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Gene: Appl2 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2) Mus musculus
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Symbol: Appl2
Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
Description: Predicted to have Rab GTPase binding activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including adiponectin-activated signaling pathway; regulation of defense response; and regulation of vesicle-mediated transport. Localizes to the early phagosome membrane; macropinosome; and ruffle membrane. Is expressed in several structures, including alimentary system; autopod; forebrain; neural retina; and ventricular layer. Orthologous to human APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; Aroclor 1254.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adapter protein containing PH domain, PTB domain and leucine zipper motif 2; DCC-interacting protein 13-beta; DIP13 beta; dip13-beta; Dip3 beta; Dip3b
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1083,600,033 - 83,648,738 (-)Ensembl
GRCm381083,600,033 - 83,648,877 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371083,062,778 - 83,111,409 (-)NCBIGRCm37mm9NCBIm37
MGSCv361083,029,832 - 83,078,463 (-)NCBImm8
Celera1085,587,519 - 85,636,067 (-)NCBICelera
Cytogenetic Map10 C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Appl2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1558154
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.