Magee1 (MAGE family member E1) - Rat Genome Database

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Gene: Magee1 (MAGE family member E1) Rattus norvegicus
Analyze
Symbol: Magee1
Name: MAGE family member E1
RGD ID: 1560259
Description: Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in dendrite; perinuclear region of cytoplasm; and postsynaptic membrane. Predicted to be active in nucleus. Orthologous to human MAGEE1 (MAGE family member E1); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: alpha-dystrobrevin-associated MAGE Protein; DAMAGE; hepatocellular carcinoma-associated protein HCA1; LOC317232; MAGE-E1 antigen; melanoma antigen, family E, 1; melanoma-associated antigen E1; MGC156731; RGD1560259; similar to melanoma antigen, family E, 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X74,254,848 - 74,258,395 (+)NCBIGRCr8
mRatBN7.2X70,189,242 - 70,192,789 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX70,189,187 - 70,192,810 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX71,698,216 - 71,701,763 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X75,198,504 - 75,202,051 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X72,761,663 - 72,765,210 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X76,083,553 - 76,087,100 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX76,083,549 - 76,087,117 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X76,881,860 - 76,885,407 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X93,192,218 - 93,195,765 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX71,522,118 - 71,525,665 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14623885   PMID:25931508  


Genomics

Comparative Map Data
Magee1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X74,254,848 - 74,258,395 (+)NCBIGRCr8
mRatBN7.2X70,189,242 - 70,192,789 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX70,189,187 - 70,192,810 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX71,698,216 - 71,701,763 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X75,198,504 - 75,202,051 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X72,761,663 - 72,765,210 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X76,083,553 - 76,087,100 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX76,083,549 - 76,087,117 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X76,881,860 - 76,885,407 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X93,192,218 - 93,195,765 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX71,522,118 - 71,525,665 (+)NCBICelera
Cytogenetic MapXq22NCBI
MAGEE1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X76,427,710 - 76,431,342 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX76,427,710 - 76,431,342 (+)EnsemblGRCh38hg38GRCh38
GRCh37X75,648,103 - 75,651,735 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X75,564,521 - 75,568,148 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X75,430,816 - 75,434,444NCBI
CeleraX75,927,786 - 75,931,486 (+)NCBICelera
Cytogenetic MapXq13.3NCBI
HuRefX69,280,072 - 69,283,772 (+)NCBIHuRef
CHM1_1X75,540,855 - 75,544,555 (+)NCBICHM1_1
T2T-CHM13v2.0X74,861,510 - 74,865,142 (+)NCBIT2T-CHM13v2.0
Magee1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X104,163,984 - 104,167,567 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX104,163,984 - 104,167,533 (+)EnsemblGRCm39 Ensembl
GRCm38X105,120,378 - 105,123,961 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX105,120,378 - 105,123,927 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X102,315,735 - 102,319,251 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X101,323,140 - 101,326,646 (+)NCBIMGSCv36mm8
CeleraX91,984,292 - 91,987,808 (+)NCBICelera
Cytogenetic MapXDNCBI
cM MapX46.84NCBI
Magee1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495555760,440 - 170,159 (+)NCBIChiLan1.0ChiLan1.0
MAGEE1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X76,053,663 - 76,057,378 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X76,057,274 - 76,060,995 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X65,654,865 - 65,658,586 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X75,769,347 - 75,772,734 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX75,769,619 - 75,772,870 (+)Ensemblpanpan1.1panPan2
LOC102153919
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X117,717,968 - 117,724,242 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX103,578,079 - 103,584,623 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X119,879,472 - 119,886,381 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X116,907,310 - 116,914,195 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X119,477,559 - 119,483,661 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X119,385,390 - 119,392,296 (+)NCBIUU_Cfam_GSD_1.0
Magee1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X42,934,661 - 42,938,826 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366832,009,167 - 2,012,570 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366832,008,949 - 2,013,104 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAGEE1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X65,650,548 - 65,653,774 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX65,650,809 - 65,653,682 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606715,917,231 - 15,920,917 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Magee1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248364,420,509 - 4,424,039 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248364,420,633 - 4,423,996 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Magee1
4 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:101
Interacting mature miRNAs:113
Transcripts:ENSRNOT00000003573
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat

Markers in Region
AI847422  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X70,192,683 - 70,192,763 (+)MAPPERmRatBN7.2
Rnor_6.0X76,086,995 - 76,087,074NCBIRnor6.0
Rnor_5.0X76,885,302 - 76,885,381UniSTSRnor5.0
RGSC_v3.4X93,195,660 - 93,195,739UniSTSRGSC3.4
CeleraX71,525,560 - 71,525,639UniSTS
Cytogenetic MapXq31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 66
Low 3 43 51 35 19 35 7 10 8 33 34 11 7
Below cutoff 6 6 6 1 1 2 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003573   ⟹   ENSRNOP00000054396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX70,189,187 - 70,192,810 (+)Ensembl
Rnor_6.0 EnsemblX76,083,549 - 76,087,117 (+)Ensembl
RefSeq Acc Id: NM_001079891   ⟹   NP_001073360
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X74,254,848 - 74,258,395 (+)NCBI
mRatBN7.2X70,189,242 - 70,192,789 (+)NCBI
Rnor_6.0X76,083,553 - 76,087,100 (+)NCBI
Rnor_5.0X76,881,860 - 76,885,407 (+)NCBI
RGSC_v3.4X93,192,218 - 93,195,765 (+)RGD
CeleraX71,522,118 - 71,525,665 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001073360 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A1A5P9 (Get FASTA)   NCBI Sequence Viewer  
  AAI28755 (Get FASTA)   NCBI Sequence Viewer  
  EDM07152 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054396
  ENSRNOP00000054396.3
  ENSRNOP00055039584
  ENSRNOP00060036566
  ENSRNOP00065037800
Reference Protein Sequences
RefSeq Acc Id: NP_001073360   ⟸   NM_001079891
- UniProtKB: A1A5P9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054396   ⟸   ENSRNOT00000003573
Protein Domains
MAGE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A1A5P9-F1-model_v2 AlphaFold A1A5P9 1-933 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701897
Promoter ID:EPDNEW_R12420
Type:single initiation site
Name:Magee1_1
Description:MAGE family member E1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X76,083,576 - 76,083,636EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560259 AgrOrtholog
BioCyc Gene G2FUF-1965 BioCyc
Ensembl Genes ENSRNOG00000002660 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055027778 UniProtKB/Swiss-Prot
  ENSRNOG00060025473 UniProtKB/Swiss-Prot
  ENSRNOG00065026710 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003573 ENTREZGENE
  ENSRNOT00000003573.8 UniProtKB/Swiss-Prot
  ENSRNOT00055048088 UniProtKB/Swiss-Prot
  ENSRNOT00060044078 UniProtKB/Swiss-Prot
  ENSRNOT00065046072 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.1200 UniProtKB/Swiss-Prot
  1.10.10.1210 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7103930 IMAGE-MGC_LOAD
InterPro MAGE UniProtKB/Swiss-Prot
  MAGE_WH1 UniProtKB/Swiss-Prot
  MAGE_WH2 UniProtKB/Swiss-Prot
  MHD_dom UniProtKB/Swiss-Prot
KEGG Report rno:317232 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156731 IMAGE-MGC_LOAD
NCBI Gene 317232 ENTREZGENE
PANTHER MELANOMA-ASSOCIATED ANTIGEN E1 UniProtKB/Swiss-Prot
  PTHR11736 UniProtKB/Swiss-Prot
Pfam MAGE UniProtKB/Swiss-Prot
PhenoGen Magee1 PhenoGen
PROSITE MAGE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002660 RatGTEx
  ENSRNOG00055027778 RatGTEx
  ENSRNOG00060025473 RatGTEx
  ENSRNOG00065026710 RatGTEx
SMART MAGE UniProtKB/Swiss-Prot
UniProt A1A5P9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Magee1  MAGE family member E1  Magee1  melanoma antigen, family E, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Magee1  melanoma antigen, family E, 1   Magee1_predicted  melanoma antigen, family E, 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Magee1_predicted  melanoma antigen, family E, 1 (predicted)  RGD1560259_predicted  similar to melanoma antigen, family E, 1 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1560259_predicted  similar to melanoma antigen, family E, 1 (predicted)  LOC317232  similar to melanoma antigen, family E, 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317232  similar to melanoma antigen, family E, 1      Symbol and Name status set to provisional 70820 PROVISIONAL