Ppp1r3a (protein phosphatase 1, regulatory subunit 3A) - Rat Genome Database

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Gene: Ppp1r3a (protein phosphatase 1, regulatory subunit 3A) Mus musculus
Analyze
Symbol: Ppp1r3a
Name: protein phosphatase 1, regulatory subunit 3A
RGD ID: 1558275
MGI Page MGI
Description: Predicted to enable glycogen binding activity; protein phosphatase 1 binding activity; and protein serine/threonine phosphatase activity. Predicted to be involved in regulation of glycogen biosynthetic process. Predicted to act upstream of or within glycogen metabolic process. Predicted to be located in membrane. Predicted to be part of protein phosphatase type 1 complex. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to human PPP1R3A (protein phosphatase 1 regulatory subunit 3A).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GM; MGC124391; MGC124392; protein phosphatase 1 glycogen-associated regulatory subunit; protein phosphatase 1 regulatory subunit 3A; protein phosphatase type-1 glycogen targeting subunit; R; RG1; RGL
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39614,713,821 - 14,755,273 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl614,713,976 - 14,755,273 (-)EnsemblGRCm39 Ensembl
GRCm38614,713,822 - 14,755,274 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl614,713,977 - 14,755,274 (-)EnsemblGRCm38mm10GRCm38
MGSCv37614,663,822 - 14,705,274 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36614,663,582 - 14,705,246 (-)NCBIMGSCv36mm8
Celera614,805,199 - 14,846,652 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map66.31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Ceulemans H and Bollen M, Physiol Rev. 2004 Jan;84(1):1-39.
2. Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus. Doney AS, etal., BMC Genet. 2003 Jun 28;4:11.
3. Polymorphism in the glycogen-associated regulatory subunit of type 1 protein phosphatase (PPP1R3) gene and insulin sensitivity. Hansen L, etal., Diabetes. 2000 Feb;49(2):298-301.
4. A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin. Hansen L, etal., Hum Mol Genet. 1995 Aug;4(8):1313-20.
5. Variation in the AU(AT)-rich element within the 3'-untranslated region of PPP1R3 is associated with variation in plasma glucose in aboriginal Canadians. Hegele RA, etal., J Clin Endocrinol Metab. 1998 Nov;83(11):3980-3.
6. The 3'-untranslated region polymorphism of the gene for skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in the type 2 diabetic Japanese population. Maegawa H, etal., Diabetes. 1999 Jul;48(7):1469-72.
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. MGD IEA MGD IEA
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Digenic inheritance of severe insulin resistance in a human pedigree. Savage DB, etal., Nat Genet. 2002 Aug;31(4):379-84. Epub 2002 Jul 15.
17. Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM. Shen GQ, etal., Diabetes Care. 1998 Jul;21(7):1086-9.
18. The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus. Wang G, etal., Chin Med J (Engl). 2001 Dec;114(12):1258-62.
19. A common variant in PPP1R3 associated with insulin resistance and type 2 diabetes. Xia J, etal., Diabetes. 1998 Sep;47(9):1519-24.
Additional References at PubMed
PMID:1651919   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11283248   PMID:11361130   PMID:11522787   PMID:12477932   PMID:12606498   PMID:16141072   PMID:16141073  
PMID:16919269   PMID:17022935   PMID:17257813   PMID:18232732   PMID:18234908   PMID:18325784   PMID:21677750   PMID:21873635   PMID:29786422   PMID:31185731   PMID:31235787   PMID:31286141  
PMID:32325033   PMID:37102430  


Genomics

Comparative Map Data
Ppp1r3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39614,713,821 - 14,755,273 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl614,713,976 - 14,755,273 (-)EnsemblGRCm39 Ensembl
GRCm38614,713,822 - 14,755,274 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl614,713,977 - 14,755,274 (-)EnsemblGRCm38mm10GRCm38
MGSCv37614,663,822 - 14,705,274 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36614,663,582 - 14,705,246 (-)NCBIMGSCv36mm8
Celera614,805,199 - 14,846,652 (-)NCBICelera
Cytogenetic Map6A1NCBI
cM Map66.31NCBI
PPP1R3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387113,876,777 - 113,919,009 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7113,876,777 - 114,075,920 (-)EnsemblGRCh38hg38GRCh38
GRCh377113,516,832 - 113,559,064 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367113,301,622 - 113,346,300 (-)NCBINCBI36Build 36hg18NCBI36
Build 347113,108,336 - 113,153,015NCBI
Celera7108,323,366 - 108,365,567 (-)NCBICelera
Cytogenetic Map7q31.1NCBI
HuRef7107,880,214 - 107,922,483 (-)NCBIHuRef
CHM1_17113,450,259 - 113,492,463 (-)NCBICHM1_1
T2T-CHM13v2.07115,191,582 - 115,233,899 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27112,912,237 - 112,954,446 (-)NCBI
Ppp1r3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8443,905,648 - 43,946,236 (-)NCBIGRCr8
mRatBN7.2442,937,353 - 42,980,195 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl442,939,599 - 42,980,638 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx447,935,810 - 47,976,403 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0443,856,823 - 43,897,416 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0442,265,462 - 42,306,053 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0441,171,486 - 41,212,116 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl441,171,486 - 41,212,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0440,763,443 - 40,804,029 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4440,195,325 - 40,235,913 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera438,272,622 - 38,313,215 (-)NCBICelera
Cytogenetic Map4q22NCBI
Ppp1r3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543219,858,423 - 19,893,175 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543219,854,649 - 19,893,148 (-)NCBIChiLan1.0ChiLan1.0
PPP1R3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26150,689,220 - 150,887,917 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan172,699,476 - 2,898,173 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07105,831,567 - 105,873,793 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17118,529,362 - 118,571,591 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7118,529,362 - 118,571,770 (-)Ensemblpanpan1.1panPan2
PPP1R3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11453,169,836 - 53,216,817 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1453,170,954 - 53,217,169 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1452,629,027 - 52,654,678 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01453,207,268 - 53,254,477 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1453,207,282 - 53,254,421 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11453,239,468 - 53,286,626 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01452,925,489 - 52,972,439 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01453,298,675 - 53,345,641 (-)NCBIUU_Cfam_GSD_1.0
Ppp1r3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511841,864,856 - 41,900,319 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365894,789,570 - 4,826,752 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365894,789,547 - 4,827,727 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1831,997,713 - 32,039,852 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11831,997,667 - 32,039,949 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21834,430,740 - 34,471,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12182,596,714 - 82,635,779 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2182,595,511 - 82,635,309 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604221,132,063 - 21,169,665 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248275,543,420 - 5,581,847 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248275,543,497 - 5,581,779 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1r3a
1343 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1071
Count of miRNA genes:511
Interacting mature miRNAs:664
Transcripts:ENSMUST00000045096
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14746985Manh59_mmandible shape 59 (mouse)6120847193Mouse
1301178Lith10_mlithogenic gene 10 (mouse)Not determined6121465015Mouse
10043884Bhr8_mbronchial hyperresponsiveness 8 (mouse)Not determined6121465015Mouse
10044000Mobq9_mmultigenetic obesity QTL 9 (mouse)Not determined6121465015Mouse
1357503Nhdlq5_mnon-HDL QTL 5 (mouse)Not determined6121465015Mouse
12904934Edlmmq4_mextensor digitorum longus muscle mass QTL 4 (mouse)6125514064Mouse
12904942Tammq3_mtibialis anterior muscle mass QTL 3 (mouse)6125514064Mouse
12904955Gmmq3_mgastrocnemius muscle mass QTL 3 (mouse)6125514064Mouse
1301131Chol2_mcholesterol 2 (mouse)Not determined6132144495Mouse
5491191Mobq2_mmultigenic obesity QTL 2 (mouse)Not determined6132144495Mouse
1302024Skull7_mskull morphology 7 (mouse)Not determined6132144495Mouse
15039372Nmrs22_mNAFLD-associated magnetic resonance shift 22 (mouse)6147633435476334Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1300731Smdq3_msegregation of mitochondrial DNA QTL 3 (mouse)Not determined6424920638249325Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
11353836Bmiq1_mbody mass index QTL 1 (mouse)6450382329751333Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000045096   ⟹   ENSMUSP00000049054
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl614,713,976 - 14,755,273 (-)Ensembl
GRCm38.p6 Ensembl614,713,977 - 14,755,274 (-)Ensembl
RefSeq Acc Id: NM_080464   ⟹   NP_536712
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39614,713,821 - 14,755,273 (-)NCBI
GRCm38614,713,822 - 14,755,274 (-)ENTREZGENE
MGSCv37614,663,822 - 14,705,274 (-)RGD
Celera614,805,199 - 14,846,652 (-)RGD
cM Map6 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_536712 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI09008 (Get FASTA)   NCBI Sequence Viewer  
  AAK31072 (Get FASTA)   NCBI Sequence Viewer  
  BAC39208 (Get FASTA)   NCBI Sequence Viewer  
  BAC39262 (Get FASTA)   NCBI Sequence Viewer  
  EDL13902 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000049054
  ENSMUSP00000049054.5
GenBank Protein Q99MR9 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_536712   ⟸   NM_080464
- UniProtKB: Q8BUJ4 (UniProtKB/Swiss-Prot),   Q32MS0 (UniProtKB/Swiss-Prot),   Q8BUL0 (UniProtKB/Swiss-Prot),   Q99MR9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000049054   ⟸   ENSMUST00000045096
Protein Domains
CBM21

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MR9-F1-model_v2 AlphaFold Q99MR9 1-1089 view protein structure

Promoters
RGD ID:6889036
Promoter ID:EPDNEW_M7969
Type:initiation region
Name:Ppp1r3a_1
Description:Mus musculus protein phosphatase 1, regulatory subunit 3A , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38614,755,274 - 14,755,334EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2153588 AgrOrtholog
Ensembl Genes ENSMUSG00000042717 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000045096 ENTREZGENE
  ENSMUST00000045096.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.2440 UniProtKB/Swiss-Prot
InterPro CBM21_dom UniProtKB/Swiss-Prot
  CBM21_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:140491 UniProtKB/Swiss-Prot
MGD MGI:2153588 ENTREZGENE
NCBI Gene 140491 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT UniProtKB/Swiss-Prot
  PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 3A UniProtKB/Swiss-Prot
Pfam CBM_21 UniProtKB/Swiss-Prot
PhenoGen Ppp1r3a PhenoGen
PROSITE CBM21 UniProtKB/Swiss-Prot
UniProt PPR3A_MOUSE UniProtKB/Swiss-Prot
  Q32MS0 ENTREZGENE
  Q8BUJ4 ENTREZGENE
  Q8BUL0 ENTREZGENE
  Q99MR9 ENTREZGENE
UniProt Secondary Q32MS0 UniProtKB/Swiss-Prot
  Q8BUJ4 UniProtKB/Swiss-Prot
  Q8BUL0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-29 Ppp1r3a  protein phosphatase 1, regulatory subunit 3A    protein phosphatase 1, regulatory (inhibitor) subunit 3A  Symbol and/or name change 5135510 APPROVED