Ccdc185 (coiled-coil domain containing 185) - Rat Genome Database

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Gene: Ccdc185 (coiled-coil domain containing 185) Rattus norvegicus
Analyze
Symbol: Ccdc185
Name: coiled-coil domain containing 185
RGD ID: 1560145
Description: Orthologous to human CCDC185 (coiled-coil domain containing 185); INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; 17beta-estradiol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: coiled-coil domain-containing protein 185; hypothetical protein LOC289334; LOC289334; similar to hypothetical protein FLJ35728; uncharacterized protein LOC289334
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81396,966,443 - 96,968,455 (-)NCBIGRCr8
mRatBN7.21394,434,772 - 94,436,784 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1394,434,773 - 94,436,784 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1396,940,036 - 96,942,048 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01398,339,966 - 98,341,978 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01395,522,149 - 95,524,161 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013101,161,305 - 101,163,317 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13101,161,303 - 101,163,393 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013106,095,418 - 106,097,430 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41398,810,667 - 98,812,679 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1393,965,098 - 93,967,110 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data
Ccdc185
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81396,966,443 - 96,968,455 (-)NCBIGRCr8
mRatBN7.21394,434,772 - 94,436,784 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1394,434,773 - 94,436,784 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1396,940,036 - 96,942,048 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01398,339,966 - 98,341,978 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01395,522,149 - 95,524,161 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013101,161,305 - 101,163,317 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13101,161,303 - 101,163,393 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013106,095,418 - 106,097,430 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41398,810,667 - 98,812,679 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1393,965,098 - 93,967,110 (-)NCBICelera
Cytogenetic Map13q26NCBI
CCDC185
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381223,393,415 - 223,395,465 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1223,393,415 - 223,395,465 (+)EnsemblGRCh38hg38GRCh38
GRCh371223,566,757 - 223,568,807 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,633,391 - 221,635,435 (+)NCBINCBI36Build 36hg18NCBI36
Celera1196,786,071 - 196,788,168 (+)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1194,241,738 - 194,243,835 (+)NCBIHuRef
CHM1_11224,839,849 - 224,841,946 (+)NCBICHM1_1
T2T-CHM13v2.01222,631,516 - 222,633,566 (+)NCBIT2T-CHM13v2.0
Ccdc185
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,574,691 - 182,576,745 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,574,691 - 182,576,745 (-)EnsemblGRCm39 Ensembl
GRCm381182,747,126 - 182,749,180 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,747,126 - 182,749,180 (-)EnsemblGRCm38mm10GRCm38
MGSCv371184,677,257 - 184,679,311 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361184,583,802 - 184,585,855 (-)NCBIMGSCv36mm8
Celera1189,789,692 - 189,791,746 (-)NCBICelera
Cytogenetic Map1H5NCBI
cM Map185.92NCBI
CCDC185
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2125,910,962 - 25,919,387 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1125,867,005 - 25,877,041 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01199,071,852 - 199,074,056 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11204,083,633 - 204,085,724 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1204,083,730 - 204,085,601 (+)Ensemblpanpan1.1panPan2
CCDC185
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13823,632,411 - 23,634,118 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3823,658,316 - 23,659,988 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03823,801,773 - 23,803,448 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13823,545,596 - 23,547,259 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03824,098,099 - 24,099,760 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03824,499,696 - 24,501,359 (-)NCBIUU_Cfam_GSD_1.0
Ccdc185
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934454,110,207 - 54,112,273 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936526635,109 - 636,965 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936526634,895 - 637,032 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCDC185
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11019,584,307 - 19,586,761 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21022,082,560 - 22,084,623 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCDC185
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1256,159,806 - 6,162,687 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl256,159,933 - 6,161,804 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660556,390,750 - 6,392,952 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ccdc185
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:23
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000037997
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system appendage
High
Medium 7
Low 1 1
Below cutoff 5 2 3 2 2 4 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000037997   ⟹   ENSRNOP00000054355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,434,773 - 94,436,784 (-)Ensembl
Rnor_6.0 Ensembl13101,161,303 - 101,163,393 (-)Ensembl
RefSeq Acc Id: NM_001170428   ⟹   NP_001163899
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81396,966,443 - 96,968,455 (-)NCBI
mRatBN7.21394,434,772 - 94,436,784 (-)NCBI
Rnor_6.013101,161,305 - 101,163,317 (-)NCBI
Rnor_5.013106,095,418 - 106,097,430 (-)NCBI
RGSC_v3.41398,810,667 - 98,812,679 (-)RGD
Celera1393,965,098 - 93,967,110 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001163899 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98032 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054355
  ENSRNOP00000054355.2
Reference Protein Sequences
RefSeq Acc Id: NP_001163899   ⟸   NM_001170428
- UniProtKB: F1LST7 (UniProtKB/TrEMBL),   Q4V7B7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054355   ⟸   ENSRNOT00000037997

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LST7-F1-model_v2 AlphaFold F1LST7 1-621 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699080
Promoter ID:EPDNEW_R9605
Type:multiple initiation site
Name:Ccdc185_1
Description:coiled-coil domain containing 185
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013101,163,355 - 101,163,415EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560145 AgrOrtholog
BioCyc Gene G2FUF-17061 BioCyc
Ensembl Genes ENSRNOG00000022104 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037997 ENTREZGENE
  ENSRNOT00000037997.6 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7456462 IMAGE-MGC_LOAD
InterPro DUF4659 UniProtKB/TrEMBL
KEGG Report rno:289334 UniProtKB/TrEMBL
MGC_CLONE MGC:116187 IMAGE-MGC_LOAD
NCBI Gene 289334 ENTREZGENE
PANTHER COILED-COIL DOMAIN-CONTAINING PROTEIN 185 UniProtKB/TrEMBL
  PTHR33663 UniProtKB/TrEMBL
Pfam DUF4659 UniProtKB/TrEMBL
PhenoGen Ccdc185 PhenoGen
RatGTEx ENSRNOG00000022104 RatGTEx
UniProt F1LST7 ENTREZGENE, UniProtKB/TrEMBL
  Q4V7B7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-05-14 Ccdc185  coiled-coil domain containing 185  LOC289334  similar to hypothetical protein FLJ35728  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC289334  similar to hypothetical protein FLJ35728      Symbol and Name status set to provisional 70820 PROVISIONAL