Klhl13 (kelch-like family member 13) - Rat Genome Database
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Gene: Klhl13 (kelch-like family member 13) Rattus norvegicus
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Symbol: Klhl13
Name: kelch-like family member 13
RGD ID: 1559646
Description: Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination and regulation of cytokinesis. Predicted to localize to Cul3-RING ubiquitin ligase complex and midbody. Orthologous to human KLHL13 (kelch like family member 13); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; amphetamine.
Type: protein-coding
RefSeq Status: MODEL
Also known as: kelch-like 13; kelch-like protein 13
Orthologs:
Homo sapiens (human) : KLHL13 (kelch like family member 13)  HGNC  Alliance
Mus musculus (house mouse) : Klhl13 (kelch-like 13)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Klhl13 (kelch like family member 13)
Pan paniscus (bonobo/pygmy chimpanzee) : KLHL13 (kelch like family member 13)
Canis lupus familiaris (dog) : KLHL13 (kelch like family member 13)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Klhl13 (kelch like family member 13)
Sus scrofa (pig) : KLHL13 (kelch like family member 13)
Chlorocebus sabaeus (African green monkey) : KLHL13 (kelch like family member 13)
Heterocephalus glaber (naked mole-rat) : Klhl13 (kelch like family member 13)
more info ...
Allele / Splice: Klhl13Tn(sb-T2/Bart3)2.176Mcwi  
Genetic Models: F344-Klhl13Tn(sb-T2/Bart3)2.176Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X121,578,965 - 121,735,014 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX121,578,940 - 121,731,543 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X121,716,856 - 121,876,640 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X10,344,050 - 10,424,665 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX113,160,518 - 113,316,894 (-)NCBICelera
Cytogenetic MapXq34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:14528312   PMID:17543862  


Genomics

Comparative Map Data
Klhl13
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X121,578,965 - 121,735,014 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX121,578,940 - 121,731,543 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X121,716,856 - 121,876,640 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X10,344,050 - 10,424,665 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX113,160,518 - 113,316,894 (-)NCBICelera
Cytogenetic MapXq34NCBI
KLHL13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX117,897,813 - 118,117,340 (-)EnsemblGRCh38hg38GRCh38
GRCh38X117,897,813 - 118,117,340 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X117,031,776 - 117,251,303 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X116,915,804 - 116,990,881 (-)NCBINCBI36hg18NCBI36
Build 34X116,813,657 - 116,888,735NCBI
CeleraX117,486,583 - 117,706,100 (-)NCBI
Cytogenetic MapXq24NCBI
HuRefX106,526,310 - 106,745,823 (-)NCBIHuRef
CHM1_1X116,942,701 - 117,162,205 (-)NCBICHM1_1
Klhl13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X23,085,510 - 23,231,340 (-)NCBI
GRCm38X23,219,271 - 23,365,161 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX23,219,271 - 23,365,082 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X22,796,397 - 22,942,179 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X22,376,230 - 22,522,012 (-)NCBImm8
CeleraX21,314,201 - 21,459,747 (-)NCBICelera
Cytogenetic MapXA2NCBI
Klhl13
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555341,906,928 - 2,127,485 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555341,906,783 - 2,127,266 (+)NCBIChiLan1.0ChiLan1.0
KLHL13
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X117,320,192 - 117,538,413 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX117,320,192 - 117,450,771 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X106,904,105 - 107,122,969 (-)NCBIMhudiblu_PPA_v0panPan3
KLHL13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX90,139,103 - 90,355,188 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X90,138,375 - 90,355,105 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Klhl13
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647911,671,773 - 11,853,531 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL13
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX96,544,092 - 96,744,764 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X96,545,099 - 96,950,242 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X114,935,916 - 115,075,998 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL13
(Chlorocebus sabaeus - African green monkey)
No map positions available.
Klhl13
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248951,714,144 - 1,917,653 (-)NCBI

Position Markers
AI451128  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X121,578,992 - 121,579,278NCBIRnor6.0
Rnor_5.0X121,716,883 - 121,717,169UniSTSRnor5.0
RGSC_v3.4X10,424,352 - 10,424,638UniSTSRGSC3.4
CeleraX113,160,545 - 113,160,831UniSTS
Cytogenetic MapXq12UniSTS
KLHL13  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X121,607,676 - 121,608,411NCBIRnor6.0
Rnor_5.0X121,746,152 - 121,746,887UniSTSRnor5.0
RGSC_v3.4X10,389,642 - 10,390,377UniSTSRGSC3.4
CeleraX113,191,116 - 113,191,851UniSTS
Cytogenetic MapXq12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X15688119127888215Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X44320616158345622Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X70352120127888215Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X82930791127930791Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X101333032146333032Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX107886746152409805Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X110957467155957467Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X110957467155957467Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118715462159970021Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX120045041143145818Rat
5685004Bss104Bone structure and strength QTL 1043.9tibia area (VT:1000281)tibia area measurement (CMO:0001382)X121442246134627946Rat


Genetic Models
This gene Klhl13 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1903
Count of miRNA genes:322
Interacting mature miRNAs:431
Transcripts:ENSRNOT00000018788, ENSRNOT00000063868, ENSRNOT00000065459, ENSRNOT00000067114
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 37 15 14 11 14 6 7 74 22 34 11 6
Low 3 6 42 27 8 27 2 4 13 6 2
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_002727661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_002730180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003752130 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_003754837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006227515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07041178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07041179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07041180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07041181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07041182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07041183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01113803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01113804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01113805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01113806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01113807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01113808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01113809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01113810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01113811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01113812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01113813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01113814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000018788   ⟹   ENSRNOP00000018788
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX121,578,940 - 121,731,543 (-)Ensembl
RefSeq Acc Id: XM_002727661   ⟹   XP_002727707
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
CeleraX113,160,522 - 113,230,532 (-)NCBI
Sequence:
RefSeq Acc Id: XM_002730180   ⟹   XP_002730226
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X121,578,969 - 121,652,200 (-)NCBI
Rnor_5.0X121,716,856 - 121,876,640 (-)NCBI
RGSC_v3.4X10,344,050 - 10,424,665 (+)RGD
Sequence:
RefSeq Acc Id: XM_003752130   ⟹   XP_003752178
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X121,578,969 - 121,665,004 (-)NCBI
Rnor_5.0X121,716,856 - 121,876,640 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003754837   ⟹   XP_003754885
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
CeleraX113,160,522 - 113,243,336 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006227513   ⟹   XP_006227575
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
CeleraX113,160,518 - 113,316,894 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006227514   ⟹   XP_006227576
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
CeleraX113,160,522 - 113,229,814 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006227515   ⟹   XP_006227577
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
CeleraX113,160,522 - 113,316,894 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006257443   ⟹   XP_006257505
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X121,578,965 - 121,735,014 (-)NCBI
Rnor_5.0X121,716,856 - 121,876,640 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006257444   ⟹   XP_006257506
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X121,578,969 - 121,651,482 (-)NCBI
Rnor_5.0X121,716,856 - 121,876,640 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006257445   ⟹   XP_006257507
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X121,578,969 - 121,735,014 (-)NCBI
Rnor_5.0X121,716,856 - 121,876,640 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588309   ⟹   XP_017443798
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
CeleraX113,160,522 - 113,230,075 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588310   ⟹   XP_017443799
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
CeleraX113,160,518 - 113,213,911 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602373   ⟹   XP_017457862
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X121,578,969 - 121,651,743 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017602374   ⟹   XP_017457863
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X121,578,965 - 121,630,470 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_002727707   ⟸   XM_002727661
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_002730226   ⟸   XM_002730180
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_003752178   ⟸   XM_003752130
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003754885   ⟸   XM_003754837
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006227577   ⟸   XM_006227515
- Peptide Label: isoform X5
- UniProtKB: F1LM44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227575   ⟸   XM_006227513
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006227576   ⟸   XM_006227514
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006257507   ⟸   XM_006257445
- Peptide Label: isoform X5
- UniProtKB: F1LM44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257505   ⟸   XM_006257443
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006257506   ⟸   XM_006257444
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017443799   ⟸   XM_017588310
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017443798   ⟸   XM_017588309
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017457863   ⟸   XM_017602374
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017457862   ⟸   XM_017602373
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000018788   ⟸   ENSRNOT00000018788
Protein Domains
BTB

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559646 AgrOrtholog
Ensembl Genes ENSRNOG00000014029 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000018788 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018788 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.80 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7462401 IMAGE-MGC_LOAD
InterPro BACK UniProtKB/TrEMBL
  BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  Kelch-like_gigaxonin UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
MGC_CLONE MGC:125265 IMAGE-MGC_LOAD
NCBI Gene 313445 ENTREZGENE
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PhenoGen Klhl13 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF117281 UniProtKB/TrEMBL
UniGene Rn.24229 ENTREZGENE
UniProt F1LM44 ENTREZGENE, UniProtKB/TrEMBL
  Q3MHT7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Klhl13  kelch-like 13 (Drosophila)    kelch-like 13  Name updated 1299863 APPROVED
2006-02-09 Klhl13  kelch-like 13      Symbol and Name status set to provisional 70820 PROVISIONAL