Wasf1 (WASP family, member 1) - Rat Genome Database

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Gene: Wasf1 (WASP family, member 1) Mus musculus
Analyze
Symbol: Wasf1
Name: WASP family, member 1
RGD ID: 1558118
MGI Page MGI
Description: Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Predicted to contribute to small GTPase binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; dendrite extension; and modification of postsynaptic actin cytoskeleton. Acts upstream of or within lamellipodium morphogenesis. Located in lamellipodium; mitochondrial outer membrane; and postsynapse. Is expressed in several structures, including central nervous system; liver; spleen; testis; and tooth. Orthologous to human WASF1 (WASP family member 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI195380; AI838537; S; Scar; WA; WAS protein family, member 1; WASP family 1; WASP family protein member 1; WAVE; WAVE-1; wiskott-Aldrich syndrome protein family member 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm17888  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391040,759,476 - 40,814,565 (+)NCBIGRCm39mm39
GRCm39 Ensembl1040,759,471 - 40,814,566 (+)Ensembl
GRCm381040,883,480 - 40,938,569 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1040,883,475 - 40,938,570 (+)EnsemblGRCm38mm10GRCm38
MGSCv371040,603,340 - 40,658,375 (+)NCBIGRCm37mm9NCBIm37
MGSCv361040,571,988 - 40,626,982 (+)NCBImm8
Celera1041,779,631 - 41,834,540 (+)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1022.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10512203   PMID:10970852   PMID:11042159   PMID:11076861   PMID:11130076   PMID:11217851   PMID:12062808   PMID:12477932   PMID:12578964   PMID:12716942  
PMID:12856283   PMID:12879075   PMID:12904583   PMID:12931191   PMID:14536061   PMID:14610273   PMID:14697212   PMID:15143189   PMID:15148305   PMID:15489334   PMID:15840001   PMID:16141072  
PMID:16141073   PMID:16190876   PMID:16602821   PMID:16723544   PMID:16831833   PMID:16862120   PMID:17101133   PMID:17182853   PMID:17215396   PMID:17319906   PMID:17664349   PMID:18032787  
PMID:18644894   PMID:18765479   PMID:18799693   PMID:19200726   PMID:19497998   PMID:20368433   PMID:21267068   PMID:21693517   PMID:21873635   PMID:21944720   PMID:21946561   PMID:23934128  
PMID:23990560   PMID:24086480   PMID:24247431   PMID:24439376   PMID:24439377   PMID:26280122   PMID:26634693   PMID:26996666   PMID:27507650   PMID:27605705   PMID:27889896   PMID:28115704  
PMID:28671696   PMID:28706196   PMID:29911975   PMID:30352064   PMID:30562941   PMID:30687000   PMID:32325033   PMID:33378226  


Genomics

Comparative Map Data
Wasf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391040,759,476 - 40,814,565 (+)NCBIGRCm39mm39
GRCm39 Ensembl1040,759,471 - 40,814,566 (+)Ensembl
GRCm381040,883,480 - 40,938,569 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1040,883,475 - 40,938,570 (+)EnsemblGRCm38mm10GRCm38
MGSCv371040,603,340 - 40,658,375 (+)NCBIGRCm37mm9NCBIm37
MGSCv361040,571,988 - 40,626,982 (+)NCBImm8
Celera1041,779,631 - 41,834,540 (+)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1022.07NCBI
WASF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6110,099,819 - 110,180,004 (-)EnsemblGRCh38hg38GRCh38
GRCh386110,099,819 - 110,179,670 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376110,421,022 - 110,500,873 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366110,527,715 - 110,607,900 (-)NCBINCBI36hg18NCBI36
Build 346110,527,714 - 110,606,609NCBI
Celera6111,167,684 - 111,247,873 (-)NCBI
Cytogenetic Map6q21NCBI
HuRef6107,987,658 - 108,067,845 (-)NCBIHuRef
CHM1_16110,684,246 - 110,764,410 (-)NCBICHM1_1
Wasf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22044,325,815 - 44,372,999 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2044,325,795 - 44,372,996 (+)Ensembl
Rnor_6.02048,456,191 - 48,503,768 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2048,455,705 - 48,503,898 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02050,107,711 - 50,155,913 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2045,130,786 - 45,177,385 (+)NCBICelera
Cytogenetic Map20q13NCBI
Wasf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541134,889,566 - 34,965,769 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541134,893,287 - 34,966,670 (-)NCBIChiLan1.0ChiLan1.0
WASF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16111,951,725 - 112,058,554 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6111,951,726 - 111,979,329 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06107,911,751 - 107,988,821 (-)NCBIMhudiblu_PPA_v0panPan3
WASF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11266,833,776 - 66,897,500 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1266,833,995 - 66,897,483 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1266,653,278 - 66,717,426 (-)NCBI
ROS_Cfam_1.01267,717,606 - 67,781,968 (-)NCBI
UMICH_Zoey_3.11267,069,337 - 67,133,320 (-)NCBI
UNSW_CanFamBas_1.01266,915,644 - 66,979,778 (-)NCBI
UU_Cfam_GSD_1.01267,187,405 - 67,251,555 (-)NCBI
Wasf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946101,761,273 - 101,821,206 (-)NCBI
SpeTri2.0NW_0049365646,036,135 - 6,096,046 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WASF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1176,107,595 - 76,180,335 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2185,590,358 - 85,660,191 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WASF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11363,718,784 - 63,793,024 (+)NCBI
ChlSab1.1 Ensembl1363,718,737 - 63,793,151 (+)Ensembl
Vero_WHO_p1.0NW_02366604036,004,710 - 36,077,937 (+)NCBI
Wasf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249161,183,291 - 1,301,925 (-)NCBI

Position Markers
RH135950  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381040,938,108 - 40,938,298UniSTSGRCm38
MGSCv371040,657,914 - 40,658,104UniSTSGRCm37
Celera1041,834,079 - 41,834,269UniSTS
Cytogenetic Map10B1UniSTS
cM Map1025.0UniSTS
AI838537  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381040,938,202 - 40,938,296UniSTSGRCm38
MGSCv371040,658,008 - 40,658,102UniSTSGRCm37
Celera1041,834,173 - 41,834,267UniSTS
Cytogenetic Map10B1UniSTS
cM Map1025.0UniSTS
Whitehead/MRC_RH10535.15UniSTS
Wasf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10B1UniSTS
cM Map1025.0UniSTS
1634  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381040,938,327 - 40,938,415UniSTSGRCm38
MGSCv371040,658,133 - 40,658,221UniSTSGRCm37
Celera1041,834,298 - 41,834,386UniSTS
Cytogenetic Map10B1UniSTS
cM Map1025.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208561Wght8_mweight 8 (mouse)10500000044000000Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10620194558857699Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108359714116355075Mouse
1558865Lith21_mlithogenic gene 21 (mouse)Not determined10864910542649228Mouse
1302133Alcp16_malcohol preference locus 16 (mouse)Not determined101001426844014395Mouse
1301129Alcp15_malcohol preference locus 15 (mouse)Not determined101001426844014395Mouse
1301448Pas11_mpulmonary adenoma susceptibility 11 (mouse)Not determined101001426844014395Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101023252187565233Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101282830784243920Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101282830784243920Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101282830784243920Mouse
1357893Lvrq4_mliver weight QTL 4 (mouse)Not determined101282830784243920Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1282830784243920Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1282830784243920Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1282830784243920Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1282830784243920Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101282830784243920Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018383585125739363Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
10755518Chol16_mcholesterol 16 (mouse)101903904753039047Mouse
1302160Mbis2_mMycobacterium bovis-induced systemic lupus erythematosus 2 (mouse)Not determined102040743956155127Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021532255114381325Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102171529368255809Mouse
26884394Humsd3_mhumerus midshaft diameter 3, 10 week (mouse)102250000051200000Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102300000091200000Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024800000121200000Mouse
4142209Psrs1_mpsoriasis susceptibility 1 (mouse)Not determined102701426846844387Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102984430763844387Mouse
10045632Heal16_mwound healing/regeneration 16 (mouse)Not determined103109840365098534Mouse
1357558Bmch4_mbone mechanical trait 4 (mouse)Not determined103170104065701188Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103390000071000000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:316
Count of miRNA genes:146
Interacting mature miRNAs:153
Transcripts:ENSMUST00000019975, ENSMUST00000105509
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000019975   ⟹   ENSMUSP00000019975
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1040,759,471 - 40,814,565 (+)Ensembl
GRCm38.p6 Ensembl1040,883,475 - 40,938,569 (+)Ensembl
RefSeq Acc Id: ENSMUST00000105509   ⟹   ENSMUSP00000101148
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1040,759,823 - 40,814,566 (+)Ensembl
GRCm38.p6 Ensembl1040,883,827 - 40,938,570 (+)Ensembl
RefSeq Acc Id: NM_001379453   ⟹   NP_001366382
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391040,759,823 - 40,814,565 (+)NCBI
GRCm381040,883,827 - 40,938,569 (+)NCBI
RefSeq Acc Id: NM_001379454   ⟹   NP_001366383
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391040,759,823 - 40,814,565 (+)NCBI
GRCm381040,883,827 - 40,938,569 (+)NCBI
RefSeq Acc Id: NM_031877   ⟹   NP_114083
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391040,759,530 - 40,814,565 (+)NCBI
GRCm381040,883,534 - 40,938,569 (+)ENTREZGENE
MGSCv371040,603,340 - 40,658,375 (+)RGD
Celera1041,779,631 - 41,834,540 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030245406   ⟹   XP_030101266
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391040,759,476 - 40,814,565 (+)NCBI
GRCm381040,883,480 - 40,938,569 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_114083   ⟸   NM_031877
- Peptide Label: isoform 1
- UniProtKB: Q8R5H6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030101266   ⟸   XM_030245406
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001366382   ⟸   NM_001379453
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001366383   ⟸   NM_001379454
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000101148   ⟸   ENSMUST00000105509
RefSeq Acc Id: ENSMUSP00000019975   ⟸   ENSMUST00000019975
Protein Domains
WH2

Promoters
RGD ID:6819095
Promoter ID:MM_KWN:3971
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000044166,   ENSMUST00000105509,   OTTMUST00000049339,   UC007EXF.1,   UC007EXG.1,   UC007EXH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361040,602,641 - 40,603,517 (-)MPROMDB
RGD ID:8671856
Promoter ID:EPDNEW_M13959
Type:initiation region
Name:Wasf1_2
Description:Mus musculus WAS protein family, member 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13960  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381040,883,500 - 40,883,560EPDNEW
RGD ID:8671858
Promoter ID:EPDNEW_M13960
Type:initiation region
Name:Wasf1_1
Description:Mus musculus WAS protein family, member 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13959  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381040,883,848 - 40,883,908EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1890563 AgrOrtholog
Ensembl Genes ENSMUSG00000019831 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000019975 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000101148 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000019975 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000105509 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro SCAR/WAVE_fam UniProtKB/Swiss-Prot
  WH2_dom UniProtKB/Swiss-Prot
KEGG Report mmu:83767 UniProtKB/Swiss-Prot
MGD MGI:1890563 ENTREZGENE
NCBI Gene 83767 ENTREZGENE
PANTHER PTHR12902 UniProtKB/Swiss-Prot
Pfam WH2 UniProtKB/Swiss-Prot
PhenoGen Wasf1 PhenoGen
PROSITE WH2 UniProtKB/Swiss-Prot
SMART WH2 UniProtKB/Swiss-Prot
UniProt Q8R5H6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q91W51 UniProtKB/Swiss-Prot
  Q9ERQ9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-09-01 Wasf1  WASP family, member 1  Wasf1  WAS protein family, member 1  Symbol and/or name change 5135510 APPROVED
2012-05-22 Wasf1  WAS protein family, member 1  Wasf1  WASP family 1  Symbol and/or name change 5135510 APPROVED