363472  similar to hypothetical protein      Symbol and Name status set to provisional 70820 PROVISIONAL