Hgsnat (heparan-alpha-glucosaminide N-acetyltransferase) - Rat Genome Database

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Gene: Hgsnat (heparan-alpha-glucosaminide N-acetyltransferase) Rattus norvegicus
Analyze
Symbol: Hgsnat
Name: heparan-alpha-glucosaminide N-acetyltransferase
RGD ID: 1560755
Description: Predicted to enable heparan-alpha-glucosaminide N-acetyltransferase activity. Predicted to be involved in heparan sulfate proteoglycan catabolic process; lysosomal transport; and protein complex oligomerization. Predicted to be located in lysosomal membrane. Predicted to be active in lysosomal lumen. Human ortholog(s) of this gene implicated in mucopolysaccharidosis type IIIC and retinitis pigmentosa 73. Orthologous to human HGSNAT (heparan-alpha-glucosaminide N-acetyltransferase); INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100360010; LOC361165; MGC108996; RGD1560755; RGD1560755 protein-like; similar to D8Ertd354e protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81672,807,967 - 72,840,180 (+)NCBIGRCr8
mRatBN7.21666,105,233 - 66,137,444 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,105,181 - 66,136,138 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,384,094 - 71,416,277 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01674,790,423 - 74,822,606 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,030,536 - 70,062,632 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01670,876,557 - 70,909,443 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01670,540,794 - 70,572,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,511,545 - 70,513,470 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1664,016,244 - 64,048,685 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:17897319   PMID:19823584   PMID:20650889  


Genomics

Comparative Map Data
Hgsnat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81672,807,967 - 72,840,180 (+)NCBIGRCr8
mRatBN7.21666,105,233 - 66,137,444 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1666,105,181 - 66,136,138 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1671,384,094 - 71,416,277 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01674,790,423 - 74,822,606 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01670,030,536 - 70,062,632 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01670,876,557 - 70,909,443 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01670,540,794 - 70,572,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,511,545 - 70,513,470 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1664,016,244 - 64,048,685 (+)NCBICelera
Cytogenetic Map16q12.4NCBI
HGSNAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38843,140,464 - 43,202,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl843,140,464 - 43,202,855 (+)EnsemblGRCh38hg38GRCh38
GRCh37842,995,607 - 43,057,998 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36843,114,749 - 43,177,127 (+)NCBINCBI36Build 36hg18NCBI36
Celera841,950,967 - 42,005,677 (+)NCBICelera
Cytogenetic Map8p11.21-p11.1NCBI
HuRef841,518,326 - 41,580,566 (+)NCBIHuRef
CHM1_1843,042,515 - 43,105,151 (+)NCBICHM1_1
T2T-CHM13v2.0843,409,397 - 43,471,962 (+)NCBIT2T-CHM13v2.0
Hgsnat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,432,495 - 26,466,704 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl826,434,481 - 26,466,781 (-)EnsemblGRCm39 Ensembl
GRCm38825,944,459 - 25,976,744 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,944,453 - 25,976,753 (-)EnsemblGRCm38mm10GRCm38
MGSCv37827,054,931 - 27,087,216 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36827,410,004 - 27,412,027 (-)NCBIMGSCv36mm8
Celera827,412,295 - 27,443,966 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.22NCBI
Hgsnat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545713,349,213 - 13,387,251 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545713,351,963 - 13,386,521 (+)NCBIChiLan1.0ChiLan1.0
HGSNAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2761,597,533 - 61,657,575 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1837,313,523 - 37,373,552 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0842,388,406 - 42,448,466 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1839,832,143 - 39,888,948 (+)NCBIpanpan1.1PanPan1.1panPan2
HGSNAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11622,640,912 - 22,683,733 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1622,642,289 - 22,683,879 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,146,111 - 23,188,937 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01624,392,606 - 24,435,430 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1624,392,606 - 24,435,665 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11622,760,972 - 22,803,889 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01623,325,689 - 23,368,698 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01623,376,944 - 23,419,965 (-)NCBIUU_Cfam_GSD_1.0
Hgsnat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494345,659,294 - 45,699,457 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936570258,820 - 297,762 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936570257,636 - 297,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100154844
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1178,644,388 - 8,665,004 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2179,522,494 - 9,545,601 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HGSNAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1841,146,280 - 41,196,192 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl841,146,483 - 41,197,518 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666052551,844 - 602,374 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hgsnat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624992101,546 - 153,599 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462499286,403 - 153,100 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hgsnat
211 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:585
Count of miRNA genes:261
Interacting mature miRNAs:331
Transcripts:ENSRNOT00000019755
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat

Markers in Region
RH130939  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,137,223 - 66,137,422 (+)MAPPERmRatBN7.2
Rnor_6.01670,909,223 - 70,909,421NCBIRnor6.0
Rnor_5.01670,573,598 - 70,573,796UniSTSRnor5.0
RGSC_v3.41670,513,250 - 70,513,448UniSTSRGSC3.4
Celera1664,048,465 - 64,048,663UniSTS
Cytogenetic Map16q12.4UniSTS
BF392550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,103,601 - 66,103,785 (+)MAPPERmRatBN7.2
Rnor_6.01670,874,867 - 70,875,050NCBIRnor6.0
Rnor_5.01670,539,205 - 70,539,388UniSTSRnor5.0
RGSC_v3.41670,478,584 - 70,478,767UniSTSRGSC3.4
RH 3.4 Map16623.6UniSTS
Cytogenetic Map16q12.4UniSTS
RH141580  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,135,941 - 66,136,121 (+)MAPPERmRatBN7.2
Rnor_6.01670,907,941 - 70,908,120NCBIRnor6.0
Rnor_5.01670,572,316 - 70,572,495UniSTSRnor5.0
RGSC_v3.41670,511,968 - 70,512,147UniSTSRGSC3.4
Celera1664,047,183 - 64,047,362UniSTS
RH 3.4 Map16622.8UniSTS
Cytogenetic Map16q12.4UniSTS
AW529878  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21666,099,967 - 66,100,141 (+)MAPPERmRatBN7.2
Rnor_6.01670,871,233 - 70,871,406NCBIRnor6.0
Rnor_5.01670,535,571 - 70,535,744UniSTSRnor5.0
RGSC_v3.41670,474,942 - 70,475,115UniSTSRGSC3.4
Celera1664,010,972 - 64,011,145UniSTS
RH 3.4 Map16620.0UniSTS
Cytogenetic Map16q12.4UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000097105   ⟹   ENSRNOP00000080474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,106,104 - 66,136,138 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110809   ⟹   ENSRNOP00000092597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1666,105,181 - 66,136,138 (+)Ensembl
RefSeq Acc Id: NM_001402470   ⟹   NP_001389399
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81672,808,069 - 72,840,180 (+)NCBI
mRatBN7.21666,105,332 - 66,137,444 (+)NCBI
RefSeq Acc Id: XM_056984882   ⟹   XP_056840862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81672,807,967 - 72,829,991 (+)NCBI
mRatBN7.21666,105,233 - 66,127,255 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001389399 (Get FASTA)   NCBI Sequence Viewer  
  XP_056840862 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88231 (Get FASTA)   NCBI Sequence Viewer  
  AAI66540 (Get FASTA)   NCBI Sequence Viewer  
  EDM09073 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000080474.1
  ENSRNOP00000092597.1
Ensembl Acc Id: ENSRNOP00000080474   ⟸   ENSRNOT00000097105
Ensembl Acc Id: ENSRNOP00000092597   ⟸   ENSRNOT00000110809
RefSeq Acc Id: XP_056840862   ⟸   XM_056984882
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001389399   ⟸   NM_001402470
- Peptide Label: precursor
- UniProtKB: A6IVZ9 (UniProtKB/TrEMBL)
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560755 AgrOrtholog
BioCyc Gene G2FUF-10983 BioCyc
Ensembl Genes ENSRNOG00000069796 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097105.1 UniProtKB/TrEMBL
  ENSRNOT00000110809.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7192549 IMAGE-MGC_LOAD
InterPro HGSNAT_cat UniProtKB/TrEMBL
MGC_CLONE MGC:188135 IMAGE-MGC_LOAD
NCBI Gene 361165 ENTREZGENE
PANTHER HEPARAN-ALPHA-GLUCOSAMINIDE N-ACETYLTRANSFERASE UniProtKB/TrEMBL
  LD22376P UniProtKB/TrEMBL
Pfam HGSNAT_cat UniProtKB/TrEMBL
PhenoGen Hgsnat PhenoGen
RatGTEx ENSRNOG00000069796 RatGTEx
UniProt A0A8I5ZT54_RAT UniProtKB/TrEMBL
  A0A8I6AE78_RAT UniProtKB/TrEMBL
  A6IVZ9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Hgsnat  heparan-alpha-glucosaminide N-acetyltransferase  Hgsnat  heparan-alpha-glucosaminide N-acetyltransferase  Data merged from RGD:149736316 737654 PROVISIONAL
2021-08-09 Hgsnat  heparan-alpha-glucosaminide N-acetyltransferase      Symbol and Name status set to provisional 45752 PROVISIONAL
2015-07-29 Hgsnat  heparan-alpha-glucosaminide N-acetyltransferase  LOC100360010  RGD1560755 protein-like  Data merged from RGD:2322935 737654 PROVISIONAL
2014-07-29 Hgsnat  heparan-alpha-glucosaminide N-acetyltransferase  RGD1560755  similar to D8Ertd354e protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 RGD1560755  similar to D8Ertd354e protein  LOC100364957  RGD1560755 protein-like  Data merged from RGD:2320009 1643240 APPROVED
2010-05-06 LOC100360010  RGD1560755 protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-05-05 LOC100364957  RGD1560755 protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1560755  similar to D8Ertd354e protein   RGD1560755_predicted  similar to D8Ertd354e protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560755_predicted  similar to D8Ertd354e protein (predicted)  LOC361165  similar to D8Ertd354e protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC361165  similar to D8Ertd354e protein      Symbol and Name status set to provisional 70820 PROVISIONAL