Ofd1 (OFD1, centriole and centriolar satellite protein) - Rat Genome Database

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Gene: Ofd1 (OFD1, centriole and centriolar satellite protein) Mus musculus
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Symbol: Ofd1
Name: OFD1, centriole and centriolar satellite protein
RGD ID: 1558019
MGI Page MGI
Description: Enables alpha-tubulin binding activity and gamma-tubulin binding activity. Involved in several processes, including embryonic body morphogenesis; epithelial cilium movement involved in determination of left/right asymmetry; and negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation. Acts upstream of or within axoneme assembly. Located in centriolar satellite; centriole; and ciliary basal body. Is expressed in several structures, including alimentary system epithelium; brain; reproductive system; sensory organ; and skin. Used to study orofaciodigital syndrome I. Human ortholog(s) of this gene implicated in Joubert syndrome 10; Simpson-Golabi-Behmel syndrome type 2; orofaciodigital syndrome I; retinitis pigmentosa; and retinitis pigmentosa 23. Orthologous to human OFD1 (OFD1 centriole and centriolar satellite protein); INTERACTS WITH 1,2-dimethylhydrazine; 4,4'-diaminodiphenylmethane; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cxorf5; DXGgc7e; oral-facial-digital syndrome 1 gene homolog; oral-facial-digital syndrome 1 gene homolog (human); oral-facial-digital syndrome 1 protein homolog; ORF2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm13615  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X165,171,503 - 165,223,700 (-)NCBIGRCm39mm39
GRCm39 EnsemblX165,173,029 - 165,223,700 (-)Ensembl
GRCm38X166,386,573 - 166,440,704 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX166,390,033 - 166,440,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X162,827,965 - 162,878,636 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X161,735,041 - 161,784,660 (-)NCBImm8
CeleraX149,569,705 - 149,620,495 (-)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX77.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:9722947   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11179005   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:12782125  
PMID:14610273   PMID:15466260   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16311594   PMID:16602821   PMID:17251353   PMID:18287559   PMID:19783798   PMID:20230748   PMID:20444807  
PMID:20843830   PMID:20873986   PMID:20920500   PMID:21677750   PMID:21873635   PMID:23300826   PMID:23537390   PMID:23806618   PMID:24089205   PMID:24469809   PMID:24691443   PMID:27591083  
PMID:28450740   PMID:29487109   PMID:31719045   PMID:32325033  


Genomics

Comparative Map Data
Ofd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X165,171,503 - 165,223,700 (-)NCBIGRCm39mm39
GRCm39 EnsemblX165,173,029 - 165,223,700 (-)Ensembl
GRCm38X166,386,573 - 166,440,704 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX166,390,033 - 166,440,704 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X162,827,965 - 162,878,636 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X161,735,041 - 161,784,660 (-)NCBImm8
CeleraX149,569,705 - 149,620,495 (-)NCBICelera
Cytogenetic MapXF5NCBI
cM MapX77.28NCBI
OFD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX13,734,743 - 13,777,955 (+)EnsemblGRCh38hg38GRCh38
GRCh38X13,734,726 - 13,773,978 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X13,752,867 - 13,787,476 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X13,662,801 - 13,697,393 (+)NCBINCBI36hg18NCBI36
Build 34X13,512,536 - 13,547,127NCBI
CeleraX17,869,913 - 17,904,562 (+)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX11,510,937 - 11,544,940 (+)NCBIHuRef
CHM1_1X13,783,650 - 13,818,298 (+)NCBICHM1_1
Ofd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X28,015,347 - 28,056,115 (+)NCBI
Rnor_6.0 EnsemblX29,562,165 - 29,602,925 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X29,562,165 - 29,602,934 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X29,955,456 - 29,996,224 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X48,701,675 - 48,742,443 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX28,388,104 - 28,428,825 (+)NCBICelera
Cytogenetic MapXq13NCBI
Ofd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555194,433,855 - 4,471,070 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555194,433,747 - 4,470,842 (-)NCBIChiLan1.0ChiLan1.0
OFD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X13,630,006 - 13,669,285 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX13,611,304 - 13,664,512 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X6,296,597 - 6,376,197 (+)NCBIMhudiblu_PPA_v0panPan3
OFD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X10,140,439 - 10,194,478 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX10,140,067 - 10,194,472 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX10,114,679 - 10,168,786 (+)NCBI
ROS_Cfam_1.0X10,098,262 - 10,152,653 (+)NCBI
UMICH_Zoey_3.1X10,166,885 - 10,220,990 (+)NCBI
UNSW_CanFamBas_1.0X10,158,225 - 10,212,581 (+)NCBI
UU_Cfam_GSD_1.0X10,184,578 - 10,238,702 (+)NCBI
Ofd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X3,292,935 - 3,331,915 (+)NCBI
SpeTri2.0NW_0049364703,292,961 - 3,331,915 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OFD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X10,361,403 - 10,415,502 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X11,314,606 - 11,369,244 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OFD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X12,222,396 - 12,256,802 (+)NCBI
ChlSab1.1 EnsemblX12,222,760 - 12,256,557 (+)Ensembl
Vero_WHO_p1.0NW_02366605614,039,780 - 14,076,648 (+)NCBI
Ofd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624882376,447 - 417,066 (-)NCBI

Position Markers
UniSTS:238109  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X166,406,025 - 166,406,233UniSTSGRCm38
MGSCv37X162,843,957 - 162,844,165UniSTSGRCm37
CeleraX149,585,718 - 149,585,926UniSTS
Cytogenetic MapXF5UniSTS
cM MapX72.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX145691384171031299Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX134639291166515599Mouse
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX145691384171031299Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:320
Count of miRNA genes:253
Interacting mature miRNAs:278
Transcripts:ENSMUST00000049501
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000049501   ⟹   ENSMUSP00000041744
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 EnsemblX166,390,033 - 166,440,704 (-)Ensembl
RefSeq Acc Id: NM_177429   ⟹   NP_803178
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X165,173,029 - 165,223,700 (-)NCBI
GRCm38X166,390,033 - 166,440,704 (-)NCBI
MGSCv37X162,827,965 - 162,878,636 (-)RGD
CeleraX149,569,705 - 149,620,495 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006528839   ⟹   XP_006528902
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X165,171,565 - 165,223,692 (-)NCBI
GRCm38X166,386,573 - 166,440,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036161946   ⟹   XP_036017839
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X165,171,565 - 165,209,989 (-)NCBI
RefSeq Acc Id: XM_036161947   ⟹   XP_036017840
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X165,171,565 - 165,209,989 (-)NCBI
RefSeq Acc Id: XR_004940336
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X165,171,503 - 165,223,692 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_803178   ⟸   NM_177429
- UniProtKB: Q80Z25 (UniProtKB/Swiss-Prot),   A2AEG2 (UniProtKB/TrEMBL),   Q3URP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528902   ⟸   XM_006528839
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000041744   ⟸   ENSMUST00000049501
RefSeq Acc Id: XP_036017840   ⟸   XM_036161947
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036017839   ⟸   XM_036161946
- Peptide Label: isoform X2
Protein Domains
LisH

Promoters
RGD ID:6846049
Promoter ID:MM_KWN:62718
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_177429
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X162,878,221 - 162,879,617 (-)MPROMDB
RGD ID:13681838
Promoter ID:EPDNEW_M25068
Type:initiation region
Name:Ofd1_1
Description:Mus musculus OFD1, centriole and centriolar satellite protein, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X166,440,708 - 166,440,768EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1350328 AgrOrtholog
Ensembl Genes ENSMUSG00000040586 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000041744 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000049501 ENTREZGENE, UniProtKB/TrEMBL
InterPro LisH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:237222 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1350328 ENTREZGENE
NCBI Gene 237222 ENTREZGENE
Pfam LisH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ofd1 PhenoGen
PROSITE LISH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LisH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AEG2 ENTREZGENE, UniProtKB/TrEMBL
  OFD1_MOUSE UniProtKB/Swiss-Prot
  Q3URP3 ENTREZGENE, UniProtKB/TrEMBL
  Q80Z25 ENTREZGENE
  Q99JH6_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-21 Ofd1  OFD1, centriole and centriolar satellite protein    oral-facial-digital syndrome 1 gene homolog (human)  Symbol and/or name change 5135510 APPROVED