Gene: Appl2 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2) Mus musculus
Analyze
Symbol:
Appl2
Name:
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
Description:
Predicted to have Rab GTPase binding activity; phospholipid binding activity; and protein homodimerization activity. Involved in several processes, including adiponectin-activated signaling pathway; regulation of defense response; and regulation of vesicle-mediated transport. Localizes to the early phagosome membrane; macropinosome; and ruffle membrane. Is expressed in several structures, including alimentary system; autopod; forebrain; neural retina; and ventricular layer. Orthologous to human APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; Aroclor 1254.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
adapter protein containing PH domain, PTB domain and leucine zipper motif 2; DCC-interacting protein 13-beta; DIP13 beta; dip13-beta; Dip3 beta; Dip3b
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
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Orthologs 1
Homo sapiens (human):
APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Appl2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Appl2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Appl2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Appl2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) HGNC
OrthoMCL
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Appl2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
appl2 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam, ZFIN)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 Ensembl 10 83,600,033 - 83,648,738 (-) Ensembl GRCm38 10 83,600,033 - 83,648,877 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 10 83,062,778 - 83,111,409 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 10 83,029,832 - 83,078,463 (-) NCBI mm8 Celera 10 85,587,519 - 85,636,067 (-) NCBI Celera Cytogenetic Map 10 C1 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(+)-schisandrin B multiple interactions ISO RGD:1563028 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of APPL2 mRNA] CTD PMID:31150632 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1605653 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of APPL2 mRNA CTD PMID:22079256 1,3,5-trinitro-1,3,5-triazinane decreases expression ISO RGD:1563028 6480464 cyclonite results in decreased expression of APPL2 mRNA CTD PMID:25559034 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of APPL2 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to APPL2 promoter] CTD PMID:19654925 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of APPL2 mRNA CTD PMID:21570461 2-hydroxypropanoic acid decreases expression ISO RGD:1605653 6480464 Lactic Acid results in decreased expression of APPL2 mRNA CTD PMID:30851411 Aroclor 1254 decreases expression EXP 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of APPL2 mRNA CTD PMID:23650126 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of APPL2 mRNA CTD PMID:19770486 benzo[a]pyrene decreases expression ISO RGD:1605653 6480464 Benzo(a)pyrene results in decreased expression of APPL2 mRNA CTD PMID:22316170 bisphenol A affects expression ISO RGD:1563028 6480464 bisphenol A affects the expression of APPL2 mRNA CTD PMID:25181051 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of APPL2 mRNA, Nanotubes, Carbon results in decreased expression of APPL2 mRNA CTD PMID:25554681 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of APPL2 gene CTD PMID:20938992 chromium(6+) affects expression EXP 6480464 chromium hexavalent ion affects the expression of APPL2 mRNA CTD PMID:28472532 cisplatin increases expression ISO RGD:1605653 6480464 Cisplatin results in increased expression of APPL2 mRNA CTD PMID:27392435 cobalt dichloride decreases expression ISO RGD:1605653 6480464 cobaltous chloride results in decreased expression of APPL2 mRNA CTD PMID:19320972 cyclosporin A decreases expression ISO RGD:1605653 6480464 Cyclosporine results in decreased expression of APPL2 mRNA CTD PMID:20106945 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of APPL2 mRNA CTD PMID:20880076 dioxygen multiple interactions EXP 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of APPL2 mRNA CTD PMID:30529165 dorsomorphin multiple interactions ISO RGD:1605653 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APPL2 mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:1605653 6480464 Doxorubicin results in decreased expression of APPL2 mRNA CTD PMID:29803840 endosulfan decreases expression ISO RGD:1563028 6480464 Endosulfan results in decreased expression of APPL2 mRNA CTD PMID:29391264 ethanol increases expression EXP 6480464 Ethanol results in increased expression of APPL2 mRNA CTD PMID:30319688 flutamide increases expression ISO RGD:1563028 6480464 Flutamide results in increased expression of APPL2 mRNA CTD PMID:24793618 folic acid multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of APPL2 gene CTD PMID:20938992 geldanamycin increases expression ISO RGD:1605653 6480464 geldanamycin results in increased expression of APPL2 mRNA CTD PMID:26705709 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of APPL2 mRNA CTD PMID:20003209 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of APPL2 gene CTD PMID:20938992 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of APPL2 mRNA CTD PMID:26307267 methyl methanesulfonate increases expression ISO RGD:1605653 6480464 Methyl Methanesulfonate results in increased expression of APPL2 mRNA CTD PMID:23649840 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of APPL2 mRNA CTD PMID:17562736 potassium chromate decreases expression ISO RGD:1605653 6480464 potassium chromate(VI) results in decreased expression of APPL2 mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:1605653 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of APPL2 mRNA CTD PMID:22079256 quercetin decreases expression ISO RGD:1605653 6480464 Quercetin results in decreased expression of APPL2 mRNA CTD PMID:21632981 rac-lactic acid decreases expression ISO RGD:1605653 6480464 Lactic Acid results in decreased expression of APPL2 mRNA CTD PMID:30851411 SB 431542 multiple interactions ISO RGD:1605653 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APPL2 mRNA CTD PMID:27188386 tert-butyl hydroperoxide decreases expression ISO RGD:1605653 6480464 tert-Butylhydroperoxide results in decreased expression of APPL2 mRNA CTD PMID:15336504 tetrachloromethane increases expression ISO RGD:1563028 6480464 Carbon Tetrachloride results in increased expression of APPL2 mRNA CTD PMID:31150632 tetrachloromethane multiple interactions ISO RGD:1563028 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of APPL2 mRNA] CTD PMID:31150632 tetraphene increases expression EXP 6480464 benz(a)anthracene results in increased expression of APPL2 mRNA CTD PMID:26377693 thimerosal decreases expression ISO RGD:1605653 6480464 Thimerosal results in decreased expression of APPL2 mRNA CTD PMID:27188386 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of APPL2 mRNA CTD PMID:23557971 trichloroethene increases methylation ISO RGD:1563028 6480464 Trichloroethylene results in increased methylation of APPL2 gene CTD PMID:27618143 trichostatin A decreases expression ISO RGD:1605653 6480464 trichostatin A results in decreased expression of APPL2 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:1605653 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of APPL2 mRNA CTD PMID:27188386 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of APPL2 mRNA CTD PMID:28973697 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of APPL2 mRNA CTD PMID:21427059 valproic acid decreases expression ISO RGD:1605653 6480464 Valproic Acid results in decreased expression of APPL2 mRNA CTD PMID:23179753 vorinostat decreases expression ISO RGD:1605653 6480464 vorinostat results in decreased expression of APPL2 mRNA CTD PMID:27188386 
Gene-Chemical Interaction Annotations
