Swi5 (SWI5 recombination repair homolog (yeast)) - Rat Genome Database
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Gene: Swi5 (SWI5 recombination repair homolog (yeast)) Mus musculus
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Symbol: Swi5
Name: SWI5 recombination repair homolog (yeast)
RGD ID: 1558235
Description: Involved in double-strand break repair via homologous recombination. Localizes to Swi5-Sfr1 complex. Is expressed in pancreas epithelium. Orthologous to human SWI5 (SWI5 homologous recombination repair protein); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; tetrachloromethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1500019F05Rik; 2900010J23Rik; AI046671; DNA repair protein Swi5; DNA repair protein SWI5 homolog; hypothetical protein LOC72931; protein SAE3 homolog; RP23-161B9.6
Orthologs:
Homo sapiens (human) : SWI5 (SWI5 homologous recombination repair protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Swi5 (SWI5 homologous recombination repair protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Swi5 (SWI5 homologous recombination repair protein)
Pan paniscus (bonobo/pygmy chimpanzee) : SWI5 (SWI5 homologous recombination repair protein)
Canis lupus familiaris (dog) : SWI5 (SWI5 homologous recombination repair protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Swi5 (SWI5 homologous recombination repair protein)
Sus scrofa (pig) : SWI5 (SWI5 homologous recombination repair protein)
Chlorocebus sabaeus (African green monkey) : SWI5 (SWI5 homologous recombination repair protein)
Heterocephalus glaber (naked mole-rat) : Swi5 (SWI5 homologous recombination repair protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,168,817 - 32,178,154 (-)NCBI
GRCm38232,278,805 - 32,288,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,278,816 - 32,288,075 (-)EnsemblGRCm38mm10GRCm38
MGSCv37232,134,336 - 32,143,588 (-)NCBIGRCm37mm9NCBIm37
MGSCv36232,100,826 - 32,110,022 (-)NCBImm8
Celera231,983,292 - 31,992,544 (-)NCBICelera
Cytogenetic Map2BNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IDA)
Swi5-Sfr1 complex  (IBA,IDA,ISO)

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18554416  
PMID:18799693   PMID:20976249   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22492707   PMID:27131790   PMID:30297419  


Genomics

Comparative Map Data
Swi5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,168,817 - 32,178,154 (-)NCBI
GRCm38232,278,805 - 32,288,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,278,816 - 32,288,075 (-)EnsemblGRCm38mm10GRCm38
MGSCv37232,134,336 - 32,143,588 (-)NCBIGRCm37mm9NCBIm37
MGSCv36232,100,826 - 32,110,022 (-)NCBImm8
Celera231,983,292 - 31,992,544 (-)NCBICelera
Cytogenetic Map2BNCBI
SWI5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9128,275,379 - 128,316,123 (+)EnsemblGRCh38hg38GRCh38
GRCh389128,275,356 - 128,288,989 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379131,037,663 - 131,051,268 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,078,246 - 130,091,089 (+)NCBINCBI36hg18NCBI36
Build 349128,118,054 - 128,130,821NCBI
Celera9101,689,329 - 101,702,173 (+)NCBI
Cytogenetic Map9q34.11NCBI
HuRef9100,651,879 - 100,664,564 (+)NCBIHuRef
CHM1_19131,188,681 - 131,202,290 (+)NCBICHM1_1
Swi5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0311,307,981 - 11,317,049 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,307,981 - 11,317,049 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0316,656,849 - 16,665,919 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4311,402,738 - 11,411,870 (-)NCBIRGSC3.4rn4RGSC3.4
Celera310,319,249 - 10,328,317 (-)NCBICelera
Cytogenetic Map3p12NCBI
Swi5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955570799,332 - 808,368 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955570799,332 - 808,368 (+)NCBIChiLan1.0ChiLan1.0
SWI5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19128,065,237 - 128,078,380 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9128,064,569 - 128,078,380 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0999,396,439 - 99,410,054 (+)NCBIMhudiblu_PPA_v0panPan3
SWI5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl955,229,550 - 55,234,489 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1955,229,510 - 55,234,645 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Swi5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648715,814,463 - 15,822,783 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SWI5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,719,554 - 268,726,527 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,720,232 - 268,726,527 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,710,680 - 302,716,860 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SWI5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,840,286 - 9,852,397 (-)NCBI
Swi5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247606,581,471 - 6,588,294 (-)NCBI

Position Markers
AI046671  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38232,278,941 - 32,279,050UniSTSGRCm38
MGSCv37232,134,461 - 32,134,570UniSTSGRCm37
Celera239,284,992 - 39,285,098UniSTS
Celera231,983,417 - 31,983,526UniSTS
Cytogenetic Map2BUniSTS
Whitehead/MRC_RH2538.12UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388608993591306Mouse
1301980Fcsa5_mfemoral cross-sectional area 5 (mouse)Not determined2778910341789249Mouse
1301790Pcfm1_mperiosteal circumference and femur length 1 (mouse)Not determined2834628442346384Mouse
10043876Adip22_madiposity 22 (mouse)Not determined2841803942418228Mouse
1300624Insq7_minsulin QTL 7 (mouse)Not determined2949443443494563Mouse
10755513Amzn4_manatomical modifier of Zfp423 4 (mouse)2949443443494563Mouse
8552707Cia23_mcollagen induced arthritis QTL 23 (mouse)Not determined21212472666726109Mouse
1301641Sbmd2_mspinal bone mineral density 2 (mouse)Not determined21432455548324701Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357829Lvrq1_mliver weight QTL 1 (mouse)Not determined220892967119064359Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220892967119064359Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220892967119064359Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220892967119064359Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220892967119064359Mouse
4141708Pbwg1.2_mpostnatal body weight growth 1.2 (mouse)Not determined2123971355239859Mouse
1301376Etohc1_methanol consumption 1 (mouse)Not determined22123971355239859Mouse
13463470Tubisq1_mtubulointerstitial injury severity, QTL 1 (mouse)22379913357799257Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
26884438Sklq12_mskull length QTL 12, 16 week (mouse)22470000055000000Mouse
8552705Cia25_mcollagen induced arthritis 25 (mouse)Not determined22478910333633160Mouse
8552706Cia24_mcollagen induced arthritis QTL 24 (mouse)Not determined22478910333633160Mouse
4142130Pgis2_mproteoglycan induced spondylitis 2 (mouse)Not determined22541803957081799Mouse
12904005Cfq2_mconditioned fear QTL 2 (mouse)22713263056506216Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22771204884183040Mouse
14746979Manh51_mmandible shape 51 (mouse)22907111763071117Mouse
14746997Mancz2_mmandible centroid size 2 (mouse)22907111763071117Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
12904008Cfq6_mconditioned fear QTL 6 (mouse)23131302344618192Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31324555105313225Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:871
Count of miRNA genes:335
Interacting mature miRNAs:382
Transcripts:ENSMUST00000050410, ENSMUST00000113395, ENSMUST00000113397, ENSMUST00000113400, ENSMUST00000127131, ENSMUST00000140406, ENSMUST00000183946
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001290552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_175190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_110965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_374118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB597964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB597965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK018775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK039840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL808027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY611716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY683904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000050410   ⟹   ENSMUSP00000057512
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl232,278,816 - 32,288,075 (-)Ensembl
RefSeq Acc Id: ENSMUST00000113395   ⟹   ENSMUSP00000109022
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl232,278,816 - 32,282,864 (-)Ensembl
RefSeq Acc Id: ENSMUST00000113397   ⟹   ENSMUSP00000109024
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl232,278,816 - 32,288,005 (-)Ensembl
RefSeq Acc Id: ENSMUST00000113400   ⟹   ENSMUSP00000109027
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl232,278,918 - 32,288,069 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127131
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl232,283,281 - 32,288,031 (-)Ensembl
RefSeq Acc Id: ENSMUST00000140406   ⟹   ENSMUSP00000139369
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl232,278,816 - 32,287,935 (-)Ensembl
RefSeq Acc Id: ENSMUST00000183946   ⟹   ENSMUSP00000139299
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl232,278,816 - 32,288,068 (-)Ensembl
RefSeq Acc Id: NM_001290552   ⟹   NP_001277481
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39232,168,817 - 32,178,081 (-)NCBI
GRCm38232,278,805 - 32,288,069 (-)NCBI
Celera231,983,281 - 31,992,545 (-)NCBI
Sequence:
RefSeq Acc Id: NM_175190   ⟹   NP_780399
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39232,168,817 - 32,178,081 (-)NCBI
GRCm38232,278,805 - 32,288,069 (-)NCBI
MGSCv37232,134,336 - 32,143,588 (-)RGD
Celera231,983,281 - 31,992,545 (-)NCBI
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_110965
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39232,168,817 - 32,178,081 (-)NCBI
GRCm38232,278,805 - 32,288,069 (-)NCBI
Celera231,983,281 - 31,992,545 (-)NCBI
Sequence:
RefSeq Acc Id: XR_374118
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39232,168,828 - 32,178,154 (-)NCBI
GRCm38232,278,816 - 32,288,136 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_780399   ⟸   NM_175190
- Peptide Label: isoform b
- UniProtKB: Q8K3D3 (UniProtKB/Swiss-Prot),   E3WH32 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277481   ⟸   NM_001290552
- Peptide Label: isoform a
- UniProtKB: Q8K3D3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000139299   ⟸   ENSMUST00000183946
RefSeq Acc Id: ENSMUSP00000109027   ⟸   ENSMUST00000113400
RefSeq Acc Id: ENSMUSP00000109022   ⟸   ENSMUST00000113395
RefSeq Acc Id: ENSMUSP00000109024   ⟸   ENSMUST00000113397
RefSeq Acc Id: ENSMUSP00000139369   ⟸   ENSMUST00000140406
RefSeq Acc Id: ENSMUSP00000057512   ⟸   ENSMUST00000050410

Promoters
RGD ID:6830589
Promoter ID:MM_KWN:28683
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   Brain,   ES_Cell,   Kidney,   Liver
Transcripts:ENSMUST00000113395
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36232,138,136 - 32,138,636 (-)MPROMDB
RGD ID:6830596
Promoter ID:MM_KWN:28685
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000081670,   ENSMUST00000113375,   ENSMUST00000113386,   ENSMUST00000113397,   NM_001080968,   NM_133852,   OTTMUST00000031176,   OTTMUST00000031177,   OTTMUST00000031179,   OTTMUST00000031180,   OTTMUST00000031192,   OTTMUST00000031193,   OTTMUST00000031194,   OTTMUST00000031195,   OTTMUST00000031196
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36232,143,076 - 32,144,387 (-)MPROMDB
RGD ID:6876984
Promoter ID:EPDNEW_M1943
Type:initiation region
Name:Swi5_1
Description:Mus musculus SWI5 recombination repair homolog , transcript variant3, non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38232,288,036 - 32,288,096EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1920181 AgrOrtholog
Ensembl Genes ENSMUSG00000044627 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000057512 UniProtKB/TrEMBL
  ENSMUSP00000109022 UniProtKB/Swiss-Prot
  ENSMUSP00000109024 UniProtKB/TrEMBL
  ENSMUSP00000109027 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000139299 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000139369 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000050410 UniProtKB/TrEMBL
  ENSMUST00000113395 UniProtKB/Swiss-Prot
  ENSMUST00000113397 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000113400 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000140406 UniProtKB/TrEMBL
  ENSMUST00000183946 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro DNA-repair_Swi5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:72931 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1920181 ENTREZGENE
NCBI Gene 72931 ENTREZGENE
PANTHER PTHR28529 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Swi5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Swi5 PhenoGen
UniGene Mm.27344 ENTREZGENE
UniProt A0A0A0MQ99_MOUSE UniProtKB/TrEMBL
  A2AN40_MOUSE UniProtKB/TrEMBL
  E3WH32 ENTREZGENE, UniProtKB/TrEMBL
  Q8K3D3 ENTREZGENE, UniProtKB/Swiss-Prot
  V9GXX7_MOUSE UniProtKB/TrEMBL
UniProt Secondary A2AN41 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-10 Swi5  SWI5 recombination repair homolog (yeast)  2900010J23Rik  RIKEN cDNA 2900010J23 gene  Symbol and/or name change 5135510 APPROVED