C1qtnf9 (C1q and TNF related 9) - Rat Genome Database

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Gene: C1qtnf9 (C1q and TNF related 9) Rattus norvegicus
Analyze
Symbol: C1qtnf9
Name: C1q and TNF related 9
RGD ID: 1560876
Description: Predicted to enable hormone activity and identical protein binding activity. Acts upstream of or within fatty acid oxidation. Predicted to be located in extracellular space. Orthologous to several human genes including C1QTNF9 (C1q and TNF related 9); INTERACTS WITH benzo[a]pyrene (ortholog); bisphenol A (ortholog).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: Adif1; adiponectin f1; C1q and tumor necrosis factor related protein 9; Ctrp9; LOC364395; RGD1560876; similar to hypothetical protein MGC48915
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81539,083,883 - 39,099,167 (+)NCBIGRCr8
mRatBN7.21534,907,791 - 34,922,985 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1534,911,286 - 34,922,980 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1536,776,879 - 36,784,636 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01537,927,500 - 37,935,253 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01536,376,449 - 36,384,104 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01541,069,579 - 41,080,961 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1541,069,507 - 41,081,159 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01544,882,217 - 44,893,080 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41539,860,425 - 39,868,076 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1534,616,332 - 34,623,981 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. CTRP9 transgenic mice are protected from diet-induced obesity and metabolic dysfunction. Peterson JM, etal., Am J Physiol Regul Integr Comp Physiol. 2013 Sep;305(5):R522-33. doi: 10.1152/ajpregu.00110.2013. Epub 2013 Jul 10.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18783346   PMID:19666007   PMID:22514273   PMID:28688765   PMID:29925877   PMID:30953351   PMID:31623508   PMID:32429302   PMID:34059748  


Genomics

Comparative Map Data
C1qtnf9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81539,083,883 - 39,099,167 (+)NCBIGRCr8
mRatBN7.21534,907,791 - 34,922,985 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1534,911,286 - 34,922,980 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1536,776,879 - 36,784,636 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01537,927,500 - 37,935,253 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01536,376,449 - 36,384,104 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01541,069,579 - 41,080,961 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1541,069,507 - 41,081,159 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01544,882,217 - 44,893,080 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41539,860,425 - 39,868,076 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1534,616,332 - 34,623,981 (+)NCBICelera
Cytogenetic Map15p12NCBI
C1QTNF9B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381323,891,099 - 23,897,502 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1323,891,099 - 23,897,502 (-)EnsemblGRCh38hg38GRCh38
GRCh371324,465,238 - 24,471,641 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361323,363,428 - 23,369,125 (-)NCBINCBI36Build 36hg18NCBI36
Celera135,528,082 - 5,533,781 (-)NCBICelera
Cytogenetic Map13q12.12NCBI
HuRef135,276,519 - 5,282,222 (-)NCBIHuRef
CHM1_11324,433,584 - 24,439,287 (-)NCBICHM1_1
T2T-CHM13v2.01323,097,537 - 23,108,727 (-)NCBIT2T-CHM13v2.0
C1qtnf9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391461,005,583 - 61,018,318 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1461,005,583 - 61,018,318 (+)EnsemblGRCm39 Ensembl
GRCm381460,768,134 - 60,780,869 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1460,768,134 - 60,780,869 (+)EnsemblGRCm38mm10GRCm38
MGSCv371461,386,971 - 61,399,705 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361459,722,244 - 59,734,978 (+)NCBIMGSCv36mm8
Celera1458,546,595 - 58,559,325 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1431.93NCBI
LOC609026
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12514,735,370 - 14,748,054 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2514,814,153 - 14,826,650 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02514,867,211 - 14,879,712 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12514,748,751 - 14,761,270 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02514,751,418 - 14,763,919 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02514,799,740 - 14,812,241 (+)NCBIUU_Cfam_GSD_1.0
LOC100522569
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1112,791,855 - 2,803,526 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2112,145,862 - 2,156,840 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in C1qtnf9
135 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000018533
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat

Markers in Region
BE114209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21534,922,759 - 34,922,964 (+)MAPPERmRatBN7.2
Rnor_6.01541,080,740 - 41,080,944NCBIRnor6.0
Rnor_5.01544,892,855 - 44,893,059UniSTSRnor5.0
RGSC_v3.41539,867,856 - 39,868,060UniSTSRGSC3.4
Celera1534,623,761 - 34,623,965UniSTS
RH 3.4 Map15225.8UniSTS
Cytogenetic Map15p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 17
Low 1 12 17 1 14 1 8 11 25 10 26 11 8
Below cutoff 2 4 13 13 4 13 41 23 8

Sequence


RefSeq Acc Id: ENSRNOT00000018533   ⟹   ENSRNOP00000018533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1534,911,286 - 34,922,980 (+)Ensembl
Rnor_6.0 Ensembl1541,069,507 - 41,081,159 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095495   ⟹   ENSRNOP00000076970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1534,914,986 - 34,922,980 (+)Ensembl
RefSeq Acc Id: NM_001191891   ⟹   NP_001178820
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,091,439 - 39,099,090 (+)NCBI
mRatBN7.21534,915,329 - 34,922,980 (+)NCBI
Rnor_6.01541,074,328 - 41,080,960 (+)NCBI
Rnor_5.01544,882,217 - 44,893,080 (+)NCBI
Celera1534,616,332 - 34,623,981 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252134   ⟹   XP_006252196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,083,883 - 39,099,167 (+)NCBI
mRatBN7.21534,907,791 - 34,922,985 (+)NCBI
Rnor_6.01541,069,579 - 41,080,961 (+)NCBI
Rnor_5.01544,882,217 - 44,893,080 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039093547   ⟹   XP_038949475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,087,845 - 39,099,167 (+)NCBI
mRatBN7.21534,911,750 - 34,922,985 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001178820 (Get FASTA)   NCBI Sequence Viewer  
  XP_006252196 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949475 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018533.7
  ENSRNOP00000076970
  ENSRNOP00000076970.1
GenBank Protein SOR70290 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001178820   ⟸   NM_001191891
- Peptide Label: precursor
- UniProtKB: D3ZJ76 (UniProtKB/TrEMBL),   A0A3B0IP20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252196   ⟸   XM_006252134
- Peptide Label: isoform X1
- UniProtKB: A0A3B0IP20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018533   ⟸   ENSRNOT00000018533
RefSeq Acc Id: XP_038949475   ⟸   XM_039093547
- Peptide Label: isoform X2
- UniProtKB: D3ZJ76 (UniProtKB/TrEMBL),   A0A3B0IP20 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000076970   ⟸   ENSRNOT00000095495
Protein Domains
C1q

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJ76-F1-model_v2 AlphaFold D3ZJ76 1-367 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560876 AgrOrtholog
BioCyc Gene G2FUF-13518 BioCyc
Ensembl Genes ENSRNOG00000013793 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018533.8 UniProtKB/TrEMBL
  ENSRNOT00000095495 ENTREZGENE
  ENSRNOT00000095495.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.40 UniProtKB/TrEMBL
InterPro C1q UniProtKB/TrEMBL
  Collagen UniProtKB/TrEMBL
  Tumour_necrosis_fac-like UniProtKB/TrEMBL
KEGG Report rno:364395 UniProtKB/TrEMBL
NCBI Gene 364395 ENTREZGENE
PANTHER COMPLEMENT C1Q AND TUMOR NECROSIS FACTOR-RELATED PROTEIN 9A UniProtKB/TrEMBL
  EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER UniProtKB/TrEMBL
Pfam C1q UniProtKB/TrEMBL
  Collagen UniProtKB/TrEMBL
PhenoGen C1qtnf9 PhenoGen
PRINTS COMPLEMNTC1Q UniProtKB/TrEMBL
PROSITE C1Q UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013793 RatGTEx
SMART C1Q UniProtKB/TrEMBL
Superfamily-SCOP TNF_like UniProtKB/TrEMBL
UniProt A0A3B0IP20 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJ76 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-09 C1qtnf9  C1q and TNF related 9  C1qtnf9  C1q and tumor necrosis factor related protein 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 C1qtnf9  C1q and tumor necrosis factor related protein 9  RGD1560876_predicted  similar to hypothetical protein MGC48915 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560876_predicted  similar to hypothetical protein MGC48915 (predicted)  LOC364395  similar to hypothetical protein MGC48915  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC364395  similar to hypothetical protein MGC48915      Symbol and Name status set to provisional 70820 PROVISIONAL