LOC500959 (triosephosphate isomerase) - Rat Genome Database

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Gene: LOC500959 (triosephosphate isomerase) Rattus norvegicus
Analyze
No known orthologs.
Symbol: LOC500959 (Ensembl: AC094212.1)
Name: triosephosphate isomerase
RGD ID: 1560534
Description: Predicted to enable methylglyoxal synthase activity and triose-phosphate isomerase activity. Predicted to be involved in gluconeogenesis and glycolytic process. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AC094212.1
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2823,647,760 - 23,654,967 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl823,647,764 - 23,655,504 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx827,706,793 - 27,707,577 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0826,004,079 - 26,004,863 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0823,873,462 - 23,874,246 (-)NCBIRnor_WKY
Rnor_6.0826,341,789 - 26,342,573 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl826,341,732 - 26,345,754 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0826,363,796 - 26,364,580 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4824,852,575 - 24,853,359 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera825,217,433 - 25,218,217 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in LOC500959
51 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000091773   ⟹   ENSRNOP00000070014
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl823,647,764 - 23,655,504 (-)Ensembl
RefSeq Acc Id: NM_001033072   ⟹   NP_001028244
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2823,648,317 - 23,649,101 (-)NCBI
Rnor_6.0826,341,789 - 26,342,573 (-)NCBI
Rnor_5.0826,363,796 - 26,364,580 (-)NCBI
RGSC_v3.4824,852,575 - 24,853,359 (-)RGD
Celera825,217,433 - 25,218,217 (-)RGD
Sequence:
RefSeq Acc Id: XM_039081927   ⟹   XP_038937855
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2823,647,760 - 23,654,967 (-)NCBI
RefSeq Acc Id: XM_039081928   ⟹   XP_038937856
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2823,647,760 - 23,649,425 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001028244   ⟸   NM_001033072
- UniProtKB: Q6SA19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038937855   ⟸   XM_039081927
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JWU1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937856   ⟸   XM_039081928
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000070014   ⟸   ENSRNOT00000091773

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JWU1-F1-model_v2 AlphaFold A0A0G2JWU1 1-253 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560534 AgrOrtholog
BioCyc Gene G2FUF-31333 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
  PWY66-373 [sucrose degradation V (sucrose alpha-glucosidase)] BioCyc
  PWY66-399 [gluconeogenesis III] BioCyc
Ensembl Genes ENSRNOG00000055222 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070014 ENTREZGENE
  ENSRNOP00000070014.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091773 ENTREZGENE
  ENSRNOT00000091773.2 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  TIM_sf UniProtKB/TrEMBL
  TrioseP_Isoase_bac/euk UniProtKB/TrEMBL
  Triosephosphate_isomerase UniProtKB/TrEMBL
  Triosephosphate_isomerase_AS UniProtKB/TrEMBL
KEGG Report rno:500959 UniProtKB/TrEMBL
NCBI Gene 500959 ENTREZGENE
PANTHER Triophos_ismrse UniProtKB/TrEMBL
  TRIOSEPHOSPHATE ISOMERASE UniProtKB/TrEMBL
Pfam TIM UniProtKB/TrEMBL
PhenoGen LOC500959 PhenoGen
PROSITE TIM_1 UniProtKB/TrEMBL
  TIM_2 UniProtKB/TrEMBL
Superfamily-SCOP Triophos_ismrse UniProtKB/TrEMBL
TIGRFAMs tim UniProtKB/TrEMBL
UniProt A0A0G2JWU1 ENTREZGENE, UniProtKB/TrEMBL
  Q6SA19 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 LOC500959  triosephosphate isomerase  AC094212.1    Data Merged 737654 PROVISIONAL
2019-11-08 AC094212.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2006-02-09 LOC500959  triosephosphate isomerase      Symbol and Name status set to provisional 70820 PROVISIONAL