Hoxb4 (homeobox B4) - Rat Genome Database

Name: Hoxb4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Hoxb4 (homeobox B4) Mus musculus

Analyze

Symbol:

Hoxb4

Name:

homeobox B4

RGD ID:

1557963

MGI Page

MGI

Description:

Enables DNA binding activity. Acts upstream of or within several processes, including embryonic skeletal system morphogenesis; hematopoietic or lymphoid organ development; and hemopoiesis. Predicted to be located in centrosome. Predicted to be active in nucleoplasm. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; nervous system; and skin. Orthologous to human HOXB4 (homeobox B4).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

homeo box B4; homeobox protein Hox-2.6; homeobox protein Hox-B4; Hox-2.; Hox-2.6

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HOXB4 (homeobox B4)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Hoxb4 (homeo box B4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hoxb4 (homeobox B4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HOXB4 (homeobox B4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HOXB4 (homeobox B4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hoxb4 (homeobox B4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HOXB4 (homeobox B4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hoxb4 (homeobox B4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	HOXB4 (homeobox B4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Hoxb4 (homeo box B4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hoxb4a (homeobox B4a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	Dfd	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|PANTHER)
Caenorhabditis elegans (roundworm):	lin-39	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	hoxb4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	96,209,093 - 96,212,464 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	96,209,093 - 96,212,464 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	96,318,267 - 96,321,638 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	96,318,267 - 96,321,638 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	96,179,581 - 96,182,952 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	96,134,357 - 96,136,690 (+)	NCBI		MGSCv36	mm8
Celera	11	105,969,132 - 105,972,500 (+)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	59.83	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,4-benzoquinone (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

4-hydroxyphenyl retinamide (EXP)

5-aza-2'-deoxycytidine (ISO)

acetaldehyde (EXP)

acetamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP,ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

carbamazepine (EXP)

chlorpyrifos (EXP)

cyproconazole (EXP)

cytarabine (ISO)

dimethylselenide (ISO)

furan (ISO)

gentamycin (ISO)

hexaconazole (EXP)

inulin (EXP)

lipopolysaccharide (ISO)

mercury atom (ISO)

mercury(0) (ISO)

methylmercury chloride (EXP,ISO)

mono(2-ethylhexyl) phthalate (EXP)

ozone (EXP)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (EXP)

phenobarbital (EXP)

reactive oxygen species (ISO)

sodium arsenite (EXP,ISO)

trichloroethene (ISO)

trichostatin A (ISO)

triclosan (ISO)

valproic acid (EXP,ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior/posterior pattern specification (IBA,IGI)

bone marrow development (IMP)

definitive hemopoiesis (IGI)

embryonic skeletal system morphogenesis (IBA,IGI)

hematopoietic stem cell differentiation (ISO)

hematopoietic stem cell proliferation (IMP)

hemopoiesis (IMP)

morphogenesis of an epithelial sheet (IGI)

negative regulation of transcription by RNA polymerase II (IDA)

positive regulation of stem cell differentiation (ISO)

positive regulation of transcription by RNA polymerase II (IBA,ISO)

regulation of DNA-templated transcription (IEA)

skeletal system morphogenesis (IGI,IMP)

somatic stem cell division (IDA)

spleen development (IMP)

Cellular Component

centrosome (ISO)

nucleoplasm (IBA,ISO,TAS)

nucleus (IEA)

Molecular Function

DNA binding (IDA)

DNA-binding transcription factor activity (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

sequence-specific double-stranded DNA binding (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal abdominal wall morphology (IAGP)

abnormal body wall morphology (IAGP)

abnormal cervical axis morphology (IAGP)

abnormal cervical vertebrae morphology (IAGP)

abnormal chest morphology (IAGP)

abnormal definitive hematopoiesis (IAGP)

abnormal heart morphology (IAGP)

abnormal heart position or orientation (IAGP)

abnormal sternebra morphology (IAGP)

abnormal sternum morphology (IAGP)

abnormal ventral body wall morphology (IAGP)

absent pericardium (IAGP)

cervical vertebral fusion (IAGP)

cervical vertebral transformation (IAGP)

decreased body size (IAGP)

decreased bone marrow cell number (IAGP)

decreased erythrocyte cell number (IAGP)

decreased hemoglobin content (IAGP)

decreased survivor rate (IAGP)

diaphragmatic hernia (IAGP)

dilated heart ventricle (IAGP)

edema (IAGP)

fusion of vertebral arches (IAGP)

neonatal lethality, complete penetrance (IAGP)

neonatal lethality, incomplete penetrance (IAGP)

no abnormal phenotype detected (IAGP)

pallor (IAGP)

postnatal lethality, complete penetrance (IAGP)

postnatal lethality, incomplete penetrance (IAGP)

prenatal lethality, incomplete penetrance (IAGP)

respiratory distress (IAGP)

spleen hypoplasia (IAGP)

split sternum (IAGP)

thin interventricular septum (IAGP)

thin ventricular wall (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Sequence and embryonic expression of the murine Hox-3.5 gene.	Geada AM, etal., Development 1992 Oct;116(2):497-506.
2.	MGDs mouse GO annotations	MGD data from the GO Consortium
3.	MGD IEA	MGD IEA
4.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:1358459	PMID:1363087	PMID:1582411	PMID:1682218	PMID:1682814	PMID:1683707	PMID:1685115	PMID:1685117	PMID:1972280	PMID:2463210	PMID:2566383	PMID:2571936
PMID:2576400	PMID:2890503	PMID:2906328	PMID:7628700	PMID:7680626	PMID:7750651	PMID:7768176	PMID:7903957	PMID:7911971	PMID:7969151	PMID:8097432	PMID:8100767
PMID:8105001	PMID:8555112	PMID:8625838	PMID:8649375	PMID:8660891	PMID:8703472	PMID:9012503	PMID:9106661	PMID:9334279	PMID:9367423	PMID:9415485	PMID:9501100
PMID:9639506	PMID:9790191	PMID:9806826	PMID:10208743	PMID:10349636	PMID:10373014	PMID:10395784	PMID:10529422	PMID:10559481	PMID:10579975	PMID:10885747	PMID:11042159
PMID:11044623	PMID:11076861	PMID:11085749	PMID:11091084	PMID:11217851	PMID:11335109	PMID:11518511	PMID:11869294	PMID:11955444	PMID:12135926	PMID:12183370	PMID:12370779
PMID:12466851	PMID:12477932	PMID:12514132	PMID:12701106	PMID:12705858	PMID:12714971	PMID:12717450	PMID:12736215	PMID:12748289	PMID:12753872	PMID:12791656	PMID:12855555
PMID:12954718	PMID:14660544	PMID:14681479	PMID:14962901	PMID:15042701	PMID:15206819	PMID:15361871	PMID:15489334	PMID:15580301	PMID:15618518	PMID:15634700	PMID:15741318
PMID:15944185	PMID:16024804	PMID:16093308	PMID:16141072	PMID:16141073	PMID:16339407	PMID:16364898	PMID:16399080	PMID:16508307	PMID:16624538	PMID:16888613	PMID:16971476
PMID:17107999	PMID:17303828	PMID:17537796	PMID:17761289	PMID:17940039	PMID:18287559	PMID:18547144	PMID:18553509	PMID:18679416	PMID:18794329	PMID:18808325	PMID:18952892
PMID:19022763	PMID:19091803	PMID:19168678	PMID:19204410	PMID:19270262	PMID:19328777	PMID:19365557	PMID:19379700	PMID:19420357	PMID:19704006	PMID:19737517	PMID:19828634
PMID:19922872	PMID:20059953	PMID:20184433	PMID:20184720	PMID:20211142	PMID:20417598	PMID:20711984	PMID:21059868	PMID:21098278	PMID:21267068	PMID:21278354	PMID:21343615
PMID:21873635	PMID:22084016	PMID:22426104	PMID:22675207	PMID:22701719	PMID:22872086	PMID:23207902	PMID:23307742	PMID:23843306	PMID:24030384	PMID:24324706	PMID:24446131
PMID:24496623	PMID:24503485	PMID:24525295	PMID:24574009	PMID:24952961	PMID:25082879	PMID:25381007	PMID:25922517	PMID:26238476	PMID:26930384	PMID:27827825	PMID:28009288
PMID:28041967	PMID:28188179	PMID:29031500	PMID:29408805	PMID:29444422	PMID:29456178	PMID:30254164	PMID:30470704	PMID:32325033	PMID:32479258	PMID:32553152	PMID:32795499
PMID:33257809	PMID:33277484	PMID:35857513	PMID:35988542	PMID:36007540	PMID:36563692	PMID:37102683	PMID:37167859	PMID:38110169

Genomics

Comparative Map Data

Hoxb4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	96,209,093 - 96,212,464 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	96,209,093 - 96,212,464 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	96,318,267 - 96,321,638 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	96,318,267 - 96,321,638 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	96,179,581 - 96,182,952 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	96,134,357 - 96,136,690 (+)	NCBI		MGSCv36	mm8
Celera	11	105,969,132 - 105,972,500 (+)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	59.83	NCBI

HOXB4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	48,575,507 - 48,578,350 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	48,575,507 - 48,578,350 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	46,652,869 - 46,655,712 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	44,007,868 - 44,010,742 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	44,007,874 - 44,010,742	NCBI
Celera	17	43,107,022 - 43,109,896 (-)	NCBI		Celera
Cytogenetic Map	17	q21.32	NCBI
HuRef	17	42,021,675 - 42,024,550 (-)	NCBI		HuRef
CHM1_1	17	46,718,833 - 46,721,707 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	49,439,096 - 49,441,939 (-)	NCBI		T2T-CHM13v2.0

Hoxb4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	81,781,090 - 81,783,672 (+)	NCBI		GRCr8
mRatBN7.2	10	81,284,552 - 81,287,134 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	81,284,552 - 81,287,128 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	86,233,537 - 86,236,119 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	85,731,572 - 85,734,154 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	81,124,054 - 81,126,636 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	84,167,331 - 84,169,913 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	84,167,331 - 84,169,907 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	83,970,063 - 83,972,645 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	85,050,695 - 85,053,277 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	80,050,714 - 80,053,296 (+)	NCBI		Celera
Cytogenetic Map	10	q26	NCBI

Hoxb4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	12,662,795 - 12,664,374 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	12,661,290 - 12,665,576 (+)	NCBI	ChiLan1.0	ChiLan1.0

HOXB4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	16,524,195 - 16,527,180 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	18,489,928 - 18,492,774 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	8,958,253 - 8,961,261 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	9,143,173 - 9,146,161 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	9,143,173 - 9,146,161 (+)	Ensembl	panpan1.1		panPan2

HOXB4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	24,837,572 - 24,848,600 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	24,837,914 - 24,840,648 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	24,302,844 - 24,304,749 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	25,633,366 - 25,635,275 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	25,633,230 - 25,635,059 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	24,401,529 - 24,403,435 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	24,662,133 - 24,664,032 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	24,790,347 - 24,792,253 (-)	NCBI		UU_Cfam_GSD_1.0

Hoxb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	24,263,448 - 24,266,538 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	12,808,679 - 12,811,688 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936490	12,808,679 - 12,811,688 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HOXB4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	68,988,621 - 68,991,574 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	68,989,862 - 68,991,455 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	40,038,230 - 40,047,213 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hoxb4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	5,073,119 - 5,078,419 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	5,074,147 - 5,077,714 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Hoxb4
133 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	412
Count of miRNA genes:	327
Interacting mature miRNAs:	347
Transcripts:	ENSMUST00000049241
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
39128214	Lwq20_m	liver weight QTL 20 (mouse)					11	12268637	118022724	Mouse
4141894	Nidd6k_m	Nidd6 on KK-A (mouse)			Not determined			19124204	96897826	Mouse
4141367	Inf1_m	acute ozone induced inflammation (mouse)			Not determined			44630038	113058009	Mouse
4142121	Tmc1m2_m	Tmc1 modifier 2 (mouse)			Not determined		11	56864027	114157957	Mouse
27226730	Tibmd1_m	tibia midshaft diameter 1, 5 week (mouse)					11	62590826	109390826	Mouse
11039502	Ltpr6b_m	Leishmania tropica response 6b (mouse)					11	64830336	98830473	Mouse
11039501	Ltpr6a_m	Leishmania tropica response 6a (mouse)					11	64830336	98830473	Mouse
11039515	Ltpr6_m	Leishmania tropica response 6 (mouse)					11	64830336	98830473	Mouse
1357766	Si5lq6_m	serum IGFBP-5 level QTL 6 (mouse)			Not determined		11	66733420	100733652	Mouse
1301546	Pcir2_m	periosteal circumference 2 (mouse)			Not determined		11	66733420	100733652	Mouse
1301833	Tbbmd5_m	total body bone mineral density 5 (mouse)			Not determined		11	66733420	100733652	Mouse
1300628	Lgth6_m	body length 6 (mouse)			Not determined		11	66733420	100733652	Mouse
4141012	Femwf6_m	femur work to failure 6 (mouse)			Not determined			66733420	100733652	Mouse
1300784	Prdt3_m	prion disease incubation time 3 (mouse)			Not determined		11	66733420	100733652	Mouse
27226783	Tibl5_m	tibia length 5, 5 week (mouse)					11	68190826	101890826	Mouse
1558812	Rafar_m	retinoic acid induced forelimb autopod reduction (mouse)			Not determined		11	70691198	104691366	Mouse
1301681	Sle13_m	systematic lupus erythematosus susceptibility 13 (mouse)			Not determined		11	70691198	104691366	Mouse
1300651	Pcyts3_m	plasmacytoma susceptibility 3 (mouse)			Not determined		11	70691198	104691366	Mouse
4141339	Nilac2_m	nicotine induced locomotor activity 2 (mouse)			Not determined		11	70691198	104691366	Mouse
1301404	Sbmd4_m	spinal bone mineral density 4 (mouse)			Not determined		11	72019649	106019734	Mouse
1301310	Tmevd5_m	Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)			Not determined		11	72726125	106726289	Mouse
4142348	Pstc2_m	periosteal circumference 2 (mouse)			Not determined		11	72818615	106818733	Mouse
10043866	Adip19_m	adiposity 19 (mouse)			Not determined		11	72818615	106818733	Mouse
11038695	Par8_m	pulmonary adenoma resistance 8 (mouse)					11	77063779	111063918	Mouse
1301414	Heal10_m	wound healing/regeneration 10 (mouse)			Not determined		11	77437183	111437322	Mouse
10045616	Heal25_m	wound healing/regeneration 25 (mouse)			Not determined		11	77437183	111437322	Mouse
1302124	Eae7_m	susceptibility to experimental allergic encephalomyelitis 7 (mouse)			Not determined		11	77573873	99377820	Mouse
10413882	Moe1_m	modifier of epilepsy 1 (mouse)					11	77770978	111771099	Mouse
1301640	Lore4_m	loss of righting induced by ethanol 4 (mouse)			Not determined		11	79156009	107616472	Mouse
14746970	Manh71_m	mandible shape 71 (mouse)					11	79416257	113416257	Mouse
10043865	T2dm5sa_m	type 2 diabetes mellitus 5 in SMXA RI mice (mouse)			Not determined		11	79813759	104502698	Mouse
27226758	Femd3_m	femur midshaft diameter 3, 5 week (mouse)					11	80890826	101890826	Mouse
1300649	Crhq1_m	compensatory renal hypertrophy QTL 1 (mouse)			Not determined		11	81574481	115574636	Mouse
1300766	Skull16_m	skull morphology 16 (mouse)			Not determined		11	81574481	115574636	Mouse
10412288	Carg4_m	Candida albicans resistance gene 4 (mouse)			Not determined		11	81810267	115810267	Mouse
1301072	Eae22_m	experimental allergic encephalomyelitis 22 (mouse)			Not determined		11	82377698	116377820	Mouse
15092049	Wsigrme3_m	week six growth rate, maternal effect 3 (mouse)					11	84877324	96629512	Mouse
15092057	Lgrme3_m	late growth rate, maternal effect 3 (mouse)					11	84877324	96629512	Mouse
14747003	Mancz9_m	mandible centroid size 9 (mouse)					11	85844911	119844911	Mouse
15039374	Adip29_m	adiposity 29 (mouse)					11	86608320	120608320	Mouse
15039376	Bw42_m	body weight QTL 42 (mouse)					11	86608320	120608320	Mouse
15014785	Mvlq1_m	macrovesicular liver lesion QTL 1 (mouse)					11	86608320	120608320	Mouse
27226789	Feml16_m	femur length 16, 10 week (mouse)					11	87490826	121873369	Mouse
10044007	Hbnr14_m	Heligmosomoides bakeri nematode resistance 14 (mouse)			Not determined		11	87502600	121502698	Mouse
1357631	Motr1_m	modifier of tubby retinal degeneration 1 (mouse)			Not determined		11	87691198	103274115	Mouse
1301491	Abbp4_m	A/J and C57BL/6 blood pressure 4 (mouse)			Not determined		11	88699588	99081597	Mouse
11251723	Ewc5_m	ethanol withdrawal and consumption 5 (mouse)					11	89869251	121973369	Mouse
13524529	Bodwtq10_m	body wweight QTL 10 (mouse)					11	90679512	97699512	Mouse
1558753	Ath19_m	atherosclerosis 19 (mouse)			Not determined		11	91604608	121973369	Mouse
1302034	Pkccl_m	protein kinase C content in lungs (mouse)			Not determined		11	91604608	121973369	Mouse
10045617	Heal26_m	wound healing/regeneration 26 (mouse)			Not determined		11	92939373	112544554	Mouse
1301095	El6_m	epilepsy 6 (mouse)			Not determined		11	93229183	121973369	Mouse
4141939	Pregq2_m	pregnancy QTL 2 (mouse)			Not determined		11	94063779	118022724	Mouse
27226731	Tibmd4_m	tibia midshaft diameter 4, 10 week (mouse)					11	94190826	118890826	Mouse
4141465	Dbm2_m	diabetes modifier 2 (mouse)			Not determined			94437183	118022724	Mouse
1301958	Alcp18_m	alcohol preference locus 18 (mouse)			Not determined		11	95403965	121973369	Mouse
1300944	Alcp20_m	alcohol preference locus 20 (mouse)			Not determined		11	95403965	121973369	Mouse
14700796	Syncq9_m	synovial calcification QTL 9 (mouse)					11	95937826	96992826	Mouse
1300962	Cd8mts4_m	CD8 memory T cell subset 4 (mouse)			Not determined		11	96137674	121973369	Mouse
1301535	Pas5b_m	pulmonary adenoma susceptibility 5b (mouse)			Not determined		11	96176465	108806384	Mouse

Markers in Region

PMC155209P2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	11	96,317,253 - 96,317,662	UniSTS	GRCm38
MGSCv37	11	96,178,567 - 96,178,976	UniSTS	GRCm37
Celera	11	105,968,118 - 105,968,527	UniSTS
Cytogenetic Map	11	D	UniSTS
cM Map	11	56.05	UniSTS

PMC155209P3

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	11	96,320,642 - 96,321,040	UniSTS	GRCm38
MGSCv37	11	96,181,956 - 96,182,354	UniSTS	GRCm37
Celera	11	105,971,507 - 105,971,905	UniSTS
Cytogenetic Map	11	D	UniSTS
cM Map	11	56.05	UniSTS

G38056

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	11	96,316,652 - 96,316,850	UniSTS	GRCm38
MGSCv37	11	96,177,966 - 96,178,164	UniSTS	GRCm37
Celera	11	105,967,517 - 105,967,715	UniSTS
Cytogenetic Map	11	D	UniSTS
cM Map	11	56.05	UniSTS

Hoxb4

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	11	D	UniSTS
cM Map	11	59.83	UniSTS

Hoxb4

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	11	D	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_010459	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AK133945	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL606824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC095947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466556	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M18342	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M36654	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X71912	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000049241 ⟹ ENSMUSP00000048002

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	11	96,209,093 - 96,212,464 (+)	Ensembl
GRCm38.p6 Ensembl	11	96,318,267 - 96,321,638 (+)	Ensembl

RefSeq Acc Id:

NM_010459 ⟹ NP_034589

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	11	96,209,093 - 96,212,464 (+)	NCBI
GRCm38	11	96,318,267 - 96,321,638 (+)	ENTREZGENE
MGSCv37	11	96,179,581 - 96,182,952 (+)	RGD
Celera	11	105,969,132 - 105,972,500 (+)	RGD
cM Map	11		ENTREZGENE

Sequence:

show sequence

AGCTCCCTCTTATCCTGGGGAGGAGATGGGGCCCTATGGGAGTCAGAGAAAGGTTGGTGGAGAT
TAGGTAGGGCAGGGGTGGGGGCTACACCCGCAGCCCCAACTTCTGAGGGATGCAGGGTTTGTGC
TCTGCCCAGCCCCCTCACCCCCAAACAGGCCCTCCAATTAACCTGCTCACTCTTTCTTAGTTCA
TCACCCCTCTCTGTTGTGGAGAAAGCCAGGCGAGGAGGGGGTCTCCCCGCGGGAGCCCTATGTA
AATCCTGGTGTTGGGTGGGTGGGGAGGGGTAGAGAAGGGGAAATAAACCTCTTTGGCTGGAGTA
GGGTCCGGGTGAGCAGATTTCCTTATCCGGGAATCGCAGGCCGGGTGGCCATTGGCTCGGAGGA
TCACGTGGGCCTCTAACTTTGTTCACTTGACAGTAAGTAGGAGGGCTTTCGGAAACAGGAAAAC
GAGTCAGGGGTCGGAATAAATTTTAGTATATTTTGTGGGCAATTCCCAGAAATTAATGGCTATG
AGTTCCTTTTTGATCAACTCAAACTATGTCGACCCCAAGTTCCCTCCGTGCGAGGAGTATTCAC
AGAGCGATTACCTACCCAGCGACCACTCGCCCGGGTACTACGCCGGCGGCCAGAGGCGAGAGAG
CGGCTTCCAGCCGGAGGCGGCCTTTGGGCGCCGGGCGCCGTGCACTGTGCAGCGCTACGCGGCC
TGCCGAGACCCCGGGCCCCCGCCACCTCCGCCGCCCCCGCCGCCCCCGCCACCGCCCGGGCTGT
CCCCTCGGGCTCCAGTGCAGCCAACAGCCGGGGCCCTCCTCCCGGAGCCCGGGCAGCGCAGCGA
GGCGGTCAGCAGCAGCCCCCCGCCGCCTCCCTGCGCCCAGAACCCCCTGCATCCCAGCCCGTCC
CACTCCGCGTGCAAAGAGCCCGTCGTCTACCCCTGGATGCGCAAAGTTCACGTGAGCACGGTAA
ACCCCAATTACGCCGGCGGGGAGCCCAAGCGCTCTCGGACCGCCTACACTCGCCAGCAGGTCCT
GGAGTTGGAGAAGGAGTTTCACTACAATCGCTACCTGACGCGCCGCCGGAGGGTGGAGATCGCC
CACGCGCTCTGCCTGTCCGAGCGCCAGATCAAGATCTGGTTCCAGAATCGGCGCATGAAGTGGA
AAAAAGACCACAAGTTGCCCAACACCAAGATCCGCTCGGGTGGCACCGCGGGCGCAGCCGGAGG
CCCCCCTGGCCGGCCCAACGGAGGCCCCCCTGCGCTCTAGTGCCCCCCAAGCAGGAGTTCGAAC
ATGGGGGGGTGGGGGGAACAGCGAGCACCGAAGGGGGTGCGGGGTATGGGAGGGTCCCCGGGCT
TGAGCCCAGAAAAAATCTATCTACCCTACCCTCACTTTATCTATAAGGAATAAACACAGAGAAG
GGGGGTAGGGAAGCCTTATTTATAGAAAGGACAATAAGGGAGCCGGGTAAAGTCCTTCGGAGAC
AAGATTCGAGTCTCTTGCTTTCTTCCTTTAAAAAAAAAAAAGAAAGAAAGAAAGAAGGAAAGAA
AGAGAGAGAGAGAAAAGAAAAAGAAGAAAGGAAGGAAGCAAGAAAAGGAGGAAGAAAGGAAAAG
ACAGAAGAGAAATGGAGGAGTCTGCTGCGCCTGGTTTTCAGCTTTGGTGAAGATGGATCCAGGC
TTCATCTTTAATCACGCCAGGCCCGGGCCCATCTGTCTTGTTTACTCTGCCGAGGAGAAGACGG
GCGAGCGAGCTTCGGTGGCGACCATTACCTCGACACTTGGCTAACAAATGAGGCCAGGCTCGGC
CGCTGCCGCCGCCTCTGCTGCTGTCGCTGCTGGATCACAGCCTGGATTTTTCTTTCTTTGTCCC
CTACTCCTGACACCCAGCGAATGCACCCTCAGACTGCCAGATAGCACAGTGTTTTGGCCACGGT
AACAAACACACACACATATAACTTTCCTCCCTGTCTGTACCCACTTTGGGGTGGGGGTGGGTGG
GAAGACTGCTCACTCCCTTCCACCATAGACTTAGAAGGGGGAACAGAAGGGAATTGAAGGGCAG
TCTGCACAACGTGGGTTCCCAAATCCGAGCCCAAGAAATAAATGAAAATGAAAAAAGAAAGGTA
GCAATTGGGACACCCAAGAAGGCCTTCTGCTAGAAGGTCCAGCTAGGCCTGGCAGGGTGAGGGG
CAGTTGAGTTCTGGGAGCTGGGAATGTCTTCTGGGCAGTTCACAGTAGTAGAGTCAAGGCCTTC
TCTTAGGTTACAAATGAATGTGAAATTAGGAAATAAAATACTGTGGCCCTCCTACTCTGGAAGG
ACAATGTTGCAGAACCCTCTCCCGTTGTTATCATTGTTGCATCGTTTATTATTATTATTATTAT
TATTATTATTATTATTATTATTATTATTATTATTTTATGTCATGTGTGTCCTCTCTCCTGTTCT
CTTTCTGACATTCCAAAACCAGGCCCCTTCCTACCTCTGGGGCTGCCTGAGCCTAGAACCTTTT
GTTGGTGTGAAAATTTGTGTCCTGTACAGAGTGACAACAGAAATAAATGTTTGGTTTCTTGTGA
CCATCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_034589	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA37848	(Get FASTA)	NCBI Sequence Viewer
	AAA75162	(Get FASTA)	NCBI Sequence Viewer
	AAH95947	(Get FASTA)	NCBI Sequence Viewer
	BAE21943	(Get FASTA)	NCBI Sequence Viewer
	CAA50727	(Get FASTA)	NCBI Sequence Viewer
	EDL16028	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000048002
	ENSMUSP00000048002.8
GenBank Protein	P10284	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_034589 ⟸ NM_010459

- UniProtKB:

Q3UZB4 (UniProtKB/Swiss-Prot), Q4VBG0 (UniProtKB/Swiss-Prot), P10284 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAMSSFLINSNYVDPKFPPCEEYSQSDYLPSDHSPGYYAGGQRRESGFQPEAAFGRRAPCTVQR
YAACRDPGPPPPPPPPPPPPPPGLSPRAPVQPTAGALLPEPGQRSEAVSSSPPPPPCAQNPLHP
SPSHSACKEPVVYPWMRKVHVSTVNPNYAGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRV
EIAHALCLSERQIKIWFQNRRMKWKKDHKLPNTKIRSGGTAGAAGGPPGRPNGGPPAL

hide sequence

RefSeq Acc Id:

ENSMUSP00000048002 ⟸ ENSMUST00000049241

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P10284-F1-model_v2	AlphaFold	P10284	1-250	view protein structure

Promoters

RGD ID:

6821076

Promoter ID:

MM_KWN:9399

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day4, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Kidney, Lung

Transcripts:

OTTMUST00000003562

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	11	96,179,356 - 96,180,327 (+)	MPROMDB

RGD ID:

8676338

Promoter ID:

EPDNEW_M16200

Type:

initiation region

Name:

Hoxb4_1

Description:

Mus musculus homeobox B4 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M16201

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	11	96,318,317 - 96,318,377	EPDNEW

RGD ID:

8676340

Promoter ID:

EPDNEW_M16201

Type:

initiation region

Name:

Hoxb4_2

Description:

Mus musculus homeobox B4 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M16200

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	11	96,318,739 - 96,318,799	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:96185	AgrOrtholog
Ensembl Genes	ENSMUSG00000038692	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000049241	ENTREZGENE
	ENSMUST00000049241.9	UniProtKB/Swiss-Prot
Gene3D-CATH	Homeodomain-like	UniProtKB/Swiss-Prot
InterPro	Homeobox-like_sf	UniProtKB/Swiss-Prot
	Homeobox_antennapedia	UniProtKB/Swiss-Prot
	Homeobox_Antennapedia_CS	UniProtKB/Swiss-Prot
	Homeobox_CS	UniProtKB/Swiss-Prot
	Homeobox_dom	UniProtKB/Swiss-Prot
	Homeobox_metazoa	UniProtKB/Swiss-Prot
KEGG Report	mmu:15412	UniProtKB/Swiss-Prot
MGD	MGI:96185	ENTREZGENE
NCBI Gene	15412	ENTREZGENE
PANTHER	HOMEOBOX PROTEIN HOX-B4	UniProtKB/Swiss-Prot
	HOMEOTIC PROTEIN DEFORMED	UniProtKB/Swiss-Prot
Pfam	Homeodomain	UniProtKB/Swiss-Prot
PhenoGen	Hoxb4	PhenoGen
PRINTS	ANTENNAPEDIA	UniProtKB/Swiss-Prot
	HOMEOBOX	UniProtKB/Swiss-Prot
PROSITE	ANTENNAPEDIA	UniProtKB/Swiss-Prot
	HOMEOBOX_1	UniProtKB/Swiss-Prot
	HOMEOBOX_2	UniProtKB/Swiss-Prot
SMART	HOX	UniProtKB/Swiss-Prot
Superfamily-SCOP	Formin homology 2 domain (FH2 domain)	UniProtKB/Swiss-Prot
	SSF46689	UniProtKB/Swiss-Prot
UniProt	HXB4_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
	Q3UZB4	ENTREZGENE
	Q4VBG0	ENTREZGENE
UniProt Secondary	Q3UZB4	UniProtKB/Swiss-Prot
	Q4VBG0	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Mammalian Phenotype