Tmem174 (transmembrane protein 174) - Rat Genome Database

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Gene: Tmem174 (transmembrane protein 174) Rattus norvegicus
Analyze
Symbol: Tmem174
Name: transmembrane protein 174
RGD ID: 1561129
Description: Predicted to be involved in phosphate ion homeostasis. Located in apical plasma membrane. Orthologous to human TMEM174 (transmembrane protein 174); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC499516; similar to hypothetical protein MGC13034
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8231,695,051 - 31,738,819 (-)NCBIGRCr8
mRatBN7.2229,992,070 - 29,993,601 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl229,992,073 - 29,993,601 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx237,049,225 - 37,050,756 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0235,143,597 - 35,145,128 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0229,960,465 - 29,961,996 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0228,748,706 - 28,750,237 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl228,748,707 - 28,750,237 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0247,846,783 - 47,848,314 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4229,257,827 - 29,259,358 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera226,027,993 - 26,029,524 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Targeted Disruption of a Proximal Tubule-Specific TMEM174 Gene in Mice Causes Hyperphosphatemia and Vascular Calcification. Miyazaki-Anzai S, etal., J Am Soc Nephrol. 2022 Aug;33(8):1477-1486. doi: 10.1681/ASN.2021121578. Epub 2022 Apr 22.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334  


Genomics

Comparative Map Data
Tmem174
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8231,695,051 - 31,738,819 (-)NCBIGRCr8
mRatBN7.2229,992,070 - 29,993,601 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl229,992,073 - 29,993,601 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx237,049,225 - 37,050,756 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0235,143,597 - 35,145,128 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0229,960,465 - 29,961,996 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0228,748,706 - 28,750,237 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl228,748,707 - 28,750,237 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0247,846,783 - 47,848,314 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4229,257,827 - 29,259,358 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera226,027,993 - 26,029,524 (-)NCBICelera
Cytogenetic Map2q12NCBI
TMEM174
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38573,173,193 - 73,175,143 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl573,173,193 - 73,175,143 (+)EnsemblGRCh38hg38GRCh38
GRCh37572,469,020 - 72,470,970 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36572,499,830 - 72,506,295 (+)NCBINCBI36Build 36hg18NCBI36
Celera568,364,379 - 68,366,326 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef567,674,745 - 67,676,692 (+)NCBIHuRef
CHM1_1571,901,724 - 71,903,671 (+)NCBICHM1_1
T2T-CHM13v2.0573,654,534 - 73,656,484 (+)NCBIT2T-CHM13v2.0
Tmem174
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391398,771,486 - 98,773,918 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1398,771,486 - 98,773,918 (-)EnsemblGRCm39 Ensembl
GRCm381398,634,978 - 98,637,410 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1398,634,978 - 98,637,410 (-)EnsemblGRCm38mm10GRCm38
MGSCv371399,404,933 - 99,407,365 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361399,735,143 - 99,737,490 (-)NCBIMGSCv36mm8
Celera13107,700,981 - 107,703,413 (+)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1352.11NCBI
Tmem174
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542527,402,129 - 27,404,414 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542527,402,376 - 27,404,414 (-)NCBIChiLan1.0ChiLan1.0
TMEM174
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2442,140,063 - 42,143,046 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1540,293,697 - 40,296,316 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0542,138,978 - 42,140,805 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1542,738,383 - 42,739,894 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl542,738,383 - 42,739,992 (-)Ensemblpanpan1.1panPan2
TMEM174
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1256,066,058 - 56,068,256 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl256,065,645 - 56,067,161 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha253,039,810 - 53,042,055 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0256,587,724 - 56,589,969 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl256,588,069 - 56,588,874 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1253,648,651 - 53,650,896 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0254,416,762 - 54,419,007 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0255,308,051 - 55,310,296 (+)NCBIUU_Cfam_GSD_1.0
Tmem174
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213187,495,199 - 187,496,988 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365493,362,807 - 3,363,774 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365493,362,825 - 3,363,774 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM174
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl282,336,049 - 82,337,155 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1282,335,831 - 82,337,658 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2284,044,238 - 84,046,167 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM174
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1467,515,691 - 67,517,487 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl467,515,947 - 67,519,015 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604916,283,506 - 16,285,432 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem174
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249052,223,093 - 2,225,855 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249052,223,128 - 2,246,818 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem174
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:154
Count of miRNA genes:97
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000020879
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 31 1
Low 16 7 11 7 6 6 5 19 7 6
Below cutoff 12 24 17 5 17 2 2 5 4 11 1 2

Sequence


RefSeq Acc Id: ENSRNOT00000020879   ⟹   ENSRNOP00000020879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl229,992,073 - 29,993,601 (-)Ensembl
Rnor_6.0 Ensembl228,748,707 - 28,750,237 (-)Ensembl
RefSeq Acc Id: NM_001024298   ⟹   NP_001019469
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8231,726,280 - 31,727,811 (-)NCBI
mRatBN7.2229,992,070 - 29,993,601 (-)NCBI
Rnor_6.0228,748,706 - 28,750,237 (-)NCBI
Rnor_5.0247,846,783 - 47,848,314 (-)NCBI
RGSC_v3.4229,257,827 - 29,259,358 (-)RGD
Celera226,027,993 - 26,029,524 (-)RGD
Sequence:
RefSeq Acc Id: XM_063282344   ⟹   XP_063138414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8231,695,051 - 31,738,819 (-)NCBI
RefSeq Acc Id: XM_063282345   ⟹   XP_063138415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8231,695,051 - 31,738,819 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001019469 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138414 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138415 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79357 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020879
  ENSRNOP00000020879.3
  ENSRNOP00055035617
  ENSRNOP00060042492
  ENSRNOP00065030554
GenBank Protein Q68FU0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001019469   ⟸   NM_001024298
- UniProtKB: Q68FU0 (UniProtKB/Swiss-Prot),   A6I546 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020879   ⟸   ENSRNOT00000020879
RefSeq Acc Id: XP_063138415   ⟸   XM_063282345
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063138414   ⟸   XM_063282344
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q68FU0-F1-model_v2 AlphaFold Q68FU0 1-243 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691091
Promoter ID:EPDNEW_R1616
Type:initiation region
Name:Tmem174_1
Description:transmembrane protein 174
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0228,750,225 - 28,750,285EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561129 AgrOrtholog
BioCyc Gene G2FUF-54718 BioCyc
Ensembl Genes ENSRNOG00000015472 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055025301 UniProtKB/Swiss-Prot
  ENSRNOG00060029429 UniProtKB/Swiss-Prot
  ENSRNOG00065022176 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020879 ENTREZGENE
  ENSRNOT00000020879.6 UniProtKB/Swiss-Prot
  ENSRNOT00055043627 UniProtKB/Swiss-Prot
  ENSRNOT00060051077 UniProtKB/Swiss-Prot
  ENSRNOT00065037781 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7108570 IMAGE-MGC_LOAD
InterPro TMEM174 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:499516 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94822 IMAGE-MGC_LOAD
NCBI Gene 499516 ENTREZGENE
PANTHER PTHR31020 UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEIN 174 UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEIN 174 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 174 UniProtKB/TrEMBL
Pfam TMEM174 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmem174 PhenoGen
RatGTEx ENSRNOG00000015472 RatGTEx
  ENSRNOG00055025301 RatGTEx
  ENSRNOG00060029429 RatGTEx
  ENSRNOG00065022176 RatGTEx
UniProt A6I546 ENTREZGENE, UniProtKB/TrEMBL
  Q68FU0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Tmem174  transmembrane protein 174  LOC499516  similar to hypothetical protein MGC13034  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC499516  similar to hypothetical protein MGC13034      Symbol and Name status set to provisional 70820 PROVISIONAL