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Gene: Appl2 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2) Mus musculus
Symbol: Appl2
Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
Description: Predicted to have Rab GTPase binding activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including adiponectin-activated signaling pathway; regulation of defense response; and regulation of vesicle-mediated transport. Localizes to the early phagosome membrane; macropinosome; and ruffle membrane. Is expressed in several structures, including alimentary system; autopod; forebrain; neural retina; and ventricular layer. Orthologous to human APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; Aroclor 1254.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adapter protein containing PH domain, PTB domain and leucine zipper motif 2; DCC-interacting protein 13-beta; DIP13 beta; dip13-beta; Dip3 beta; Dip3b
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1083,600,033 - 83,648,738 (-)Ensembl
GRCm381083,600,033 - 83,648,877 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371083,062,778 - 83,111,409 (-)NCBIGRCm37mm9NCBIm37
MGSCv361083,029,832 - 83,078,463 (-)NCBImm8
Celera1085,587,519 - 85,636,067 (-)NCBICelera
Cytogenetic Map10 C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Appl2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1558154
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.