Bves (blood vessel epicardial substance) - Rat Genome Database

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Gene: Bves (blood vessel epicardial substance) Rattus norvegicus
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Symbol: Bves
Name: blood vessel epicardial substance
RGD ID: 1561100
Description: Predicted to enable cAMP binding activity and structural molecule activity. Predicted to be involved in several processes, including positive regulation of receptor recycling; response to ischemia; and substrate adhesion-dependent cell spreading. Predicted to act upstream of or within hematopoietic progenitor cell differentiation; regulation of heart rate; and sinoatrial node cell development. Predicted to be located in several cellular components, including bicellular tight junction; caveola; and lateral plasma membrane. Predicted to be active in sarcolemma. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2X. Orthologous to human BVES (blood vessel epicardial substance); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Popdc1; popeye domain-containing 1; popeye domain-containing protein 1; popeye protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22048,819,241 - 48,860,282 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2048,822,308 - 48,857,472 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2050,565,097 - 50,600,096 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02050,214,848 - 50,249,847 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02050,899,187 - 50,934,183 (+)NCBIRnor_WKY
Rnor_6.02050,439,885 - 50,474,678 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2050,439,883 - 50,474,678 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02052,052,628 - 52,086,539 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42049,671,174 - 49,671,683 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2051,164,981 - 51,200,377 (-)NCBICelera
Cytogenetic Map20q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10882522   PMID:12815060   PMID:16188940   PMID:17662479   PMID:18541910   PMID:20057356   PMID:22354168   PMID:24029230   PMID:24048452   PMID:24066022   PMID:26642364   PMID:27886395  
PMID:33261556  


Genomics

Comparative Map Data
Bves
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22048,819,241 - 48,860,282 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2048,822,308 - 48,857,472 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2050,565,097 - 50,600,096 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02050,214,848 - 50,249,847 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02050,899,187 - 50,934,183 (+)NCBIRnor_WKY
Rnor_6.02050,439,885 - 50,474,678 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2050,439,883 - 50,474,678 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02052,052,628 - 52,086,539 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42049,671,174 - 49,671,683 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2051,164,981 - 51,200,377 (-)NCBICelera
Cytogenetic Map20q13NCBI
BVES
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386105,096,822 - 105,137,157 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6105,096,822 - 105,137,157 (-)EnsemblGRCh38hg38GRCh38
GRCh376105,544,697 - 105,585,032 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366105,651,390 - 105,691,236 (-)NCBINCBI36Build 36hg18NCBI36
Build 346105,651,393 - 105,690,914NCBI
Celera6106,167,189 - 106,206,693 (-)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6102,987,978 - 103,028,002 (-)NCBIHuRef
CHM1_16105,806,724 - 105,846,753 (-)NCBICHM1_1
T2T-CHM13v2.06106,272,906 - 106,312,920 (-)NCBIT2T-CHM13v2.0
Bves
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391045,211,783 - 45,248,580 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1045,211,868 - 45,248,575 (+)EnsemblGRCm39 Ensembl
GRCm381045,335,735 - 45,372,484 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1045,335,772 - 45,372,479 (+)EnsemblGRCm38mm10GRCm38
MGSCv371045,055,568 - 45,089,514 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361045,024,177 - 45,058,123 (+)NCBIMGSCv36mm8
Celera1046,209,822 - 46,242,144 (+)NCBICelera
Cytogenetic Map10B2NCBI
cM Map1023.47NCBI
Bves
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541130,517,875 - 30,551,335 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541130,517,917 - 30,548,424 (-)NCBIChiLan1.0ChiLan1.0
BVES
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16106,784,465 - 106,822,050 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6106,787,615 - 106,822,050 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06102,915,148 - 102,951,141 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BVES
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11262,542,274 - 62,581,110 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1262,545,666 - 62,579,548 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1262,331,453 - 62,369,673 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01263,393,637 - 63,432,405 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1263,393,639 - 63,432,655 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11262,748,894 - 62,787,110 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01262,590,058 - 62,628,349 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01262,868,831 - 62,907,346 (-)NCBIUU_Cfam_GSD_1.0
Bves
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494697,512,420 - 97,548,660 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365641,788,317 - 1,823,084 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365641,791,733 - 1,823,421 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BVES
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl171,314,274 - 71,360,175 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1171,316,354 - 71,360,255 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2180,636,881 - 80,681,079 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BVES
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11368,668,248 - 68,704,661 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1368,668,321 - 68,707,885 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604041,016,271 - 41,055,600 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bves
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624952323,475 - 360,805 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624952326,812 - 360,790 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bves
374 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:29
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000066167
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat

Markers in Region
RH143305  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map11322.3UniSTS
Cytogenetic Map20q13UniSTS
RH143833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22048,857,447 - 48,857,705 (+)MAPPERmRatBN7.2
Rnor_6.02050,474,654 - 50,474,911NCBIRnor6.0
Rnor_5.02052,086,515 - 52,086,772UniSTSRnor5.0
RGSC_v3.42049,671,659 - 49,671,916UniSTSRGSC3.4
Celera2051,164,748 - 51,165,005UniSTS
RH 3.4 Map20511.0UniSTS
Cytogenetic Map20q13UniSTS
BI294843  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22048,851,924 - 48,852,076 (+)MAPPERmRatBN7.2
Rnor_6.02050,468,999 - 50,469,150NCBIRnor6.0
Rnor_5.02052,081,772 - 52,081,923UniSTSRnor5.0
Celera2051,170,174 - 51,170,325UniSTS
RH 3.4 Map20502.9UniSTS
Cytogenetic Map20q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 38 8 11 7 8
Low 3 5 13 10 6 10 71 24 29 11
Below cutoff 24 15 13 15 3 11 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000066167
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2048,822,308 - 48,857,472 (+)Ensembl
Rnor_6.0 Ensembl2050,439,883 - 50,474,678 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076504
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2050,447,139 - 50,474,678 (+)Ensembl
RefSeq Acc Id: NM_001077590   ⟹   NP_001071058
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22048,822,312 - 48,857,472 (+)NCBI
Rnor_6.02050,439,885 - 50,474,678 (+)NCBI
Rnor_5.02052,052,628 - 52,086,539 (+)NCBI
RGSC_v3.42049,671,174 - 49,671,683 (+)RGD
Celera2051,164,981 - 51,200,377 (-)RGD
Sequence:
RefSeq Acc Id: XM_039098917   ⟹   XP_038954845
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22048,819,250 - 48,860,282 (+)NCBI
RefSeq Acc Id: XM_039098918   ⟹   XP_038954846
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22048,819,250 - 48,860,282 (+)NCBI
RefSeq Acc Id: XM_039098919   ⟹   XP_038954847
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22048,819,527 - 48,860,282 (+)NCBI
RefSeq Acc Id: XM_039098920   ⟹   XP_038954848
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22048,819,241 - 48,838,828 (+)NCBI
RefSeq Acc Id: XR_005497303
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22048,819,244 - 48,860,282 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001071058   ⟸   NM_001077590
- UniProtKB: Q3BCU4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_038954848   ⟸   XM_039098920
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038954846   ⟸   XM_039098918
- Peptide Label: isoform X1
- UniProtKB: Q3BCU4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038954845   ⟸   XM_039098917
- Peptide Label: isoform X1
- UniProtKB: Q3BCU4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038954847   ⟸   XM_039098919
- Peptide Label: isoform X1
- UniProtKB: Q3BCU4 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3BCU4-F1-model_v2 AlphaFold Q3BCU4 1-356 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561100 AgrOrtholog
BioCyc Gene G2FUF-3263 BioCyc
Ensembl Genes ENSRNOG00000043199 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000091870 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000066167 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot
InterPro cNMP-bd-like UniProtKB/Swiss-Prot
  Popeye_prot UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
KEGG Report rno:365603 UniProtKB/Swiss-Prot
NCBI Gene 365603 ENTREZGENE
PANTHER PTHR12101 UniProtKB/Swiss-Prot
Pfam Popeye UniProtKB/Swiss-Prot
PhenoGen Bves PhenoGen
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot
UniProt POPD1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-02-09 Bves  blood vessel epicardial substance      Symbol and Name status set to provisional 70820 PROVISIONAL