Mef2b (myocyte enhancer factor 2B) - Rat Genome Database
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Gene: Mef2b (myocyte enhancer factor 2B) Mus musculus
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Symbol: Mef2b
Name: myocyte enhancer factor 2B
RGD ID: 1558238
MGI Page MGI
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone deacetylase binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to localize to several cellular components, including cytosol; nucleoplasm; and transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; heart; musculature; and urinary system. Orthologous to human MEF2B (myocyte enhancer factor 2B); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI451606; expressed sequence AI451606; myocyte-specific enhancer factor 2B
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,605,411 - 70,620,138 (+)NCBIGRCm39mm39
GRCm38870,152,761 - 70,167,488 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,139,711 - 70,167,488 (+)EnsemblGRCm38mm10GRCm38
MGSCv37872,676,677 - 72,691,387 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,068,698 - 73,096,477 (+)NCBImm8
Celera872,708,243 - 72,722,925 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Additional References at PubMed
PMID:7589800   PMID:7643214   PMID:7646512   PMID:8668199   PMID:8674419   PMID:8889548   PMID:8993831   PMID:9013788   PMID:9162005   PMID:9443808   PMID:10207130   PMID:10349636  
PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11585834   PMID:12130539   PMID:12466851   PMID:12477932   PMID:12694204   PMID:14610273   PMID:15363409   PMID:15728583  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:16680724   PMID:17158926   PMID:17336904   PMID:18287559   PMID:20059953   PMID:20111592   PMID:21267068   PMID:21531906   PMID:21752992  
PMID:21768366   PMID:21873635   PMID:22764880   PMID:25416778   PMID:25757744   PMID:30205047  


Genomics

Comparative Map Data
Mef2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,605,411 - 70,620,138 (+)NCBIGRCm39mm39
GRCm38870,152,761 - 70,167,488 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,139,711 - 70,167,488 (+)EnsemblGRCm38mm10GRCm38
MGSCv37872,676,677 - 72,691,387 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,068,698 - 73,096,477 (+)NCBImm8
Celera872,708,243 - 72,722,925 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
MEF2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1919,145,567 - 19,192,131 (-)EnsemblGRCh38hg38GRCh38
GRCh381919,145,567 - 19,170,263 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371919,256,376 - 19,281,098 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361919,256,376 - 19,281,098 (-)NCBINCBI36hg18NCBI36
Build 341919,117,377 - 19,163,933NCBI
Celera1919,161,210 - 19,185,929 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1918,820,880 - 18,844,909 (-)NCBIHuRef
CHM1_11919,256,090 - 19,281,608 (-)NCBICHM1_1
Mef2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01621,001,204 - 21,017,651 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1621,001,206 - 21,017,163 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,851,148 - 20,867,386 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,736,015 - 19,752,301 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1619,441,650 - 19,457,610 (-)NCBICelera
Cytogenetic Map16p14NCBI
Mef2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555242,661,278 - 2,664,084 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555242,649,413 - 2,664,173 (+)NCBIChiLan1.0ChiLan1.0
LOC100992080
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11919,585,920 - 19,610,256 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1919,585,920 - 19,610,256 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01918,583,770 - 18,609,757 (-)NCBIMhudiblu_PPA_v0panPan3
MEF2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2043,991,438 - 44,017,368 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12044,000,253 - 44,017,371 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC101954468
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365962,261,726 - 2,265,893 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEF2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl258,684,555 - 58,722,741 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1258,699,173 - 58,722,554 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Position Markers
Mef2b  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C1UniSTS
cM Map833.5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1006
Count of miRNA genes:282
Interacting mature miRNAs:317
Transcripts:ENSMUST00000110140, ENSMUST00000110141, ENSMUST00000110143, ENSMUST00000110146
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000110140   ⟹   ENSMUSP00000105767
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,152,781 - 70,167,487 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110141   ⟹   ENSMUSP00000105768
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,152,781 - 70,167,487 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110143   ⟹   ENSMUSP00000105770
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,152,778 - 70,167,488 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110146   ⟹   ENSMUSP00000105773
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,152,778 - 70,167,488 (+)Ensembl
RefSeq Acc Id: ENSMUST00000163756   ⟹   ENSMUSP00000132314
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,139,711 - 70,167,488 (+)Ensembl
RefSeq Acc Id: NM_001045484   ⟹   NP_001038949
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,605,411 - 70,620,138 (+)NCBI
GRCm38870,152,761 - 70,167,488 (+)NCBI
MGSCv37872,676,677 - 72,691,387 (+)RGD
Celera872,708,243 - 72,722,925 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001038949   ⟸   NM_001045484
- UniProtKB: Q80VR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000132314   ⟸   ENSMUST00000163756
RefSeq Acc Id: ENSMUSP00000105770   ⟸   ENSMUST00000110143
RefSeq Acc Id: ENSMUSP00000105767   ⟸   ENSMUST00000110140
RefSeq Acc Id: ENSMUSP00000105768   ⟸   ENSMUST00000110141
RefSeq Acc Id: ENSMUSP00000105773   ⟸   ENSMUST00000110146
Protein Domains
MADS-box

Promoters
RGD ID:8667281
Promoter ID:EPDNEW_M11672
Type:single initiation site
Name:Mef2b_1
Description:Mus musculus myocyte enhancer factor 2B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38870,152,761 - 70,152,821EPDNEW
RGD ID:6843466
Promoter ID:MM_KWN:54664
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Spleen
Transcripts:ENSMUST00000072500,   OTTMUST00000052771,   OTTMUST00000071536,   UC009LYX.1,   UC009LYY.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36872,662,781 - 72,663,662 (+)MPROMDB
RGD ID:6843457
Promoter ID:MM_KWN:54666
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:ENSMUST00000110140,   NM_001045484,   NM_008578,   OTTMUST00000052776
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36872,676,471 - 72,676,971 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:104526 AgrOrtholog
Ensembl Genes ENSMUSG00000079033 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000105767 UniProtKB/TrEMBL
  ENSMUSP00000105768 UniProtKB/TrEMBL
  ENSMUSP00000105770 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000110140 UniProtKB/TrEMBL
  ENSMUST00000110141 UniProtKB/TrEMBL
  ENSMUST00000110143 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.40.1810.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MADS_MEF2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_MADSbox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_MADSbox_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17259 UniProtKB/TrEMBL
MGD MGI:104526 ENTREZGENE
NCBI Gene 17259 ENTREZGENE
Pfam SRF-TF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mef2b PhenoGen
PRINTS MADSDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MADS_BOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MADS_BOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MADS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55455 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.432505 ENTREZGENE
UniProt D3Z372_MOUSE UniProtKB/TrEMBL
  E9Q2M6_MOUSE UniProtKB/TrEMBL
  MEF2B_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q80VR4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary E9Q1I9 UniProtKB/TrEMBL
  G5E8P6 UniProtKB/TrEMBL
  O55088 UniProtKB/Swiss-Prot
  O55089 UniProtKB/Swiss-Prot
  O55090 UniProtKB/Swiss-Prot
  O55231 UniProtKB/Swiss-Prot
  Q61843 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Mef2b  myocyte enhancer factor 2B  AI451606  expressed sequence AI451606  Data Merged 737654 PROVISIONAL