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Gene: Sh2d1a (SH2 domain containing 1A) Mus musculus
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Symbol: Sh2d1a
Name: SH2 domain containing 1A
Description: Predicted to have SH3/SH2 adaptor activity. Involved in humoral immune response and positive regulation of natural killer cell mediated cytotoxicity. Predicted to localize to the cytoplasm. Used to study X-linked lymphoproliferative syndrome 1. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome. Orthologous to human SH2D1A (SH2 domain containing 1A); PARTICIPATES IN measles pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; carbon nanotube; chloroprene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Duncan disease homolog; Gm686; SAP; SH2 domain protein 1A; SH2 domain-containing protein 1A; signaling lymphocytic activation molecule-associated protein; SLAM-associated protein; SLAM-associated protein isoform SAP-2; T-cell signal transduction molecule SAP
Orthologs:
Homo sapiens (human) : SH2D1A (SH2 domain containing 1A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sh2d1a (SH2 domain containing 1A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh2d1a (SH2 domain containing 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : SH2D1A (SH2 domain containing 1A)
Canis lupus familiaris (dog) : SH2D1A (SH2 domain containing 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh2d1a (SH2 domain containing 1A)
Sus scrofa (pig) : SH2D1A (SH2 domain containing 1A)
Chlorocebus sabaeus (green monkey) : SH2D1A (SH2 domain containing 1A)
Heterocephalus glaber (naked mole-rat) : Sh2d1a (SH2 domain containing 1A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 EnsemblX42,502,453 - 42,529,330 (+)Ensembl
GRCm38X42,502,565 - 42,522,097 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X39,855,785 - 39,875,252 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X38,747,235 - 38,766,702 (+)NCBImm8
CeleraX30,076,629 - 30,095,977 (+)NCBICelera
Cytogenetic MapX A4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Sh2d1a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1557879
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.