Sash3 (SAM and SH3 domain containing 3) - Rat Genome Database

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Gene: Sash3 (SAM and SH3 domain containing 3) Mus musculus
Analyze
Symbol: Sash3
Name: SAM and SH3 domain containing 3
RGD ID: 1557861
MGI Page MGI
Description: Acts upstream of or within several processes, including positive regulation of gene expression; positive regulation of lymphocyte activation; and positive regulation of organ growth. Located in cytoplasm and nucleus. Is expressed in heart ventricle and thymus primordium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human SASH3 (SAM and SH3 domain containing 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1200013B08Rik; AW413946; Novel SH3 and SAM domain containing protein; RP23-351G20.2; SAM and SH3 domain-containing protein 3; SH3 protein expressed in lymphocytes; SL; SLY1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X47,235,313 - 47,250,442 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX47,235,313 - 47,250,442 (+)EnsemblGRCm39 Ensembl
GRCm38X48,146,436 - 48,161,565 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX48,146,436 - 48,161,565 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X45,499,704 - 45,514,740 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X44,391,154 - 44,406,190 (+)NCBIMGSCv36mm8
CeleraX35,648,999 - 35,664,024 (+)NCBICelera
Cytogenetic MapXA4NCBI
cM MapX25.54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11470164   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:16227612   PMID:18950867   PMID:19604361   PMID:21267068  
PMID:21873635   PMID:22922362   PMID:26306874   PMID:30631134   PMID:30759861   PMID:33876203   PMID:36401605  


Genomics

Comparative Map Data
Sash3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X47,235,313 - 47,250,442 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX47,235,313 - 47,250,442 (+)EnsemblGRCm39 Ensembl
GRCm38X48,146,436 - 48,161,565 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX48,146,436 - 48,161,565 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X45,499,704 - 45,514,740 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X44,391,154 - 44,406,190 (+)NCBIMGSCv36mm8
CeleraX35,648,999 - 35,664,024 (+)NCBICelera
Cytogenetic MapXA4NCBI
cM MapX25.54NCBI
SASH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X129,779,949 - 129,795,201 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX129,779,949 - 129,795,201 (+)EnsemblGRCh38hg38GRCh38
GRCh37X128,913,925 - 128,929,177 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X128,741,641 - 128,756,858 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X128,639,494 - 128,654,709NCBI
CeleraX129,300,396 - 129,315,681 (+)NCBICelera
Cytogenetic MapXq26.1NCBI
HuRefX118,315,088 - 118,330,679 (+)NCBIHuRef
CHM1_1X128,825,238 - 128,840,527 (+)NCBICHM1_1
T2T-CHM13v2.0X128,098,744 - 128,113,978 (+)NCBIT2T-CHM13v2.0
Sash3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X132,204,717 - 132,219,421 (+)NCBIGRCr8
mRatBN7.2X127,326,815 - 127,341,521 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX127,326,859 - 127,341,519 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX129,452,837 - 129,467,495 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X133,023,434 - 133,038,098 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X130,549,991 - 130,564,647 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X134,979,637 - 134,994,351 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX134,979,646 - 134,994,349 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X135,052,951 - 135,067,689 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X134,511,776 - 134,526,489 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX126,277,336 - 126,292,010 (+)NCBICelera
Cytogenetic MapXq36NCBI
Sash3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554735,222,408 - 5,237,260 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554735,224,635 - 5,237,066 (-)NCBIChiLan1.0ChiLan1.0
SASH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X129,203,040 - 129,218,311 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X129,206,616 - 129,221,925 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X118,909,980 - 118,924,779 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X129,207,049 - 129,222,342 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX129,207,049 - 129,222,342 (+)Ensemblpanpan1.1panPan2
SASH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X100,989,605 - 101,003,162 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX100,989,685 - 101,001,885 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX87,163,546 - 87,177,092 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X102,841,088 - 102,854,632 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX102,841,145 - 102,854,642 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X100,259,370 - 100,272,917 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X102,105,560 - 102,119,104 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X101,883,353 - 101,896,898 (+)NCBIUU_Cfam_GSD_1.0
Sash3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X99,222,104 - 99,235,375 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364791,750,746 - 1,765,361 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364791,752,180 - 1,765,330 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SASH3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX106,373,954 - 106,389,444 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X106,373,871 - 106,389,454 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X122,142,841 - 122,158,398 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SASH3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X105,057,782 - 105,072,994 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX105,057,570 - 105,073,354 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606542,472,786 - 42,488,013 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sash3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247979,001,795 - 9,018,027 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247979,001,846 - 9,017,441 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sash3
356 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:871
Count of miRNA genes:519
Interacting mature miRNAs:625
Transcripts:ENSMUST00000033427
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse
13208553Wght11_mweight 11 (mouse)X1186623959045360Mouse
13208557Lgth13_mbody length 13 (mouse)X1186623959045360Mouse
27226750Femd9_mfemur midshaft diameter 9, 10 week (mouse)X3333746355845360Mouse
27226780Femd12_mfemur midshaft diameter 12, 16 week (mouse)X3466365356845360Mouse
13208567Bmiq12_mbody mass index QTL 12 (mouse)X3526365377043606Mouse
1301009Pbwg7_mpostnatal body weight growth 7 (mouse)Not determinedX3911371473113814Mouse
4141565Pbwg21_mpostnatal body weight growth 21 (mouse)Not determinedX3911371473113814Mouse
1300794Spha2_msperm head anomaly 2 (mouse)Not determinedX3992149886260137Mouse
4142200Rtwq1_mreduced testis weight QTL 1 (mouse)Not determined4147706075477203Mouse
1301278Bdln1_mbody length 1 (mouse)Not determinedX4170210675702218Mouse
1300702Fcsa4_mfemoral cross-sectional area 4 (mouse)Not determinedX4602744480027567Mouse
1301212Bw19_mbody weight QTL 19 (mouse)Not determinedX4637692052412327Mouse
4141630Gct6_mgranulosa cell tumorigenesis 6 (mouse)Not determined47179121129764756Mouse

Markers in Region
AW413946  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X48,161,281 - 48,161,408UniSTSGRCm38
MGSCv37X45,514,458 - 45,514,585UniSTSGRCm37
CeleraX35,663,742 - 35,663,869UniSTS
Cytogenetic MapXA4UniSTS
Whitehead/MRC_RHX551.46UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000033427   ⟹   ENSMUSP00000033427
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX47,235,313 - 47,250,442 (+)Ensembl
GRCm38.p6 EnsemblX48,146,436 - 48,161,565 (+)Ensembl
RefSeq Acc Id: NM_001313749   ⟹   NP_001300678
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X47,235,313 - 47,250,442 (+)NCBI
GRCm38X48,146,436 - 48,161,565 (+)NCBI
Sequence:
RefSeq Acc Id: NM_028773   ⟹   NP_083049
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X47,235,313 - 47,250,442 (+)NCBI
GRCm38X48,146,436 - 48,161,565 (+)NCBI
MGSCv37X45,499,704 - 45,514,740 (+)RGD
CeleraX35,648,999 - 35,664,024 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NP_083049   ⟸   NM_028773
- Peptide Label: isoform 2
- UniProtKB: Q3TBX0 (UniProtKB/Swiss-Prot),   Q9DBV2 (UniProtKB/Swiss-Prot),   Q8K352 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001300678   ⟸   NM_001313749
- Peptide Label: isoform 1
- UniProtKB: Q8K352 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000033427   ⟸   ENSMUST00000033427
Protein Domains
SAM   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K352-F1-model_v2 AlphaFold Q8K352 1-380 view protein structure

Promoters
RGD ID:6846342
Promoter ID:MM_KWN:60202
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:OTTMUST00000042517
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X45,499,421 - 45,499,921 (+)MPROMDB
RGD ID:13680394
Promoter ID:EPDNEW_M24346
Type:initiation region
Name:Sash3_1
Description:Mus musculus SAM and SH3 domain containing 3 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X48,146,514 - 48,146,574EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921381 AgrOrtholog
Ensembl Genes ENSMUSG00000031101 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000033427 ENTREZGENE
  ENSMUST00000033427.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
InterPro rSAM/SH3_domain-containing UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
  SAM/pointed_sf UniProtKB/Swiss-Prot
  SASH3_SH3 UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report mmu:74131 UniProtKB/Swiss-Prot
MGD MGI:1921381 ENTREZGENE
NCBI Gene 74131 ENTREZGENE
PANTHER PTHR12301:SF5 UniProtKB/Swiss-Prot
  SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED UniProtKB/Swiss-Prot
Pfam SAM_1 UniProtKB/Swiss-Prot
  SH3_2 UniProtKB/Swiss-Prot
  SLY UniProtKB/Swiss-Prot
PhenoGen Sash3 PhenoGen
PROSITE SAM_DOMAIN UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
SMART SAM UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
UniProt Q3TBX0 ENTREZGENE
  Q8K352 ENTREZGENE
  Q9DBV2 ENTREZGENE
  SASH3_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3TBX0 UniProtKB/Swiss-Prot
  Q9DBV2 UniProtKB/Swiss-Prot