Nat8f4 (N-acetyltransferase 8 (GCN5-related) family member 4) - Rat Genome Database
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Gene: Nat8f4 (N-acetyltransferase 8 (GCN5-related) family member 4) Mus musculus
Analyze
Symbol: Nat8f4
Name: N-acetyltransferase 8 (GCN5-related) family member 4
RGD ID: 1558513
MGI Page MGI
Description: Predicted to have N-acetyltransferase activity. Orthologous to human NAT8 (N-acetyltransferase 8 (putative)); INTERACTS WITH 4-hydroxyphenyl retinamide; bisphenol A; tetrachloromethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1700019G17Rik; hypothetical protein LOC75541; uncharacterized protein LOC75541
RGD Orthologs
Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,876,032 - 85,881,920 (-)NCBIGRCm39mm39
GRCm38685,899,050 - 85,909,315 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,899,051 - 85,904,884 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,849,044 - 85,854,932 (-)NCBIGRCm37mm9NCBIm37
MGSCv36685,864,684 - 85,870,518 (-)NCBImm8
Celera687,833,395 - 87,839,283 (-)NCBICelera
Cytogenetic Map6C3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21677750   PMID:21873635   PMID:27649575  


Genomics

Comparative Map Data
Nat8f4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,876,032 - 85,881,920 (-)NCBIGRCm39mm39
GRCm38685,899,050 - 85,909,315 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,899,051 - 85,904,884 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,849,044 - 85,854,932 (-)NCBIGRCm37mm9NCBIm37
MGSCv36685,864,684 - 85,870,518 (-)NCBImm8
Celera687,833,395 - 87,839,283 (-)NCBICelera
Cytogenetic Map6C3NCBI
Nat8f4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24118,326,092 - 118,332,591 (-)NCBI
Rnor_6.0 Ensembl4117,757,455 - 117,758,135 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04117,755,646 - 117,760,096 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04182,328,171 - 182,330,686 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44120,051,193 - 120,057,598 (-)NCBIRGSC3.4rn4RGSC3.4
Celera4107,301,452 - 107,307,856 (-)NCBICelera
Cytogenetic Map4q34NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:652
Count of miRNA genes:461
Interacting mature miRNAs:520
Transcripts:ENSMUST00000095757, ENSMUST00000159755
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000095757   ⟹   ENSMUSP00000093430
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,899,051 - 85,904,884 (-)Ensembl
RefSeq Acc Id: ENSMUST00000159755   ⟹   ENSMUSP00000124071
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,899,051 - 85,902,533 (-)Ensembl
RefSeq Acc Id: NM_001145895   ⟹   NP_001139367
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,876,033 - 85,879,515 (-)NCBI
GRCm38685,899,051 - 85,902,533 (-)NCBI
MGSCv37685,849,044 - 85,854,932 (-)RGD
Celera687,833,395 - 87,839,283 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_029331   ⟹   NP_083607
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,876,032 - 85,881,920 (-)NCBI
GRCm38685,899,050 - 85,904,938 (-)NCBI
MGSCv37685,849,044 - 85,854,932 (-)RGD
Celera687,833,395 - 87,839,283 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506720   ⟹   XP_006506783
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,876,032 - 85,881,332 (-)NCBI
GRCm38685,899,050 - 85,904,347 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_083607   ⟸   NM_029331
- Peptide Label: isoform 1
- UniProtKB: G5E8L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139367   ⟸   NM_001145895
- Peptide Label: isoform 2
- UniProtKB: E0CYM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006506783   ⟸   XM_006506720
- Peptide Label: isoform X1
- UniProtKB: G5E8L3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000124071   ⟸   ENSMUST00000159755
RefSeq Acc Id: ENSMUSP00000093430   ⟸   ENSMUST00000095757
Protein Domains
N-acetyltransferase

Promoters
RGD ID:6838694
Promoter ID:MM_KWN:46706
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:UC009CQJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36685,854,676 - 85,855,176 (-)MPROMDB
RGD ID:6890250
Promoter ID:EPDNEW_M8576
Type:multiple initiation site
Name:Nat8f4_2
Description:Mus musculus N-acetyltransferase 8 (GCN5-related) family member4 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8577  EPDNEW_M8578  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38685,902,270 - 85,902,330EPDNEW
RGD ID:6890252
Promoter ID:EPDNEW_M8577
Type:multiple initiation site
Name:Nat8f4_3
Description:Mus musculus N-acetyltransferase 8 (GCN5-related) family member4 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8576  EPDNEW_M8578  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38685,902,534 - 85,902,594EPDNEW
RGD ID:6890254
Promoter ID:EPDNEW_M8578
Type:multiple initiation site
Name:Nat8f4_1
Description:Mus musculus N-acetyltransferase 8 (GCN5-related) family member4 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8576  EPDNEW_M8577  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38685,904,925 - 85,904,985EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1922791 AgrOrtholog
Ensembl Genes ENSMUSG00000068299 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000093430 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000124071 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000095757 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000159755 ENTREZGENE, UniProtKB/TrEMBL
InterPro Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  GNAT_dom UniProtKB/TrEMBL
KEGG Report mmu:75541 UniProtKB/TrEMBL
MGD MGI:1922791 ENTREZGENE
NCBI Gene 75541 ENTREZGENE
Pfam Acetyltransf_1 UniProtKB/TrEMBL
PhenoGen Nat8f4 PhenoGen
PROSITE GNAT UniProtKB/TrEMBL
Superfamily-SCOP Acyl_CoA_acyltransferase UniProtKB/TrEMBL
UniProt E0CYM0 ENTREZGENE, UniProtKB/TrEMBL
  G5E8L3 ENTREZGENE, UniProtKB/TrEMBL
  Q8CID2_MOUSE UniProtKB/TrEMBL
  Q9DA67_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 Nat8f4  N-acetyltransferase 8 (GCN5-related) family member 4  1700019G17Rik  RIKEN cDNA 1700019G17 gene  Symbol and/or name change 5135510 APPROVED