Amer1 (APC membrane recruitment protein 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Amer1 (APC membrane recruitment protein 1) Rattus norvegicus
Analyze
Symbol: Amer1
Name: APC membrane recruitment protein 1
RGD ID: 1560322
Description: Predicted to enable beta-catenin binding activity; beta-catenin destruction complex binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in positive regulation of protein metabolic process and regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within adipose tissue development; bone development; and mesenchymal cell differentiation involved in kidney development. Predicted to be located in nuclear body. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in colorectal cancer and osteopathia striata with cranial sclerosis. Orthologous to human AMER1 (APC membrane recruitment protein 1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: APC membrane recruitment 1; Fam123b; family with sequence similarity 123, member B; family with sequence similarity 123B; LOC501584; RGD1560322; similar to hypothetical protein FLJ39827
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X64,310,492 - 64,326,377 (-)NCBIGRCr8
mRatBN7.2X60,300,595 - 60,316,480 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX60,295,751 - 60,316,440 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX61,770,840 - 61,786,727 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X65,271,355 - 65,287,243 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X62,850,325 - 62,866,210 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X64,686,620 - 64,702,504 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX64,686,623 - 64,702,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X65,585,784 - 65,601,668 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X82,986,081 - 83,001,966 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX60,720,570 - 60,736,455 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Association Between Fusobacterium nucleatum, Pathway Mutation, and Patient Prognosis in Colorectal Cancer. Lee DW, etal., Ann Surg Oncol. 2018 Oct;25(11):3389-3395. doi: 10.1245/s10434-018-6681-5. Epub 2018 Jul 30.
3. Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer. Lieu CH, etal., Clin Cancer Res. 2019 Oct 1;25(19):5852-5858. doi: 10.1158/1078-0432.CCR-19-0899. Epub 2019 Jun 26.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Exome Sequencing Reveals AMER1 as a Frequently Mutated Gene in Colorectal Cancer. Sanz-Pamplona R, etal., Clin Cancer Res. 2015 Oct 15;21(20):4709-18. doi: 10.1158/1078-0432.CCR-15-0159. Epub 2015 Jun 12.
9. The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. Slattery ML, etal., Genes Chromosomes Cancer. 2017 Nov;56(11):769-787. doi: 10.1002/gcc.22481. Epub 2017 Jul 30.
10. Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression. Zhu GF, etal., Nat Commun. 2019 Jan 10;10(1):112. doi: 10.1038/s41467-018-07998-x.
Additional References at PubMed
PMID:17510365   PMID:17925383   PMID:21304492   PMID:21498506   PMID:21571217  


Genomics

Comparative Map Data
Amer1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X64,310,492 - 64,326,377 (-)NCBIGRCr8
mRatBN7.2X60,300,595 - 60,316,480 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX60,295,751 - 60,316,440 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX61,770,840 - 61,786,727 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X65,271,355 - 65,287,243 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X62,850,325 - 62,866,210 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X64,686,620 - 64,702,504 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX64,686,623 - 64,702,441 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X65,585,784 - 65,601,668 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X82,986,081 - 83,001,966 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX60,720,570 - 60,736,455 (-)NCBICelera
Cytogenetic MapXq22NCBI
AMER1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X64,185,117 - 64,205,708 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX64,185,117 - 64,205,708 (-)EnsemblGRCh38hg38GRCh38
GRCh37X63,404,997 - 63,425,588 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X63,321,722 - 63,342,349 (-)NCBINCBI36Build 36hg18NCBI36
CeleraX63,751,829 - 63,772,456 (-)NCBICelera
Cytogenetic MapXq11.2NCBI
HuRefX57,229,959 - 57,249,860 (-)NCBIHuRef
CHM1_1X63,297,445 - 63,318,066 (-)NCBICHM1_1
T2T-CHM13v2.0X62,610,394 - 62,630,983 (-)NCBIT2T-CHM13v2.0
Amer1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X94,463,919 - 94,488,446 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX94,463,924 - 94,488,478 (-)EnsemblGRCm39 Ensembl
GRCm38X95,420,313 - 95,444,840 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX95,420,318 - 95,444,872 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X92,615,652 - 92,640,179 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X91,630,089 - 91,647,543 (-)NCBIMGSCv36mm8
CeleraX82,446,271 - 82,470,781 (-)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX41.99NCBI
Amer1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554754,463,023 - 4,466,406 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554754,451,094 - 4,470,750 (+)NCBIChiLan1.0ChiLan1.0
AMER1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X63,718,058 - 63,739,349 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X63,721,664 - 63,742,948 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X53,309,868 - 53,331,151 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X63,396,335 - 63,412,289 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX63,396,392 - 63,399,802 (-)Ensemblpanpan1.1panPan2
AMER1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X49,426,228 - 49,449,448 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX40,221,607 - 40,284,593 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X49,710,327 - 49,773,348 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX49,753,632 - 49,773,328 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X48,366,572 - 48,429,558 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X49,665,093 - 49,728,063 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X49,118,973 - 49,181,979 (-)NCBIUU_Cfam_GSD_1.0
Amer1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X52,699,841 - 52,721,120 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366353,478,598 - 3,482,008 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366353,465,473 - 3,482,311 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMER1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX50,844,683 - 50,864,032 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X50,842,049 - 50,864,105 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X57,264,271 - 57,283,693 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AMER1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X54,568,751 - 54,591,284 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX54,573,476 - 54,576,880 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660831,826,025 - 1,847,827 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Amer1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248982,724,042 - 2,727,419 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248982,704,322 - 2,731,918 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Amer1
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:116
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000051132
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
70221Bp56Blood pressure QTL 564.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X5704214165612192Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 5 4 1 4 51 12 21
Low 3 36 52 37 18 37 8 11 23 23 15 11 8
Below cutoff 1 5

Sequence


RefSeq Acc Id: ENSRNOT00000051132   ⟹   ENSRNOP00000043681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX60,295,751 - 60,316,440 (-)Ensembl
Rnor_6.0 EnsemblX64,686,623 - 64,702,441 (-)Ensembl
RefSeq Acc Id: NM_001109320   ⟹   NP_001102790
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X64,310,492 - 64,326,377 (-)NCBI
mRatBN7.2X60,300,595 - 60,316,480 (-)NCBI
Rnor_6.0X64,686,620 - 64,702,504 (-)NCBI
Rnor_5.0X65,585,784 - 65,601,668 (-)NCBI
RGSC_v3.4X82,986,081 - 83,001,966 (-)RGD
CeleraX60,720,570 - 60,736,455 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102790 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95988 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043681
  ENSRNOP00000043681.3
RefSeq Acc Id: NP_001102790   ⟸   NM_001109320
- UniProtKB: D3ZCP6 (UniProtKB/TrEMBL),   A6IQ25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000043681   ⟸   ENSRNOT00000051132

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZCP6-F1-model_v2 AlphaFold D3ZCP6 1-1111 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701846
Promoter ID:EPDNEW_R12370
Type:multiple initiation site
Name:Amer1_1
Description:APC membrane recruitment protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X64,702,441 - 64,702,501EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560322 AgrOrtholog
BioCyc Gene G2FUF-2209 BioCyc
Ensembl Genes ENSRNOG00000007984 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051132 ENTREZGENE
  ENSRNOT00000051132.5 UniProtKB/TrEMBL
InterPro WTX_protein UniProtKB/TrEMBL
KEGG Report rno:501584 UniProtKB/TrEMBL
NCBI Gene 501584 ENTREZGENE
PANTHER APC MEMBRANE RECRUITMENT PROTEIN 1 UniProtKB/TrEMBL
  PTHR22237 UniProtKB/TrEMBL
Pfam WTX UniProtKB/TrEMBL
PhenoGen Amer1 PhenoGen
RatGTEx ENSRNOG00000007984 RatGTEx
UniProt A6IQ25 ENTREZGENE, UniProtKB/TrEMBL
  D3ZCP6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-19 Amer1  APC membrane recruitment protein 1  Amer1  APC membrane recruitment 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-14 Amer1  APC membrane recruitment 1  Fam123b  family with sequence similarity 123, member B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Fam123b  family with sequence similarity 123B  RGD1560322_predicted  similar to hypothetical protein FLJ39827 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560322_predicted  similar to hypothetical protein FLJ39827 (predicted)  LOC501584  similar to hypothetical protein FLJ39827  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501584  similar to hypothetical protein FLJ39827      Symbol and Name status set to provisional 70820 PROVISIONAL