Mageb5 (MAGE family member B5) - Rat Genome Database

Name: Mageb5
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Mageb5 (MAGE family member B5) Mus musculus

Analyze

Symbol:

Mageb5

Name:

MAGE family member B5

RGD ID:

1557903

MGI Page

MGI

Description:

Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including egg cylinder and gonad. Orthologous to human MAGEB5 (MAGE family member B5).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

1700056A17Rik; melanoma antigen, family B, 5; MGC151150; MGC151152; mMage-b; mMage-b5

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MAGEB5 (MAGE family member B5)	HGNC	Ensembl, HGNC, HomoloGene, OrthoDB, Panther, PhylomeDB
Rattus norvegicus (Norway rat):	Mageb5 (MAGE family member B5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MAGEB5 (MAGE family member B5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC119868182 (melanoma-associated antigen B5-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC100513636 (melanoma-associated antigen B3-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MAGEB5 (MAGE family member B5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MAGEB5 (MAGE family member B5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Mageb5 (MAGE family member B5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ndnl2 (necdin-like 2)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	MAGE	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	NSE3	Alliance	DIOPT (Hieranoid\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	nsmce3	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)

Related Pseudogenes:

Gm4911

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	90,823,214 - 90,826,582 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	90,823,150 - 90,826,624 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	91,779,608 - 91,782,976 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	91,779,544 - 91,783,018 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	89,024,947 - 89,028,315 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	88,032,263 - 88,035,737 (-)	NCBI		MGSCv36	mm8
Celera	X	59,203,706 - 59,207,074 (+)	NCBI		Celera
Cytogenetic Map	X	C2	NCBI
cM Map	X	40.5	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Neurodevelopmental Disorders (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

bisphenol A (ISO)

genistein (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of transcription by RNA polymerase II (IBA)

Cellular Component

nucleus (IBA)

Molecular Function

molecular_function (ND)

References

References - curated

#	Reference Title	Reference Citation
1.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10349636	PMID:11042159	PMID:11076861	PMID:11454705	PMID:12466851	PMID:12477932	PMID:16141072	PMID:16141073	PMID:21267068	PMID:21873635	PMID:31143371

Genomics

Comparative Map Data

Mageb5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	90,823,214 - 90,826,582 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	90,823,150 - 90,826,624 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	91,779,608 - 91,782,976 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	91,779,544 - 91,783,018 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	89,024,947 - 89,028,315 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	88,032,263 - 88,035,737 (-)	NCBI		MGSCv36	mm8
Celera	X	59,203,706 - 59,207,074 (+)	NCBI		Celera
Cytogenetic Map	X	C2	NCBI
cM Map	X	40.5	NCBI

MAGEB5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	26,216,169 - 26,218,270 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	26,216,169 - 26,218,270 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	26,234,286 - 26,236,387 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	26,144,178 - 26,146,308 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	X	30,361,713 - 30,363,673 (+)	NCBI		Celera
Cytogenetic Map	X	p21.3	NCBI
HuRef	X	23,972,837 - 23,974,938 (+)	NCBI		HuRef
CHM1_1	X	26,265,947 - 26,268,048 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	25,803,479 - 25,805,580 (+)	NCBI		T2T-CHM13v2.0

Mageb5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	60,454,155 - 60,457,732 (-)	NCBI		GRCr8
mRatBN7.2	X	56,478,928 - 56,495,736 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	56,478,948 - 56,496,921 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	57,838,640 - 57,842,217 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	61,338,991 - 61,342,568 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	58,957,078 - 58,960,659 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	60,849,005 - 60,852,583 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	60,849,014 - 60,852,583 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	61,434,582 - 61,438,151 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	79,036,635 - 79,040,204 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	56,969,057 - 56,972,630 (-)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

MAGEB5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	28,019,097 - 28,021,331 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	28,022,478 - 28,024,711 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	18,817,671 - 18,819,765 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	26,181,734 - 26,183,828 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	26,182,861 - 26,183,688 (+)	Ensembl	panpan1.1		panPan2

LOC119868182
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ROS_Cfam_1.0	X	21,604,761 - 21,607,157 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	X	21,636,247 - 21,638,639 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	21,675,916 - 21,678,313 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	21,729,260 - 21,731,656 (+)	NCBI		UU_Cfam_GSD_1.0

LOC100513636
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	X	22,188,608 - 22,189,561 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	23,771,151 - 23,774,263 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAGEB5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	24,682,389 - 24,686,715 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666056	26,614,855 - 26,616,970 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Mageb5
95 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	19
Count of miRNA genes:	18
Interacting mature miRNAs:	18
Transcripts:	ENSMUST00000082048
Prediction methods:	Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357433	Dbts2_m	diabetes 2 (mouse)			Not determined		X	7226295	150107038	Mouse
4141630	Gct6_m	granulosa cell tumorigenesis 6 (mouse)			Not determined			47179121	129764756	Mouse
13824980	Ferq1_m	genetic fertility QTL 1 (mouse)					X	54045360	148782996	Mouse
13464140	Hdlq108_m	HDL QTL 108 (mouse)					X	57771960	91771960	Mouse
25314318	Sccor2_m	synaptonemal complex length to mean MLH1 count ratio 2 (mouse)					X	70543606	96543606	Mouse
4141665	Mhysq2_m	male hybrid sterility QTL 2 (mouse)			Not determined			71453852	139203212	Mouse
12879918	Shm4_m	sperm head morphology 4 (mouse)					X	72072050	102062720	Mouse
1357500	Mdmsc6_m	modifier of muscularity 6 (mouse)			Not determined		X	75306671	109306758	Mouse
1302054	Gct4_m	granulosa cell tumorigenesis 4 (mouse)			Not determined		X	76124336	102062720	Mouse
11075102	Modc2_m	modifier of Odc2 (mouse)					X	80189914	114190059	Mouse
4141803	Lmr30_m	leishmaniasis resistance 30 (mouse)			Not determined			85062606	119062720	Mouse

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_028847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AK006807	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL645491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC116773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC116775	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466611	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000082048 ⟹ ENSMUSP00000080706

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	X	90,823,150 - 90,826,624 (-)	Ensembl
GRCm38.p6 Ensembl	X	91,779,544 - 91,783,018 (-)	Ensembl

RefSeq Acc Id:

NM_028847 ⟹ NP_083123

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	X	90,823,214 - 90,826,582 (-)	NCBI
GRCm38	X	91,779,608 - 91,782,976 (-)	NCBI
MGSCv37	X	89,024,947 - 89,028,315 (-)	RGD
Celera	X	59,203,706 - 59,207,074 (+)	RGD
cM Map	X		ENTREZGENE

Sequence:

show sequence

CGTTTGTCCAGAGGACACTGAATCTATCCAGATGATAGGGAGAATCATCCACTTCTGAAGAGTA
TACTTCTACTTATTGTAGTCACCATGCCCAGGGGTCAGAAGAATAAGCACCACCGCAACCGCTT
GAAGAATAAGAAACACAACCAAGAGAAAGTCCATCCTCAAAAAGATGAGTCTCAGGAGAAAGGC
CATCATAAAAGAGATGATTTTCAAGATCATAAGGAAGCAAGGGATAATGCAGCAGTAGAAGAAA
AGTCTTCTTGCTCTTCCCCTTCTGTGCCTGGGGAGACTCTTGAGAAGCCACCAGCTTCCAAAAC
AAGTAGTGACGCTGGATGGCTTTCCTGTGTATCATCGCCTGCCACTGTTTGTGGAGATGAATTA
GAATTTGATGATGGTACTTACTTTCACTGTGGGGGGAACTCATTATACTCAGAGTATCGAACCT
GCCAAGAAAATCCATGCAAACATTGCCTAGATATGTATGTGAATCTTGTGGAGCAGTATGTACT
CTACAAATTTAAAATGAAAAAACTCATTGACAGAAATGAATTAATAGATCTTATTGAACCAAAG
TACCGGTATAATTTTAGTGATATATTTAAAAGAGCTTTTGAGAACATTGAAATTGTGTTTGCAG
CTAGTGTGATTGAAATTGACTCAACTAATCACGTTTATGATCTAGTCAGCAAGCTAAAACTCCC
CAACAAAGGAAGGGTTTGCCCTGGCAGGGGTTTACCAAAAACTGGTCTTCTTATGACTATCCTG
GCTATGATTTTTATGAACGGTAACTCTGCTTCTGAGGAAGACATTTGGAAATTCCTGAATTATA
TGCAAGTGTACCCAGGGAGGAAGCATTTTATTTATAGAGAGCCACGGAAGCTCATCACTCAAGA
TTTCGTAAAACTGAAGTACCTGGAATACAAGCAGATATCCCTTAGTGATCCTCCATGCTATCGG
TTCCAATGGGGTCCAAAAGCTTATACTGAAACTACCAAGATGAAAGTCCTAGAATTTATGGCTA
AAGGCAGTGGCGTTGAACCTAGTACTTTTTCTGTACAATATACAGAAGCTTTGAGAGAAGAAAA
TCAAAAGACCAAGATAAGAAAATGGTATCCCATCCTGGCACAAAAACATTGTCCAGGACATAGC
CATCAACATGTCCAGAAGGTTATGAAACCTCAATAAATTATGAGACATTACCTTCGGAAAAGAA
ATTATAACATCACGTTTGAGATTTTCTTTGAAGCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_083123	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI16774	(Get FASTA)	NCBI Sequence Viewer
	AAI16776	(Get FASTA)	NCBI Sequence Viewer
	BAB24751	(Get FASTA)	NCBI Sequence Viewer
	EDL20559	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000080706
	ENSMUSP00000080706.3

RefSeq Acc Id:

NP_083123 ⟸ NM_028847

- UniProtKB:

Q14AN0 (UniProtKB/TrEMBL), Q9D9K4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPRGQKNKHHRNRLKNKKHNQEKVHPQKDESQEKGHHKRDDFQDHKEARDNAAVEEKSSCSSPS
VPGETLEKPPASKTSSDAGWLSCVSSPATVCGDELEFDDGTYFHCGGNSLYSEYRTCQENPCKH
CLDMYVNLVEQYVLYKFKMKKLIDRNELIDLIEPKYRYNFSDIFKRAFENIEIVFAASVIEIDS
TNHVYDLVSKLKLPNKGRVCPGRGLPKTGLLMTILAMIFMNGNSASEEDIWKFLNYMQVYPGRK
HFIYREPRKLITQDFVKLKYLEYKQISLSDPPCYRFQWGPKAYTETTKMKVLEFMAKGSGVEPS
TFSVQYTEALREENQKTKIRKWYPILAQKHCPGHSHQHVQKVMKPQ

hide sequence

RefSeq Acc Id:

ENSMUSP00000080706 ⟸ ENSMUST00000082048

Protein Domains

MAGE

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q14AN0-F1-model_v2	AlphaFold	Q14AN0	1-366	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2148169	AgrOrtholog
Ensembl Genes	ENSMUSG00000061392	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000082048	ENTREZGENE
	ENSMUST00000082048.3	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.1200	UniProtKB/TrEMBL
	1.10.10.1210	UniProtKB/TrEMBL
InterPro	MAGE	UniProtKB/TrEMBL
	MAGE	UniProtKB/TrEMBL
	MAGE_N	UniProtKB/TrEMBL
	MAGE_WH1	UniProtKB/TrEMBL
	MAGE_WH2	UniProtKB/TrEMBL
KEGG Report	mmu:74271	UniProtKB/TrEMBL
MGD	MGI:2148169	ENTREZGENE
NCBI Gene	74271	ENTREZGENE
PANTHER	MELANOMA-ASSOCIATED ANTIGEN B5	UniProtKB/TrEMBL
	PTHR11736	UniProtKB/TrEMBL
Pfam	MAGE	UniProtKB/TrEMBL
	MAGE_N	UniProtKB/TrEMBL
PhenoGen	Mageb5	PhenoGen
PROSITE	MAGE	UniProtKB/TrEMBL
SMART	MAGE	UniProtKB/TrEMBL
UniProt	Q14AN0	ENTREZGENE, UniProtKB/TrEMBL
	Q9D9K4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-09-01	Mageb5	MAGE family member B5	Mageb5	melanoma antigen, family B, 5	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar