Sh2d6 (SH2 domain containing 6) - Rat Genome Database
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Gene: Sh2d6 (SH2 domain containing 6) Mus musculus
Analyze
Symbol: Sh2d6
Name: SH2 domain containing 6
RGD ID: 1558250
MGI Page MGI
Description: Orthologous to human SH2D6 (SH2 domain containing 6); INTERACTS WITH N-nitrosodiethylamine; silver atom; silver(0).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4933424C13Rik; MGC118386; SH2 domain-containing protein 6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,490,624 - 72,511,180 (-)NCBIGRCm39mm39
GRCm39 Ensembl672,490,624 - 72,498,690 (-)Ensembl
GRCm38672,513,641 - 72,534,206 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,513,641 - 72,521,707 (-)EnsemblGRCm38mm10GRCm38
MGSCv37672,463,646 - 72,470,644 (-)NCBIGRCm37mm9NCBIm37
MGSCv36672,443,161 - 72,450,159 (-)NCBImm8
Celera674,611,554 - 74,618,596 (-)NCBICelera
Cytogenetic Map6C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16141072   PMID:16141073   PMID:18799693   PMID:21873635   PMID:23375831  


Genomics

Comparative Map Data
Sh2d6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,490,624 - 72,511,180 (-)NCBIGRCm39mm39
GRCm39 Ensembl672,490,624 - 72,498,690 (-)Ensembl
GRCm38672,513,641 - 72,534,206 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,513,641 - 72,521,707 (-)EnsemblGRCm38mm10GRCm38
MGSCv37672,463,646 - 72,470,644 (-)NCBIGRCm37mm9NCBIm37
MGSCv36672,443,161 - 72,450,159 (-)NCBImm8
Celera674,611,554 - 74,618,596 (-)NCBICelera
Cytogenetic Map6C1NCBI
SH2D6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl285,418,931 - 85,437,029 (+)EnsemblGRCh38hg38GRCh38
GRCh38285,418,931 - 85,437,029 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37285,646,054 - 85,664,152 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,515,429 - 85,517,663 (+)NCBINCBI36hg18NCBI36
Celera285,490,191 - 85,492,425 (+)NCBI
Cytogenetic Map2p11.2NCBI
HuRef285,558,713 - 85,560,947 (+)NCBIHuRef
CHM1_1285,575,805 - 85,593,903 (+)NCBICHM1_1
Sh2d6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24104,566,210 - 104,574,176 (-)NCBI
Rnor_6.04100,373,808 - 100,382,209 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04165,144,159 - 165,152,087 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44105,816,758 - 105,824,421 (-)NCBIRGSC3.4rn4RGSC3.4
Celera493,718,196 - 93,726,597 (-)NCBICelera
Cytogenetic Map4q31NCBI
Sh2d6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554242,039,973 - 2,045,353 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554242,040,012 - 2,047,142 (-)NCBIChiLan1.0ChiLan1.0
SH2D6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A87,021,922 - 87,039,657 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02A85,482,199 - 85,489,284 (+)NCBIMhudiblu_PPA_v0panPan3
SH2D6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1739,603,322 - 39,604,862 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11739,599,865 - 39,611,189 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Sh2d6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367121,770,565 - 1,778,584 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH2D6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1359,319,980 - 59,327,058 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2362,397,827 - 62,405,075 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SH2D6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,719,462 - 21,734,456 (-)NCBI
Sh2d6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474917,707,508 - 17,729,432 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
12910802Pwbwq12_mpost-weaning body weight QTL 12 (mouse)64382681377811523Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
12910785Pwgrq16_mpost-weaning growth rate QTL 16 (mouse)64382681377811523Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62500000080000000Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
12910807Pwbwq11_mpost-weaning body weight QTL 11 (mouse)64382681377811523Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse
12910820Ogrq3_moverall growth rate QTL 3 (mouse)64382681377811523Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414873387692Mouse
4140983Srilp_msleep response to influenza, light phase (mouse)Not determined4872655675447710Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3285065078238974Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64211637376116515Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64211637376116515Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64160000075600000Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64211637376116515Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64211637376116515Mouse
12910798Pwgrq5_mpre-weaning growth rate QTL 5 (mouse)64382681377811523Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
12910809Pwbwq10_mpost-weaning body weight QTL 10 (mouse)64382681377811523Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1556
Count of miRNA genes:585
Interacting mature miRNAs:696
Transcripts:ENSMUST00000089687, ENSMUST00000159577, ENSMUST00000159877, ENSMUST00000160123, ENSMUST00000160761, ENSMUST00000162561, ENSMUST00000163451
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000089687   ⟹   ENSMUSP00000087117
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl672,513,654 - 72,520,538 (-)Ensembl
RefSeq Acc Id: ENSMUST00000159577   ⟹   ENSMUSP00000157033
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl672,513,656 - 72,520,015 (-)Ensembl
RefSeq Acc Id: ENSMUST00000159877   ⟹   ENSMUSP00000123776
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl672,513,652 - 72,520,650 (-)Ensembl
RefSeq Acc Id: ENSMUST00000160123   ⟹   ENSMUSP00000157091
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl672,513,644 - 72,520,036 (-)Ensembl
RefSeq Acc Id: ENSMUST00000160761   ⟹   ENSMUSP00000157201
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl672,513,652 - 72,521,689 (-)Ensembl
RefSeq Acc Id: ENSMUST00000162561   ⟹   ENSMUSP00000124673
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl672,513,641 - 72,520,627 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234038   ⟹   ENSMUSP00000157110
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl672,513,645 - 72,520,036 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234220   ⟹   ENSMUSP00000157185
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl672,513,652 - 72,520,617 (-)Ensembl
RefSeq Acc Id: ENSMUST00000234615   ⟹   ENSMUSP00000157379
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl672,513,652 - 72,521,707 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235004   ⟹   ENSMUSP00000157366
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl672,513,649 - 72,520,036 (-)Ensembl
RefSeq Acc Id: NM_001374030   ⟹   NP_001360959
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,490,624 - 72,497,019 (-)NCBI
GRCm38672,513,641 - 72,520,036 (-)NCBI
RefSeq Acc Id: XM_006506834   ⟹   XP_006506897
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,490,624 - 72,497,008 (-)NCBI
GRCm38672,513,641 - 72,520,027 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241544   ⟹   XP_011239846
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,490,624 - 72,509,576 (-)NCBI
GRCm38672,513,641 - 72,533,165 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241546   ⟹   XP_011239848
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,490,624 - 72,499,475 (-)NCBI
GRCm38672,513,641 - 72,522,484 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241547   ⟹   XP_011239849
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,490,624 - 72,511,180 (-)NCBI
GRCm38672,513,641 - 72,534,206 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241549   ⟹   XP_011239851
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,492,209 - 72,510,150 (-)NCBI
GRCm38672,515,306 - 72,533,178 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036152305   ⟹   XP_036008198
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,492,525 - 72,510,149 (-)NCBI
RefSeq Acc Id: XM_355785   ⟹   XP_355785
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,490,624 - 72,498,701 (-)NCBI
GRCm38672,513,641 - 72,521,722 (-)NCBI
MGSCv37672,463,646 - 72,470,644 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_004933622
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,494,090 - 72,499,272 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_355785   ⟸   XM_355785
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006506897   ⟸   XM_006506834
- Peptide Label: isoform X5
- UniProtKB: E0CYY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011239849   ⟸   XM_011241547
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011239846   ⟸   XM_011241544
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011239848   ⟸   XM_011241546
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011239851   ⟸   XM_011241549
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: NP_001360959   ⟸   NM_001374030
RefSeq Acc Id: ENSMUSP00000123776   ⟸   ENSMUST00000159877
RefSeq Acc Id: ENSMUSP00000157033   ⟸   ENSMUST00000159577
RefSeq Acc Id: ENSMUSP00000157091   ⟸   ENSMUST00000160123
RefSeq Acc Id: ENSMUSP00000157201   ⟸   ENSMUST00000160761
RefSeq Acc Id: ENSMUSP00000087117   ⟸   ENSMUST00000089687
RefSeq Acc Id: ENSMUSP00000124673   ⟸   ENSMUST00000162561
RefSeq Acc Id: ENSMUSP00000157366   ⟸   ENSMUST00000235004
RefSeq Acc Id: ENSMUSP00000157379   ⟸   ENSMUST00000234615
RefSeq Acc Id: ENSMUSP00000157185   ⟸   ENSMUST00000234220
RefSeq Acc Id: ENSMUSP00000157110   ⟸   ENSMUST00000234038
RefSeq Acc Id: XP_036008198   ⟸   XM_036152305
- Peptide Label: isoform X4
Protein Domains
SH2

Promoters
RGD ID:6890022
Promoter ID:EPDNEW_M8462
Type:initiation region
Name:Sh2d6_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38672,520,637 - 72,520,697EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1918380 AgrOrtholog
Ensembl Genes ENSMUSG00000052631 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000087117 UniProtKB/TrEMBL
  ENSMUSP00000123776 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000124673 UniProtKB/TrEMBL
  ENSMUSP00000157033 UniProtKB/TrEMBL
  ENSMUSP00000157091 UniProtKB/TrEMBL
  ENSMUSP00000157110 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000157185 UniProtKB/TrEMBL
  ENSMUSP00000157201 UniProtKB/TrEMBL
  ENSMUSP00000157366 UniProtKB/TrEMBL
  ENSMUSP00000157379 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000089687 UniProtKB/TrEMBL
  ENSMUST00000159577 UniProtKB/TrEMBL
  ENSMUST00000159877 UniProtKB/TrEMBL
  ENSMUST00000160123 UniProtKB/TrEMBL
  ENSMUST00000160761 UniProtKB/TrEMBL
  ENSMUST00000162561 UniProtKB/TrEMBL
  ENSMUST00000234038 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000234220 UniProtKB/TrEMBL
  ENSMUST00000234615 UniProtKB/TrEMBL
  ENSMUST00000235004 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1918380 ENTREZGENE
NCBI Gene 71130 ENTREZGENE
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sh2d6 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A3Q4EBW9_MOUSE UniProtKB/TrEMBL
  A0A3Q4ECA8_MOUSE UniProtKB/TrEMBL
  A0A3Q4EG63_MOUSE UniProtKB/TrEMBL
  A0A3Q4EGG3_MOUSE UniProtKB/TrEMBL
  A0A3Q4EGW3_MOUSE UniProtKB/TrEMBL
  E0CYY5 ENTREZGENE, UniProtKB/TrEMBL
  E9QJU1_MOUSE UniProtKB/TrEMBL
  Q9D413 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary E2QRQ0 UniProtKB/TrEMBL
  Q497J3 UniProtKB/Swiss-Prot