Rhox13 (reproductive homeobox 13)

Gene: Rhox13 (reproductive homeobox 13) Mus musculus

Analyze

Symbol:

Rhox13

Name:

reproductive homeobox 13

RGD ID:

1558431

MGI Page

MGI

Description:

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to retinoic acid. Located in nucleus. Is expressed in genitourinary system. Orthologous to human RHOXF1 (Rhox homeobox family member 1).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

1700123J19Rik; homeobox protein Rhox13; novel homeobox domain-containing protein; reproductive homeobox protein 13

RGD Orthologs

Human

Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	37,210,059 - 37,218,850 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	37,210,096 - 37,218,844 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	38,120,840 - 38,129,966 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	38,121,219 - 38,129,967 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	35,474,017 - 35,483,143 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	34,365,917 - 34,374,599 (+)	NCBI		MGSCv36	mm8
Celera	X	25,766,316 - 25,775,542 (+)	NCBI		Celera
Cytogenetic Map	X	A3.3	NCBI
cM Map	X	22.38	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Danon disease (ISO)

genetic disease (ISO)

syndromic X-linked intellectual disability 14 (ISO)

syndromic X-linked intellectual disability Cabezas type (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

5-aza-2'-deoxycytidine (ISO)

all-trans-retinoic acid (EXP)

arsane (ISO)

arsenic atom (ISO)

bisphenol A (ISO)

butanal (ISO)

CGP 52608 (ISO)

epoxiconazole (EXP)

lead(0) (ISO)

malathion (ISO)

mono(2-ethylhexyl) phthalate (EXP)

pentanal (ISO)

silicon dioxide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

androgen receptor signaling pathway (ISO)

cellular response to retinoic acid (IDA)

positive regulation of gene expression (ISO)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

cytosol (ISO)

nucleoplasm (ISO)

nucleus (IDA,ISO)

Molecular Function

DNA binding (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

protein binding (ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IBA)

sequence-specific double-stranded DNA binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal fertility/fecundity (IAGP)

abnormal seminiferous tubule epithelium morphology (IAGP)

decreased male germ cell number (IAGP)

increased male germ cell apoptosis (IAGP)

oligozoospermia (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2.	MGDs mouse GO annotations	MGD data from the GO Consortium
3.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10349636	PMID:11042159	PMID:11076861	PMID:15618518	PMID:16141072	PMID:16141073	PMID:17182866	PMID:17660561	PMID:18287559	PMID:18675325	PMID:20932939	PMID:21677750
PMID:21873635	PMID:22190708	PMID:25790000	PMID:27486269	PMID:27626380	PMID:27681428	PMID:30973865

Genomics

Comparative Map Data

Rhox13
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	37,210,059 - 37,218,850 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	37,210,096 - 37,218,844 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	38,120,840 - 38,129,966 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	38,121,219 - 38,129,967 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	35,474,017 - 35,483,143 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	34,365,917 - 34,374,599 (+)	NCBI		MGSCv36	mm8
Celera	X	25,766,316 - 25,775,542 (+)	NCBI		Celera
Cytogenetic Map	X	A3.3	NCBI
cM Map	X	22.38	NCBI

RHOXF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	120,109,051 - 120,120,438 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	120,109,051 - 120,245,267 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	119,243,009 - 119,249,823 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	119,127,053 - 119,133,875 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	X	119,708,916 - 119,715,939 (+)	NCBI		Celera
Cytogenetic Map	X	q24	NCBI
HuRef	X	108,694,949 - 108,701,800 (-)	NCBI		HuRef
CHM1_1	X	119,154,044 - 119,160,880 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	118,484,211 - 118,495,405 (-)	NCBI		T2T-CHM13v2.0

Rhox13
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	121,776,875 - 121,783,406 (+)	NCBI		GRCr8
mRatBN7.2	X	116,911,226 - 116,917,758 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	116,911,329 - 116,917,644 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	X	124,267,991 - 124,274,290 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	124,268,129 - 124,274,157 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	124,353,797 - 124,360,019 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	7,216,949 - 7,222,704 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	116,128,924 - 116,135,440 (+)	NCBI		Celera
Cytogenetic Map	X	q35	NCBI

Variants

Variants in Rhox13
197 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	64
Count of miRNA genes:	63
Interacting mature miRNAs:	64
Transcripts:	ENSMUST00000152730
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357433	Dbts2_m	diabetes 2 (mouse)			Not determined		X	7226295	150107038	Mouse
1301551	Spha1_m	sperm head anomaly 1 (mouse)			Not determined		X	10266225	39921652	Mouse
13208553	Wght11_m	weight 11 (mouse)					X	11866239	59045360	Mouse
13208557	Lgth13_m	body length 13 (mouse)					X	11866239	59045360	Mouse
1558721	Bw1_m	body weight QTL 1 (mouse)			Not determined		X	20606783	47179225	Mouse
12738418	Lfibq12_m	liver fibrosis QTL 12 (mouse)					X	25728174	43635700	Mouse
27226750	Femd9_m	femur midshaft diameter 9, 10 week (mouse)					X	33337463	55845360	Mouse
27226780	Femd12_m	femur midshaft diameter 12, 16 week (mouse)					X	34663653	56845360	Mouse
13208567	Bmiq12_m	body mass index QTL 12 (mouse)					X	35263653	77043606	Mouse

Markers in Region

Rhox13

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
cM Map	X		UniSTS

Rhox13

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	X	A3.3	UniSTS

Rhox13

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	X	A3.3	UniSTS
cM Map	X		UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001185002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AK007253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL512346	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AV490373	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000152730 ⟹ ENSMUSP00000117271

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	X	37,210,096 - 37,218,844 (+)	Ensembl
GRCm38.p6 Ensembl	X	38,121,219 - 38,129,967 (+)	Ensembl

RefSeq Acc Id:

NM_001185002 ⟹ NP_001171931

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	X	37,210,059 - 37,218,850 (+)	NCBI
GRCm38	X	38,120,840 - 38,129,966 (+)	ENTREZGENE
MGSCv37	X	35,474,017 - 35,483,143 (+)	RGD
Celera	X	25,766,316 - 25,775,542 (+)	RGD
cM Map	X		ENTREZGENE

Sequence:

show sequence

TACTGGTCGTGGTAATCCCTATAATCCATGAAGGATAGGCAGCCCATGTATGCGTGTATGTGCA
TGCAAGGGTGCAAGTTAAAGCAGCCACATGCCCCTCCCCCCTCACAATCTGTCCGCAGGTCCCA
CATGTTTTGGGCCGTACCCCGTCACTTGTACGACTAAACAAACACTATCTATTGCAACAAGTGG
GCAGAAAGCCACTGGCAGTCCATCACTGAAAAAAGAGCCACTAGCACCCATCTTGAGGGGAGTG
TGGTGACGTCGACCGTGATACACATGGAGAACGTGTGGAGCATGCGCACAAGTTCCCGGTTGTC
GTCATCGCTCATCCAGGTCCTCACTTTCGGCTGGCTTCCGTCTGGACTGGACCGGTAACAGACG
CTGGGCTTCGAGGTCTTTTTTTCCTAGGGCCCCGAAGCTGTTGGTGGCTTCGGCCCGGTTCTAG
TCATGGCCCACGGGGTCCCTTTTGACCACAATTACTACATTGTGGAGTGCAAGGAGGAAACAAA
TGCTGAAGCCCAGGCAGGGGCCATGGCCGCCACCTCAACCGAGGAGGCCCCAGGGGCTGTGGAG
GTGGCGCAGGCAGCAGTGGCGAGCAGCCACGACAGTGGAGGAGCCATAGGCTGTGCCACTGTCA
AGGAGAGTGAGAGCGACTCGGAGAGTGAGAGCGACTCGGAGAGTGAGAGCGACTCCTCCGACTC
CTCCGACGAGAGTGATGACGACTCGAGCACCAGCGACGAGGATACTTCAGATCCTGAGGAGGCG
GCAGCTCCCTCGGTGGCTGCGGTGGCTGCTGCTGCCGCTCCTCCAACTGTTCCTGCTGCCGCTG
CTATTCAGATTCCGGGGCCGTACCGCTACCGCCCCCCTCGCCGCCATGTTCGCCGTCGTCGCCG
TGGACCGCCATTCCACTTCGCACAGTGGCAGGTCGAGGAAATGGAAAGCCTGTTTGAAGAGACC
CAGTACCCGGATTTGCTTACAAGGGGAGAGCTTGCAAGAACTTTGAATGTGCCTGAGGTCAAAG
TGAAGGTGTGGTTTACCAATCGGAGAGCGAAGCAGAGGAAGATTGAGAGACGTGAAATGCTGAG
AAATATTCCGCCTGGTGCTGAAGACTTCATTTTCATAACCGATTTTGAAGAGCCTTCTTAATGT
GCCATATTTGGTCAGTAGACAAAGGGCAAATTGGCAACCTCTGTGCCCAATGCCAAGCTTAACT
ATTCAGCATGCATGTTAACAATAAAAGCATGAATTTCC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001171931	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAC25170	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000117271
	ENSMUSP00000117271.3
GenBank Protein	F6YCR7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001171931 ⟸ NM_001185002

- UniProtKB:

Q8C1Q7 (UniProtKB/Swiss-Prot), F6YCR7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAHGVPFDHNYYIVECKEETNAEAQAGAMAATSTEEAPGAVEVAQAAVASSHDSGGAIGCATVK
ESESDSESESDSESESDSSDSSDESDDDSSTSDEDTSDPEEAAAPSVAAVAAAAAPPTVPAAAA
IQIPGPYRYRPPRRHVRRRRRGPPFHFAQWQVEEMESLFEETQYPDLLTRGELARTLNVPEVKV
KVWFTNRRAKQRKIERREMLRNIPPGAEDFIFITDFEEPS

hide sequence

RefSeq Acc Id:

ENSMUSP00000117271 ⟸ ENSMUST00000152730

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F6YCR7-F1-model_v2	AlphaFold	F6YCR7	1-232	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1920864	AgrOrtholog
Ensembl Genes	ENSMUSG00000050197	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000152730	ENTREZGENE
	ENSMUST00000152730.4	UniProtKB/Swiss-Prot
Gene3D-CATH	Homeodomain-like	UniProtKB/Swiss-Prot
InterPro	Homeobox_CS	UniProtKB/Swiss-Prot
	Homeobox_dom	UniProtKB/Swiss-Prot
	Homeodomain-like	UniProtKB/Swiss-Prot
KEGG Report	mmu:73614	UniProtKB/Swiss-Prot
MGD	MGI:1920864	ENTREZGENE
NCBI Gene	73614	ENTREZGENE
PANTHER	HOMEOBOX PROTEIN ARISTALESS	UniProtKB/Swiss-Prot
	HOMEOBOX PROTEIN RHOX13	UniProtKB/Swiss-Prot
Pfam	Homeobox	UniProtKB/Swiss-Prot
PhenoGen	Rhox13	PhenoGen
PROSITE	HOMEOBOX_1	UniProtKB/Swiss-Prot
	HOMEOBOX_2	UniProtKB/Swiss-Prot
SMART	HOX	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF46689	UniProtKB/Swiss-Prot
UniProt	F6YCR7	ENTREZGENE
	Q8C1Q7	ENTREZGENE
	RHX13_MOUSE	UniProtKB/Swiss-Prot
UniProt Secondary	Q8C1Q7	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar

Mammalian Phenotype