Cd209b (CD209b antigen) - Rat Genome Database
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Gene: Cd209b (CD209b antigen) Mus musculus
Analyze
Symbol: Cd209b
Name: CD209b antigen
RGD ID: 1557900
MGI Page MGI
Description: Exhibits (1->3)-beta-D-glucan binding activity and mannose binding activity. Involved in several processes, including detection of other organism; phagocytosis, recognition; and positive regulation of tumor necrosis factor production. Localizes to external side of plasma membrane. Human ortholog(s) of this gene implicated in Coronavirus infectious disease (multiple); aspergillosis; dengue disease; human immunodeficiency virus infectious disease; and tuberculosis. Orthologous to several human genes including CD209 (CD209 molecule); PARTICIPATES IN measles pathway; tuberculosis pathway; INTERACTS WITH 4-hydroxyphenyl retinamide; benzo[a]pyrene; dibutyl phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1810030I22Rik; CD209 antigen-like protein B; DC-SIGN-related protein 1; DC-SIGNR1; mSI; mSIGNR1; OtB7; SI; SIGNR1
RGD Orthologs
Human
Rat
Bonobo
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,967,655 - 3,976,841 (-)NCBIGRCm39mm39
GRCm3883,917,655 - 3,926,841 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,917,655 - 3,926,844 (-)EnsemblGRCm38mm10GRCm38
MGSCv3783,917,657 - 3,926,814 (-)NCBIGRCm37mm9NCBIm37
MGSCv3683,917,657 - 3,926,814 (-)NCBImm8
Celera83,005,643 - 3,014,800 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Chan VS, etal., Nat Genet. 2006 Jan;38(1):38-46. doi: 10.1038/ng1698. Epub 2005 Dec 20.
2. da Silva RC, etal., Mol Biol Rep. 2014 Aug;41(8):5449-57. doi: 10.1007/s11033-014-3416-y. Epub 2014 May 30.
3. Fayssel N, etal., Clin Microbiol Infect. 2015 May;21(5):513.e1-5. doi: 10.1016/j.cmi.2014.12.012. Epub 2014 Dec 27.
4. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Khoo US, etal., Hong Kong Med J. 2008 Aug;14 Suppl 4:31-5.
6. Koppel EA, etal., Eur J Immunol. 2005 Oct;35(10):2962-9. doi: 10.1002/eji.200526216.
7. Liu H, etal., J Infect Dis. 2006 Mar 1;193(5):698-702. doi: 10.1086/499820. Epub 2006 Jan 27.
8. MGD data from the GO Consortium
9. MGD IEA
10. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. Pipeline to import KEGG annotations from KEGG into RGD
12. RGD automated import pipeline
13. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. RGD automated import pipeline for gene-chemical interactions
15. Saunders SP, etal., Infect Immun. 2009 Jan;77(1):399-404. doi: 10.1128/IAI.00762-08. Epub 2008 Nov 3.
16. Tang NL, etal., Nat Genet. 2007 Jun;39(6):691-2; author reply 694-6. doi: 10.1038/ng0607-691.
17. Tanne A, etal., J Exp Med. 2009 Sep 28;206(10):2205-20. doi: 10.1084/jem.20090188. Epub 2009 Sep 21.
18. Wieland CW, etal., Microbes Infect. 2007 Feb;9(2):134-41. doi: 10.1016/j.micinf.2006.10.018. Epub 2006 Dec 14.
19. Zhi L, etal., Nat Genet. 2007 Jun;39(6):692-4; author reply 694-6. doi: 10.1038/ng0607-692.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11581173   PMID:11581396   PMID:12137941   PMID:12351402   PMID:14707091   PMID:15136555   PMID:15583012   PMID:15588578   PMID:16141072  
PMID:16141073   PMID:16386217   PMID:16682406   PMID:17617634   PMID:18343501   PMID:19520061   PMID:19617348   PMID:20130211   PMID:20488784   PMID:20835248   PMID:21257969   PMID:21267068  
PMID:21400494   PMID:21899704   PMID:22207132   PMID:22331432   PMID:23118208   PMID:23238564   PMID:23926325   PMID:24204274   PMID:24434373   PMID:24478092   PMID:24491912   PMID:25226443  
PMID:25870292   PMID:26079881   PMID:26106150   PMID:26447454   PMID:27480124   PMID:29275858   PMID:31201093   PMID:31358982   PMID:31998663  


Genomics

Comparative Map Data
Cd209b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,967,655 - 3,976,841 (-)NCBIGRCm39mm39
GRCm3883,917,655 - 3,926,841 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,917,655 - 3,926,844 (-)EnsemblGRCm38mm10GRCm38
MGSCv3783,917,657 - 3,926,814 (-)NCBIGRCm37mm9NCBIm37
MGSCv3683,917,657 - 3,926,814 (-)NCBImm8
Celera83,005,643 - 3,014,800 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
CLEC4M
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl197,763,149 - 7,769,605 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl197,763,210 - 7,769,605 (+)EnsemblGRCh38hg38GRCh38
GRCh38197,763,243 - 7,769,605 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37197,828,035 - 7,834,491 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,734,081 - 7,740,491 (+)NCBINCBI36hg18NCBI36
Celera197,699,445 - 7,705,764 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef197,498,098 - 7,504,416 (+)NCBIHuRef
CHM1_1197,827,770 - 7,834,226 (+)NCBICHM1_1
Clec4m
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0122,817,633 - 2,826,303 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,816,065 - 2,826,378 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,967,129 - 4,975,729 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,256,452 - 2,265,053 (+)NCBIRGSC3.4rn4RGSC3.4
Celera123,768,182 - 3,776,781 (-)NCBICelera
Cytogenetic Map12p12NCBI
LOC100978434
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1197,916,430 - 7,922,634 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0197,062,961 - 7,069,381 (+)NCBIMhudiblu_PPA_v0panPan3


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124701082Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130397432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131723288Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:774
Count of miRNA genes:344
Interacting mature miRNAs:379
Transcripts:ENSMUST00000084086, ENSMUST00000111014, ENSMUST00000171635
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001037800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001287211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_026972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_104430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006508870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC121948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF373409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF374471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF422108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424801 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF424803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK007656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DS033264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000084086   ⟹   ENSMUSP00000081104
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl83,917,657 - 3,926,833 (-)Ensembl
RefSeq Acc Id: ENSMUST00000111014   ⟹   ENSMUSP00000106643
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl83,917,655 - 3,926,844 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171635   ⟹   ENSMUSP00000126070
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl83,918,606 - 3,926,833 (-)Ensembl
RefSeq Acc Id: ENSMUST00000188386   ⟹   ENSMUSP00000140695
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl83,918,677 - 3,926,813 (-)Ensembl
RefSeq Acc Id: NM_001037800   ⟹   NP_001032889
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3983,967,655 - 3,976,841 (-)NCBI
GRCm3883,917,655 - 3,926,841 (-)NCBI
MGSCv3783,917,657 - 3,926,814 (-)RGD
Celera83,005,641 - 3,014,827 (-)NCBI
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001287211   ⟹   NP_001274140
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3983,967,655 - 3,976,841 (-)NCBI
GRCm3883,917,655 - 3,926,841 (-)NCBI
Celera83,005,641 - 3,014,827 (-)NCBI
Sequence:
RefSeq Acc Id: NM_026972   ⟹   NP_081248
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3983,967,655 - 3,976,841 (-)NCBI
GRCm3883,917,655 - 3,926,841 (-)NCBI
MGSCv3783,917,657 - 3,926,814 (-)RGD
Celera83,005,641 - 3,014,827 (-)NCBI
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_104430
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3983,967,655 - 3,976,841 (-)NCBI
GRCm3883,917,655 - 3,926,841 (-)NCBI
Celera83,005,641 - 3,014,827 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006508870   ⟹   XP_006508933
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3983,968,706 - 3,976,838 (-)NCBI
GRCm3883,918,714 - 3,926,838 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001032889 (Get FASTA)   NCBI Sequence Viewer  
  NP_001274140 (Get FASTA)   NCBI Sequence Viewer  
  NP_081248 (Get FASTA)   NCBI Sequence Viewer  
  XP_006508933 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL13235 (Get FASTA)   NCBI Sequence Viewer  
  AAL27540 (Get FASTA)   NCBI Sequence Viewer  
  AAN31450 (Get FASTA)   NCBI Sequence Viewer  
  AAN75585 (Get FASTA)   NCBI Sequence Viewer  
  AAN75586 (Get FASTA)   NCBI Sequence Viewer  
  AAN75587 (Get FASTA)   NCBI Sequence Viewer  
  AAN75588 (Get FASTA)   NCBI Sequence Viewer  
  AAN75589 (Get FASTA)   NCBI Sequence Viewer  
  AAN75590 (Get FASTA)   NCBI Sequence Viewer  
  AAN75591 (Get FASTA)   NCBI Sequence Viewer  
  AAN75592 (Get FASTA)   NCBI Sequence Viewer  
  AAN75593 (Get FASTA)   NCBI Sequence Viewer  
  AAN75594 (Get FASTA)   NCBI Sequence Viewer  
  AAN75595 (Get FASTA)   NCBI Sequence Viewer  
  AAN75596 (Get FASTA)   NCBI Sequence Viewer  
  AAN75597 (Get FASTA)   NCBI Sequence Viewer  
  AAN75598 (Get FASTA)   NCBI Sequence Viewer  
  BAB25166 (Get FASTA)   NCBI Sequence Viewer  
  BAE23855 (Get FASTA)   NCBI Sequence Viewer  
  EDL01253 (Get FASTA)   NCBI Sequence Viewer  
  EDL01254 (Get FASTA)   NCBI Sequence Viewer  
  EDL01255 (Get FASTA)   NCBI Sequence Viewer  
  EDL01256 (Get FASTA)   NCBI Sequence Viewer  
  Q8CJ91 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_081248   ⟸   NM_026972
- Peptide Label: isoform a
- UniProtKB: Q8CJ91 (UniProtKB/Swiss-Prot),   Q3UTX5 (UniProtKB/TrEMBL),   Q8CJ85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001032889   ⟸   NM_001037800
- Peptide Label: isoform b
- UniProtKB: Q8CJ91 (UniProtKB/Swiss-Prot),   Q3UTX5 (UniProtKB/TrEMBL),   Q8CJ85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001274140   ⟸   NM_001287211
- Peptide Label: isoform c
- UniProtKB: Q8CJ91 (UniProtKB/Swiss-Prot),   Q3UTX5 (UniProtKB/TrEMBL),   Q8CJ85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006508933   ⟸   XM_006508870
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000106643   ⟸   ENSMUST00000111014
RefSeq Acc Id: ENSMUSP00000126070   ⟸   ENSMUST00000171635
RefSeq Acc Id: ENSMUSP00000140695   ⟸   ENSMUST00000188386
RefSeq Acc Id: ENSMUSP00000081104   ⟸   ENSMUST00000084086
Protein Domains
C-type lectin

Promoters
RGD ID:8666361
Promoter ID:EPDNEW_M11212
Type:multiple initiation site
Name:Cd209b_1
Description:Mus musculus CD209b antigen , transcript variant 3, non-codingRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3883,926,814 - 3,926,874EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916415 AgrOrtholog
Ensembl Genes ENSMUSG00000065987 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000081104 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000106643 UniProtKB/TrEMBL
  ENSMUSP00000126070 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000140695 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000084086 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000111014 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000171635 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000188386 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CD209-like_CTLD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:69165 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1916415 ENTREZGENE
NCBI Gene 69165 ENTREZGENE
Pfam Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd209b PhenoGen
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.175163 ENTREZGENE
UniProt C209B_MOUSE UniProtKB/Swiss-Prot
  Q3UTX5 ENTREZGENE, UniProtKB/TrEMBL
  Q8CJ85 ENTREZGENE, UniProtKB/TrEMBL
  Q8CJ91 ENTREZGENE
UniProt Secondary Q8BGZ0 UniProtKB/Swiss-Prot
  Q8BHK7 UniProtKB/Swiss-Prot
  Q8CJ86 UniProtKB/Swiss-Prot
  Q8CJ87 UniProtKB/Swiss-Prot
  Q8CJ88 UniProtKB/Swiss-Prot
  Q8CJ89 UniProtKB/Swiss-Prot
  Q8CJ90 UniProtKB/Swiss-Prot
  Q8CJ92 UniProtKB/Swiss-Prot
  Q8CJ93 UniProtKB/Swiss-Prot
  Q8CJ94 UniProtKB/Swiss-Prot
  Q91ZW4 UniProtKB/Swiss-Prot
  Q91ZX0 UniProtKB/Swiss-Prot
  Q9D8V4 UniProtKB/Swiss-Prot