Amer2 (APC membrane recruitment protein 2) - Rat Genome Database

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Gene: Amer2 (APC membrane recruitment protein 2) Rattus norvegicus
Analyze
Symbol: Amer2
Name: APC membrane recruitment protein 2
RGD ID: 1559605
Description: Predicted to enable beta-catenin binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be active in plasma membrane. Orthologous to human AMER2 (APC membrane recruitment protein 2); INTERACTS WITH bisphenol A; cefaloridine; mercury dichloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fam123a; family with sequence similarity 123A; LOC498529; RGD1559605; similar to hypothetical protein FLJ25477 isoform 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81538,701,509 - 38,711,817 (+)NCBIGRCr8
mRatBN7.21534,525,352 - 34,535,660 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1534,524,542 - 34,528,455 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1536,387,500 - 36,397,825 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01537,538,132 - 37,548,457 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01535,986,485 - 35,996,793 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01540,663,183 - 40,667,705 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1540,665,041 - 40,667,173 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01544,476,186 - 44,479,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41539,469,071 - 39,471,815 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1534,225,681 - 34,230,285 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
plasma membrane  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22128170   PMID:22898821  


Genomics

Comparative Map Data
Amer2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81538,701,509 - 38,711,817 (+)NCBIGRCr8
mRatBN7.21534,525,352 - 34,535,660 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1534,524,542 - 34,528,455 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1536,387,500 - 36,397,825 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01537,538,132 - 37,548,457 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01535,986,485 - 35,996,793 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01540,663,183 - 40,667,705 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1540,665,041 - 40,667,173 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01544,476,186 - 44,479,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41539,469,071 - 39,471,815 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1534,225,681 - 34,230,285 (+)NCBICelera
Cytogenetic Map15p12NCBI
AMER2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381325,161,679 - 25,172,288 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1325,161,679 - 25,172,288 (-)EnsemblGRCh38hg38GRCh38
GRCh371325,735,817 - 25,746,426 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361324,640,660 - 24,643,857 (-)NCBINCBI36Build 36hg18NCBI36
Celera136,806,916 - 6,810,113 (-)NCBICelera
Cytogenetic Map13q12.13NCBI
HuRef136,556,685 - 6,559,882 (-)NCBIHuRef
CHM1_11325,710,908 - 25,714,105 (-)NCBICHM1_1
T2T-CHM13v2.01324,371,351 - 24,382,125 (-)NCBIT2T-CHM13v2.0
Amer2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391460,615,141 - 60,625,642 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1460,610,708 - 60,625,646 (+)EnsemblGRCm39 Ensembl
GRCm381460,373,288 - 60,388,197 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1460,373,259 - 60,388,197 (+)EnsemblGRCm38mm10GRCm38
MGSCv371460,997,123 - 60,999,840 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361459,332,456 - 59,335,107 (+)NCBIMGSCv36mm8
Celera1458,156,596 - 58,159,314 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1431.62NCBI
Amer2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554974,640,343 - 4,645,314 (-)NCBIChiLan1.0ChiLan1.0
AMER2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21424,757,957 - 24,768,597 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11315,867,634 - 15,878,275 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0136,453,492 - 6,464,127 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11324,808,749 - 24,815,910 (-)NCBIpanpan1.1PanPan1.1panPan2
AMER2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12514,281,391 - 14,296,885 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2514,366,397 - 14,376,245 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02514,417,596 - 14,427,519 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12514,299,599 - 14,309,485 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02514,301,630 - 14,311,510 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02514,350,576 - 14,360,464 (+)NCBIUU_Cfam_GSD_1.0
Amer2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945116,523,815 - 116,534,061 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366881,136,224 - 1,138,275 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366881,136,060 - 1,139,078 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMER2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl113,124,317 - 3,127,433 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1113,118,314 - 3,128,420 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2112,516,168 - 2,519,637 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AMER2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.134,559,549 - 4,567,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl34,564,141 - 4,566,159 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605739,878,100 - 39,888,769 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Amer2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477613,376,677 - 13,381,037 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477613,376,849 - 13,387,540 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Amer2
42 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:37
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000018300
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152024860037896129Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
BF400972  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21534,524,677 - 34,524,848 (+)MAPPERmRatBN7.2
Rnor_6.01540,663,940 - 40,664,110NCBIRnor6.0
Rnor_5.01544,475,863 - 44,476,033UniSTSRnor5.0
RGSC_v3.41539,468,050 - 39,468,220UniSTSRGSC3.4
Celera1534,226,433 - 34,226,603UniSTS
RH 3.4 Map15229.1UniSTS
Cytogenetic Map15p12UniSTS
RH135443  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81538,704,317 - 38,704,509 (+)Marker Load Pipeline
mRatBN7.21534,528,160 - 34,528,352 (+)MAPPERmRatBN7.2
Rnor_6.01540,667,423 - 40,667,614NCBIRnor6.0
Rnor_5.01544,479,346 - 44,479,537UniSTSRnor5.0
RGSC_v3.41539,471,533 - 39,471,724UniSTSRGSC3.4
Celera1534,230,003 - 34,230,194UniSTS
Cytogenetic Map15p12UniSTS
Fam123a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21534,527,173 - 34,527,236 (+)MAPPERmRatBN7.2
Rnor_6.01540,666,436 - 40,666,498NCBIRnor6.0
Rnor_5.01544,478,359 - 44,478,421UniSTSRnor5.0
Celera1534,229,016 - 34,229,078UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 7 36 113 63 62 35 14 35 6 164 70 93 45 60 27

Sequence


Ensembl Acc Id: ENSRNOT00000018300   ⟹   ENSRNOP00000069918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1534,524,542 - 34,528,455 (+)Ensembl
Rnor_6.0 Ensembl1540,665,041 - 40,667,173 (+)Ensembl
RefSeq Acc Id: NM_001399520   ⟹   NP_001386449
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81538,701,509 - 38,711,817 (+)NCBI
mRatBN7.21534,525,352 - 34,535,660 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386449 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069918.2
Ensembl Acc Id: ENSRNOP00000069918   ⟸   ENSRNOT00000018300
RefSeq Acc Id: NP_001386449   ⟸   NM_001399520
- UniProtKB: A0A0G2JWK6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JWK6-F1-model_v2 AlphaFold A0A0G2JWK6 1-509 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699740
Promoter ID:EPDNEW_R10259
Type:single initiation site
Name:Amer2_1
Description:APC membrane recruitment protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01540,664,973 - 40,665,033EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559605 AgrOrtholog
BioCyc Gene G2FUF-13533 BioCyc
Ensembl Genes ENSRNOG00000013623 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018300.6 UniProtKB/TrEMBL
InterPro Uncharacterised_FAM123 UniProtKB/TrEMBL
NCBI Gene 498529 ENTREZGENE
PANTHER APC MEMBRANE RECRUITMENT PROTEIN 2 UniProtKB/TrEMBL
  PTHR22237 UniProtKB/TrEMBL
Pfam WTX UniProtKB/TrEMBL
PhenoGen Amer2 PhenoGen
RatGTEx ENSRNOG00000013623 RatGTEx
UniProt A0A0G2JWK6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Amer2  APC membrane recruitment protein 2  Fam123a  family with sequence similarity 123A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Fam123a  family with sequence similarity 123A  RGD1559605_predicted  similar to hypothetical protein FLJ25477 isoform 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559605_predicted  similar to hypothetical protein FLJ25477 isoform 2 (predicted)  LOC498529  similar to hypothetical protein FLJ25477 isoform 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498529  similar to hypothetical protein FLJ25477 isoform 2      Symbol and Name status set to provisional 70820 PROVISIONAL