Znhit3 (zinc finger, HIT type 3) - Rat Genome Database

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Gene: Znhit3 (zinc finger, HIT type 3) Mus musculus
Analyze
Symbol: Znhit3
Name: zinc finger, HIT type 3
RGD ID: 1558381
MGI Page MGI
Description: Predicted to enable metal ion binding activity. Predicted to be involved in box C/D snoRNP assembly; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and snoRNA localization. Predicted to be located in cytoplasm. Predicted to be part of pre-snoRNP complex. Predicted to be active in nucleus. Is expressed in liver; pancreas; submandibular gland primordium; thymus primordium; and vibrissa. Human ortholog(s) of this gene implicated in PEHO syndrome. Orthologous to human ZNHIT3 (zinc finger HIT-type containing 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC107312; Myohd1; myosin head domain containing 1; thyroid hormone receptor interactor 3; thyroid receptor-interacting protein 3; Tr; TR-interacting protein 3; TRIP-3; Trip3; zinc finger HIT domain-containing protein 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391184,801,776 - 84,807,192 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1184,801,776 - 84,807,192 (-)EnsemblGRCm39 Ensembl
GRCm381184,910,950 - 84,916,366 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1184,910,950 - 84,916,366 (-)EnsemblGRCm38mm10GRCm38
MGSCv371184,724,457 - 84,729,858 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361184,727,150 - 84,732,551 (-)NCBIMGSCv36mm8
Celera1194,531,165 - 94,536,566 (-)NCBICelera
Cytogenetic Map11CNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
nucleus  (IBA,ISO)
pre-snoRNP complex  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10512203   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:15840001  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:17967808   PMID:18799693   PMID:21267068   PMID:21677750   PMID:21873635   PMID:27480124  


Genomics

Comparative Map Data
Znhit3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391184,801,776 - 84,807,192 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1184,801,776 - 84,807,192 (-)EnsemblGRCm39 Ensembl
GRCm381184,910,950 - 84,916,366 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1184,910,950 - 84,916,366 (-)EnsemblGRCm38mm10GRCm38
MGSCv371184,724,457 - 84,729,858 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361184,727,150 - 84,732,551 (-)NCBIMGSCv36mm8
Celera1194,531,165 - 94,536,566 (-)NCBICelera
Cytogenetic Map11CNCBI
ZNHIT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381736,486,681 - 36,499,312 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1736,486,629 - 36,499,310 (+)EnsemblGRCh38hg38GRCh38
GRCh371734,842,525 - 34,855,156 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,916,586 - 31,925,775 (+)NCBINCBI36Build 36hg18NCBI36
Build 341731,916,618 - 31,925,775NCBI
Celera1731,664,561 - 31,673,750 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1730,779,285 - 30,791,968 (+)NCBIHuRef
CHM1_11734,878,192 - 34,890,875 (+)NCBICHM1_1
T2T-CHM13v2.01737,472,439 - 37,485,065 (+)NCBIT2T-CHM13v2.0
Znhit3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21069,775,885 - 69,790,471 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1069,748,789 - 69,790,475 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1074,402,263 - 74,410,459 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01073,907,030 - 73,915,226 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01069,371,699 - 69,379,896 (-)NCBIRnor_WKY
Rnor_6.01072,227,710 - 72,235,932 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1072,228,222 - 72,235,888 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01072,133,125 - 72,142,791 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41073,185,704 - 73,193,810 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1068,710,254 - 68,718,476 (-)NCBICelera
Cytogenetic Map10q26NCBI
Znhit3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554511,436,440 - 1,444,484 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554511,436,440 - 1,444,484 (-)NCBIChiLan1.0ChiLan1.0
ZNHIT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11720,878,333 - 20,889,078 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1720,878,333 - 20,889,078 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01720,583,614 - 20,595,332 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ZNHIT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1936,378,226 - 36,383,906 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl936,378,211 - 36,383,966 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha935,604,231 - 35,609,982 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0937,190,951 - 37,196,719 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl937,190,232 - 37,196,716 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1935,969,621 - 35,976,444 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0936,256,556 - 36,262,354 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0936,344,813 - 36,350,592 (+)NCBIUU_Cfam_GSD_1.0
Znhit3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560235,358,708 - 35,367,854 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364901,707,660 - 1,716,361 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364901,707,309 - 1,716,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNHIT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1238,013,963 - 38,022,927 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11238,013,931 - 38,027,928 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21239,575,940 - 39,590,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZNHIT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11631,313,087 - 31,322,303 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660772,054,594 - 2,064,124 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znhit3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248713,576,939 - 3,585,018 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248713,573,030 - 3,585,012 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:622
Count of miRNA genes:344
Interacting mature miRNAs:373
Transcripts:ENSMUST00000103195, ENSMUST00000127838, ENSMUST00000136656, ENSMUST00000144552, ENSMUST00000156046
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000103195   ⟹   ENSMUSP00000099484
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1184,801,776 - 84,807,192 (-)Ensembl
GRCm38.p6 Ensembl1184,910,950 - 84,916,366 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127838
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1184,802,331 - 84,807,131 (-)Ensembl
GRCm38.p6 Ensembl1184,911,505 - 84,916,305 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136656
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1184,802,295 - 84,807,192 (-)Ensembl
GRCm38.p6 Ensembl1184,911,469 - 84,916,366 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144552
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1184,802,117 - 84,807,175 (-)Ensembl
GRCm38.p6 Ensembl1184,911,291 - 84,916,349 (-)Ensembl
RefSeq Acc Id: ENSMUST00000156046
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1184,806,265 - 84,807,150 (-)Ensembl
GRCm38.p6 Ensembl1184,915,439 - 84,916,324 (-)Ensembl
RefSeq Acc Id: NM_001005223   ⟹   NP_001005223
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391184,801,776 - 84,807,192 (-)NCBI
GRCm381184,910,950 - 84,916,366 (-)NCBI
MGSCv371184,724,457 - 84,729,858 (-)RGD
Celera1194,531,165 - 94,536,566 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001359182   ⟹   NP_001346111
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391184,801,776 - 84,807,192 (-)NCBI
GRCm381184,910,950 - 84,916,366 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001005223   ⟸   NM_001005223
- Peptide Label: isoform 1
- UniProtKB: Q9CQK1 (UniProtKB/Swiss-Prot),   A0A8C6GXM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001346111   ⟸   NM_001359182
- Peptide Label: isoform 2
- UniProtKB: Q5FW88 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000099484   ⟸   ENSMUST00000103195

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CQK1-F1-model_v2 AlphaFold Q9CQK1 1-151 view protein structure

Promoters
RGD ID:6822515
Promoter ID:MM_KWN:8965
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:OTTMUST00000002021,   OTTMUST00000002022,   OTTMUST00000002024,   OTTMUST00000002025,   UC007KRF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361184,729,629 - 84,730,129 (-)MPROMDB
RGD ID:8675974
Promoter ID:EPDNEW_M16018
Type:multiple initiation site
Name:Znhit3_1
Description:Mus musculus zinc finger, HIT type 3 , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381184,916,347 - 84,916,407EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3051596 AgrOrtholog
Ensembl Genes ENSMUSG00000020526 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000099484 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000103195 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Znf_HIT UniProtKB/Swiss-Prot
  ZNHIT3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:448850 UniProtKB/Swiss-Prot
MGD MGI:3051596 ENTREZGENE
NCBI Gene 448850 ENTREZGENE
PANTHER PTHR13483:SF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-HIT UniProtKB/Swiss-Prot
PhenoGen Znhit3 PhenoGen
PROSITE ZF_HIT UniProtKB/Swiss-Prot
UniProt A0A8C6GXM5 ENTREZGENE
  Q5FW88 ENTREZGENE, UniProtKB/TrEMBL
  Q9CQK1 ENTREZGENE, UniProtKB/Swiss-Prot