Rbak (RB-associated KRAB zinc finger) - Rat Genome Database

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Gene: Rbak (RB-associated KRAB zinc finger) Mus musculus
Analyze
Symbol: Rbak
Name: RB-associated KRAB zinc finger
RGD ID: 1558489
MGI Page MGI
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human RBAK (RB associated KRAB zinc finger).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: RB-associated KRAB repressor; RB-associated KRAB zinc finger protein; zinc finger protein 769
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395143,157,941 - 143,166,530 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5143,157,941 - 143,166,530 (-)EnsemblGRCm39 Ensembl
GRCm385143,172,186 - 143,180,775 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5143,172,186 - 143,180,775 (-)EnsemblGRCm38mm10GRCm38
MGSCv375143,933,867 - 143,942,422 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365143,437,326 - 143,445,915 (-)NCBIMGSCv36mm8
Celera5140,216,911 - 140,225,466 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map581.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (ISO)
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10702291   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14691545   PMID:16141072   PMID:16141073   PMID:18287559  
PMID:20059953   PMID:20412781   PMID:21267068   PMID:21677750   PMID:21873635   PMID:30973865   PMID:32325033  


Genomics

Comparative Map Data
Rbak
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395143,157,941 - 143,166,530 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5143,157,941 - 143,166,530 (-)EnsemblGRCm39 Ensembl
GRCm385143,172,186 - 143,180,775 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5143,172,186 - 143,180,775 (-)EnsemblGRCm38mm10GRCm38
MGSCv375143,933,867 - 143,942,422 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365143,437,326 - 143,445,915 (-)NCBIMGSCv36mm8
Celera5140,216,911 - 140,225,466 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map581.98NCBI
RBAK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3875,045,860 - 5,069,487 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl75,045,821 - 5,069,487 (+)EnsemblGRCh38hg38GRCh38
GRCh3775,085,491 - 5,109,118 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3675,052,079 - 5,075,645 (+)NCBINCBI36Build 36hg18NCBI36
Celera75,044,901 - 5,068,467 (+)NCBICelera
Cytogenetic Map7p22.1NCBI
HuRef75,000,481 - 5,024,148 (+)NCBIHuRef
CHM1_175,085,039 - 5,108,706 (+)NCBICHM1_1
T2T-CHM13v2.075,163,659 - 5,187,282 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v275,131,807 - 5,155,474 (+)NCBI
Rbak
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,488,895 - 16,502,523 (+)NCBIGRCr8
mRatBN7.21211,375,314 - 11,388,937 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1211,375,318 - 11,388,934 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1212,184,277 - 12,196,488 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,807,555 - 12,819,766 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,833,653 - 11,845,864 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,428,648 - 13,442,279 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,428,685 - 13,442,286 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01215,468,852 - 15,482,466 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,748,333 - 11,760,544 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1213,168,595 - 13,180,802 (+)NCBICelera
Cytogenetic Map12p11NCBI
RBAK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2610,013,378 - 10,037,654 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1758,338,781 - 58,358,815 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v075,304,827 - 5,328,372 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.175,332,884 - 5,356,307 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl75,344,120 - 5,356,307 (+)Ensemblpanpan1.1panPan2
RBAK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1612,072,465 - 12,097,422 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl612,073,368 - 12,093,811 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,326,735 - 18,342,501 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0612,166,066 - 12,194,774 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1612,033,522 - 12,049,283 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0611,954,564 - 11,982,773 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0612,207,419 - 12,259,386 (+)NCBIUU_Cfam_GSD_1.0
Rbak
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344140,321,392 - 140,339,751 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936765315,255 - 326,409 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936765312,474 - 327,089 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBAK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl34,422,784 - 4,439,945 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.134,422,481 - 4,439,943 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23144,137,154 - 144,154,400 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RBAK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12816,594,449 - 16,648,577 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660905,279,291 - 5,326,056 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbak
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474027,682,835 - 27,701,904 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474027,681,328 - 27,700,055 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rbak
340 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:816
Count of miRNA genes:262
Interacting mature miRNAs:290
Transcripts:ENSMUST00000049861, ENSMUST00000164068, ENSMUST00000165318, ENSMUST00000166382
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse
13504735Ifvrq7_minfluenza virus resistance QTL 7 (mouse)5139509801151658149Mouse
13504737Ifvrq5_minfluenza virus resistance QTL 5 (mouse)5139509801151658149Mouse
13504734Ifvrq4_minfluenza virus resistance QTL 4 (mouse)5139985755151658149Mouse

Markers in Region
UniSTS:235361  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385143,172,259 - 143,172,479UniSTSGRCm38
MGSCv375143,933,938 - 143,934,158UniSTSGRCm37
Celera5140,216,982 - 140,217,202UniSTS
Cytogenetic Map5G2UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000049861   ⟹   ENSMUSP00000059273
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5143,157,941 - 143,166,485 (-)Ensembl
GRCm38.p6 Ensembl5143,172,186 - 143,180,730 (-)Ensembl
RefSeq Acc Id: ENSMUST00000165318   ⟹   ENSMUSP00000128731
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5143,157,941 - 143,166,530 (-)Ensembl
GRCm38.p6 Ensembl5143,172,186 - 143,180,775 (-)Ensembl
RefSeq Acc Id: ENSMUST00000166382
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5143,157,942 - 143,162,489 (-)Ensembl
GRCm38.p6 Ensembl5143,172,187 - 143,176,734 (-)Ensembl
RefSeq Acc Id: ENSMUST00000199880
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5143,164,721 - 143,166,487 (-)Ensembl
GRCm38.p6 Ensembl5143,178,966 - 143,180,732 (-)Ensembl
RefSeq Acc Id: NM_001045482   ⟹   NP_001038947
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395143,157,941 - 143,166,530 (-)NCBI
GRCm385143,172,186 - 143,180,775 (-)NCBI
MGSCv375143,933,867 - 143,942,422 (-)RGD
Celera5140,216,909 - 140,225,498 (-)NCBI
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001359235   ⟹   NP_001346164
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395143,157,941 - 143,166,530 (-)NCBI
GRCm385143,172,186 - 143,180,775 (-)NCBI
Sequence:
RefSeq Acc Id: NM_021326   ⟹   NP_067301
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395143,157,941 - 143,166,530 (-)NCBI
GRCm385143,172,186 - 143,180,775 (-)NCBI
MGSCv375143,933,867 - 143,942,422 (-)RGD
Celera5140,216,909 - 140,225,498 (-)NCBI
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_067301   ⟸   NM_021326
- UniProtKB: Q6PB38 (UniProtKB/Swiss-Prot),   Q9JKU4 (UniProtKB/Swiss-Prot),   Q8BQC8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001038947   ⟸   NM_001045482
- UniProtKB: Q6PB38 (UniProtKB/Swiss-Prot),   Q9JKU4 (UniProtKB/Swiss-Prot),   Q8BQC8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001346164   ⟸   NM_001359235
- UniProtKB: Q8BQC8 (UniProtKB/Swiss-Prot),   Q6PB38 (UniProtKB/Swiss-Prot),   Q9JKU4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000128731   ⟸   ENSMUST00000165318
RefSeq Acc Id: ENSMUSP00000059273   ⟸   ENSMUST00000049861
Protein Domains
KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BQC8-F1-model_v2 AlphaFold Q8BQC8 1-711 view protein structure

Promoters
RGD ID:6888654
Promoter ID:EPDNEW_M7778
Type:initiation region
Name:Rbak_1
Description:Mus musculus RB-associated KRAB zinc finger , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385143,180,758 - 143,180,818EPDNEW
RGD ID:6836915
Promoter ID:MM_KWN:44725
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000049861,   NM_021326,   OTTMUST00000075344,   OTTMUST00000075345
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365143,942,326 - 143,942,826 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1927369 AgrOrtholog
Ensembl Genes ENSMUSG00000061898 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000049861 ENTREZGENE
  ENSMUST00000049861.11 UniProtKB/Swiss-Prot
  ENSMUST00000165318 ENTREZGENE
  ENSMUST00000165318.4 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.140.140 UniProtKB/Swiss-Prot
  Classic Zinc Finger UniProtKB/Swiss-Prot
InterPro KRAB UniProtKB/Swiss-Prot
  KRAB_dom_sf UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report mmu:57782 UniProtKB/Swiss-Prot
MGD MGI:1927369 ENTREZGENE
NCBI Gene 57782 ENTREZGENE
PANTHER KRAB DOMAIN C2H2 ZINC FINGER UniProtKB/Swiss-Prot
  KRAB DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam KRAB UniProtKB/Swiss-Prot
  zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Rbak PhenoGen
PROSITE KRAB UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART KRAB UniProtKB/Swiss-Prot
  ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF109640 UniProtKB/Swiss-Prot
  SSF57667 UniProtKB/Swiss-Prot
UniProt Q6PB38 ENTREZGENE
  Q8BQC8 ENTREZGENE
  Q9JKU4 ENTREZGENE
  RBAK_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q6PB38 UniProtKB/Swiss-Prot
  Q9JKU4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-05-12 Rbak  RB-associated KRAB zinc finger    RB-associated KRAB repressor  Symbol and/or name change 5135510 APPROVED