Kbtbd12 (kelch repeat and BTB (POZ) domain containing 12) - Rat Genome Database
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Gene: Kbtbd12 (kelch repeat and BTB (POZ) domain containing 12) Mus musculus
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Symbol: Kbtbd12
Name: kelch repeat and BTB (POZ) domain containing 12
RGD ID: 1557941
MGI Page MGI
Description: Is expressed in brain. Orthologous to human KBTBD12 (kelch repeat and BTB domain containing 12); INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4833415F11Rik; 4933428M03Rik; kelch domain containing 6; kelch domain-containing protein 6; kelch repeat and BTB domain-containing protein 12; Klhdc; Klhdc6; riken cdna 4933428m03 gene
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39688,521,931 - 88,604,636 (-)NCBIGRCm39mm39
GRCm39 Ensembl688,522,096 - 88,614,932 (-)Ensembl
GRCm38688,545,079 - 88,627,691 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl688,545,114 - 88,637,950 (-)EnsemblGRCm38mm10GRCm38
MGSCv37688,563,745 - 88,577,439 (-)NCBIGRCm37mm9NCBIm37
MGSCv36688,583,077 - 88,593,086 (-)NCBImm8
Celera690,551,268 - 90,564,956 (-)NCBICelera
Cytogenetic Map6D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
amenorrhea  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:18799693   PMID:21873635  


Genomics

Comparative Map Data
Kbtbd12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39688,521,931 - 88,604,636 (-)NCBIGRCm39mm39
GRCm39 Ensembl688,522,096 - 88,614,932 (-)Ensembl
GRCm38688,545,079 - 88,627,691 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl688,545,114 - 88,637,950 (-)EnsemblGRCm38mm10GRCm38
MGSCv37688,563,745 - 88,577,439 (-)NCBIGRCm37mm9NCBIm37
MGSCv36688,583,077 - 88,593,086 (-)NCBImm8
Celera690,551,268 - 90,564,956 (-)NCBICelera
Cytogenetic Map6D1NCBI
KBTBD12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3127,915,232 - 127,987,671 (+)EnsemblGRCh38hg38GRCh38
GRCh383127,915,232 - 127,987,677 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373127,634,075 - 127,706,520 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363129,124,592 - 129,189,204 (+)NCBINCBI36hg18NCBI36
Celera3126,071,864 - 126,136,471 (+)NCBI
Cytogenetic Map3q21.3NCBI
HuRef3125,022,230 - 125,086,838 (+)NCBIHuRef
CHM1_13127,605,168 - 127,669,755 (+)NCBICHM1_1
Kbtbd12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24121,014,636 - 121,088,701 (-)NCBI
Rnor_6.0 Ensembl4120,551,599 - 120,559,078 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04120,492,541 - 120,567,755 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04185,734,266 - 185,800,067 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44122,641,116 - 122,709,295 (-)NCBIRGSC3.4rn4RGSC3.4
Celera4109,968,801 - 110,042,733 (-)NCBICelera
Cytogenetic Map4q34NCBI
Kbtbd12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542915,698,881 - 15,760,645 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542915,698,544 - 15,760,071 (-)NCBIChiLan1.0ChiLan1.0
KBTBD12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13132,271,212 - 132,336,005 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3132,271,194 - 132,336,005 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03124,953,061 - 125,029,289 (+)NCBIMhudiblu_PPA_v0panPan3
KBTBD12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl201,964,607 - 2,032,036 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1201,955,638 - 2,034,355 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Kbtbd12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936798598,027 - 618,672 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KBTBD12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1372,299,098 - 72,365,512 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11372,299,096 - 72,365,575 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21379,780,522 - 79,846,875 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KBTBD12
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12253,058,678 - 53,128,987 (-)NCBI
ChlSab1.1 Ensembl2253,062,102 - 53,128,978 (-)Ensembl
Kbtbd12
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624974263,569 - 317,211 (+)NCBI

Position Markers
Klhdc6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
cM Map6 UniSTS
Kbtbd12  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:721
Count of miRNA genes:402
Interacting mature miRNAs:458
Transcripts:ENSMUST00000038804, ENSMUST00000120933, ENSMUST00000169512, ENSMUST00000184591, ENSMUST00000184664, ENSMUST00000184743, ENSMUST00000184878
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000038804
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl688,617,436 - 88,627,445 (-)Ensembl
RefSeq Acc Id: ENSMUST00000120933   ⟹   ENSMUSP00000112581
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl688,545,114 - 88,627,442 (-)Ensembl
RefSeq Acc Id: ENSMUST00000184591
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl688,613,751 - 88,627,448 (-)Ensembl
RefSeq Acc Id: ENSMUST00000184664   ⟹   ENSMUSP00000139069
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl688,618,617 - 88,637,950 (-)Ensembl
RefSeq Acc Id: ENSMUST00000184743
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl688,586,526 - 88,590,659 (-)Ensembl
RefSeq Acc Id: ENSMUST00000184878   ⟹   ENSMUSP00000139333
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl688,545,120 - 88,618,501 (-)Ensembl
RefSeq Acc Id: ENSMUST00000203223
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl688,614,030 - 88,618,522 (-)Ensembl
RefSeq Acc Id: NM_001278671   ⟹   NP_001265600
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39688,522,099 - 88,604,411 (-)NCBI
GRCm38688,545,117 - 88,627,429 (-)NCBI
Celera690,489,389 - 90,564,959 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030255648   ⟹   XP_030111508
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39688,521,931 - 88,604,635 (-)NCBI
GRCm38688,545,079 - 88,627,691 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036152374   ⟹   XP_036008267
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39688,550,453 - 88,604,636 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001265600   ⟸   NM_001278671
- UniProtKB: Q9D618 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030111508   ⟸   XM_030255648
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000139333   ⟸   ENSMUST00000184878
RefSeq Acc Id: ENSMUSP00000139069   ⟸   ENSMUST00000184664
RefSeq Acc Id: ENSMUSP00000112581   ⟸   ENSMUST00000120933
RefSeq Acc Id: XP_036008267   ⟸   XM_036152374
- Peptide Label: isoform X1
Protein Domains
BACK   BTB

Promoters
RGD ID:6839555
Promoter ID:MM_KWN:46824
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   Brain,   ES_Cell
Transcripts:ENSMUST00000120933,   NM_001142724,   NM_029013
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36688,577,271 - 88,577,771 (-)MPROMDB
RGD ID:6890376
Promoter ID:EPDNEW_M8639
Type:multiple initiation site
Name:Kbtbd12_1
Description:Mus musculus kelch repeat and BTB domain containing 12 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38688,627,429 - 88,627,489EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1918481 AgrOrtholog
Ensembl Genes ENSMUSG00000033182 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000112581 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000139069 UniProtKB/TrEMBL
  ENSMUSP00000139333 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000120933 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000184664 UniProtKB/TrEMBL
  ENSMUST00000184878 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB-kelch_protein UniProtKB/Swiss-Prot
  BTB/POZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:74589 UniProtKB/Swiss-Prot
MGD MGI:1918481 ENTREZGENE
NCBI Gene 74589 ENTREZGENE
Pfam BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kbtbd12 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/Swiss-Prot
PROSITE BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BACK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kelch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RT73_MOUSE UniProtKB/TrEMBL
  KBTBC_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  V9GXB1_MOUSE UniProtKB/TrEMBL
  V9GXV2_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9QJU5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Kbtbd12  kelch repeat and BTB (POZ) domain containing 12  Klhdc6  kelch domain containing 6  Symbol and/or name change 5135510 APPROVED