Gpr143 (G protein-coupled receptor 143) - Rat Genome Database

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Gene: Gpr143 (G protein-coupled receptor 143) Mus musculus
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Symbol: Gpr143
Name: G protein-coupled receptor 143
RGD ID: 1558529
MGI Page MGI
Description: Predicted to have L-DOPA receptor activity; dopamine binding activity; and organic acid binding activity. Involved in regulation of melanosome organization and regulation of melanosome transport. Predicted to localize to Golgi apparatus; apical plasma membrane; and bounding membrane of organelle. Is expressed in several structures, including eye; hair follicle; and inner ear. Used to study ocular albinism. Human ortholog(s) of this gene implicated in congenital nystagmus 6. Orthologous to human GPR143 (G protein-coupled receptor 143); INTERACTS WITH 5-aza-2'-deoxycytidine (ortholog); 6-propyl-2-thiouracil (ortholog); arsenite(3-) (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: G-protein coupled receptor 143; homolog of human ocular albinism 1 (Nettleship-Falls); MOA1; O; Oa1; ocular albinism type 1 protein homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X151,564,917 - 151,591,647 (+)NCBIGRCm39mm39
GRCm39 EnsemblX151,564,917 - 151,591,642 (+)Ensembl
GRCm38X152,781,921 - 152,808,651 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX152,781,921 - 152,808,646 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X149,216,464 - 149,243,189 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X148,122,702 - 148,149,362 (+)NCBImm8
CeleraX136,442,756 - 136,469,491 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8661129   PMID:8889556   PMID:8921399   PMID:9215685   PMID:9503026   PMID:9529334   PMID:9721213   PMID:9722947   PMID:9722956   PMID:10349636   PMID:10920247   PMID:11042159  
PMID:11076861   PMID:11092754   PMID:11095635   PMID:11180981   PMID:11217851   PMID:11775061   PMID:12477932   PMID:15254223   PMID:15782199   PMID:16023414   PMID:16141072   PMID:16141073  
PMID:16154128   PMID:16303920   PMID:18378571   PMID:18697795   PMID:19717472   PMID:21267068   PMID:21677750   PMID:21873635   PMID:21931697   PMID:22984402   PMID:24098784   PMID:24650003  
PMID:25601010  


Genomics

Comparative Map Data
Gpr143
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X151,564,917 - 151,591,647 (+)NCBIGRCm39mm39
GRCm39 EnsemblX151,564,917 - 151,591,642 (+)Ensembl
GRCm38X152,781,921 - 152,808,651 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX152,781,921 - 152,808,646 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X149,216,464 - 149,243,189 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X148,122,702 - 148,149,362 (+)NCBImm8
CeleraX136,442,756 - 136,469,491 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX68.46NCBI
GPR143
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX9,725,346 - 9,786,297 (-)EnsemblGRCh38hg38GRCh38
GRCh38X9,725,346 - 9,786,260 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X9,693,386 - 9,733,887 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X9,653,454 - 9,693,917 (-)NCBINCBI36hg18NCBI36
Build 34X9,503,189 - 9,543,653NCBI
CeleraX13,865,374 - 13,905,925 (-)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX7,525,733 - 7,566,160 (-)NCBIHuRef
CHM1_1X9,723,929 - 9,764,313 (-)NCBICHM1_1
Gpr143
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X22,002,914 - 22,027,720 (+)NCBI
Rnor_6.0 EnsemblX23,668,363 - 23,693,162 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X23,668,363 - 23,693,162 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X24,084,931 - 24,109,730 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X42,481,440 - 42,506,239 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX22,403,114 - 22,427,887 (+)NCBICelera
Cytogenetic MapXq13NCBI
Gpr143
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554997,909,019 - 7,928,431 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554997,900,276 - 7,953,847 (-)NCBIChiLan1.0ChiLan1.0
GPR143
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X9,609,597 - 9,650,069 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX9,609,598 - 9,650,075 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X2,357,835 - 2,398,389 (-)NCBIMhudiblu_PPA_v0panPan3
GPR143
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X6,438,068 - 6,479,731 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX6,437,660 - 6,474,447 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX6,385,711 - 6,433,423 (-)NCBI
ROS_Cfam_1.0X6,374,640 - 6,424,234 (-)NCBI
UMICH_Zoey_3.1X6,367,596 - 6,415,264 (-)NCBI
UNSW_CanFamBas_1.0X6,402,457 - 6,450,986 (-)NCBI
UU_Cfam_GSD_1.0X6,395,377 - 6,440,848 (-)NCBI
Gpr143
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049534,141,453 - 4,180,471 (-)NCBI
SpeTri2.0NW_004936644196,344 - 236,659 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR143
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X6,242,296 - 6,276,654 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1Y4,669,764 - 4,704,304 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X6,541,506 - 6,575,924 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPR143
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X8,178,818 - 8,223,291 (-)NCBI
ChlSab1.1 EnsemblX8,179,154 - 8,222,603 (-)Ensembl
Gpr143
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248347,281,962 - 7,329,484 (-)NCBI

Position Markers
DXMit218  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X152,789,460 - 152,789,545UniSTSGRCm38
MGSCv37X149,224,003 - 149,224,088UniSTSGRCm37
CeleraX136,461,842 - 136,461,927UniSTS
Cytogenetic MapXF2-F3UniSTS
cM MapX64.0UniSTS
Whitehead GeneticX50.3UniSTS
Whitehead_YACX UniSTS
Gpr143  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXF2-F3UniSTS
cM MapX65.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX103012242163975945Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX122083468161430042Mouse
25314309Syncl5_msynaptonemal complex length 5 (mouse)X123000000153800000Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX126902153160902273Mouse
13824981Svwq2_mseminal vesicle weight QTL 2 (mouse)X130000000155000000Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX134639291166515599Mouse
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX145691384171031299Mouse
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX145691384171031299Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:237
Count of miRNA genes:204
Interacting mature miRNAs:223
Transcripts:ENSMUST00000026383, ENSMUST00000139310, ENSMUST00000151819
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000026383   ⟹   ENSMUSP00000026383
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 EnsemblX152,781,986 - 152,808,646 (+)Ensembl
RefSeq Acc Id: ENSMUST00000139310
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 EnsemblX152,782,018 - 152,790,920 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151819
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 EnsemblX152,781,921 - 152,795,615 (+)Ensembl
RefSeq Acc Id: NM_010951   ⟹   NP_035081
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X151,564,917 - 151,591,642 (+)NCBI
GRCm38X152,781,921 - 152,808,646 (+)NCBI
MGSCv37X149,216,464 - 149,243,189 (+)RGD
CeleraX136,442,756 - 136,469,491 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006528746   ⟹   XP_006528809
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X151,565,207 - 151,591,647 (+)NCBI
GRCm38X152,782,211 - 152,808,651 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035081   ⟸   NM_010951
- UniProtKB: P70259 (UniProtKB/Swiss-Prot),   Q549B6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528809   ⟸   XM_006528746
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000026383   ⟸   ENSMUST00000026383

Promoters
RGD ID:13681664
Promoter ID:EPDNEW_M24981
Type:initiation region
Name:Gpr143_1
Description:Mus musculus G protein-coupled receptor 143 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X152,781,915 - 152,781,975EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107193 AgrOrtholog
Ensembl Genes ENSMUSG00000025333 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000026383 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000026383 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPR143 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18241 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107193 ENTREZGENE
NCBI Gene 18241 ENTREZGENE
PANTHER PTHR15177 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ocular_alb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpr143 PhenoGen
PRINTS OCULARALBNSM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt GP143_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q549B6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O89031 UniProtKB/Swiss-Prot