Rpgr (retinitis pigmentosa GTPase regulator) - Rat Genome Database

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Gene: Rpgr (retinitis pigmentosa GTPase regulator) Rattus norvegicus
Analyze
Symbol: Rpgr
Name: retinitis pigmentosa GTPase regulator
RGD ID: 1560136
Description: Predicted to be involved in cilium assembly and intraciliary transport. Predicted to act upstream of or within cellular response to light stimulus; eye morphogenesis; and visual perception. Located in cell projection. Human ortholog(s) of this gene implicated in X-linked atrophic macular degeneration; X-linked cone-rod dystrophy 1; X-linked retinitis pigmentosa and sinorespiratory infections; retinitis pigmentosa; and retinitis pigmentosa 3. Orthologous to human RPGR (retinitis pigmentosa GTPase regulator); PARTICIPATES IN retinitis pigmentosa pathway; INTERACTS WITH 1,2-dimethylhydrazine; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC187915; X-linked retinitis pigmentosa GTPase regulator
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X15,238,961 - 15,299,004 (+)NCBIGRCr8
mRatBN7.2X12,566,447 - 12,628,171 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX12,566,645 - 12,747,882 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX12,751,149 - 12,818,019 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X16,248,089 - 16,314,960 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X12,504,656 - 12,571,528 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X14,271,012 - 14,331,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX14,271,017 - 14,331,486 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X15,053,729 - 15,077,792 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X15,092,648 - 15,113,954 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X24,722,378 - 24,782,679 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX13,178,490 - 13,236,459 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. X-linked retinitis pigmentosa: RPGR mutations in most families with definite X linkage and clustering of mutations in a short sequence stretch of exon ORF15. Bader I, etal., Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1458-63.
2. Overexpression of RPGR leads to male infertility in mice due to defects in flagellar assembly. Brunner S, etal., Biol Reprod. 2008 Oct;79(4):608-17. doi: 10.1095/biolreprod.107.067454. Epub 2008 Jun 25.
3. Cone versus rod disease in a mutant Rpgr mouse caused by different genetic backgrounds. Brunner S, etal., Invest Ophthalmol Vis Sci. 2010 Feb;51(2):1106-15. doi: 10.1167/iovs.08-2742. Epub 2009 Dec 10.
4. A novel de novo frameshift mutation of RPGR ORF15 is associated with X-linked retinitis pigmentosa in a Chinese family. Chang W, etal., Mol Vis. 2007 Aug 30;13:1548-54.
5. Genes and mutations causing retinitis pigmentosa. Daiger SP, etal., Clin Genet. 2013 Aug;84(2):132-41. doi: 10.1111/cge.12203. Epub 2013 Jun 19.
6. X-linked cone-rod dystrophy (locus COD1): identification of mutations in RPGR exon ORF15. Demirci FY, etal., Am J Hum Genet. 2002 Apr;70(4):1049-53. Epub 2002 Feb 20.
7. Identification of a 5' splice site mutation in the RPGR gene in a family with X-linked retinitis pigmentosa (RP3). Dry KL, etal., Hum Mutat. 1999;13(2):141-5.
8. X-linked retinitis pigmentosa in two families with a missense mutation in the RPGR gene and putative change of glycine to valine at codon 60. Fishman GA, etal., Ophthalmology. 1998 Dec;105(12):2286-96.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. A single, abbreviated RPGR-ORF15 variant reconstitutes RPGR function in vivo. Hong DH, etal., Invest Ophthalmol Vis Sci. 2005 Feb;46(2):435-41.
11. A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3). Hong DH, etal., Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3649-54.
12. Disease expression in X-linked retinitis pigmentosa caused by a putative null mutation in the RPGR gene. Jacobson SG, etal., Invest Ophthalmol Vis Sci. 1997 Sep;38(10):1983-97.
13. Mutations in RPGR and RP2 of Chinese patients with X-linked retinitis pigmentosa. Ji Y, etal., Curr Eye Res. 2010 Jan;35(1):73-9. doi: 10.3109/02713680903395299.
14. Two novel mutations of the retinitis pigmentosa GTPase regulator gene in two Chinese families with X-linked retinitis pigmentosa. Liu L, etal., Chin Med J (Engl). 2002 Jun;115(6):833-6.
15. RPGR is mutated in patients with a complex X linked phenotype combining primary ciliary dyskinesia and retinitis pigmentosa. Moore A, etal., J Med Genet. 2006 Apr;43(4):326-33. Epub 2005 Jul 31.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Expression and localization of the ciliary disease protein retinitis pigmentosa GTPase regulator in mammalian kidney. Patil SB, etal., Kidney Int. 2010 Sep;78(6):622-3. doi: 10.1038/ki.2010.252.
18. Replacement gene therapy with a human RPGRIP1 sequence slows photoreceptor degeneration in a murine model of Leber congenital amaurosis. Pawlyk BS, etal., Hum Gene Ther. 2010 Aug;21(8):993-1004. doi: 10.1089/hum.2009.218.
19. Analysis of RPGR in a South African family with X-linked retinitis pigmentosa: research and diagnostic implications. Rebello G, etal., Clin Genet. 2003 Aug;64(2):137-41.
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Comprehensive gene review and curation RGD comprehensive gene curation
23. X-linked retinitis pigmentosa: mutation spectrum of the RPGR and RP2 genes and correlation with visual function. Sharon D, etal., Invest Ophthalmol Vis Sci. 2000 Aug;41(9):2712-21.
24. The human retinitis pigmentosa GTPase regulator gene variant database. Shu X, etal., Hum Mutat. 2008 May;29(5):605-8. doi: 10.1002/humu.20733.
25. Rd9 is a naturally occurring mouse model of a common form of retinitis pigmentosa caused by mutations in RPGR-ORF15. Thompson DA, etal., PLoS One. 2012;7(5):e35865. doi: 10.1371/journal.pone.0035865. Epub 2012 May 1.
26. Mutations of RPGR in X-linked retinitis pigmentosa (RP3). Vervoort R and Wright AF, Hum Mutat. 2002 May;19(5):486-500.
27. Mutations in the RPGR gene cause X-linked cone dystrophy. Yang Z, etal., Hum Mol Genet. 2002 Mar 1;11(5):605-11.
Additional References at PubMed
PMID:9399904   PMID:9677393   PMID:11104772   PMID:12140192   PMID:12477932   PMID:12651948   PMID:15772089   PMID:16043481   PMID:21212183   PMID:21933838   PMID:22658674   PMID:29899041  


Genomics

Comparative Map Data
Rpgr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X15,238,961 - 15,299,004 (+)NCBIGRCr8
mRatBN7.2X12,566,447 - 12,628,171 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX12,566,645 - 12,747,882 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX12,751,149 - 12,818,019 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X16,248,089 - 16,314,960 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X12,504,656 - 12,571,528 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X14,271,012 - 14,331,745 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX14,271,017 - 14,331,486 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X15,053,729 - 15,077,792 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X15,092,648 - 15,113,954 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X24,722,378 - 24,782,679 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX13,178,490 - 13,236,459 (+)NCBICelera
Cytogenetic MapXq12NCBI
RPGR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X38,269,163 - 38,327,509 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX38,269,163 - 38,327,544 (-)EnsemblGRCh38hg38GRCh38
GRCh37X38,128,416 - 38,186,762 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X38,013,367 - 38,071,732 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X37,884,818 - 37,942,896NCBI
CeleraX42,266,066 - 42,324,437 (-)NCBICelera
Cytogenetic MapXp11.4NCBI
HuRefX35,873,257 - 35,932,248 (-)NCBIHuRef
CHM1_1X38,159,472 - 38,217,832 (-)NCBICHM1_1
T2T-CHM13v2.0X37,672,761 - 37,731,102 (-)NCBIT2T-CHM13v2.0
Rpgr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X10,024,455 - 10,083,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX9,939,860 - 10,083,159 (-)EnsemblGRCm39 Ensembl
GRCm38X10,158,216 - 10,216,795 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX10,073,621 - 10,216,920 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X9,735,342 - 9,793,921 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X9,315,178 - 9,373,672 (-)NCBIMGSCv36mm8
CeleraX7,863,918 - 7,924,303 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX4.62NCBI
Rpgr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955601398,772 - 453,271 (-)NCBIChiLan1.0ChiLan1.0
RPGR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X39,910,004 - 39,976,124 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X39,920,272 - 39,979,505 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X30,718,669 - 30,777,671 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X38,426,895 - 38,485,140 (-)NCBIpanpan1.1PanPan1.1panPan2
RPGR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X33,056,371 - 33,105,036 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX32,745,020 - 33,330,841 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX20,405,036 - 20,453,690 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X33,082,215 - 33,156,658 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX32,954,294 - 33,380,900 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X33,184,774 - 33,233,420 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X33,156,625 - 33,205,531 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X33,198,692 - 33,247,323 (-)NCBIUU_Cfam_GSD_1.0
Rpgr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X25,322,460 - 25,372,387 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365025,163,164 - 5,212,940 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPGR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX34,228,124 - 34,296,589 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X34,238,961 - 34,522,814 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RPGR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1930,008,681 - 30,033,475 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666076599,245 - 642,706 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rpgr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476217,135,870 - 17,199,693 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rpgr
305 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:118
Interacting mature miRNAs:124
Transcripts:ENSRNOT00000067603
Prediction methods:Miranda, Pita
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 6 73 16 35 11
Low 3 43 51 41 13 41 8 10 1 19 6 8
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001127601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001374059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003754732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010061211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010061212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010061213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010061214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY855168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC162028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000045753   ⟹   ENSRNOP00000048924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX12,676,973 - 12,747,881 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000067603   ⟹   ENSRNOP00000060034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX12,566,645 - 12,626,485 (+)Ensembl
Rnor_6.0 EnsemblX14,271,017 - 14,331,486 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104202   ⟹   ENSRNOP00000095069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX12,566,645 - 12,630,404 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107551   ⟹   ENSRNOP00000093511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX12,717,909 - 12,747,881 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107782   ⟹   ENSRNOP00000094523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX12,677,155 - 12,747,882 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108154   ⟹   ENSRNOP00000086725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX12,566,645 - 12,719,794 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108262   ⟹   ENSRNOP00000092956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX12,566,645 - 12,626,485 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114608   ⟹   ENSRNOP00000083955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX12,677,031 - 12,747,882 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118721   ⟹   ENSRNOP00000088888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX12,718,621 - 12,747,881 (+)Ensembl
RefSeq Acc Id: NM_001127601   ⟹   NP_001121073
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,239,159 - 15,299,004 (+)NCBI
mRatBN7.2X12,566,645 - 12,626,490 (+)NCBI
RefSeq Acc Id: NM_001374059   ⟹   NP_001360988
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,239,159 - 15,299,004 (+)NCBI
mRatBN7.2X12,566,645 - 12,626,490 (+)NCBI
RefSeq Acc Id: XM_008773081   ⟹   XP_008771303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,238,968 - 15,299,004 (+)NCBI
mRatBN7.2X12,566,454 - 12,628,171 (+)NCBI
Rnor_6.0X14,271,012 - 14,331,745 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773082   ⟹   XP_008771304
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,238,961 - 15,299,004 (+)NCBI
mRatBN7.2X12,566,455 - 12,626,166 (+)NCBI
Rnor_6.0X14,271,336 - 14,331,744 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773083   ⟹   XP_008771305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,238,971 - 15,299,004 (+)NCBI
mRatBN7.2X12,566,457 - 12,628,171 (+)NCBI
Rnor_6.0X14,271,012 - 14,331,735 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602250   ⟹   XP_017457739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,238,971 - 15,299,004 (+)NCBI
mRatBN7.2X12,566,457 - 12,628,171 (+)NCBI
Rnor_6.0X14,271,012 - 14,331,735 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099935   ⟹   XP_038955863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,238,967 - 15,299,004 (+)NCBI
mRatBN7.2X12,566,453 - 12,626,009 (+)NCBI
RefSeq Acc Id: XM_063280166   ⟹   XP_063136236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,238,968 - 15,299,004 (+)NCBI
RefSeq Acc Id: XM_063280167   ⟹   XP_063136237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,239,460 - 15,299,004 (+)NCBI
RefSeq Acc Id: XM_063280168   ⟹   XP_063136238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,238,970 - 15,299,004 (+)NCBI
RefSeq Acc Id: XM_063280169   ⟹   XP_063136239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,238,970 - 15,299,004 (+)NCBI
RefSeq Acc Id: XM_063280170   ⟹   XP_063136240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,238,969 - 15,299,004 (+)NCBI
RefSeq Acc Id: XM_063280171   ⟹   XP_063136241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,239,462 - 15,299,004 (+)NCBI
RefSeq Acc Id: XM_063280172   ⟹   XP_063136242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,239,466 - 15,299,004 (+)NCBI
RefSeq Acc Id: XR_010061211
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,238,962 - 15,291,319 (+)NCBI
RefSeq Acc Id: XR_010061212
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,239,448 - 15,291,319 (+)NCBI
RefSeq Acc Id: XR_010061213
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,239,448 - 15,291,319 (+)NCBI
RefSeq Acc Id: XR_010061214
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X15,239,448 - 15,291,319 (+)NCBI
RefSeq Acc Id: XP_008771304   ⟸   XM_008773082
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008771303   ⟸   XM_008773081
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008771305   ⟸   XM_008773083
- Peptide Label: isoform X5
- UniProtKB: A0A8I6ANX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457739   ⟸   XM_017602250
- Peptide Label: isoform X6
- UniProtKB: F7F384 (UniProtKB/TrEMBL),   A0A8I6ANX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060034   ⟸   ENSRNOT00000067603
RefSeq Acc Id: XP_038955863   ⟸   XM_039099935
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001360988   ⟸   NM_001374059
- Peptide Label: isoform 1
- UniProtKB: A0A8I6AFA8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001121073   ⟸   NM_001127601
- Peptide Label: isoform 2
- UniProtKB: B1WC72 (UniProtKB/TrEMBL),   A0A8I6ANX7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093511   ⟸   ENSRNOT00000107551
RefSeq Acc Id: ENSRNOP00000083955   ⟸   ENSRNOT00000114608
RefSeq Acc Id: ENSRNOP00000094523   ⟸   ENSRNOT00000107782
RefSeq Acc Id: ENSRNOP00000086725   ⟸   ENSRNOT00000108154
RefSeq Acc Id: ENSRNOP00000092956   ⟸   ENSRNOT00000108262
RefSeq Acc Id: ENSRNOP00000088888   ⟸   ENSRNOT00000118721
RefSeq Acc Id: ENSRNOP00000048924   ⟸   ENSRNOT00000045753
RefSeq Acc Id: ENSRNOP00000095069   ⟸   ENSRNOT00000104202
RefSeq Acc Id: XP_063136236   ⟸   XM_063280166
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063136240   ⟸   XM_063280170
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063136238   ⟸   XM_063280168
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063136239   ⟸   XM_063280169
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063136237   ⟸   XM_063280167
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063136241   ⟸   XM_063280171
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063136242   ⟸   XM_063280172
- Peptide Label: isoform X12
Protein Domains
HYR   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1WC72-F1-model_v2 AlphaFold B1WC72 1-677 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701725
Promoter ID:EPDNEW_R12245
Type:multiple initiation site
Name:Rpgr_1
Description:retinitis pigmentosa GTPase regulator
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X14,331,495 - 14,331,555EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560136 AgrOrtholog
BioCyc Gene G2FUF-3028 BioCyc
Ensembl Genes ENSRNOG00000003013 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067603.2 UniProtKB/TrEMBL
  ENSRNOT00000104202 ENTREZGENE
  ENSRNOT00000104202.1 UniProtKB/TrEMBL
  ENSRNOT00000107551.1 UniProtKB/TrEMBL
  ENSRNOT00000107782.1 UniProtKB/TrEMBL
  ENSRNOT00000108154.1 UniProtKB/TrEMBL
  ENSRNOT00000108262 ENTREZGENE
  ENSRNOT00000108262.1 UniProtKB/TrEMBL
  ENSRNOT00000118721.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.30 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9100258 IMAGE-MGC_LOAD
InterPro DUF4174 UniProtKB/TrEMBL
  HYR_dom UniProtKB/TrEMBL
  RCC1/BLIP-II UniProtKB/TrEMBL
  Reg_chr_condens UniProtKB/TrEMBL
  SRPX-like UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/TrEMBL
MGC_CLONE MGC:187915 IMAGE-MGC_LOAD
NCBI Gene 367733 ENTREZGENE
PANTHER PTHR46343 UniProtKB/TrEMBL
  PTHR46343:SF1 UniProtKB/TrEMBL
  UBIQUITIN-PROTEIN LIGASE E3A-RELATED UniProtKB/TrEMBL
  X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR UniProtKB/TrEMBL
Pfam DUF4174 UniProtKB/TrEMBL
  HYR UniProtKB/TrEMBL
  RCC1 UniProtKB/TrEMBL
  Sushi UniProtKB/TrEMBL
PhenoGen Rpgr PhenoGen
PRINTS RCCNDNSATION UniProtKB/TrEMBL
PROSITE HYR UniProtKB/TrEMBL
  RCC1_2 UniProtKB/TrEMBL
  RCC1_3 UniProtKB/TrEMBL
  SUSHI UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003013 RatGTEx
SMART CCP UniProtKB/TrEMBL
Superfamily-SCOP SSF50985 UniProtKB/TrEMBL
  SSF57535 UniProtKB/TrEMBL
UniProt A0A8I6A4C7_RAT UniProtKB/TrEMBL
  A0A8I6AAL5_RAT UniProtKB/TrEMBL
  A0A8I6AFA8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AL59_RAT UniProtKB/TrEMBL
  A0A8I6ALI3_RAT UniProtKB/TrEMBL
  A0A8I6ANX7 ENTREZGENE, UniProtKB/TrEMBL
  B1WC72 ENTREZGENE, UniProtKB/TrEMBL
  F7F384 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-02-09 Rpgr  retinitis pigmentosa GTPase regulator      Symbol and Name status set to provisional 70820 PROVISIONAL