Glce (glucuronyl C5-epimerase) - Rat Genome Database

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Gene: Glce (glucuronyl C5-epimerase) Mus musculus
Analyze
Symbol: Glce
Name: glucuronyl C5-epimerase
RGD ID: 1557997
MGI Page MGI
Description: Enables racemase and epimerase activity, acting on carbohydrates and derivatives. Involved in heparan sulfate proteoglycan biosynthetic process and heparin biosynthetic process. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and integumental system. Orthologous to human GLCE (glucuronic acid epimerase); PARTICIPATES IN heparan sulfate biosynthetic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110017N23Rik; AI747411; C130034A12Rik; D-glucuronyl C5-epimerase; heparan sulfate C5-epimerase; heparan sulfate-glucuronic acid C5-epimerase; heparin sulfate C5-epimerase; heparin/heparan sulfate:glucuronic acid C5-epimerase; heparosan-N-sulfate-glucuronate 5-epimerase; Hs; Hsepi
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39961,964,526 - 62,029,891 (-)NCBIGRCm39mm39
GRCm39 Ensembl961,964,530 - 62,029,937 (-)Ensembl
GRCm38962,057,244 - 62,122,609 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl962,057,248 - 62,122,655 (-)EnsemblGRCm38mm10GRCm38
MGSCv37961,905,055 - 61,918,413 (-)NCBIGRCm37mm9NCBIm37
MGSCv36961,855,254 - 61,868,612 (-)NCBImm8
Celera959,282,349 - 59,295,707 (-)NCBICelera
Cytogenetic Map9BNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11274177   PMID:11279150   PMID:11687650   PMID:12477932   PMID:12788935   PMID:14610273   PMID:14681479   PMID:15292174   PMID:15368895  
PMID:15582152   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17289920   PMID:18799693   PMID:19336402   PMID:20118238   PMID:20208005   PMID:21267068   PMID:21471524   PMID:21873635  
PMID:26116392   PMID:28082324   PMID:30228991   PMID:30458230   PMID:30550785   PMID:32201365   PMID:32541003  


Genomics

Comparative Map Data
Glce
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39961,964,526 - 62,029,891 (-)NCBIGRCm39mm39
GRCm39 Ensembl961,964,530 - 62,029,937 (-)Ensembl
GRCm38962,057,244 - 62,122,609 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl962,057,248 - 62,122,655 (-)EnsemblGRCm38mm10GRCm38
MGSCv37961,905,055 - 61,918,413 (-)NCBIGRCm37mm9NCBIm37
MGSCv36961,855,254 - 61,868,612 (-)NCBImm8
Celera959,282,349 - 59,295,707 (-)NCBICelera
Cytogenetic Map9BNCBI
GLCE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1569,160,584 - 69,272,217 (+)EnsemblGRCh38hg38GRCh38
GRCh381569,160,555 - 69,272,209 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371569,452,974 - 69,564,546 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361567,240,027 - 67,351,598 (+)NCBINCBI36hg18NCBI36
Celera1546,342,293 - 46,453,794 (+)NCBI
Cytogenetic Map15q23NCBI
HuRef1546,285,927 - 46,397,426 (+)NCBIHuRef
CHM1_11569,571,150 - 69,682,613 (+)NCBICHM1_1
Glce
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2862,546,104 - 62,612,144 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl867,006,592 - 67,040,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0867,006,588 - 67,073,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0866,742,121 - 66,808,110 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4866,199,172 - 66,268,727 (-)NCBIRGSC3.4rn4RGSC3.4
Celera861,964,353 - 62,030,080 (-)NCBICelera
Cytogenetic Map8q24NCBI
Glce
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554507,149,721 - 7,227,524 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554507,149,721 - 7,226,835 (-)NCBIChiLan1.0ChiLan1.0
GLCE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11566,884,203 - 66,995,654 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1566,979,271 - 66,995,646 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01548,110,725 - 48,222,251 (+)NCBIMhudiblu_PPA_v0panPan3
GLCE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13033,093,318 - 33,208,754 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3033,110,947 - 33,206,095 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3033,026,823 - 33,141,852 (+)NCBI
ROS_Cfam_1.03033,292,160 - 33,407,357 (+)NCBI
UMICH_Zoey_3.13033,218,466 - 33,333,109 (+)NCBI
UNSW_CanFamBas_1.03033,280,176 - 33,394,763 (+)NCBI
UU_Cfam_GSD_1.03033,527,094 - 33,642,556 (+)NCBI
Glce
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640111,137,374 - 111,187,803 (+)NCBI
SpeTri2.0NW_00493647128,984,777 - 29,035,878 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLCE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1167,007,964 - 167,122,185 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11167,007,930 - 167,122,196 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21184,978,725 - 185,090,175 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLCE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12614,181,625 - 14,295,414 (-)NCBI
ChlSab1.1 Ensembl2614,184,606 - 14,295,372 (-)Ensembl
Vero_WHO_p1.0NW_023666048127,179,011 - 127,301,763 (+)NCBI
Glce
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247814,135,829 - 4,228,910 (-)NCBI

Position Markers
AI747411  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38962,057,426 - 62,057,554UniSTSGRCm38
MGSCv37961,905,233 - 61,905,361UniSTSGRCm37
Celera959,282,527 - 59,282,655UniSTS
Cytogenetic Map9C-DUniSTS
Whitehead/MRC_RH9608.36UniSTS
RH91714  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38962,057,285 - 62,057,412UniSTSGRCm38
MGSCv37961,905,092 - 61,905,219UniSTSGRCm37
Celera959,282,386 - 59,282,513UniSTS
Cytogenetic Map9C-DUniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208563Bmiq8_mbody mass index QTL 8 (mouse)92500000069000000Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92938163163381774Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92938163163381774Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93014186664141979Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93082861764828723Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93252326366523557Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93254112166541246Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93259987266600121Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93297840266978536Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93319972567199840Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93406754473531973Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93512317869123299Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93512317869123299Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93512317869123299Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93791224471912244Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93819229172192291Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93819229172192291Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93819229172192291Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93949260173492601Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94050829874700643Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94089776474897921Mouse
1301558Stheal8_msoft tissue heal 8 (mouse)Not determined94357343177573577Mouse
10045639Heal28_mwound healing/regeneration 28 (mouse)Not determined94357343177573577Mouse
1301435Trigq1_mtriglyceride QTL 1 (mouse)Not determined94452089278520980Mouse
4141572Ntta3_mneurotensin transcript abundance 3 (mouse)Not determined4668637365923895Mouse
1300716Cd4ts4_mCD4 T cell subset 4 (mouse)Not determined94892377482923895Mouse
1300563Pgia5_mproteoglycan induced arthritis 5 (mouse)Not determined94892377482923895Mouse
1301051Eae9_msusceptibility to experimental allergic encephalomyelitis 9 (mouse)Not determined94950899863332570Mouse
1301049El4_mepilepsy 4 (mouse)Not determined94950899867244166Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse
14746993Manh66_mmandible shape 66 (mouse)94990676683906766Mouse
1301184Bdln4_mbody length 4 (mouse)Not determined95024403884244166Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
13525008Hrtiq1_mheart rate time index, QTL 1 (mouse)95251479868648726Mouse
12790990Tgl7_mtriglyceride 7 (mouse)95465267888652678Mouse
10043877Adip21_madiposity 21 (mouse)Not determined95653182690531973Mouse
1301287Feml2_mfemur length in high growth mice 2 (mouse)Not determined95760000063300000Mouse
1301965Vmbic5_mventral midbrain iron content 5 (mouse)Not determined95768420965923895Mouse
1301549Bbaa9_mB.burgdorferi-associated arthritis 9 (mouse)Not determined95789776471574472Mouse
4141676Neogq1_mneonatal growth QTL 1 (mouse)Not determined95789776486239920Mouse
13525007Lfhrvq1_mlow frequency time index heart rate varaiblity, QTL 1 (mouse)95887703568648726Mouse
1301172Fembrs6_mfemur breaking strength 6 (mouse)Not determined95911710593117252Mouse
1301803Stheal9_msoft tissue heal 9 (mouse)Not determined95911710593117252Mouse
5491195Mobq8_mmultigenic obesity QTL 8 (mouse)Not determined95946266493462846Mouse
1300848Skull13_mskull morphology 13 (mouse)Not determined95946266493462846Mouse
1301456Adip5_madiposity 5 (mouse)Not determined95946266493462846Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1015
Count of miRNA genes:528
Interacting mature miRNAs:650
Transcripts:ENSMUST00000034785
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034785   ⟹   ENSMUSP00000034785
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl962,057,248 - 62,070,606 (-)Ensembl
RefSeq Acc Id: ENSMUST00000185510
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl962,080,320 - 62,122,609 (-)Ensembl
RefSeq Acc Id: ENSMUST00000185675   ⟹   ENSMUSP00000139949
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl962,057,248 - 62,122,610 (-)Ensembl
RefSeq Acc Id: ENSMUST00000185873   ⟹   ENSMUSP00000140671
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl962,070,468 - 62,122,655 (-)Ensembl
RefSeq Acc Id: ENSMUST00000186514
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl962,060,011 - 62,070,840 (-)Ensembl
RefSeq Acc Id: NM_001368304   ⟹   NP_001355233
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39961,964,526 - 62,029,891 (-)NCBI
GRCm38962,057,244 - 62,122,609 (-)NCBI
Sequence:
RefSeq Acc Id: NM_033320   ⟹   NP_201577
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39961,964,526 - 62,029,891 (-)NCBI
GRCm38962,057,244 - 62,122,609 (-)NCBI
MGSCv37961,905,055 - 61,918,413 (-)RGD
Celera959,282,349 - 59,295,707 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_160774
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39961,983,791 - 62,029,891 (-)NCBI
GRCm38962,076,509 - 62,122,609 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_201577   ⟸   NM_033320
- UniProtKB: Q9EPS3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001355233   ⟸   NM_001368304
RefSeq Acc Id: ENSMUSP00000034785   ⟸   ENSMUST00000034785
RefSeq Acc Id: ENSMUSP00000139949   ⟸   ENSMUST00000185675
RefSeq Acc Id: ENSMUSP00000140671   ⟸   ENSMUST00000185873
Protein Domains
C5-epim_C

Promoters
RGD ID:8669890
Promoter ID:EPDNEW_M12975
Type:single initiation site
Name:Glce_1
Description:Mus musculus glucuronyl C5-epimerase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38962,070,852 - 62,070,912EPDNEW
RGD ID:8669892
Promoter ID:EPDNEW_M12976
Type:initiation region
Name:AK043361_1
Description:n/a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38962,122,609 - 62,122,669EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2136405 AgrOrtholog
Ensembl Genes ENSMUSG00000032252 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034785 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000139949 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000140671 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034785 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000185675 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000185873 UniProtKB/TrEMBL
InterPro C5-epim UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C5-epimerase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:93683 UniProtKB/Swiss-Prot
MGD MGI:2136405 ENTREZGENE
NCBI Gene 93683 ENTREZGENE
PANTHER PTHR13174 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C5-epim_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Glce PhenoGen
UniProt A0A087WRK5_MOUSE UniProtKB/TrEMBL
  GLCE_MOUSE UniProtKB/Swiss-Prot
  Q69ZY0_MOUSE UniProtKB/TrEMBL
  Q9EPS3 ENTREZGENE
UniProt Secondary Q505E6 UniProtKB/Swiss-Prot
  Q99MM0 UniProtKB/Swiss-Prot