Appl2 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2) - Rat Genome Database

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Gene: Appl2 (adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2) Mus musculus
Analyze
Symbol: Appl2
Name: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
RGD ID: 1558154
MGI Page MGI
Description: Predicted to enable phospholipid binding activity; protein homodimerization activity; and small GTPase binding activity. Involved in several processes, including adiponectin-activated signaling pathway; cellular response to hepatocyte growth factor stimulus; and positive regulation of endocytosis. Located in early phagosome membrane; macropinosome; and ruffle membrane. Is expressed in several structures, including alimentary system; autopod; brain; neural retina; and ventricular layer. Orthologous to human APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adapter protein containing PH domain, PTB domain and leucine zipper motif 2; DCC-interacting protein 13-beta; Dip; DIP13 beta; dip13-beta; Dip3 beta; Dip3b
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391083,435,897 - 83,484,741 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1083,435,897 - 83,484,602 (-)EnsemblGRCm39 Ensembl
GRCm381083,600,033 - 83,648,877 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1083,600,033 - 83,648,738 (-)EnsemblGRCm38mm10GRCm38
MGSCv371083,062,778 - 83,111,409 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361083,029,832 - 83,078,463 (-)NCBIMGSCv36mm8
Celera1085,587,519 - 85,636,067 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1041.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15226823   PMID:15489334   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:16622416   PMID:18799693   PMID:19661063   PMID:20040596   PMID:20665729   PMID:21267068   PMID:21677750   PMID:21873635   PMID:24879834   PMID:25328665   PMID:25568335  
PMID:26445298   PMID:26764384   PMID:27219021   PMID:28965332   PMID:29467283   PMID:29675572   PMID:30973865   PMID:31146259   PMID:32325033   PMID:32468397   PMID:32553114   PMID:32581705  
PMID:33122440   PMID:34162682  


Genomics

Comparative Map Data
Appl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391083,435,897 - 83,484,741 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1083,435,897 - 83,484,602 (-)EnsemblGRCm39 Ensembl
GRCm381083,600,033 - 83,648,877 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1083,600,033 - 83,648,738 (-)EnsemblGRCm38mm10GRCm38
MGSCv371083,062,778 - 83,111,409 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361083,029,832 - 83,078,463 (-)NCBIMGSCv36mm8
Celera1085,587,519 - 85,636,067 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1041.29NCBI
APPL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812105,173,300 - 105,236,174 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12105,173,297 - 105,236,203 (-)EnsemblGRCh38hg38GRCh38
GRCh3712105,567,078 - 105,629,952 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612104,091,205 - 104,154,138 (-)NCBINCBI36Build 36hg18NCBI36
Celera12105,231,366 - 105,294,273 (-)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12102,626,453 - 102,689,404 (-)NCBIHuRef
CHM1_112105,532,775 - 105,595,738 (-)NCBICHM1_1
T2T-CHM13v2.012105,135,121 - 105,197,990 (-)NCBIT2T-CHM13v2.0
Appl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8722,019,480 - 22,072,386 (+)NCBIGRCr8
mRatBN7.2720,135,248 - 20,184,757 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl720,135,375 - 20,184,754 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx722,105,205 - 22,156,954 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0724,267,960 - 24,319,709 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0724,044,969 - 24,096,718 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0726,256,179 - 26,306,128 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl726,256,459 - 26,306,126 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0726,387,115 - 26,436,564 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4722,279,273 - 22,328,427 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera717,339,053 - 17,386,872 (+)NCBICelera
Cytogenetic Map7q13NCBI
Appl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540539,503,020 - 39,540,335 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540539,503,020 - 39,540,069 (-)NCBIChiLan1.0ChiLan1.0
APPL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210113,243,186 - 113,306,443 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112113,239,582 - 113,302,821 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012102,755,388 - 102,818,686 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112106,150,955 - 106,214,038 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12106,151,969 - 106,206,879 (-)Ensemblpanpan1.1panPan2
APPL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11033,192,261 - 33,243,034 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1033,191,602 - 33,242,669 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1033,111,933 - 33,162,406 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01034,033,756 - 34,084,221 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1034,033,772 - 34,084,225 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11033,769,093 - 33,819,698 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01034,053,225 - 34,103,854 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01034,246,325 - 34,297,170 (+)NCBIUU_Cfam_GSD_1.0
Appl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494516,467,066 - 16,530,048 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364929,477,373 - 9,526,692 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364929,477,483 - 9,526,692 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APPL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl579,356,067 - 79,412,235 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1579,356,046 - 79,412,235 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2582,650,763 - 82,706,934 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q2.3NCBI
APPL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111100,400,093 - 100,469,234 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11100,400,084 - 100,462,507 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037144,551,093 - 144,614,465 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Appl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247503,789,022 - 3,827,079 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247503,789,015 - 3,827,079 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Appl2
797 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1932
Count of miRNA genes:793
Interacting mature miRNAs:1052
Transcripts:ENSMUST00000020500, ENSMUST00000127788, ENSMUST00000130285, ENSMUST00000133719, ENSMUST00000141048, ENSMUST00000146876, ENSMUST00000147118, ENSMUST00000147582, ENSMUST00000148096, ENSMUST00000150351, ENSMUST00000150685, ENSMUST00000176294, ENSMUST00000176675, ENSMUST00000177187
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078381268112381268Mouse
14747004Mancz8_mmandible centroid size 8 (mouse)1082078412116078412Mouse
11059554Lmr32e_mleishmaniasis resistance 32e (mouse)1082309418116309657Mouse
11059555Lmr32f_mleishmaniasis resistance 32f (mouse)1082309418116309657Mouse
11059550Lmr32a_mleishmaniasis resistance 32a (mouse)1082309418116309657Mouse
11059551Lmr32b_mleishmaniasis resistance 32b (mouse)1082309418116309657Mouse
11059553Lmr32d_mleishmaniasis resistance 32d (mouse)1082309418116309657Mouse
1301165Lith7_mlithogenic gene 7 (mouse)Not determined1082309418116309657Mouse
10043881Adip24_madiposity 24 (mouse)Not determined1082392803116392952Mouse
4141382Ssrq4_mstress response QTL 4 (mouse)Not determined8249093890856102Mouse
12910789Pwgrq19_mpost-weaning growth rate QTL 19 (mouse)108282870092169056Mouse
4141054mwfh_mmodifier of white forlock hypopigmentation (mouse)Not determined83017003117017136Mouse

Markers in Region
D19286  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381083,600,262 - 83,600,452UniSTSGRCm38
MGSCv371083,063,007 - 83,063,197UniSTSGRCm37
Celera1085,587,748 - 85,587,938UniSTS
Cytogenetic Map10C1UniSTS
Whitehead_YAC10 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_145220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245026 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_380384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC153508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK171512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY113706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000020500   ⟹   ENSMUSP00000020500
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1083,435,897 - 83,484,602 (-)Ensembl
GRCm38.p6 Ensembl1083,600,033 - 83,648,738 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127788
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1083,444,471 - 83,446,966 (-)Ensembl
GRCm38.p6 Ensembl1083,608,607 - 83,611,102 (-)Ensembl
RefSeq Acc Id: ENSMUST00000130285
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1083,438,631 - 83,447,745 (-)Ensembl
GRCm38.p6 Ensembl1083,602,767 - 83,611,881 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133719
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1083,456,691 - 83,473,307 (-)Ensembl
GRCm38.p6 Ensembl1083,620,827 - 83,637,443 (-)Ensembl
RefSeq Acc Id: ENSMUST00000141048
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1083,437,768 - 83,439,248 (-)Ensembl
GRCm38.p6 Ensembl1083,601,904 - 83,603,384 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146876   ⟹   ENSMUSP00000121336
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1083,453,283 - 83,484,529 (-)Ensembl
GRCm38.p6 Ensembl1083,617,419 - 83,648,665 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147118
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1083,450,123 - 83,464,166 (-)Ensembl
GRCm38.p6 Ensembl1083,614,259 - 83,628,302 (-)Ensembl
RefSeq Acc Id: ENSMUST00000147582
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1083,441,509 - 83,484,534 (-)Ensembl
GRCm38.p6 Ensembl1083,605,645 - 83,648,670 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148096
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1083,438,735 - 83,447,132 (-)Ensembl
GRCm38.p6 Ensembl1083,602,871 - 83,611,268 (-)Ensembl
RefSeq Acc Id: ENSMUST00000150351
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1083,441,629 - 83,447,592 (-)Ensembl
GRCm38.p6 Ensembl1083,605,765 - 83,611,728 (-)Ensembl
RefSeq Acc Id: ENSMUST00000150685   ⟹   ENSMUSP00000115903
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1083,456,577 - 83,484,467 (-)Ensembl
GRCm38.p6 Ensembl1083,620,713 - 83,648,603 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176294   ⟹   ENSMUSP00000135645
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1083,460,510 - 83,484,539 (-)Ensembl
GRCm38.p6 Ensembl1083,624,646 - 83,648,675 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176675   ⟹   ENSMUSP00000135672
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1083,436,606 - 83,444,872 (-)Ensembl
GRCm38.p6 Ensembl1083,600,742 - 83,609,008 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177187   ⟹   ENSMUSP00000135157
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1083,436,261 - 83,438,994 (-)Ensembl
GRCm38.p6 Ensembl1083,600,397 - 83,603,130 (-)Ensembl
RefSeq Acc Id: NM_145220   ⟹   NP_660255
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391083,435,897 - 83,484,528 (-)NCBI
GRCm381083,600,033 - 83,648,664 (-)NCBI
MGSCv371083,062,778 - 83,111,409 (-)RGD
Celera1085,587,519 - 85,636,067 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006513508   ⟹   XP_006513571
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391083,435,897 - 83,476,958 (-)NCBI
GRCm381083,600,039 - 83,630,943 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513509   ⟹   XP_006513572
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391083,435,903 - 83,484,741 (-)NCBI
GRCm381083,600,039 - 83,648,877 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513510   ⟹   XP_006513573
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391083,435,897 - 83,474,790 (-)NCBI
GRCm381083,600,039 - 83,638,924 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513511   ⟹   XP_006513574
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391083,435,897 - 83,484,645 (-)NCBI
GRCm381083,600,039 - 83,648,843 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017313895   ⟹   XP_017169384
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391083,435,903 - 83,474,790 (-)NCBI
GRCm381083,600,039 - 83,638,924 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245026   ⟹   XP_030100886
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391083,435,897 - 83,474,790 (-)NCBI
GRCm381083,600,039 - 83,638,924 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245027   ⟹   XP_030100887
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391083,435,897 - 83,474,790 (-)NCBI
GRCm381083,600,039 - 83,638,924 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155744   ⟹   XP_036011637
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391083,435,897 - 83,474,790 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155745   ⟹   XP_036011638
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391083,435,897 - 83,474,790 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155746   ⟹   XP_036011639
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391083,435,897 - 83,476,955 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155747   ⟹   XP_036011640
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391083,435,897 - 83,474,790 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155748   ⟹   XP_036011641
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391083,435,897 - 83,484,476 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155749   ⟹   XP_036011642
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391083,435,897 - 83,472,017 (-)NCBI
Sequence:
RefSeq Acc Id: XR_380384
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391083,435,897 - 83,484,741 (-)NCBI
GRCm381083,602,850 - 83,648,877 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_660255 (Get FASTA)   NCBI Sequence Viewer  
  XP_006513571 (Get FASTA)   NCBI Sequence Viewer  
  XP_006513572 (Get FASTA)   NCBI Sequence Viewer  
  XP_006513573 (Get FASTA)   NCBI Sequence Viewer  
  XP_006513574 (Get FASTA)   NCBI Sequence Viewer  
  XP_017169384 (Get FASTA)   NCBI Sequence Viewer  
  XP_030100886 (Get FASTA)   NCBI Sequence Viewer  
  XP_030100887 (Get FASTA)   NCBI Sequence Viewer  
  XP_036011637 (Get FASTA)   NCBI Sequence Viewer  
  XP_036011638 (Get FASTA)   NCBI Sequence Viewer  
  XP_036011639 (Get FASTA)   NCBI Sequence Viewer  
  XP_036011640 (Get FASTA)   NCBI Sequence Viewer  
  XP_036011641 (Get FASTA)   NCBI Sequence Viewer  
  XP_036011642 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH02232 (Get FASTA)   NCBI Sequence Viewer  
  AAH48906 (Get FASTA)   NCBI Sequence Viewer  
  AAM55532 (Get FASTA)   NCBI Sequence Viewer  
  BAE32652 (Get FASTA)   NCBI Sequence Viewer  
  BAE35609 (Get FASTA)   NCBI Sequence Viewer  
  BAE35632 (Get FASTA)   NCBI Sequence Viewer  
  BAE40588 (Get FASTA)   NCBI Sequence Viewer  
  BAE42499 (Get FASTA)   NCBI Sequence Viewer  
  EDL21394 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000020500
  ENSMUSP00000020500.8
  ENSMUSP00000115903.2
  ENSMUSP00000121336.3
  ENSMUSP00000135157.2
  ENSMUSP00000135645.2
  ENSMUSP00000135672.2
GenBank Protein Q8K3G9 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_660255   ⟸   NM_145220
- UniProtKB: Q99LT7 (UniProtKB/Swiss-Prot),   Q8K3G9 (UniProtKB/Swiss-Prot),   Q3TVI6 (UniProtKB/TrEMBL),   Q3TB15 (UniProtKB/TrEMBL),   Q3TGG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006513574   ⟸   XM_006513511
- Peptide Label: isoform X5
- UniProtKB: Q3TB15 (UniProtKB/TrEMBL),   Q3TGG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006513572   ⟸   XM_006513509
- Peptide Label: isoform X2
- UniProtKB: Q3TB15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006513573   ⟸   XM_006513510
- Peptide Label: isoform X3
- UniProtKB: Q3TB15 (UniProtKB/TrEMBL),   Q3TGG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006513571   ⟸   XM_006513508
- Peptide Label: isoform X1
- UniProtKB: Q3TB15 (UniProtKB/TrEMBL),   Q3TGG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017169384   ⟸   XM_017313895
- Peptide Label: isoform X4
- UniProtKB: Q3TB15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030100887   ⟸   XM_030245027
- Peptide Label: isoform X3
- UniProtKB: Q3TB15 (UniProtKB/TrEMBL),   Q3TGG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030100886   ⟸   XM_030245026
- Peptide Label: isoform X3
- UniProtKB: Q3TB15 (UniProtKB/TrEMBL),   Q3TGG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000115903   ⟸   ENSMUST00000150685
RefSeq Acc Id: ENSMUSP00000135157   ⟸   ENSMUST00000177187
RefSeq Acc Id: ENSMUSP00000020500   ⟸   ENSMUST00000020500
RefSeq Acc Id: ENSMUSP00000121336   ⟸   ENSMUST00000146876
RefSeq Acc Id: ENSMUSP00000135672   ⟸   ENSMUST00000176675
RefSeq Acc Id: ENSMUSP00000135645   ⟸   ENSMUST00000176294
RefSeq Acc Id: XP_036011641   ⟸   XM_036155748
- Peptide Label: isoform X3
- UniProtKB: Q3TB15 (UniProtKB/TrEMBL),   Q3TGG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036011639   ⟸   XM_036155746
- Peptide Label: isoform X1
- UniProtKB: Q3TB15 (UniProtKB/TrEMBL),   Q3TGG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036011640   ⟸   XM_036155747
- Peptide Label: isoform X1
- UniProtKB: Q3TB15 (UniProtKB/TrEMBL),   Q3TGG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036011638   ⟸   XM_036155745
- Peptide Label: isoform X1
- UniProtKB: Q3TB15 (UniProtKB/TrEMBL),   Q3TGG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036011637   ⟸   XM_036155744
- Peptide Label: isoform X1
- UniProtKB: Q3TB15 (UniProtKB/TrEMBL),   Q3TGG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036011642   ⟸   XM_036155749
- Peptide Label: isoform X5
- UniProtKB: Q3TB15 (UniProtKB/TrEMBL),   Q3TGG0 (UniProtKB/TrEMBL)
Protein Domains
BAR   PH   PID

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K3G9-F1-model_v2 AlphaFold Q8K3G9 1-662 view protein structure

Promoters
RGD ID:6819004
Promoter ID:MM_KWN:5127
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   MEF_B6
Transcripts:OTTMUST00000069204
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361083,065,691 - 83,066,992 (-)MPROMDB
RGD ID:6819003
Promoter ID:MM_KWN:5128
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B6
Transcripts:OTTMUST00000069203,   OTTMUST00000069205,   OTTMUST00000069206,   OTTMUST00000069207,   OTTMUST00000069208
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361083,073,941 - 83,075,572 (-)MPROMDB
RGD ID:6819005
Promoter ID:MM_KWN:5129
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:OTTMUST00000069209
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361083,091,631 - 83,092,131 (-)MPROMDB
RGD ID:6819001
Promoter ID:MM_KWN:5130
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000069201
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361083,099,981 - 83,100,481 (-)MPROMDB
RGD ID:6819002
Promoter ID:MM_KWN:5131
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000068884,   OTTMUST00000069007,   OTTMUST00000069200,   OTTMUST00000069202
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361083,111,201 - 83,111,747 (-)MPROMDB
RGD ID:8672884
Promoter ID:EPDNEW_M14473
Type:initiation region
Name:Appl2_1
Description:Mus musculus adaptor protein, phosphotyrosine interaction, PHdomain and leucine zipper containing 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381083,648,646 - 83,648,706EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2384914 AgrOrtholog
Ensembl Genes ENSMUSG00000020263 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020500 ENTREZGENE
  ENSMUST00000020500.14 UniProtKB/Swiss-Prot
  ENSMUST00000146876.9 UniProtKB/TrEMBL
  ENSMUST00000150685.8 UniProtKB/TrEMBL
  ENSMUST00000176294.2 UniProtKB/TrEMBL
  ENSMUST00000176675.8 UniProtKB/TrEMBL
  ENSMUST00000177187.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAR_APPL2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DP13A/B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DP13A/B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTB_APPL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:216190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2384914 ENTREZGENE
NCBI Gene 216190 ENTREZGENE
PANTHER ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DCC-INTERACTING PROTEIN 13-BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BAR_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Appl2 PhenoGen
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z340_MOUSE UniProtKB/TrEMBL
  D6RFR7_MOUSE UniProtKB/TrEMBL
  DP13B_MOUSE UniProtKB/Swiss-Prot
  H3BJX0_MOUSE UniProtKB/TrEMBL
  H3BL43_MOUSE UniProtKB/TrEMBL
  H3BL67_MOUSE UniProtKB/TrEMBL
  Q3TB15 ENTREZGENE, UniProtKB/TrEMBL
  Q3TGG0 ENTREZGENE, UniProtKB/TrEMBL
  Q3TVI6 ENTREZGENE, UniProtKB/TrEMBL
  Q3U3Y3_MOUSE UniProtKB/TrEMBL
  Q8K3G9 ENTREZGENE
  Q99LT7 ENTREZGENE
UniProt Secondary Q99LT7 UniProtKB/Swiss-Prot